TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBK8_LEIMA

TriTrypDb:

LmjF.22.1390 , LMJLV39_220019600 , LMJSD75_220020200

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.422
CLV_PCSK_KEX2_1	69	71	PF00082	0.340
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.340
CLV_PCSK_SKI1_1	158	162	PF00082	0.382
CLV_PCSK_SKI1_1	197	201	PF00082	0.328
CLV_PCSK_SKI1_1	212	216	PF00082	0.361
CLV_PCSK_SKI1_1	29	33	PF00082	0.379
CLV_Separin_Metazoa	10	14	PF03568	0.592
DOC_CYCLIN_RxL_1	192	203	PF00134	0.409
DOC_MAPK_MEF2A_6	197	206	PF00069	0.274
DOC_PP2B_LxvP_1	249	252	PF13499	0.404
DOC_USP7_MATH_1	186	190	PF00917	0.538
DOC_USP7_MATH_1	40	44	PF00917	0.741
DOC_USP7_UBL2_3	82	86	PF12436	0.491
DOC_WW_Pin1_4	45	50	PF00397	0.567
LIG_14-3-3_CanoR_1	158	164	PF00244	0.322
LIG_14-3-3_CanoR_1	17	22	PF00244	0.521
LIG_14-3-3_CanoR_1	212	220	PF00244	0.307
LIG_APCC_ABBA_1	145	150	PF00400	0.404
LIG_APCC_ABBA_1	220	225	PF00400	0.343
LIG_APCC_ABBAyCdc20_2	219	225	PF00400	0.343
LIG_FHA_1	160	166	PF00498	0.393
LIG_FHA_1	201	207	PF00498	0.285
LIG_FHA_1	213	219	PF00498	0.308
LIG_FHA_2	36	42	PF00498	0.672
LIG_LIR_Nem_3	225	230	PF02991	0.446
LIG_PDZ_Class_3	253	258	PF00595	0.522
LIG_REV1ctd_RIR_1	81	90	PF16727	0.337
LIG_SH2_SRC	108	111	PF00017	0.352
LIG_SH2_STAP1	108	112	PF00017	0.320
LIG_SH2_STAP1	79	83	PF00017	0.341
LIG_SH2_STAT5	135	138	PF00017	0.517
LIG_TRAF2_1	48	51	PF00917	0.561
LIG_UBA3_1	199	207	PF00899	0.336
LIG_WRC_WIRS_1	18	23	PF05994	0.500
MOD_CK1_1	20	26	PF00069	0.604
MOD_CK2_1	250	256	PF00069	0.437
MOD_CK2_1	35	41	PF00069	0.547
MOD_CK2_1	4	10	PF00069	0.633
MOD_CK2_1	45	51	PF00069	0.697
MOD_Cter_Amidation	67	70	PF01082	0.362
MOD_GlcNHglycan	23	26	PF01048	0.666
MOD_GlcNHglycan	41	45	PF01048	0.693
MOD_GlcNHglycan	5	9	PF01048	0.535
MOD_GSK3_1	13	20	PF00069	0.565
MOD_GSK3_1	191	198	PF00069	0.453
MOD_GSK3_1	250	257	PF00069	0.522
MOD_GSK3_1	32	39	PF00069	0.538
MOD_GSK3_1	40	47	PF00069	0.638
MOD_NEK2_1	200	205	PF00069	0.314
MOD_NEK2_1	21	26	PF00069	0.577
MOD_PKA_2	176	182	PF00069	0.579
MOD_Plk_1	108	114	PF00069	0.313
MOD_Plk_4	250	256	PF00069	0.349
MOD_ProDKin_1	45	51	PF00069	0.563
MOD_SUMO_rev_2	174	183	PF00179	0.428
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J7D9	Bodo saltans	46%	76%
A0A1X0NU43	Trypanosomatidae	38%	72%
A0A422N2C4	Trypanosoma rangeli	41%	74%
A4HCH6	Leishmania braziliensis	74%	97%
C9ZSQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	68%
E9AH07	Leishmania infantum	97%	100%
E9AVX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5D4J4	Trypanosoma cruzi	39%	75%