Protein arginine methyltransferase NDUFAF7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative S-adenosyl-L-methionine-dependent methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QBL3_LEIMA

TriTrypDb:

LmjF.22.1340 , LMJLV39_220019100 , LMJSD75_220019700

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

Q4QBL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBL3

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	1
GO:0004190	aspartic-type endopeptidase activity	5	1
GO:0008168	methyltransferase activity	4	11
GO:0008170	N-methyltransferase activity	5	11
GO:0008233	peptidase activity	3	1
GO:0008276	protein methyltransferase activity	3	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016273	arginine N-methyltransferase activity	6	11
GO:0016274	protein-arginine N-methyltransferase activity	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.446
CLV_C14_Caspase3-7	349	353	PF00656	0.446
CLV_NRD_NRD_1	108	110	PF00675	0.426
CLV_NRD_NRD_1	254	256	PF00675	0.320
CLV_NRD_NRD_1	343	345	PF00675	0.446
CLV_NRD_NRD_1	425	427	PF00675	0.336
CLV_NRD_NRD_1	56	58	PF00675	0.503
CLV_NRD_NRD_1	61	63	PF00675	0.554
CLV_PCSK_KEX2_1	253	255	PF00082	0.321
CLV_PCSK_KEX2_1	342	344	PF00082	0.447

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E5	Leptomonas seymouri	86%	83%
A0A0S4JG91	Bodo saltans	60%	99%
A0A1X0NTX7	Trypanosomatidae	68%	85%
A0A3S7WXD7	Leishmania donovani	98%	100%
A4HCH2	Leishmania braziliensis	93%	100%
C9ZSP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	86%
E9AH02	Leishmania infantum	98%	100%
E9AVW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5D4I8	Trypanosoma cruzi	71%	85%

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