RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBK3_LEIMA

TriTrypDb:

LmjF.22.1440 , LMJLV39_220020100 , LMJSD75_220020700

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBK3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.430
CLV_C14_Caspase3-7	412	416	PF00656	0.520
CLV_C14_Caspase3-7	440	444	PF00656	0.614
CLV_NRD_NRD_1	282	284	PF00675	0.359
CLV_NRD_NRD_1	311	313	PF00675	0.496
CLV_NRD_NRD_1	494	496	PF00675	0.467
CLV_PCSK_KEX2_1	282	284	PF00082	0.371
CLV_PCSK_KEX2_1	311	313	PF00082	0.541
CLV_PCSK_KEX2_1	334	336	PF00082	0.500
CLV_PCSK_KEX2_1	494	496	PF00082	0.521
CLV_PCSK_KEX2_1	50	52	PF00082	0.648
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.586
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.612
CLV_PCSK_SKI1_1	275	279	PF00082	0.402
CLV_PCSK_SKI1_1	334	338	PF00082	0.429
CLV_PCSK_SKI1_1	342	346	PF00082	0.301
CLV_PCSK_SKI1_1	4	8	PF00082	0.768
CLV_PCSK_SKI1_1	426	430	PF00082	0.630
CLV_PCSK_SKI1_1	50	54	PF00082	0.618
DEG_APCC_DBOX_1	198	206	PF00400	0.465
DEG_APCC_DBOX_1	274	282	PF00400	0.466
DOC_CKS1_1	389	394	PF01111	0.468
DOC_MAPK_DCC_7	199	207	PF00069	0.434
DOC_MAPK_MEF2A_6	199	207	PF00069	0.426
DOC_PP1_RVXF_1	340	346	PF00149	0.384
DOC_PP2B_LxvP_1	158	161	PF13499	0.529
DOC_USP7_MATH_1	304	308	PF00917	0.452
DOC_USP7_MATH_1	364	368	PF00917	0.517
DOC_USP7_MATH_1	405	409	PF00917	0.601
DOC_USP7_MATH_1	436	440	PF00917	0.676
DOC_USP7_MATH_1	455	459	PF00917	0.645
DOC_USP7_UBL2_3	4	8	PF12436	0.587
DOC_WW_Pin1_4	14	19	PF00397	0.683
DOC_WW_Pin1_4	23	28	PF00397	0.609
DOC_WW_Pin1_4	240	245	PF00397	0.507
DOC_WW_Pin1_4	388	393	PF00397	0.458
DOC_WW_Pin1_4	448	453	PF00397	0.609
LIG_14-3-3_CanoR_1	153	162	PF00244	0.609
LIG_14-3-3_CanoR_1	163	168	PF00244	0.491
LIG_14-3-3_CanoR_1	199	203	PF00244	0.444
LIG_14-3-3_CanoR_1	204	208	PF00244	0.421
LIG_14-3-3_CanoR_1	426	432	PF00244	0.575
LIG_Actin_RPEL_3	487	506	PF02755	0.483
LIG_BRCT_BRCA1_1	135	139	PF00533	0.662
LIG_BRCT_BRCA1_1	392	396	PF00533	0.576
LIG_BRCT_BRCA1_1	87	91	PF00533	0.644
LIG_Clathr_ClatBox_1	305	309	PF01394	0.423
LIG_deltaCOP1_diTrp_1	172	181	PF00928	0.462
LIG_FHA_1	157	163	PF00498	0.511
LIG_FHA_1	282	288	PF00498	0.445
LIG_FHA_1	300	306	PF00498	0.426
LIG_FHA_1	384	390	PF00498	0.425
LIG_FHA_1	415	421	PF00498	0.605
LIG_FHA_1	68	74	PF00498	0.669
LIG_FHA_1	80	86	PF00498	0.525
LIG_FHA_2	10	16	PF00498	0.680
LIG_FHA_2	167	173	PF00498	0.604
LIG_FHA_2	324	330	PF00498	0.418
LIG_FHA_2	410	416	PF00498	0.520
LIG_FHA_2	467	473	PF00498	0.654
LIG_IBAR_NPY_1	501	503	PF08397	0.566
LIG_LIR_Apic_2	243	248	PF02991	0.464
LIG_LIR_Apic_2	352	358	PF02991	0.393
LIG_LIR_Gen_1	172	183	PF02991	0.458
LIG_LIR_Nem_3	172	178	PF02991	0.534
LIG_LIR_Nem_3	471	476	PF02991	0.635
LIG_LIR_Nem_3	479	485	PF02991	0.529
LIG_MYND_3	220	224	PF01753	0.293
LIG_Pex14_1	175	179	PF04695	0.445
LIG_PTAP_UEV_1	391	396	PF05743	0.466
LIG_PTB_Apo_2	292	299	PF02174	0.351
LIG_SH2_CRK	485	489	PF00017	0.580
LIG_SH2_CRK	503	507	PF00017	0.406
LIG_SH2_NCK_1	108	112	PF00017	0.646
LIG_SH2_NCK_1	433	437	PF00017	0.612
LIG_SH2_STAP1	503	507	PF00017	0.609
LIG_SH2_STAT5	167	170	PF00017	0.583
LIG_SH2_STAT5	485	488	PF00017	0.540
LIG_SH2_STAT5	503	506	PF00017	0.568
LIG_SH3_3	386	392	PF00018	0.422
LIG_SH3_3	449	455	PF00018	0.624
LIG_SH3_4	267	274	PF00018	0.447
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.550
LIG_SUMO_SIM_par_1	304	309	PF11976	0.423
LIG_SUMO_SIM_par_1	385	391	PF11976	0.419
LIG_TRAF2_1	416	419	PF00917	0.588
LIG_TRAF2_1	458	461	PF00917	0.705
LIG_TRFH_1	498	502	PF08558	0.533
LIG_WRC_WIRS_1	178	183	PF05994	0.470
MOD_CDC14_SPxK_1	17	20	PF00782	0.572
MOD_CDC14_SPxK_1	26	29	PF00782	0.514
MOD_CDK_SPxK_1	14	20	PF00069	0.681
MOD_CDK_SPxK_1	23	29	PF00069	0.582
MOD_CK1_1	101	107	PF00069	0.693
MOD_CK1_1	109	115	PF00069	0.667
MOD_CK1_1	127	133	PF00069	0.628
MOD_CK1_1	156	162	PF00069	0.676
MOD_CK1_1	23	29	PF00069	0.752
MOD_CK1_1	367	373	PF00069	0.502
MOD_CK1_1	427	433	PF00069	0.765
MOD_CK1_1	434	440	PF00069	0.715
MOD_CK1_1	442	448	PF00069	0.639
MOD_CK1_1	78	84	PF00069	0.594
MOD_CK2_1	166	172	PF00069	0.526
MOD_CK2_1	226	232	PF00069	0.327
MOD_CK2_1	323	329	PF00069	0.325
MOD_CK2_1	455	461	PF00069	0.705
MOD_CK2_1	466	472	PF00069	0.716
MOD_CK2_1	9	15	PF00069	0.678
MOD_GlcNHglycan	109	112	PF01048	0.660
MOD_GlcNHglycan	22	25	PF01048	0.597
MOD_GlcNHglycan	271	274	PF01048	0.465
MOD_GlcNHglycan	392	395	PF01048	0.494
MOD_GlcNHglycan	407	410	PF01048	0.556
MOD_GlcNHglycan	426	429	PF01048	0.650
MOD_GlcNHglycan	433	436	PF01048	0.657
MOD_GSK3_1	106	113	PF00069	0.602
MOD_GSK3_1	120	127	PF00069	0.619
MOD_GSK3_1	405	412	PF00069	0.538
MOD_GSK3_1	427	434	PF00069	0.761
MOD_GSK3_1	437	444	PF00069	0.670
MOD_GSK3_1	75	82	PF00069	0.592
MOD_GSK3_1	98	105	PF00069	0.626
MOD_N-GLC_1	298	303	PF02516	0.515
MOD_N-GLC_1	476	481	PF02516	0.475
MOD_N-GLC_1	9	14	PF02516	0.631
MOD_N-GLC_1	98	103	PF02516	0.644
MOD_N-GLC_2	263	265	PF02516	0.492
MOD_NEK2_1	198	203	PF00069	0.403
MOD_NEK2_1	281	286	PF00069	0.444
MOD_NEK2_1	298	303	PF00069	0.307
MOD_NEK2_1	344	349	PF00069	0.438
MOD_NEK2_1	431	436	PF00069	0.642
MOD_NEK2_2	2	7	PF00069	0.606
MOD_PIKK_1	153	159	PF00454	0.660
MOD_PIKK_1	313	319	PF00454	0.601
MOD_PIKK_1	434	440	PF00454	0.633
MOD_PKA_1	311	317	PF00069	0.516
MOD_PKA_2	198	204	PF00069	0.478
MOD_PKA_2	281	287	PF00069	0.422
MOD_PKA_2	311	317	PF00069	0.526
MOD_PKA_2	383	389	PF00069	0.498
MOD_PKA_2	46	52	PF00069	0.643
MOD_PKA_2	93	99	PF00069	0.682
MOD_Plk_1	329	335	PF00069	0.475
MOD_Plk_1	367	373	PF00069	0.502
MOD_Plk_1	442	448	PF00069	0.618
MOD_Plk_1	55	61	PF00069	0.527
MOD_Plk_1	9	15	PF00069	0.632
MOD_Plk_4	103	109	PF00069	0.703
MOD_Plk_4	163	169	PF00069	0.545
MOD_Plk_4	383	389	PF00069	0.452
MOD_Plk_4	478	484	PF00069	0.619
MOD_Plk_4	501	507	PF00069	0.574
MOD_Plk_4	75	81	PF00069	0.632
MOD_Plk_4	9	15	PF00069	0.656
MOD_ProDKin_1	14	20	PF00069	0.685
MOD_ProDKin_1	23	29	PF00069	0.611
MOD_ProDKin_1	240	246	PF00069	0.504
MOD_ProDKin_1	388	394	PF00069	0.472
MOD_ProDKin_1	448	454	PF00069	0.608
MOD_SUMO_for_1	97	100	PF00179	0.652
TRG_DiLeu_BaEn_1	352	357	PF01217	0.443
TRG_DiLeu_BaEn_1	56	61	PF01217	0.478
TRG_ENDOCYTIC_2	503	506	PF00928	0.581
TRG_ER_diArg_1	281	283	PF00400	0.348
TRG_ER_diArg_1	493	495	PF00400	0.500
TRG_ER_diArg_1	91	94	PF00400	0.665
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J803	Bodo saltans	35%	97%
A0A1X0NV61	Trypanosomatidae	38%	100%
A0A3Q8ICC1	Leishmania donovani	94%	100%
A4HCI4	Leishmania braziliensis	84%	100%
A4I003	Leishmania infantum	94%	100%
E9AVX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5ANV0	Trypanosoma cruzi	34%	100%