Protein MAK16 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mak-16-like RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QBK9_LEIMA

TriTrypDb:

LmjF.22.1380 , LMJLV39_220019500 , LMJSD75_220020100

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	2
GO:0005840	ribosome	5	1

Expansion

Sequence features

Q4QBK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBK9

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.393
CLV_NRD_NRD_1	148	150	PF00675	0.285
CLV_NRD_NRD_1	171	173	PF00675	0.342
CLV_NRD_NRD_1	238	240	PF00675	0.575
CLV_NRD_NRD_1	76	78	PF00675	0.285
CLV_PCSK_KEX2_1	124	126	PF00082	0.394
CLV_PCSK_KEX2_1	140	142	PF00082	0.301
CLV_PCSK_KEX2_1	147	149	PF00082	0.285
CLV_PCSK_KEX2_1	240	242	PF00082	0.572
CLV_PCSK_KEX2_1	76	78	PF00082	0.285
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.454
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.183
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.627
CLV_PCSK_SKI1_1	125	129	PF00082	0.413
CLV_PCSK_SKI1_1	165	169	PF00082	0.312
CLV_PCSK_SKI1_1	184	188	PF00082	0.285
DEG_APCC_DBOX_1	258	266	PF00400	0.659
DEG_Nend_UBRbox_3	1	3	PF02207	0.468
DOC_CYCLIN_RxL_1	162	169	PF00134	0.274
DOC_MAPK_gen_1	109	117	PF00069	0.285
DOC_MAPK_gen_1	237	246	PF00069	0.558
DOC_MAPK_gen_1	76	84	PF00069	0.285
DOC_MAPK_MEF2A_6	77	86	PF00069	0.406
DOC_PP1_RVXF_1	24	30	PF00149	0.370
DOC_USP7_UBL2_3	105	109	PF12436	0.285
LIG_Actin_WH2_2	156	174	PF00022	0.285
LIG_deltaCOP1_diTrp_1	4	15	PF00928	0.301
LIG_FHA_2	20	26	PF00498	0.285
LIG_FHA_2	52	58	PF00498	0.285
LIG_GBD_Chelix_1	106	114	PF00786	0.394
LIG_IBAR_NPY_1	32	34	PF08397	0.285
LIG_LIR_Gen_1	175	182	PF02991	0.294
LIG_LIR_Gen_1	185	191	PF02991	0.274
LIG_LIR_Gen_1	198	207	PF02991	0.285
LIG_LIR_Gen_1	5	15	PF02991	0.301
LIG_LIR_Gen_1	60	69	PF02991	0.293
LIG_LIR_Nem_3	133	138	PF02991	0.449
LIG_LIR_Nem_3	14	18	PF02991	0.342
LIG_LIR_Nem_3	175	179	PF02991	0.303
LIG_LIR_Nem_3	185	190	PF02991	0.304
LIG_LIR_Nem_3	198	203	PF02991	0.301
LIG_LIR_Nem_3	208	214	PF02991	0.271
LIG_LIR_Nem_3	60	66	PF02991	0.293
LIG_PTB_Apo_2	46	53	PF02174	0.285
LIG_PTB_Phospho_1	46	52	PF10480	0.285
LIG_SH2_CRK	176	180	PF00017	0.285
LIG_SH2_CRK	52	56	PF00017	0.285
LIG_SH2_PTP2	135	138	PF00017	0.455
LIG_SH2_SRC	63	66	PF00017	0.301
LIG_SH2_STAP1	176	180	PF00017	0.285
LIG_SH2_STAP1	52	56	PF00017	0.285
LIG_SH2_STAT5	120	123	PF00017	0.371
LIG_SH2_STAT5	135	138	PF00017	0.455
LIG_SH2_STAT5	63	66	PF00017	0.287
LIG_SH3_3	83	89	PF00018	0.406
LIG_UBA3_1	114	118	PF00899	0.285
LIG_UBA3_1	167	173	PF00899	0.320
LIG_WRC_WIRS_1	15	20	PF05994	0.285
MOD_CK2_1	51	57	PF00069	0.272
MOD_N-GLC_1	233	238	PF02516	0.607
MOD_N-GLC_1	34	39	PF02516	0.285
MOD_NEK2_1	11	16	PF00069	0.342
MOD_NEK2_1	84	89	PF00069	0.301
MOD_PKA_1	172	178	PF00069	0.342
MOD_PKB_1	170	178	PF00069	0.301
MOD_Plk_1	84	90	PF00069	0.320
MOD_Plk_4	175	181	PF00069	0.285
MOD_Plk_4	51	57	PF00069	0.285
MOD_SUMO_rev_2	137	146	PF00179	0.290
MOD_SUMO_rev_2	97	107	PF00179	0.285
TRG_DiLeu_BaEn_3	209	215	PF01217	0.320
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.285
TRG_ENDOCYTIC_2	135	138	PF00928	0.455
TRG_ENDOCYTIC_2	176	179	PF00928	0.285
TRG_ENDOCYTIC_2	52	55	PF00928	0.285
TRG_ENDOCYTIC_2	63	66	PF00928	0.285
TRG_ER_diArg_1	122	125	PF00400	0.390
TRG_ER_diArg_1	146	149	PF00400	0.287
TRG_ER_diArg_1	256	259	PF00400	0.675
TRG_ER_diArg_1	75	77	PF00400	0.285
TRG_NLS_MonoCore_2	122	127	PF00514	0.480
TRG_NLS_MonoExtN_4	123	128	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR3	Leptomonas seymouri	85%	100%
A0A0S4J1F1	Bodo saltans	70%	100%
A0A1X0NTJ2	Trypanosomatidae	78%	100%
A0A3Q8IBI4	Leishmania donovani	96%	100%
A0A422N295	Trypanosoma rangeli	78%	100%
A4HCH9	Leishmania braziliensis	94%	100%
C9ZSQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	97%
E9AH06	Leishmania infantum	96%	100%
E9AVX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P10962	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	87%
P46435	Schistosoma mansoni	44%	100%
Q1RML7	Bos taurus	46%	90%
Q55DJ3	Dictyostelium discoideum	44%	86%
Q66L33	Xenopus laevis	46%	89%
Q6NYD4	Danio rerio	49%	88%
Q6P7N1	Xenopus tropicalis	46%	89%
Q7ZYG5	Xenopus laevis	46%	88%
Q8BGS0	Mus musculus	46%	90%
Q9BXY0	Homo sapiens	46%	89%
Q9UTE6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	88%
V5ANU4	Trypanosoma cruzi	73%	99%