Putative aquaporin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative aquaporin

Gene product:

aquaporin, putative

Species:

Leishmania major

UniProt:

Q4QBK5_LEIMA

TriTrypDb:

LmjF.22.1420 , LMJLV39_220019900 , LMJSD75_220020500

Length:

301

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	35
GO:0110165	cellular anatomical entity	1	35
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QBK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBK5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006833	water transport	5	2
GO:0042044	fluid transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	35
GO:0015267	channel activity	4	35
GO:0022803	passive transmembrane transporter activity	3	35
GO:0022857	transmembrane transporter activity	2	35
GO:0005372	water transmembrane transporter activity	4	2
GO:0015250	water channel activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.659
CLV_NRD_NRD_1	150	152	PF00675	0.271
CLV_PCSK_KEX2_1	149	151	PF00082	0.312
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.283
CLV_PCSK_SKI1_1	192	196	PF00082	0.456
CLV_PCSK_SKI1_1	257	261	PF00082	0.528
DOC_CKS1_1	249	254	PF01111	0.425
DOC_CYCLIN_RxL_1	254	264	PF00134	0.210
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.190
DOC_MAPK_gen_1	149	156	PF00069	0.490
DOC_MAPK_MEF2A_6	27	34	PF00069	0.560
DOC_PP2B_LxvP_1	90	93	PF13499	0.238
DOC_PP2B_PxIxI_1	251	257	PF00149	0.394
DOC_PP4_FxxP_1	178	181	PF00568	0.268
DOC_USP7_MATH_1	269	273	PF00917	0.227
DOC_USP7_MATH_1	30	34	PF00917	0.701
DOC_USP7_MATH_1	73	77	PF00917	0.455
DOC_WW_Pin1_4	248	253	PF00397	0.427
DOC_WW_Pin1_4	265	270	PF00397	0.204
LIG_14-3-3_CanoR_1	257	263	PF00244	0.255
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BRCT_BRCA1_1	105	109	PF00533	0.333
LIG_BRCT_BRCA1_1	112	116	PF00533	0.302
LIG_BRCT_BRCA1_1	67	71	PF00533	0.611
LIG_FHA_1	129	135	PF00498	0.337
LIG_FHA_1	199	205	PF00498	0.272
LIG_FHA_1	249	255	PF00498	0.329
LIG_FHA_1	54	60	PF00498	0.632
LIG_FHA_1	83	89	PF00498	0.285
LIG_GBD_Chelix_1	79	87	PF00786	0.288
LIG_Integrin_isoDGR_2	174	176	PF01839	0.523
LIG_LIR_Apic_2	177	181	PF02991	0.267
LIG_LIR_Gen_1	106	116	PF02991	0.346
LIG_LIR_Gen_1	142	152	PF02991	0.461
LIG_LIR_Gen_1	186	195	PF02991	0.264
LIG_LIR_Gen_1	197	208	PF02991	0.300
LIG_LIR_Gen_1	288	297	PF02991	0.373
LIG_LIR_Gen_1	68	79	PF02991	0.524
LIG_LIR_Gen_1	85	94	PF02991	0.256
LIG_LIR_Nem_3	117	121	PF02991	0.275
LIG_LIR_Nem_3	142	147	PF02991	0.483
LIG_LIR_Nem_3	197	203	PF02991	0.272
LIG_LIR_Nem_3	288	294	PF02991	0.299
LIG_LIR_Nem_3	68	74	PF02991	0.542
LIG_LIR_Nem_3	85	89	PF02991	0.262
LIG_PCNA_yPIPBox_3	185	195	PF02747	0.317
LIG_PDZ_Class_3	296	301	PF00595	0.582
LIG_Pex14_2	224	228	PF04695	0.210
LIG_Pex14_2	82	86	PF04695	0.327
LIG_SH2_STAT5	120	123	PF00017	0.444
LIG_SH2_STAT5	155	158	PF00017	0.288
LIG_SH2_STAT5	169	172	PF00017	0.278
LIG_SH2_STAT5	291	294	PF00017	0.505
LIG_SH3_3	14	20	PF00018	0.777
LIG_SH3_3	241	247	PF00018	0.422
LIG_SH3_3	32	38	PF00018	0.735
LIG_SH3_3	44	50	PF00018	0.579
LIG_SUMO_SIM_anti_2	251	257	PF11976	0.307
LIG_SUMO_SIM_anti_2	85	91	PF11976	0.296
LIG_SUMO_SIM_par_1	33	39	PF11976	0.545
LIG_SUMO_SIM_par_1	85	91	PF11976	0.286
LIG_TYR_ITIM	289	294	PF00017	0.299
LIG_WRC_WIRS_1	115	120	PF05994	0.237
LIG_WRC_WIRS_1	129	134	PF05994	0.184
LIG_WRC_WIRS_1	144	149	PF05994	0.443
LIG_WRC_WIRS_1	199	204	PF05994	0.270
LIG_WRC_WIRS_1	259	264	PF05994	0.233
LIG_WRC_WIRS_1	83	88	PF05994	0.281
MOD_CK1_1	198	204	PF00069	0.257
MOD_CK1_1	28	34	PF00069	0.694
MOD_CK2_1	136	142	PF00069	0.371
MOD_CK2_1	258	264	PF00069	0.257
MOD_CMANNOS	274	277	PF00535	0.274
MOD_GlcNHglycan	121	124	PF01048	0.237
MOD_GlcNHglycan	21	24	PF01048	0.514
MOD_GlcNHglycan	240	243	PF01048	0.433
MOD_GlcNHglycan	27	30	PF01048	0.485
MOD_GlcNHglycan	44	47	PF01048	0.413
MOD_GlcNHglycan	75	78	PF01048	0.212
MOD_GSK3_1	110	117	PF00069	0.306
MOD_GSK3_1	265	272	PF00069	0.251
MOD_GSK3_1	61	68	PF00069	0.608
MOD_GSK3_1	88	95	PF00069	0.284
MOD_NEK2_1	110	115	PF00069	0.260
MOD_NEK2_1	136	141	PF00069	0.493
MOD_NEK2_1	183	188	PF00069	0.258
MOD_NEK2_1	195	200	PF00069	0.249
MOD_NEK2_1	82	87	PF00069	0.301
MOD_NEK2_1	88	93	PF00069	0.317
MOD_NEK2_2	65	70	PF00069	0.651
MOD_OFUCOSY	232	237	PF10250	0.210
MOD_PIKK_1	211	217	PF00454	0.540
MOD_Plk_4	110	116	PF00069	0.292
MOD_Plk_4	195	201	PF00069	0.275
MOD_Plk_4	203	209	PF00069	0.271
MOD_Plk_4	269	275	PF00069	0.243
MOD_Plk_4	285	291	PF00069	0.256
MOD_Plk_4	30	36	PF00069	0.576
MOD_Plk_4	55	61	PF00069	0.512
MOD_Plk_4	82	88	PF00069	0.285
MOD_Plk_4	92	98	PF00069	0.290
MOD_ProDKin_1	248	254	PF00069	0.427
MOD_ProDKin_1	265	271	PF00069	0.204
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.528
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.355
TRG_ENDOCYTIC_2	144	147	PF00928	0.508
TRG_ENDOCYTIC_2	169	172	PF00928	0.291
TRG_ENDOCYTIC_2	291	294	PF00928	0.444
TRG_ER_diArg_1	150	152	PF00400	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D2	Leptomonas seymouri	78%	100%
A0A0N1ILB4	Leptomonas seymouri	42%	100%
A0A0N1PB10	Leptomonas seymouri	39%	100%
A0A0S4IS36	Bodo saltans	31%	86%
A0A0S4IS78	Bodo saltans	38%	100%
A0A0S4JRP5	Bodo saltans	28%	90%
A0A0S4KLV5	Bodo saltans	42%	100%
A0A1X0ND19	Trypanosomatidae	42%	100%
A0A1X0NRT6	Trypanosomatidae	38%	67%
A0A1X0NT73	Trypanosomatidae	38%	100%
A0A1X0NTY8	Trypanosomatidae	66%	100%
A0A3R7RFH0	Trypanosoma rangeli	39%	100%
A0A3S5H7B2	Leishmania donovani	94%	100%
A0A3S5H7S4	Leishmania donovani	37%	100%
A0A3S7X8F2	Leishmania donovani	41%	100%
A0A422N493	Trypanosoma rangeli	64%	100%
A0A422N886	Trypanosoma rangeli	37%	71%
A0A422NSX8	Trypanosoma rangeli	42%	100%
A0A6M3QG69	Musa acuminata	25%	100%
A2IBY8	Canis lupus familiaris	28%	100%
A4HBA6	Leishmania braziliensis	41%	100%
A4HCI0	Leishmania braziliensis	75%	100%
A4HKM8	Leishmania braziliensis	35%	100%
A4HKM9	Leishmania braziliensis	37%	75%
A4I001	Leishmania infantum	94%	100%
A4I859	Leishmania infantum	37%	100%
A4IAF4	Leishmania infantum	41%	100%
A4L9J0	Oryctolagus cuniculus	29%	100%
A8W649	Sus scrofa	26%	100%
E9AVX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B316	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B5H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
F9UUD2	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	27%	100%
O26206	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
O62735	Ovis aries	28%	100%
O68874	Shigella flexneri	26%	100%
O94778	Homo sapiens	26%	100%
P06624	Bos taurus	29%	100%
P08995	Glycine max	28%	100%
P09011	Rattus norvegicus	28%	100%
P0C112	Brucella abortus biovar 1 (strain 9-941)	29%	100%
P0CD91	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	99%
P0DO54	Musa acuminata	26%	100%
P25794	Pisum sativum	26%	100%
P25818	Arabidopsis thaliana	30%	100%
P29975	Rattus norvegicus	25%	100%
P30302	Arabidopsis thaliana	27%	100%
P34080	Rattus norvegicus	28%	100%
P41181	Homo sapiens	27%	100%
P42767	Atriplex canescens	27%	100%
P43287	Arabidopsis thaliana	27%	100%
P47863	Rattus norvegicus	26%	93%
P47864	Rattus norvegicus	26%	100%
P47865	Bos taurus	26%	100%
P49173	Nicotiana alata	22%	100%
P50501	Pelophylax lessonae	25%	100%
P51180	Mus musculus	28%	100%
P55064	Homo sapiens	26%	100%
P55087	Homo sapiens	26%	93%
P55088	Mus musculus	27%	93%
P56401	Ovis aries	24%	100%
P56402	Mus musculus	29%	100%
P56404	Mus musculus	24%	100%
P56405	Rattus norvegicus	26%	100%
P60844	Escherichia coli (strain K12)	26%	100%
P60845	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	100%
P61837	Arabidopsis thaliana	23%	100%
P61838	Vicia faba	23%	100%
P73809	Synechocystis sp. (strain PCC 6803 / Kazusa)	28%	100%
P79099	Bos taurus	28%	100%
P93004	Arabidopsis thaliana	25%	100%
Q06019	Lithobates pipiens	28%	100%
Q06611	Arabidopsis thaliana	26%	100%
Q08451	Solanum lycopersicum	23%	100%
Q08733	Arabidopsis thaliana	24%	100%
Q0DK16	Oryza sativa subsp. japonica	26%	100%
Q0IWF3	Oryza sativa subsp. japonica	26%	97%
Q19KC1	Zea mays	23%	100%
Q23808	Cicadella viridis	30%	100%
Q25074	Haematobia irritans exigua	27%	100%
Q2YR68	Brucella abortus (strain 2308)	29%	100%
Q39196	Arabidopsis thaliana	23%	100%
Q40746	Oryza sativa subsp. japonica	27%	100%
Q41870	Zea mays	25%	100%
Q41951	Arabidopsis thaliana	28%	100%
Q41963	Arabidopsis thaliana	31%	100%
Q4Q2F7	Leishmania major	41%	100%
Q4Q538	Leishmania major	38%	100%
Q54WT8	Dictyostelium discoideum	28%	100%
Q5I4F8	Notomys alexis	25%	100%
Q5I4F9	Notomys alexis	26%	92%
Q5R819	Pongo abelii	26%	100%
Q5Z6F0	Oryza sativa subsp. japonica	28%	100%
Q5Z9E2	Oryza sativa subsp. japonica	27%	100%
Q651D5	Oryza sativa subsp. japonica	25%	100%
Q67WJ8	Oryza sativa subsp. japonica	23%	100%
Q6EU94	Oryza sativa subsp. japonica	25%	100%
Q6J8I9	Ovis aries	29%	100%
Q6K215	Oryza sativa subsp. japonica	23%	100%
Q6PQZ1	Sus scrofa	26%	100%
Q6Z2T3	Oryza sativa subsp. japonica	26%	100%
Q7EYH7	Oryza sativa subsp. japonica	26%	99%
Q7MIV9	Vibrio vulnificus (strain YJ016)	25%	100%
Q7N5C1	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	24%	100%
Q7NNP3	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	28%	100%
Q7NU39	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	27%	100%
Q7PWV1	Anopheles gambiae	28%	100%
Q7XLR1	Oryza sativa subsp. japonica	26%	100%
Q7XSQ9	Oryza sativa subsp. japonica	23%	100%
Q7XUA6	Oryza sativa subsp. japonica	25%	100%
Q7Y1E6	Oryza sativa subsp. japonica	27%	100%
Q84RL6	Zea mays	29%	100%
Q84RL7	Zea mays	24%	100%
Q84S07	Oryza sativa subsp. japonica	24%	100%
Q866S3	Ovis aries	25%	100%
Q87MQ5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	25%	100%
Q88F17	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	26%	100%
Q89EG9	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	26%	100%
Q8DB17	Vibrio vulnificus (strain CMCP6)	25%	100%
Q8EHC1	Shewanella oneidensis (strain MR-1)	26%	100%
Q8FY85	Brucella suis biovar 1 (strain 1330)	28%	100%
Q8LAA6	Arabidopsis thaliana	25%	100%
Q8LAI1	Arabidopsis thaliana	25%	100%
Q8LFP7	Arabidopsis thaliana	27%	100%
Q8VZW1	Arabidopsis thaliana	27%	100%
Q8W036	Arabidopsis thaliana	22%	100%
Q8X6K6	Escherichia coli O157:H7	26%	100%
Q92NM3	Rhizobium meliloti (strain 1021)	27%	100%
Q9AQU5	Zea mays	23%	100%
Q9AR14	Zea mays	24%	100%
Q9AT74	Zea mays	25%	100%
Q9ATL2	Zea mays	28%	100%
Q9ATM4	Zea mays	26%	100%
Q9ATM6	Zea mays	23%	100%
Q9ATM7	Zea mays	23%	100%
Q9ATN1	Zea mays	26%	100%
Q9ATN2	Zea mays	25%	100%
Q9C4Z5	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	24%	100%
Q9C6T0	Arabidopsis thaliana	26%	93%
Q9FF53	Arabidopsis thaliana	24%	100%
Q9FIZ9	Arabidopsis thaliana	23%	100%
Q9FY14	Medicago truncatula	26%	100%
Q9HWZ3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
Q9L772	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	29%	100%
Q9N2J4	Canis lupus familiaris	24%	100%
Q9NHW7	Aedes aegypti	28%	100%
Q9SAI4	Arabidopsis thaliana	25%	99%
Q9SV84	Arabidopsis thaliana	27%	99%
Q9SXF8	Oryza sativa subsp. japonica	24%	100%
Q9U8P7	Dictyostelium discoideum	27%	100%
Q9V5Z7	Drosophila melanogaster	26%	100%
Q9WTY4	Mus musculus	27%	100%
Q9XF59	Zea mays	23%	100%
Q9ZVX8	Arabidopsis thaliana	27%	100%
S5ZH89	Musa acuminata	24%	100%
V5ANF5	Trypanosoma cruzi	40%	100%
V5B469	Trypanosoma cruzi	68%	100%
V5BW46	Trypanosoma cruzi	40%	100%
V5D449	Trypanosoma cruzi	38%	67%