DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QBL9_LEIMA

TriTrypDb:

LmjF.22.1280 , LMJLV39_220018300 , LMJSD75_220018500

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.742
CLV_PCSK_KEX2_1	64	66	PF00082	0.718
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.718
CLV_PCSK_SKI1_1	11	15	PF00082	0.620
CLV_PCSK_SKI1_1	210	214	PF00082	0.665
CLV_PCSK_SKI1_1	345	349	PF00082	0.748
CLV_PCSK_SKI1_1	92	96	PF00082	0.629
DEG_COP1_1	150	158	PF00400	0.628
DEG_COP1_1	312	321	PF00400	0.564
DEG_Nend_UBRbox_2	1	3	PF02207	0.822
DOC_CKS1_1	259	264	PF01111	0.697
DOC_CYCLIN_RxL_1	207	217	PF00134	0.660
DOC_CYCLIN_RxL_1	8	16	PF00134	0.681
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.658
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.777
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.735
DOC_MAPK_gen_1	344	352	PF00069	0.590
DOC_PP2B_LxvP_1	133	136	PF13499	0.837
DOC_PP2B_LxvP_1	350	353	PF13499	0.733
DOC_PP2B_PxIxI_1	109	115	PF00149	0.702
DOC_USP7_MATH_1	128	132	PF00917	0.801
DOC_USP7_MATH_1	221	225	PF00917	0.542
DOC_USP7_MATH_1	244	248	PF00917	0.754
DOC_USP7_MATH_1	252	256	PF00917	0.654
DOC_USP7_MATH_1	30	34	PF00917	0.647
DOC_USP7_MATH_1	306	310	PF00917	0.789
DOC_USP7_MATH_1	378	382	PF00917	0.741
DOC_USP7_MATH_1	47	51	PF00917	0.509
DOC_USP7_MATH_1	52	56	PF00917	0.608
DOC_USP7_UBL2_3	98	102	PF12436	0.768
DOC_WW_Pin1_4	258	263	PF00397	0.702
DOC_WW_Pin1_4	283	288	PF00397	0.764
DOC_WW_Pin1_4	362	367	PF00397	0.786
DOC_WW_Pin1_4	42	47	PF00397	0.719
DOC_WW_Pin1_4	50	55	PF00397	0.588
DOC_WW_Pin1_4	80	85	PF00397	0.598
LIG_14-3-3_CanoR_1	3	13	PF00244	0.660
LIG_14-3-3_CanoR_1	328	338	PF00244	0.594
LIG_BIR_III_4	41	45	PF00653	0.723
LIG_EH1_1	7	15	PF00400	0.761
LIG_eIF4E_1	73	79	PF01652	0.796
LIG_FHA_1	119	125	PF00498	0.578
LIG_FHA_1	259	265	PF00498	0.774
LIG_FHA_1	5	11	PF00498	0.640
LIG_FHA_2	271	277	PF00498	0.750
LIG_FHA_2	298	304	PF00498	0.770
LIG_GBD_Chelix_1	382	390	PF00786	0.588
LIG_MYND_1	137	141	PF01753	0.770
LIG_NRP_CendR_1	388	391	PF00754	0.700
LIG_Pex14_2	17	21	PF04695	0.701
LIG_SH2_NCK_1	253	257	PF00017	0.716
LIG_SH2_NCK_1	272	276	PF00017	0.511
LIG_SH2_PTP2	111	114	PF00017	0.785
LIG_SH2_SRC	71	74	PF00017	0.797
LIG_SH2_STAP1	253	257	PF00017	0.712
LIG_SH2_STAP1	71	75	PF00017	0.795
LIG_SH2_STAT5	111	114	PF00017	0.785
LIG_SH2_STAT5	272	275	PF00017	0.748
LIG_SUMO_SIM_anti_2	261	268	PF11976	0.688
LIG_SUMO_SIM_par_1	111	117	PF11976	0.785
LIG_SUMO_SIM_par_1	261	268	PF11976	0.688
LIG_SUMO_SIM_par_1	286	292	PF11976	0.793
LIG_TRAF2_1	247	250	PF00917	0.529
LIG_TRAF2_1	300	303	PF00917	0.772
MOD_CK1_1	129	135	PF00069	0.848
MOD_CK1_1	150	156	PF00069	0.707
MOD_CK1_1	50	56	PF00069	0.586
MOD_CK2_1	244	250	PF00069	0.640
MOD_CK2_1	291	297	PF00069	0.826
MOD_CK2_1	378	384	PF00069	0.741
MOD_Cter_Amidation	96	99	PF01082	0.700
MOD_GlcNHglycan	106	109	PF01048	0.762
MOD_GlcNHglycan	127	131	PF01048	0.800
MOD_GlcNHglycan	156	159	PF01048	0.733
MOD_GlcNHglycan	163	166	PF01048	0.588
MOD_GlcNHglycan	223	226	PF01048	0.554
MOD_GlcNHglycan	254	257	PF01048	0.775
MOD_GlcNHglycan	302	307	PF01048	0.856
MOD_GlcNHglycan	308	311	PF01048	0.757
MOD_GlcNHglycan	319	322	PF01048	0.529
MOD_GlcNHglycan	331	334	PF01048	0.505
MOD_GlcNHglycan	41	45	PF01048	0.798
MOD_GlcNHglycan	49	52	PF01048	0.619
MOD_GlcNHglycan	54	57	PF01048	0.531
MOD_GSK3_1	147	154	PF00069	0.825
MOD_GSK3_1	298	305	PF00069	0.818
MOD_GSK3_1	306	313	PF00069	0.718
MOD_GSK3_1	324	331	PF00069	0.536
MOD_GSK3_1	348	355	PF00069	0.665
MOD_GSK3_1	80	87	PF00069	0.684
MOD_NEK2_1	104	109	PF00069	0.648
MOD_NEK2_1	147	152	PF00069	0.812
MOD_NEK2_1	181	186	PF00069	0.674
MOD_NEK2_1	79	84	PF00069	0.752
MOD_OFUCOSY	311	316	PF10250	0.620
MOD_PIKK_1	245	251	PF00454	0.525
MOD_PKA_1	345	351	PF00069	0.710
MOD_PKA_1	98	104	PF00069	0.497
MOD_Plk_1	147	153	PF00069	0.735
MOD_ProDKin_1	258	264	PF00069	0.698
MOD_ProDKin_1	283	289	PF00069	0.767
MOD_ProDKin_1	362	368	PF00069	0.790
MOD_ProDKin_1	42	48	PF00069	0.720
MOD_ProDKin_1	50	56	PF00069	0.585
MOD_ProDKin_1	80	86	PF00069	0.596
MOD_SUMO_rev_2	292	300	PF00179	0.636
TRG_ENDOCYTIC_2	111	114	PF00928	0.785
TRG_ENDOCYTIC_2	59	62	PF00928	0.679
TRG_NES_CRM1_1	9	20	PF08389	0.516
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.752
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.794

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICA2	Leishmania donovani	87%	100%
A4HCG5	Leishmania braziliensis	68%	100%
E9AGZ8	Leishmania infantum	87%	100%
E9AVW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%