Mitochondrial glyco protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4QBJ9_LEIMA

TriTrypDb:

LmjF.22.1480 , LMJLV39_220020500 , LMJSD75_220021100

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 18
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	20
GO:0031974	membrane-enclosed lumen	2	20
GO:0043233	organelle lumen	3	20
GO:0070013	intracellular organelle lumen	4	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

Q4QBJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBJ9

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.560
CLV_NRD_NRD_1	123	125	PF00675	0.318
CLV_NRD_NRD_1	186	188	PF00675	0.333
CLV_NRD_NRD_1	244	246	PF00675	0.343
CLV_NRD_NRD_1	30	32	PF00675	0.542
CLV_PCSK_KEX2_1	185	187	PF00082	0.308
CLV_PCSK_KEX2_1	30	32	PF00082	0.559
CLV_PCSK_PC7_1	26	32	PF00082	0.617
CLV_PCSK_SKI1_1	187	191	PF00082	0.277
CLV_PCSK_SKI1_1	49	53	PF00082	0.449
CLV_PCSK_SKI1_1	6	10	PF00082	0.557
DOC_MAPK_MEF2A_6	136	144	PF00069	0.379
DOC_PP4_FxxP_1	51	54	PF00568	0.441
DOC_USP7_MATH_1	16	20	PF00917	0.645
DOC_USP7_MATH_1	24	28	PF00917	0.632
DOC_USP7_MATH_1	67	71	PF00917	0.498
LIG_14-3-3_CanoR_1	136	144	PF00244	0.385
LIG_14-3-3_CterR_2	245	249	PF00244	0.543
LIG_BRCT_BRCA1_1	69	73	PF00533	0.390
LIG_eIF4E_1	116	122	PF01652	0.464
LIG_FHA_1	18	24	PF00498	0.677
LIG_FHA_2	136	142	PF00498	0.464
LIG_FHA_2	37	43	PF00498	0.427
LIG_FHA_2	91	97	PF00498	0.480
LIG_LIR_Apic_2	50	54	PF02991	0.444
LIG_LIR_Gen_1	113	123	PF02991	0.452
LIG_LIR_Gen_1	70	81	PF02991	0.359
LIG_LIR_Nem_3	113	119	PF02991	0.470
LIG_LIR_Nem_3	70	76	PF02991	0.523
LIG_SH2_CRK	192	196	PF00017	0.488
LIG_SH2_GRB2like	116	119	PF00017	0.560
LIG_SH2_GRB2like	237	240	PF00017	0.464
LIG_SH2_SRC	44	47	PF00017	0.349
LIG_SH2_STAT5	116	119	PF00017	0.498
LIG_SH2_STAT5	211	214	PF00017	0.464
LIG_SH2_STAT5	237	240	PF00017	0.484
LIG_SH3_3	50	56	PF00018	0.430
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.442
LIG_SUMO_SIM_par_1	90	97	PF11976	0.394
LIG_TRAF2_1	153	156	PF00917	0.543
MOD_CK2_1	16	22	PF00069	0.497
MOD_CK2_1	36	42	PF00069	0.423
MOD_CK2_1	90	96	PF00069	0.467
MOD_GlcNHglycan	180	183	PF01048	0.397
MOD_GlcNHglycan	67	70	PF01048	0.544
MOD_GSK3_1	147	154	PF00069	0.466
MOD_GSK3_1	90	97	PF00069	0.517
MOD_NEK2_1	135	140	PF00069	0.457
MOD_NEK2_1	177	182	PF00069	0.569
MOD_NEK2_1	9	14	PF00069	0.638
MOD_NEK2_1	94	99	PF00069	0.566
MOD_NEK2_2	36	41	PF00069	0.536
MOD_PK_1	136	142	PF00069	0.379
MOD_PKA_2	135	141	PF00069	0.379
MOD_Plk_2-3	202	208	PF00069	0.467
TRG_DiLeu_BaEn_4	112	118	PF01217	0.543
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.464
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.524
TRG_ENDOCYTIC_2	116	119	PF00928	0.484
TRG_ER_diArg_1	185	187	PF00400	0.475
TRG_ER_diArg_1	29	31	PF00400	0.577
TRG_NES_CRM1_1	141	155	PF08389	0.507
TRG_NLS_MonoCore_2	123	128	PF00514	0.442
TRG_NLS_MonoExtC_3	124	129	PF00514	0.442
TRG_NLS_MonoExtN_4	124	129	PF00514	0.442
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	29%	100%
A0A0N1HS24	Leptomonas seymouri	71%	98%
A0A0S4ITN8	Bodo saltans	32%	100%
A0A1X0NTH7	Trypanosomatidae	65%	95%
A0A1X0P207	Trypanosomatidae	29%	100%
A0A3Q8IBW7	Leishmania donovani	27%	100%
A0A3Q8IFM4	Leishmania donovani	93%	98%
A4HCI6	Leishmania braziliensis	83%	100%
A4HI52	Leishmania braziliensis	29%	100%
A4I007	Leishmania infantum	93%	98%
A4I5C8	Leishmania infantum	27%	100%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	96%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	67%
E9AVY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q7K6	Leishmania major	28%	87%
V5BDB3	Trypanosoma cruzi	64%	95%