Intraflagellar transport protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein-like protein

Species:

Leishmania major

UniProt:

Q4QBL0_LEIMA

TriTrypDb:

LmjF.22.1370 , LMJLV39_220019400 , LMJSD75_220020000

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	11
GO:0030990	intraciliary transport particle	2	2
GO:0030992	intraciliary transport particle B	2	11
GO:0031514	motile cilium	5	9
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	4	1
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	1
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

Q4QBL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBL0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0035735	intraciliary transport involved in cilium assembly	4	2
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11
GO:0006996	organelle organization	4	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0030030	cell projection organization	4	9
GO:0030031	cell projection assembly	5	9
GO:0044782	cilium organization	5	9
GO:0060271	cilium assembly	6	9
GO:0070925	organelle assembly	5	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0120031	plasma membrane bounded cell projection assembly	6	9
GO:0120036	plasma membrane bounded cell projection organization	5	9
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006754	ATP biosynthetic process	8	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009142	nucleoside triphosphate biosynthetic process	6	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009145	purine nucleoside triphosphate biosynthetic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0015986	proton motive force-driven ATP synthesis	9	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046034	ATP metabolic process	7	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0048487	beta-tubulin binding	5	11
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.525
CLV_C14_Caspase3-7	66	70	PF00656	0.299
CLV_NRD_NRD_1	110	112	PF00675	0.369
CLV_NRD_NRD_1	144	146	PF00675	0.382
CLV_NRD_NRD_1	208	210	PF00675	0.478
CLV_NRD_NRD_1	211	213	PF00675	0.485
CLV_NRD_NRD_1	373	375	PF00675	0.442
CLV_NRD_NRD_1	422	424	PF00675	0.391
CLV_NRD_NRD_1	453	455	PF00675	0.396
CLV_PCSK_FUR_1	209	213	PF00082	0.518
CLV_PCSK_KEX2_1	110	112	PF00082	0.386
CLV_PCSK_KEX2_1	144	146	PF00082	0.382
CLV_PCSK_KEX2_1	198	200	PF00082	0.427
CLV_PCSK_KEX2_1	210	212	PF00082	0.436
CLV_PCSK_KEX2_1	353	355	PF00082	0.482
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.427
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.436
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.513
CLV_PCSK_SKI1_1	144	148	PF00082	0.504
CLV_PCSK_SKI1_1	205	209	PF00082	0.403
CLV_PCSK_SKI1_1	369	373	PF00082	0.428
CLV_PCSK_SKI1_1	386	390	PF00082	0.421
CLV_PCSK_SKI1_1	423	427	PF00082	0.397
CLV_Separin_Metazoa	202	206	PF03568	0.408
DEG_APCC_DBOX_1	303	311	PF00400	0.511
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DOC_CYCLIN_RxL_1	364	373	PF00134	0.438
DOC_MAPK_gen_1	110	119	PF00069	0.366
DOC_MAPK_gen_1	237	245	PF00069	0.367
DOC_MAPK_MEF2A_6	112	121	PF00069	0.382
DOC_MAPK_MEF2A_6	506	515	PF00069	0.411
DOC_PP1_SILK_1	205	210	PF00149	0.448
DOC_USP7_MATH_1	238	242	PF00917	0.431
DOC_USP7_MATH_1	262	266	PF00917	0.524
DOC_USP7_MATH_1	393	397	PF00917	0.406
DOC_USP7_MATH_1	4	8	PF00917	0.536
LIG_14-3-3_CanoR_1	261	271	PF00244	0.444
LIG_14-3-3_CanoR_1	323	330	PF00244	0.458
LIG_14-3-3_CanoR_1	423	433	PF00244	0.559
LIG_14-3-3_CanoR_1	52	57	PF00244	0.518
LIG_EH1_1	163	171	PF00400	0.421
LIG_FHA_1	338	344	PF00498	0.547
LIG_FHA_1	345	351	PF00498	0.453
LIG_FHA_1	420	426	PF00498	0.455
LIG_FHA_1	479	485	PF00498	0.487
LIG_FHA_1	493	499	PF00498	0.359
LIG_FHA_1	524	530	PF00498	0.644
LIG_FHA_2	237	243	PF00498	0.430
LIG_FHA_2	254	260	PF00498	0.544
LIG_FHA_2	292	298	PF00498	0.507
LIG_FHA_2	340	346	PF00498	0.687
LIG_FHA_2	498	504	PF00498	0.455
LIG_FHA_2	64	70	PF00498	0.488
LIG_FHA_2	75	81	PF00498	0.348
LIG_LIR_Gen_1	115	126	PF02991	0.463
LIG_LIR_Gen_1	407	417	PF02991	0.547
LIG_LIR_Gen_1	462	471	PF02991	0.517
LIG_LIR_Gen_1	485	494	PF02991	0.377
LIG_LIR_Nem_3	115	121	PF02991	0.469
LIG_LIR_Nem_3	152	156	PF02991	0.359
LIG_LIR_Nem_3	23	28	PF02991	0.395
LIG_LIR_Nem_3	407	412	PF02991	0.557
LIG_LIR_Nem_3	462	467	PF02991	0.475
LIG_LIR_Nem_3	485	490	PF02991	0.365
LIG_Pex14_1	478	482	PF04695	0.491
LIG_SH2_CRK	156	160	PF00017	0.482
LIG_SH2_CRK	433	437	PF00017	0.433
LIG_SH2_PTP2	25	28	PF00017	0.380
LIG_SH2_PTP2	487	490	PF00017	0.435
LIG_SH2_STAT5	25	28	PF00017	0.380
LIG_SH2_STAT5	433	436	PF00017	0.468
LIG_SH2_STAT5	487	490	PF00017	0.428
LIG_SH2_STAT5	497	500	PF00017	0.352
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.370
LIG_TRAF2_1	134	137	PF00917	0.393
LIG_TRAF2_1	182	185	PF00917	0.372
LIG_TRAF2_1	256	259	PF00917	0.524
LIG_TRAF2_1	266	269	PF00917	0.440
LIG_TRAF2_1	281	284	PF00917	0.328
LIG_TRAF2_1	468	471	PF00917	0.442
LIG_UBA3_1	203	210	PF00899	0.449
LIG_UBA3_1	232	237	PF00899	0.540
LIG_Vh1_VBS_1	117	135	PF01044	0.431
LIG_WRC_WIRS_1	292	297	PF05994	0.392
MOD_CK1_1	322	328	PF00069	0.507
MOD_CK1_1	480	486	PF00069	0.402
MOD_CK1_1	55	61	PF00069	0.457
MOD_CK2_1	131	137	PF00069	0.432
MOD_CK2_1	221	227	PF00069	0.394
MOD_CK2_1	238	244	PF00069	0.366
MOD_CK2_1	253	259	PF00069	0.355
MOD_CK2_1	262	268	PF00069	0.401
MOD_CK2_1	465	471	PF00069	0.412
MOD_CK2_1	497	503	PF00069	0.486
MOD_GlcNHglycan	11	14	PF01048	0.528
MOD_GlcNHglycan	264	267	PF01048	0.430
MOD_GlcNHglycan	274	277	PF01048	0.370
MOD_GlcNHglycan	35	39	PF01048	0.426
MOD_GlcNHglycan	395	398	PF01048	0.454
MOD_GlcNHglycan	426	429	PF01048	0.366
MOD_GlcNHglycan	530	533	PF01048	0.550
MOD_GlcNHglycan	6	9	PF01048	0.578
MOD_GlcNHglycan	98	102	PF01048	0.493
MOD_GSK3_1	121	128	PF00069	0.445
MOD_GSK3_1	253	260	PF00069	0.481
MOD_GSK3_1	333	340	PF00069	0.758
MOD_GSK3_1	4	11	PF00069	0.624
MOD_GSK3_1	462	469	PF00069	0.499
MOD_GSK3_1	51	58	PF00069	0.447
MOD_GSK3_1	528	535	PF00069	0.571
MOD_N-GLC_1	272	277	PF02516	0.490
MOD_N-GLC_1	337	342	PF02516	0.542
MOD_N-GLC_1	52	57	PF02516	0.400
MOD_N-GLC_1	86	91	PF02516	0.543
MOD_N-GLC_2	219	221	PF02516	0.337
MOD_NEK2_1	236	241	PF00069	0.485
MOD_NEK2_1	257	262	PF00069	0.393
MOD_NEK2_1	477	482	PF00069	0.359
MOD_NEK2_1	530	535	PF00069	0.550
MOD_NEK2_1	74	79	PF00069	0.361
MOD_NEK2_2	221	226	PF00069	0.530
MOD_PIKK_1	310	316	PF00454	0.430
MOD_PIKK_1	322	328	PF00454	0.404
MOD_PIKK_1	345	351	PF00454	0.557
MOD_PIKK_1	466	472	PF00454	0.435
MOD_PIKK_1	492	498	PF00454	0.537
MOD_PIKK_1	55	61	PF00454	0.457
MOD_PK_1	52	58	PF00069	0.399
MOD_PKA_1	211	217	PF00069	0.399
MOD_PKA_2	211	217	PF00069	0.399
MOD_PKA_2	253	259	PF00069	0.522
MOD_PKA_2	262	268	PF00069	0.524
MOD_PKA_2	322	328	PF00069	0.426
MOD_PKA_2	51	57	PF00069	0.555
MOD_PKB_1	209	217	PF00069	0.402
MOD_PKB_1	435	443	PF00069	0.503
MOD_Plk_1	20	26	PF00069	0.408
MOD_Plk_1	52	58	PF00069	0.399
MOD_Plk_1	86	92	PF00069	0.558
MOD_Plk_2-3	291	297	PF00069	0.391
MOD_Plk_2-3	407	413	PF00069	0.563
MOD_Plk_4	291	297	PF00069	0.391
MOD_Plk_4	52	58	PF00069	0.393
MOD_SUMO_for_1	182	185	PF00179	0.395
MOD_SUMO_for_1	225	228	PF00179	0.473
MOD_SUMO_for_1	388	391	PF00179	0.461
MOD_SUMO_for_1	96	99	PF00179	0.515
MOD_SUMO_rev_2	123	128	PF00179	0.489
MOD_SUMO_rev_2	194	200	PF00179	0.461
MOD_SUMO_rev_2	265	274	PF00179	0.424
MOD_SUMO_rev_2	355	363	PF00179	0.529
MOD_SUMO_rev_2	368	376	PF00179	0.350
MOD_SUMO_rev_2	379	388	PF00179	0.398
MOD_SUMO_rev_2	396	404	PF00179	0.397
TRG_AP2beta_CARGO_1	407	416	PF09066	0.550
TRG_DiLeu_BaEn_1	228	233	PF01217	0.381
TRG_DiLeu_BaEn_1	45	50	PF01217	0.380
TRG_DiLeu_BaEn_1	510	515	PF01217	0.375
TRG_DiLeu_BaEn_2	290	296	PF01217	0.393
TRG_DiLeu_BaEn_4	137	143	PF01217	0.358
TRG_DiLeu_BaEn_4	98	104	PF01217	0.480
TRG_ENDOCYTIC_2	156	159	PF00928	0.491
TRG_ENDOCYTIC_2	25	28	PF00928	0.380
TRG_ENDOCYTIC_2	433	436	PF00928	0.433
TRG_ENDOCYTIC_2	487	490	PF00928	0.503
TRG_ER_diArg_1	144	146	PF00400	0.382
TRG_ER_diArg_1	208	211	PF00400	0.453
TRG_ER_diArg_1	473	476	PF00400	0.494
TRG_ER_diArg_1	488	491	PF00400	0.507
TRG_NES_CRM1_1	319	333	PF08389	0.501
TRG_NES_CRM1_1	503	516	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E7	Leptomonas seymouri	79%	90%
A0A1X0NTR4	Trypanosomatidae	59%	89%
A0A3R7KQW5	Trypanosoma rangeli	58%	90%
A0A3S7WX98	Leishmania donovani	98%	90%
A4HCH3	Leishmania braziliensis	92%	100%
C9ZSP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	90%
E9AH05	Leishmania infantum	98%	100%
E9AVW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q6RCE1	Chlamydomonas reinhardtii	23%	84%
Q8BKE9	Mus musculus	25%	89%
Q96LB3	Homo sapiens	26%	89%
V5B464	Trypanosoma cruzi	58%	90%