Autophagy-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATG12/APG12, putative

Species:

Leishmania major

UniProt:

Q4QBL7_LEIMA

TriTrypDb:

LmjF.22.1300 , LMJLV39_220018500 , LMJSD75_220018700

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QBL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBL7

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	7
GO:0006950	response to stress	2	2
GO:0006995	cellular response to nitrogen starvation	5	2
GO:0007154	cell communication	2	2
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009267	cellular response to starvation	4	2
GO:0009605	response to external stimulus	2	2
GO:0009987	cellular process	1	7
GO:0009991	response to extracellular stimulus	3	2
GO:0031667	response to nutrient levels	4	2
GO:0031668	cellular response to extracellular stimulus	3	2
GO:0031669	cellular response to nutrient levels	4	2
GO:0033554	cellular response to stress	3	2
GO:0042594	response to starvation	3	2
GO:0043562	cellular response to nitrogen levels	5	2
GO:0044237	cellular metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0061919	process utilizing autophagic mechanism	2	7
GO:0071496	cellular response to external stimulus	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	198	200	PF00675	0.501
CLV_PCSK_KEX2_1	198	200	PF00082	0.501
CLV_PCSK_SKI1_1	112	116	PF00082	0.491
CLV_PCSK_SKI1_1	131	135	PF00082	0.206
CLV_PCSK_SKI1_1	24	28	PF00082	0.473
CLV_PCSK_SKI1_1	29	33	PF00082	0.487
DOC_MAPK_gen_1	117	126	PF00069	0.389
DOC_MAPK_HePTP_8	116	128	PF00069	0.233
DOC_MAPK_MEF2A_6	119	128	PF00069	0.508
DOC_PP4_FxxP_1	102	105	PF00568	0.695
DOC_USP7_MATH_1	133	137	PF00917	0.508
DOC_USP7_MATH_1	152	156	PF00917	0.508
DOC_USP7_MATH_1	46	50	PF00917	0.578
DOC_USP7_UBL2_3	108	112	PF12436	0.612
DOC_WW_Pin1_4	101	106	PF00397	0.723
DOC_WW_Pin1_4	51	56	PF00397	0.727
LIG_14-3-3_CanoR_1	117	122	PF00244	0.486
LIG_Actin_WH2_2	37	54	PF00022	0.647
LIG_FHA_1	37	43	PF00498	0.574
LIG_LIR_Apic_2	100	105	PF02991	0.693
LIG_LIR_Gen_1	13	21	PF02991	0.638
LIG_LIR_Gen_1	139	149	PF02991	0.437
LIG_LIR_Gen_1	168	177	PF02991	0.366
LIG_LIR_Nem_3	139	144	PF02991	0.437
LIG_LIR_Nem_3	159	164	PF02991	0.523
LIG_LIR_Nem_3	168	173	PF02991	0.437
LIG_NRBOX	172	178	PF00104	0.508
LIG_PCNA_yPIPBox_3	154	165	PF02747	0.508
LIG_RPA_C_Insects	114	129	PF08784	0.233
LIG_SH2_STAT5	172	175	PF00017	0.395
LIG_SH3_1	52	58	PF00018	0.719
LIG_SH3_2	7	12	PF14604	0.668
LIG_SH3_3	1	7	PF00018	0.763
LIG_SH3_3	146	152	PF00018	0.508
LIG_SH3_3	194	200	PF00018	0.496
LIG_SH3_3	52	58	PF00018	0.673
LIG_SH3_CIN85_PxpxPR_1	7	12	PF14604	0.668
LIG_SUMO_SIM_par_1	38	45	PF11976	0.554
LIG_WRC_WIRS_1	18	23	PF05994	0.530
LIG_WW_3	9	13	PF00397	0.717
MOD_CDK_SPxxK_3	101	108	PF00069	0.724
MOD_CK1_1	106	112	PF00069	0.411
MOD_CK1_1	136	142	PF00069	0.418
MOD_CK1_1	56	62	PF00069	0.725
MOD_CK1_1	64	70	PF00069	0.768
MOD_CK1_1	97	103	PF00069	0.662
MOD_CK2_1	117	123	PF00069	0.471
MOD_CK2_1	140	146	PF00069	0.508
MOD_GlcNHglycan	105	108	PF01048	0.485
MOD_GlcNHglycan	186	189	PF01048	0.651
MOD_GlcNHglycan	66	69	PF01048	0.707
MOD_GlcNHglycan	85	88	PF01048	0.758
MOD_GlcNHglycan	99	102	PF01048	0.561
MOD_GSK3_1	103	110	PF00069	0.509
MOD_GSK3_1	136	143	PF00069	0.508
MOD_GSK3_1	63	70	PF00069	0.730
MOD_GSK3_1	93	100	PF00069	0.647
MOD_NEK2_1	115	120	PF00069	0.350
MOD_NEK2_1	140	145	PF00069	0.508
MOD_NEK2_1	177	182	PF00069	0.395
MOD_NEK2_1	83	88	PF00069	0.642
MOD_NEK2_2	107	112	PF00069	0.553
MOD_NEK2_2	193	198	PF00069	0.492
MOD_PK_1	117	123	PF00069	0.433
MOD_Plk_1	177	183	PF00069	0.397
MOD_Plk_4	136	142	PF00069	0.508
MOD_Plk_4	152	158	PF00069	0.508
MOD_ProDKin_1	101	107	PF00069	0.719
MOD_ProDKin_1	51	57	PF00069	0.727
MOD_SUMO_rev_2	59	67	PF00179	0.724
TRG_DiLeu_BaEn_1	146	151	PF01217	0.508
TRG_DiLeu_BaEn_1	22	27	PF01217	0.586
TRG_ENDOCYTIC_2	15	18	PF00928	0.538
TRG_ER_diArg_1	128	131	PF00400	0.410
TRG_ER_diArg_1	197	199	PF00400	0.504
TRG_NES_CRM1_1	123	135	PF08389	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WX93	Leishmania donovani	93%	100%
A0A422MXH5	Trypanosoma rangeli	27%	100%
A4HCG9	Leishmania braziliensis	81%	100%
E9AH00	Leishmania infantum	93%	100%
E9AVW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%