TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBK0_LEIMA

TriTrypDb:

LmjF.22.1470 , LMJLV39_220020400 , LMJSD75_220021000

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBK0

PDB structure(s): 7am2_BQ

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.561
CLV_C14_Caspase3-7	97	101	PF00656	0.539
CLV_MEL_PAP_1	425	431	PF00089	0.455
CLV_NRD_NRD_1	184	186	PF00675	0.458
CLV_NRD_NRD_1	3	5	PF00675	0.654
CLV_NRD_NRD_1	313	315	PF00675	0.670
CLV_NRD_NRD_1	427	429	PF00675	0.469
CLV_PCSK_KEX2_1	184	186	PF00082	0.446
CLV_PCSK_KEX2_1	3	5	PF00082	0.685
CLV_PCSK_KEX2_1	427	429	PF00082	0.469
CLV_PCSK_SKI1_1	152	156	PF00082	0.480
CLV_PCSK_SKI1_1	188	192	PF00082	0.577
CLV_PCSK_SKI1_1	241	245	PF00082	0.516
CLV_PCSK_SKI1_1	387	391	PF00082	0.559
CLV_PCSK_SKI1_1	99	103	PF00082	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_CYCLIN_RxL_1	382	393	PF00134	0.547
DOC_MAPK_gen_1	184	191	PF00069	0.588
DOC_MAPK_gen_1	3	9	PF00069	0.628
DOC_MAPK_MEF2A_6	211	218	PF00069	0.644
DOC_PP1_RVXF_1	186	192	PF00149	0.597
DOC_PP2B_LxvP_1	195	198	PF13499	0.738
DOC_PP4_FxxP_1	131	134	PF00568	0.531
DOC_PP4_FxxP_1	191	194	PF00568	0.596
DOC_PP4_FxxP_1	37	40	PF00568	0.424
DOC_PP4_FxxP_1	65	68	PF00568	0.496
DOC_USP7_MATH_1	101	105	PF00917	0.519
DOC_USP7_MATH_1	177	181	PF00917	0.531
DOC_USP7_MATH_1	221	225	PF00917	0.649
DOC_USP7_MATH_1	228	232	PF00917	0.613
DOC_USP7_MATH_1	310	314	PF00917	0.669
DOC_USP7_MATH_1	366	370	PF00917	0.600
DOC_WW_Pin1_4	154	159	PF00397	0.481
DOC_WW_Pin1_4	178	183	PF00397	0.419
DOC_WW_Pin1_4	224	229	PF00397	0.545
DOC_WW_Pin1_4	369	374	PF00397	0.683
LIG_14-3-3_CanoR_1	211	217	PF00244	0.678
LIG_14-3-3_CanoR_1	241	247	PF00244	0.500
LIG_Actin_WH2_2	84	101	PF00022	0.524
LIG_APCC_ABBA_1	345	350	PF00400	0.561
LIG_BRCT_BRCA1_1	265	269	PF00533	0.516
LIG_deltaCOP1_diTrp_1	400	406	PF00928	0.426
LIG_deltaCOP1_diTrp_1	84	90	PF00928	0.460
LIG_FHA_1	100	106	PF00498	0.510
LIG_FHA_1	273	279	PF00498	0.488
LIG_FHA_1	29	35	PF00498	0.437
LIG_FHA_1	374	380	PF00498	0.685
LIG_FHA_2	230	236	PF00498	0.412
LIG_FHA_2	243	249	PF00498	0.381
LIG_FHA_2	57	63	PF00498	0.402
LIG_IBAR_NPY_1	93	95	PF08397	0.566
LIG_LIR_Apic_2	129	134	PF02991	0.547
LIG_LIR_Apic_2	224	228	PF02991	0.660
LIG_LIR_Apic_2	62	68	PF02991	0.494
LIG_LIR_Gen_1	257	267	PF02991	0.501
LIG_LIR_Gen_1	398	406	PF02991	0.424
LIG_LIR_Nem_3	118	124	PF02991	0.533
LIG_LIR_Nem_3	257	263	PF02991	0.497
LIG_LIR_Nem_3	398	404	PF02991	0.421
LIG_LIR_Nem_3	424	429	PF02991	0.454
LIG_NRBOX	238	244	PF00104	0.423
LIG_PDZ_Class_3	440	445	PF00595	0.520
LIG_Pex14_1	86	90	PF04695	0.444
LIG_Pex14_2	397	401	PF04695	0.433
LIG_PTB_Apo_2	405	412	PF02174	0.443
LIG_PTB_Phospho_1	405	411	PF10480	0.447
LIG_Rb_LxCxE_1	102	123	PF01857	0.518
LIG_SH2_CRK	225	229	PF00017	0.606
LIG_SH2_NCK_1	225	229	PF00017	0.606
LIG_SH2_NCK_1	256	260	PF00017	0.395
LIG_SH2_STAP1	256	260	PF00017	0.472
LIG_SH2_STAT3	74	77	PF00017	0.552
LIG_SH2_STAT5	321	324	PF00017	0.491
LIG_SH2_STAT5	33	36	PF00017	0.435
LIG_SH2_STAT5	46	49	PF00017	0.399
LIG_SH3_3	141	147	PF00018	0.503
LIG_SH3_3	37	43	PF00018	0.424
LIG_SH3_3	88	94	PF00018	0.488
LIG_SUMO_SIM_par_1	79	85	PF11976	0.442
LIG_TRAF2_1	329	332	PF00917	0.559
LIG_TRAF2_1	356	359	PF00917	0.550
LIG_TRAF2_1	94	97	PF00917	0.457
LIG_UBA3_1	288	294	PF00899	0.479
LIG_WRC_WIRS_1	128	133	PF05994	0.548
LIG_WRC_WIRS_1	243	248	PF05994	0.531
MOD_CDK_SPxK_1	178	184	PF00069	0.421
MOD_CDK_SPxxK_3	154	161	PF00069	0.516
MOD_CDK_SPxxK_3	178	185	PF00069	0.421
MOD_CK1_1	123	129	PF00069	0.584
MOD_CK1_1	204	210	PF00069	0.678
MOD_CK1_1	224	230	PF00069	0.514
MOD_CK1_1	258	264	PF00069	0.499
MOD_CK1_1	281	287	PF00069	0.439
MOD_CK1_1	313	319	PF00069	0.588
MOD_CK1_1	369	375	PF00069	0.647
MOD_CK1_1	393	399	PF00069	0.514
MOD_CK2_1	230	236	PF00069	0.489
MOD_CK2_1	242	248	PF00069	0.303
MOD_CK2_1	353	359	PF00069	0.514
MOD_CK2_1	415	421	PF00069	0.479
MOD_CK2_1	56	62	PF00069	0.391
MOD_GlcNHglycan	125	128	PF01048	0.538
MOD_GlcNHglycan	175	178	PF01048	0.515
MOD_GlcNHglycan	257	260	PF01048	0.482
MOD_GlcNHglycan	283	286	PF01048	0.452
MOD_GlcNHglycan	315	318	PF01048	0.522
MOD_GlcNHglycan	369	372	PF01048	0.641
MOD_GlcNHglycan	392	395	PF01048	0.499
MOD_GSK3_1	123	130	PF00069	0.533
MOD_GSK3_1	173	180	PF00069	0.508
MOD_GSK3_1	212	219	PF00069	0.608
MOD_GSK3_1	224	231	PF00069	0.475
MOD_GSK3_1	24	31	PF00069	0.457
MOD_GSK3_1	244	251	PF00069	0.473
MOD_GSK3_1	258	265	PF00069	0.462
MOD_GSK3_1	309	316	PF00069	0.595
MOD_GSK3_1	369	376	PF00069	0.547
MOD_GSK3_1	434	441	PF00069	0.493
MOD_LATS_1	22	28	PF00433	0.470
MOD_N-GLC_1	171	176	PF02516	0.511
MOD_N-GLC_1	201	206	PF02516	0.644
MOD_N-GLC_1	281	286	PF02516	0.488
MOD_NEK2_1	242	247	PF00069	0.381
MOD_NEK2_1	262	267	PF00069	0.213
MOD_NEK2_1	323	328	PF00069	0.486
MOD_NEK2_1	378	383	PF00069	0.501
MOD_NEK2_1	390	395	PF00069	0.501
MOD_NEK2_1	70	75	PF00069	0.424
MOD_PKA_2	12	18	PF00069	0.511
MOD_PKA_2	313	319	PF00069	0.612
MOD_PKA_2	335	341	PF00069	0.482
MOD_Plk_1	171	177	PF00069	0.476
MOD_Plk_2-3	248	254	PF00069	0.322
MOD_Plk_2-3	353	359	PF00069	0.505
MOD_Plk_4	101	107	PF00069	0.468
MOD_Plk_4	28	34	PF00069	0.437
MOD_Plk_4	421	427	PF00069	0.463
MOD_ProDKin_1	154	160	PF00069	0.475
MOD_ProDKin_1	178	184	PF00069	0.421
MOD_ProDKin_1	224	230	PF00069	0.543
MOD_ProDKin_1	369	375	PF00069	0.680
MOD_SUMO_rev_2	231	240	PF00179	0.448
MOD_SUMO_rev_2	350	357	PF00179	0.492
MOD_SUMO_rev_2	96	101	PF00179	0.500
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.517
TRG_ENDOCYTIC_2	121	124	PF00928	0.495
TRG_ENDOCYTIC_2	95	98	PF00928	0.553
TRG_ER_diArg_1	184	186	PF00400	0.446
TRG_ER_diArg_1	2	4	PF00400	0.663
TRG_ER_diArg_1	426	428	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGW5	Leptomonas seymouri	71%	100%
A0A1X0NU50	Trypanosomatidae	50%	99%
A0A3R7M6E1	Trypanosoma rangeli	52%	100%
A0A3S7WXB0	Leishmania donovani	96%	100%
A4HCI5	Leishmania braziliensis	84%	100%
A4I006	Leishmania infantum	96%	100%
C9ZSQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
E9AVX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B8Q9	Trypanosoma cruzi	50%	98%