I/6 autoantigen-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

i/6 autoantigen-like protein

Species:

Leishmania major

UniProt:

Q4QBK1_LEIMA

TriTrypDb:

LmjF.22.1460 , LMJLV39_220020300 , LMJSD75_220020900

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBK1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.458
CLV_C14_Caspase3-7	114	118	PF00656	0.365
CLV_C14_Caspase3-7	121	125	PF00656	0.365
CLV_C14_Caspase3-7	15	19	PF00656	0.424
CLV_C14_Caspase3-7	4	8	PF00656	0.527
CLV_NRD_NRD_1	152	154	PF00675	0.457
CLV_NRD_NRD_1	162	164	PF00675	0.503
CLV_NRD_NRD_1	94	96	PF00675	0.478
CLV_PCSK_KEX2_1	11	13	PF00082	0.485
CLV_PCSK_KEX2_1	152	154	PF00082	0.501
CLV_PCSK_KEX2_1	161	163	PF00082	0.543
CLV_PCSK_KEX2_1	94	96	PF00082	0.478
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.485
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.616
CLV_PCSK_SKI1_1	12	16	PF00082	0.459
CLV_PCSK_SKI1_1	6	10	PF00082	0.480
DEG_APCC_DBOX_1	93	101	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DOC_USP7_MATH_1	102	106	PF00917	0.397
DOC_USP7_UBL2_3	103	107	PF12436	0.455
DOC_USP7_UBL2_3	179	183	PF12436	0.471
DOC_USP7_UBL2_3	196	200	PF12436	0.751
DOC_WW_Pin1_4	38	43	PF00397	0.539
LIG_14-3-3_CanoR_1	147	155	PF00244	0.360
LIG_14-3-3_CanoR_1	70	74	PF00244	0.564
LIG_14-3-3_CanoR_1	94	98	PF00244	0.365
LIG_FHA_2	13	19	PF00498	0.562
LIG_FHA_2	130	136	PF00498	0.503
LIG_FHA_2	41	47	PF00498	0.519
LIG_FHA_2	56	62	PF00498	0.443
LIG_LIR_Gen_1	117	125	PF02991	0.369
LIG_LIR_Gen_1	61	68	PF02991	0.446
LIG_LIR_Nem_3	117	123	PF02991	0.369
LIG_LIR_Nem_3	61	65	PF02991	0.480
LIG_SH2_CRK	141	145	PF00017	0.348
LIG_SH2_STAT3	53	56	PF00017	0.579
LIG_SH2_STAT5	37	40	PF00017	0.528
LIG_SH3_3	82	88	PF00018	0.481
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.516
LIG_TRAF2_1	112	115	PF00917	0.422
LIG_TRAF2_1	173	176	PF00917	0.510
LIG_TRAF2_1	96	99	PF00917	0.369
LIG_UBA3_1	119	128	PF00899	0.513
MOD_CK1_1	72	78	PF00069	0.594
MOD_CK2_1	109	115	PF00069	0.339
MOD_CK2_1	40	46	PF00069	0.496
MOD_CK2_1	55	61	PF00069	0.446
MOD_CK2_1	93	99	PF00069	0.369
MOD_GlcNHglycan	149	152	PF01048	0.503
MOD_GlcNHglycan	74	77	PF01048	0.565
MOD_GSK3_1	68	75	PF00069	0.576
MOD_N-GLC_1	68	73	PF02516	0.585
MOD_NEK2_1	1	6	PF00069	0.592
MOD_PKA_2	69	75	PF00069	0.558
MOD_PKA_2	93	99	PF00069	0.353
MOD_Plk_1	68	74	PF00069	0.550
MOD_Plk_2-3	109	115	PF00069	0.389
MOD_Plk_4	69	75	PF00069	0.560
MOD_ProDKin_1	38	44	PF00069	0.537
MOD_SUMO_for_1	178	181	PF00179	0.508
MOD_SUMO_rev_2	121	130	PF00179	0.475
MOD_SUMO_rev_2	175	185	PF00179	0.661
TRG_ENDOCYTIC_2	141	144	PF00928	0.475
TRG_ER_FFAT_2	67	78	PF00635	0.452
TRG_NLS_MonoExtC_3	160	166	PF00514	0.413
TRG_NLS_MonoExtN_4	196	203	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S4	Leptomonas seymouri	67%	92%
A0A1X0NTK1	Trypanosomatidae	45%	93%
A0A3Q8IAT1	Leishmania donovani	85%	100%
A0A422N4A4	Trypanosoma rangeli	46%	100%
A4HCI3	Leishmania braziliensis	58%	97%
A4I005	Leishmania infantum	85%	100%
C9ZSQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	84%
C9ZSQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q26768	Trypanosoma brucei brucei	41%	85%