Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 11, putative

Species:

Leishmania major

UniProt:

Q4QBL2_LEIMA

TriTrypDb:

LmjF.22.1350 , LMJLV39_220019200 , LMJSD75_220019800

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	3
GO:0005794	Golgi apparatus	5	3
GO:0016020	membrane	2	13
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4QBL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBL2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	3
GO:0006605	protein targeting	5	3
GO:0006612	protein targeting to membrane	5	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0006897	endocytosis	5	3
GO:0008104	protein localization	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016192	vesicle-mediated transport	4	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018198	peptidyl-cysteine modification	6	3
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	3
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	3
GO:0018345	protein palmitoylation	6	3
GO:0019538	protein metabolic process	3	3
GO:0033036	macromolecule localization	2	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0043543	protein acylation	5	3
GO:0044238	primary metabolic process	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0051668	localization within membrane	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071704	organic substance metabolic process	2	3
GO:0071705	nitrogen compound transport	4	3
GO:0072657	protein localization to membrane	4	3
GO:0090150	establishment of protein localization to membrane	4	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016409	palmitoyltransferase activity	5	13
GO:0016417	S-acyltransferase activity	5	13
GO:0016740	transferase activity	2	13
GO:0016746	acyltransferase activity	3	13
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	13
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	13
GO:0019707	protein-cysteine S-acyltransferase activity	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.779
CLV_NRD_NRD_1	125	127	PF00675	0.262
CLV_NRD_NRD_1	257	259	PF00675	0.377
CLV_NRD_NRD_1	26	28	PF00675	0.293
CLV_NRD_NRD_1	285	287	PF00675	0.435
CLV_NRD_NRD_1	288	290	PF00675	0.428
CLV_NRD_NRD_1	352	354	PF00675	0.586
CLV_PCSK_FUR_1	24	28	PF00082	0.323
CLV_PCSK_FUR_1	286	290	PF00082	0.447
CLV_PCSK_KEX2_1	125	127	PF00082	0.263
CLV_PCSK_KEX2_1	197	199	PF00082	0.471
CLV_PCSK_KEX2_1	256	258	PF00082	0.368
CLV_PCSK_KEX2_1	26	28	PF00082	0.293
CLV_PCSK_KEX2_1	261	263	PF00082	0.377
CLV_PCSK_KEX2_1	287	289	PF00082	0.432
CLV_PCSK_KEX2_1	292	294	PF00082	0.480
CLV_PCSK_KEX2_1	351	353	PF00082	0.592
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.535
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.363
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.368
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.432
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.507
CLV_PCSK_PC7_1	257	263	PF00082	0.437
CLV_PCSK_PC7_1	288	294	PF00082	0.518
CLV_PCSK_SKI1_1	261	265	PF00082	0.405
CLV_PCSK_SKI1_1	289	293	PF00082	0.520
CLV_PCSK_SKI1_1	83	87	PF00082	0.321
DEG_APCC_DBOX_1	97	105	PF00400	0.555
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DOC_MAPK_MEF2A_6	210	217	PF00069	0.252
DOC_MAPK_MEF2A_6	64	71	PF00069	0.252
DOC_PP1_RVXF_1	233	240	PF00149	0.371
DOC_PP2B_LxvP_1	365	368	PF13499	0.692
DOC_SPAK_OSR1_1	64	68	PF12202	0.252
DOC_USP7_MATH_1	114	118	PF00917	0.614
DOC_USP7_MATH_1	25	29	PF00917	0.535
DOC_USP7_MATH_1	315	319	PF00917	0.777
DOC_USP7_MATH_1	354	358	PF00917	0.786
DOC_WW_Pin1_4	204	209	PF00397	0.312
LIG_14-3-3_CanoR_1	162	168	PF00244	0.512
LIG_14-3-3_CanoR_1	198	208	PF00244	0.278
LIG_14-3-3_CanoR_1	7	15	PF00244	0.690
LIG_APCC_ABBA_1	239	244	PF00400	0.512
LIG_BIR_III_4	327	331	PF00653	0.692
LIG_BRCT_BRCA1_1	384	388	PF00533	0.700
LIG_CaM_IQ_9	183	199	PF13499	0.416
LIG_EH1_1	183	191	PF00400	0.384
LIG_EVH1_2	208	212	PF00568	0.232
LIG_FHA_1	183	189	PF00498	0.458
LIG_FHA_1	329	335	PF00498	0.708
LIG_FHA_1	75	81	PF00498	0.298
LIG_FHA_2	322	328	PF00498	0.730
LIG_GBD_Chelix_1	67	75	PF00786	0.303
LIG_IRF3_LxIS_1	33	40	PF10401	0.518
LIG_IRF3_LxIS_1	65	72	PF10401	0.459
LIG_LIR_Apic_2	17	22	PF02991	0.568
LIG_LIR_Apic_2	202	208	PF02991	0.312
LIG_LIR_Apic_2	28	33	PF02991	0.507
LIG_LIR_Gen_1	249	255	PF02991	0.462
LIG_LIR_Gen_1	40	50	PF02991	0.430
LIG_LIR_Nem_3	12	18	PF02991	0.589
LIG_LIR_Nem_3	166	170	PF02991	0.400
LIG_LIR_Nem_3	249	254	PF02991	0.515
LIG_LIR_Nem_3	385	391	PF02991	0.733
LIG_LIR_Nem_3	40	45	PF02991	0.433
LIG_Pex14_1	15	19	PF04695	0.565
LIG_Pex14_2	123	127	PF04695	0.448
LIG_SH2_CRK	205	209	PF00017	0.312
LIG_SH2_SRC	242	245	PF00017	0.512
LIG_SH2_SRC	251	254	PF00017	0.516
LIG_SH2_SRC	30	33	PF00017	0.574
LIG_SH2_STAP1	184	188	PF00017	0.402
LIG_SH2_STAP1	251	255	PF00017	0.480
LIG_SH2_STAT3	184	187	PF00017	0.416
LIG_SH2_STAT3	267	270	PF00017	0.640
LIG_SH2_STAT3	89	92	PF00017	0.558
LIG_SH2_STAT5	184	187	PF00017	0.284
LIG_SH2_STAT5	242	245	PF00017	0.480
LIG_SH2_STAT5	364	367	PF00017	0.736
LIG_SH2_STAT5	386	389	PF00017	0.681
LIG_SH3_1	19	25	PF00018	0.549
LIG_SH3_2	22	27	PF14604	0.522
LIG_SH3_2	320	325	PF14604	0.651
LIG_SH3_3	19	25	PF00018	0.549
LIG_SH3_3	316	322	PF00018	0.777
LIG_SUMO_SIM_par_1	66	73	PF11976	0.330
LIG_Vh1_VBS_1	70	88	PF01044	0.216
LIG_WRC_WIRS_1	164	169	PF05994	0.386
LIG_WW_3	207	211	PF00397	0.192
MOD_CDC14_SPxK_1	207	210	PF00782	0.252
MOD_CDK_SPxK_1	204	210	PF00069	0.252
MOD_CK1_1	182	188	PF00069	0.410
MOD_CK1_1	276	282	PF00069	0.709
MOD_CK1_1	339	345	PF00069	0.751
MOD_CK1_1	382	388	PF00069	0.661
MOD_CK2_1	246	252	PF00069	0.503
MOD_CK2_1	25	31	PF00069	0.496
MOD_CK2_1	342	348	PF00069	0.776
MOD_GlcNHglycan	112	115	PF01048	0.420
MOD_GlcNHglycan	27	30	PF01048	0.311
MOD_GlcNHglycan	327	331	PF01048	0.540
MOD_GlcNHglycan	341	345	PF01048	0.607
MOD_GlcNHglycan	357	360	PF01048	0.550
MOD_GlcNHglycan	381	384	PF01048	0.520
MOD_GlcNHglycan	39	42	PF01048	0.339
MOD_GSK3_1	110	117	PF00069	0.649
MOD_GSK3_1	243	250	PF00069	0.448
MOD_GSK3_1	336	343	PF00069	0.759
MOD_GSK3_1	377	384	PF00069	0.756
MOD_GSK3_1	70	77	PF00069	0.298
MOD_N-GLC_2	153	155	PF02516	0.253
MOD_NEK2_1	163	168	PF00069	0.323
MOD_NEK2_1	243	248	PF00069	0.460
MOD_NEK2_1	37	42	PF00069	0.514
MOD_NEK2_1	69	74	PF00069	0.338
MOD_NEK2_1	75	80	PF00069	0.280
MOD_OFUCOSY	149	155	PF10250	0.262
MOD_PIKK_1	199	205	PF00454	0.272
MOD_PIKK_1	266	272	PF00454	0.599
MOD_PIKK_1	336	342	PF00454	0.741
MOD_PK_1	133	139	PF00069	0.503
MOD_PKA_2	25	31	PF00069	0.504
MOD_Plk_1	315	321	PF00069	0.727
MOD_Plk_4	163	169	PF00069	0.425
MOD_Plk_4	179	185	PF00069	0.443
MOD_Plk_4	70	76	PF00069	0.363
MOD_ProDKin_1	204	210	PF00069	0.312
MOD_SUMO_rev_2	11	18	PF00179	0.659
MOD_SUMO_rev_2	269	279	PF00179	0.657
TRG_DiLeu_BaEn_4	259	265	PF01217	0.499
TRG_ENDOCYTIC_2	161	164	PF00928	0.463
TRG_ENDOCYTIC_2	242	245	PF00928	0.550
TRG_ENDOCYTIC_2	251	254	PF00928	0.463
TRG_ENDOCYTIC_2	364	367	PF00928	0.777
TRG_ER_diArg_1	125	127	PF00400	0.463
TRG_ER_diArg_1	23	26	PF00400	0.504
TRG_ER_diArg_1	285	288	PF00400	0.647
TRG_ER_diArg_1	350	353	PF00400	0.791
TRG_NLS_MonoCore_2	285	290	PF00514	0.696
TRG_NLS_MonoExtN_4	286	291	PF00514	0.695
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	66%	97%
A0A0S4IT15	Bodo saltans	24%	100%
A0A1X0NUX2	Trypanosomatidae	50%	100%
A0A3R7RC91	Trypanosoma rangeli	46%	100%
A0A3S5H6J6	Leishmania donovani	31%	100%
A0A3S7WX91	Leishmania donovani	93%	100%
A4HCH5	Leishmania braziliensis	73%	99%
C9ZSP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A148	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E7EZI4	Danio rerio	27%	92%
E7F4Z4	Danio rerio	26%	68%
E7FH11	Danio rerio	26%	85%
E9AH03	Leishmania infantum	93%	100%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9QCD3	Danio rerio	27%	77%
P0C7U3	Homo sapiens	26%	100%
Q14AK4	Mus musculus	28%	100%
Q2TGJ1	Rattus norvegicus	26%	100%
Q4QGX1	Leishmania major	30%	100%
Q6DR03	Arabidopsis thaliana	26%	70%
Q8R0N9	Mus musculus	28%	82%
Q8WTX9	Homo sapiens	28%	81%
Q9H8X9	Homo sapiens	26%	96%
V5B8P9	Trypanosoma cruzi	46%	100%
V5BWI0	Trypanosoma cruzi	27%	100%