Calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QBJ6_LEIMA

TriTrypDb:

LmjF.22.1510 , LMJLV39_220020800 , LMJSD75_220021500

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.363
CLV_NRD_NRD_1	222	224	PF00675	0.619
CLV_NRD_NRD_1	4	6	PF00675	0.425
CLV_PCSK_KEX2_1	383	385	PF00082	0.526
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.476
CLV_PCSK_SKI1_1	176	180	PF00082	0.684
CLV_PCSK_SKI1_1	240	244	PF00082	0.396
CLV_PCSK_SKI1_1	392	396	PF00082	0.452
CLV_PCSK_SKI1_1	6	10	PF00082	0.445
DEG_MDM2_SWIB_1	404	411	PF02201	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.471
DEG_SCF_FBW7_1	281	288	PF00400	0.453
DOC_CKS1_1	127	132	PF01111	0.558
DOC_CKS1_1	282	287	PF01111	0.453
DOC_CKS1_1	326	331	PF01111	0.532
DOC_CYCLIN_RxL_1	2	11	PF00134	0.430
DOC_MAPK_FxFP_2	343	346	PF00069	0.392
DOC_PP4_FxxP_1	343	346	PF00568	0.392
DOC_PP4_FxxP_1	376	379	PF00568	0.430
DOC_USP7_MATH_1	114	118	PF00917	0.817
DOC_USP7_MATH_1	159	163	PF00917	0.643
DOC_USP7_MATH_1	268	272	PF00917	0.563
DOC_USP7_MATH_1	319	323	PF00917	0.458
DOC_USP7_MATH_1	59	63	PF00917	0.584
DOC_USP7_MATH_1	93	97	PF00917	0.675
DOC_USP7_UBL2_3	176	180	PF12436	0.684
DOC_USP7_UBL2_3	392	396	PF12436	0.443
DOC_WW_Pin1_4	110	115	PF00397	0.608
DOC_WW_Pin1_4	126	131	PF00397	0.597
DOC_WW_Pin1_4	146	151	PF00397	0.500
DOC_WW_Pin1_4	178	183	PF00397	0.606
DOC_WW_Pin1_4	195	200	PF00397	0.588
DOC_WW_Pin1_4	228	233	PF00397	0.476
DOC_WW_Pin1_4	270	275	PF00397	0.471
DOC_WW_Pin1_4	281	286	PF00397	0.444
DOC_WW_Pin1_4	325	330	PF00397	0.689
DOC_WW_Pin1_4	409	414	PF00397	0.494
DOC_WW_Pin1_4	84	89	PF00397	0.810
LIG_14-3-3_CanoR_1	401	411	PF00244	0.386
LIG_CSL_BTD_1	212	215	PF09270	0.538
LIG_CtBP_PxDLS_1	488	492	PF00389	0.492
LIG_DCNL_PONY_1	1	4	PF03556	0.392
LIG_FHA_1	143	149	PF00498	0.547
LIG_FHA_1	306	312	PF00498	0.419
LIG_FHA_1	357	363	PF00498	0.391
LIG_FHA_1	369	375	PF00498	0.371
LIG_FHA_1	405	411	PF00498	0.397
LIG_FHA_1	453	459	PF00498	0.558
LIG_FHA_1	491	497	PF00498	0.586
LIG_FHA_1	61	67	PF00498	0.516
LIG_FHA_2	179	185	PF00498	0.565
LIG_FHA_2	286	292	PF00498	0.524
LIG_FHA_2	46	52	PF00498	0.516
LIG_IRF3_LxIS_1	483	490	PF10401	0.456
LIG_LIR_Apic_2	340	346	PF02991	0.395
LIG_LIR_Apic_2	375	379	PF02991	0.430
LIG_LIR_Gen_1	301	306	PF02991	0.354
LIG_LIR_Gen_1	371	379	PF02991	0.319
LIG_LIR_Gen_1	405	415	PF02991	0.456
LIG_LIR_Gen_1	459	468	PF02991	0.468
LIG_LIR_Gen_1	480	491	PF02991	0.416
LIG_LIR_Nem_3	301	305	PF02991	0.350
LIG_LIR_Nem_3	371	376	PF02991	0.308
LIG_LIR_Nem_3	405	411	PF02991	0.423
LIG_LIR_Nem_3	459	464	PF02991	0.520
LIG_LIR_Nem_3	480	486	PF02991	0.413
LIG_PDZ_Class_3	492	497	PF00595	0.488
LIG_Pex14_1	68	72	PF04695	0.562
LIG_Pex14_2	345	349	PF04695	0.498
LIG_Pex14_2	404	408	PF04695	0.366
LIG_SH2_CRK	279	283	PF00017	0.424
LIG_SH2_SRC	140	143	PF00017	0.646
LIG_SH2_STAP1	279	283	PF00017	0.424
LIG_SH2_STAT5	344	347	PF00017	0.554
LIG_SH2_STAT5	356	359	PF00017	0.391
LIG_SH2_STAT5	373	376	PF00017	0.362
LIG_SH2_STAT5	403	406	PF00017	0.460
LIG_SH2_STAT5	414	417	PF00017	0.516
LIG_SH3_2	77	82	PF14604	0.596
LIG_SH3_3	104	110	PF00018	0.653
LIG_SH3_3	149	155	PF00018	0.699
LIG_SH3_3	179	185	PF00018	0.659
LIG_SH3_3	193	199	PF00018	0.561
LIG_SH3_3	407	413	PF00018	0.477
LIG_SH3_3	446	452	PF00018	0.510
LIG_SH3_3	49	55	PF00018	0.562
LIG_SH3_3	74	80	PF00018	0.571
LIG_SH3_3	85	91	PF00018	0.609
LIG_SUMO_SIM_anti_2	445	451	PF11976	0.452
LIG_SUMO_SIM_par_1	487	493	PF11976	0.486
LIG_TRAF2_1	73	76	PF00917	0.760
LIG_TRAF2_1	83	86	PF00917	0.601
LIG_UBA3_1	1	6	PF00899	0.407
LIG_UBA3_1	462	469	PF00899	0.418
MOD_CDK_SPxK_1	325	331	PF00069	0.539
MOD_CK1_1	113	119	PF00069	0.793
MOD_CK1_1	162	168	PF00069	0.673
MOD_CK1_1	198	204	PF00069	0.754
MOD_CK1_1	228	234	PF00069	0.631
MOD_CK1_1	292	298	PF00069	0.551
MOD_CK1_1	339	345	PF00069	0.605
MOD_CK1_1	368	374	PF00069	0.416
MOD_CK1_1	423	429	PF00069	0.528
MOD_CK1_1	454	460	PF00069	0.723
MOD_CK1_1	490	496	PF00069	0.731
MOD_CK2_1	261	267	PF00069	0.512
MOD_CK2_1	285	291	PF00069	0.512
MOD_CK2_1	84	90	PF00069	0.836
MOD_CK2_1	93	99	PF00069	0.673
MOD_GlcNHglycan	116	119	PF01048	0.709
MOD_GlcNHglycan	207	211	PF01048	0.766
MOD_GlcNHglycan	227	230	PF01048	0.513
MOD_GlcNHglycan	291	294	PF01048	0.521
MOD_GlcNHglycan	319	322	PF01048	0.512
MOD_GlcNHglycan	350	353	PF01048	0.596
MOD_GlcNHglycan	426	429	PF01048	0.534
MOD_GSK3_1	110	117	PF00069	0.610
MOD_GSK3_1	142	149	PF00069	0.557
MOD_GSK3_1	165	172	PF00069	0.685
MOD_GSK3_1	174	181	PF00069	0.595
MOD_GSK3_1	183	190	PF00069	0.498
MOD_GSK3_1	198	205	PF00069	0.586
MOD_GSK3_1	246	253	PF00069	0.389
MOD_GSK3_1	281	288	PF00069	0.474
MOD_GSK3_1	306	313	PF00069	0.416
MOD_GSK3_1	332	339	PF00069	0.485
MOD_GSK3_1	344	351	PF00069	0.509
MOD_GSK3_1	420	427	PF00069	0.568
MOD_GSK3_1	60	67	PF00069	0.550
MOD_N-GLC_1	471	476	PF02516	0.474
MOD_N-GLC_2	473	475	PF02516	0.510
MOD_NEK2_1	300	305	PF00069	0.364
MOD_NEK2_1	317	322	PF00069	0.594
MOD_NEK2_1	45	50	PF00069	0.434
MOD_PIKK_1	420	426	PF00454	0.669
MOD_PKA_2	225	231	PF00069	0.479
MOD_Plk_1	162	168	PF00069	0.623
MOD_Plk_1	300	306	PF00069	0.356
MOD_Plk_1	368	374	PF00069	0.416
MOD_Plk_4	116	122	PF00069	0.572
MOD_Plk_4	14	20	PF00069	0.505
MOD_Plk_4	183	189	PF00069	0.662
MOD_Plk_4	261	267	PF00069	0.512
MOD_Plk_4	310	316	PF00069	0.479
MOD_Plk_4	339	345	PF00069	0.509
MOD_Plk_4	368	374	PF00069	0.316
MOD_Plk_4	64	70	PF00069	0.477
MOD_ProDKin_1	110	116	PF00069	0.609
MOD_ProDKin_1	126	132	PF00069	0.599
MOD_ProDKin_1	146	152	PF00069	0.495
MOD_ProDKin_1	178	184	PF00069	0.605
MOD_ProDKin_1	195	201	PF00069	0.588
MOD_ProDKin_1	228	234	PF00069	0.473
MOD_ProDKin_1	270	276	PF00069	0.461
MOD_ProDKin_1	281	287	PF00069	0.453
MOD_ProDKin_1	325	331	PF00069	0.685
MOD_ProDKin_1	409	415	PF00069	0.497
MOD_ProDKin_1	84	90	PF00069	0.812
MOD_SUMO_rev_2	375	385	PF00179	0.456
TRG_ENDOCYTIC_2	279	282	PF00928	0.431
TRG_ENDOCYTIC_2	29	32	PF00928	0.496
TRG_ENDOCYTIC_2	323	326	PF00928	0.532
TRG_ENDOCYTIC_2	373	376	PF00928	0.313
TRG_ENDOCYTIC_2	461	464	PF00928	0.526
TRG_NLS_MonoCore_2	222	227	PF00514	0.533
TRG_NLS_MonoExtN_4	220	227	PF00514	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC61	Leptomonas seymouri	40%	91%
A0A3Q8IBJ7	Leishmania donovani	92%	100%
A4I010	Leishmania infantum	92%	100%
E9AVY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%