C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBJ2_LEIMA

TriTrypDb:

LmjF.22.1550 , LMJLV39_220021400 , LMJSD75_220022000

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.536
CLV_NRD_NRD_1	534	536	PF00675	0.453
CLV_PCSK_SKI1_1	132	136	PF00082	0.468
CLV_PCSK_SKI1_1	333	337	PF00082	0.551
CLV_PCSK_SKI1_1	40	44	PF00082	0.395
CLV_PCSK_SKI1_1	65	69	PF00082	0.523
CLV_PCSK_SKI1_1	85	89	PF00082	0.566
DEG_APCC_DBOX_1	458	466	PF00400	0.617
DEG_APCC_DBOX_1	546	554	PF00400	0.424
DEG_SCF_FBW7_1	310	317	PF00400	0.417
DOC_CKS1_1	311	316	PF01111	0.423
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.683
DOC_MAPK_FxFP_2	209	212	PF00069	0.362
DOC_MAPK_gen_1	128	137	PF00069	0.531
DOC_MAPK_gen_1	372	380	PF00069	0.535
DOC_MAPK_HePTP_8	102	114	PF00069	0.572
DOC_MAPK_MEF2A_6	105	114	PF00069	0.581
DOC_MAPK_MEF2A_6	131	139	PF00069	0.516
DOC_MAPK_MEF2A_6	284	292	PF00069	0.434
DOC_MAPK_MEF2A_6	297	306	PF00069	0.462
DOC_MAPK_MEF2A_6	381	389	PF00069	0.604
DOC_MAPK_MEF2A_6	543	550	PF00069	0.498
DOC_MAPK_NFAT4_5	132	140	PF00069	0.507
DOC_PP1_RVXF_1	266	272	PF00149	0.430
DOC_PP1_RVXF_1	33	40	PF00149	0.423
DOC_PP1_RVXF_1	82	89	PF00149	0.564
DOC_PP4_FxxP_1	209	212	PF00568	0.362
DOC_PP4_FxxP_1	88	91	PF00568	0.655
DOC_USP7_MATH_1	11	15	PF00917	0.711
DOC_USP7_MATH_1	245	249	PF00917	0.529
DOC_USP7_MATH_1	455	459	PF00917	0.670
DOC_USP7_MATH_1	47	51	PF00917	0.525
DOC_USP7_MATH_1	5	9	PF00917	0.752
DOC_USP7_MATH_1	522	526	PF00917	0.479
DOC_USP7_MATH_1	91	95	PF00917	0.671
DOC_WW_Pin1_4	190	195	PF00397	0.578
DOC_WW_Pin1_4	310	315	PF00397	0.458
DOC_WW_Pin1_4	400	405	PF00397	0.753
DOC_WW_Pin1_4	432	437	PF00397	0.765
DOC_WW_Pin1_4	490	495	PF00397	0.492
DOC_WW_Pin1_4	558	563	PF00397	0.489
LIG_14-3-3_CanoR_1	180	184	PF00244	0.468
LIG_14-3-3_CanoR_1	203	212	PF00244	0.360
LIG_14-3-3_CanoR_1	268	277	PF00244	0.401
LIG_14-3-3_CanoR_1	547	555	PF00244	0.471
LIG_14-3-3_CanoR_1	575	584	PF00244	0.596
LIG_Actin_WH2_2	115	130	PF00022	0.512
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_BRCT_BRCA1_1	492	496	PF00533	0.448
LIG_BRCT_BRCA1_1	541	545	PF00533	0.544
LIG_BRCT_BRCA1_1	582	586	PF00533	0.517
LIG_BRCT_BRCA1_1	71	75	PF00533	0.552
LIG_Clathr_ClatBox_1	41	45	PF01394	0.399
LIG_EH_1	453	457	PF12763	0.711
LIG_FHA_1	154	160	PF00498	0.514
LIG_FHA_1	199	205	PF00498	0.489
LIG_FHA_1	272	278	PF00498	0.385
LIG_FHA_1	31	37	PF00498	0.421
LIG_FHA_1	325	331	PF00498	0.413
LIG_FHA_1	471	477	PF00498	0.434
LIG_FHA_1	487	493	PF00498	0.562
LIG_FHA_1	589	595	PF00498	0.483
LIG_FHA_2	162	168	PF00498	0.447
LIG_FHA_2	191	197	PF00498	0.578
LIG_FHA_2	44	50	PF00498	0.462
LIG_FHA_2	499	505	PF00498	0.445
LIG_LIR_Apic_2	206	212	PF02991	0.368
LIG_LIR_Gen_1	149	160	PF02991	0.364
LIG_LIR_Gen_1	234	244	PF02991	0.545
LIG_LIR_Gen_1	542	553	PF02991	0.485
LIG_LIR_Gen_1	593	603	PF02991	0.483
LIG_LIR_Nem_3	149	155	PF02991	0.504
LIG_LIR_Nem_3	189	195	PF02991	0.523
LIG_LIR_Nem_3	196	202	PF02991	0.410
LIG_LIR_Nem_3	208	214	PF02991	0.260
LIG_LIR_Nem_3	234	239	PF02991	0.570
LIG_LIR_Nem_3	31	37	PF02991	0.433
LIG_LIR_Nem_3	542	548	PF02991	0.500
LIG_LIR_Nem_3	583	589	PF02991	0.432
LIG_LIR_Nem_3	590	595	PF02991	0.445
LIG_LIR_Nem_3	98	102	PF02991	0.535
LIG_Pex14_2	271	275	PF04695	0.348
LIG_PTAP_UEV_1	297	302	PF05743	0.479
LIG_SH2_CRK	199	203	PF00017	0.530
LIG_SH2_CRK	351	355	PF00017	0.591
LIG_SH2_CRK	595	599	PF00017	0.501
LIG_SH2_PTP2	111	114	PF00017	0.319
LIG_SH2_STAT5	111	114	PF00017	0.319
LIG_SH2_STAT5	152	155	PF00017	0.436
LIG_SH2_STAT5	222	225	PF00017	0.412
LIG_SH2_STAT5	252	255	PF00017	0.410
LIG_SH2_STAT5	270	273	PF00017	0.379
LIG_SH2_STAT5	577	580	PF00017	0.568
LIG_SH2_STAT5	587	590	PF00017	0.439
LIG_SH3_3	295	301	PF00018	0.466
LIG_SH3_3	308	314	PF00018	0.473
LIG_SH3_3	449	455	PF00018	0.712
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.471
LIG_SUMO_SIM_par_1	115	123	PF11976	0.416
LIG_SUMO_SIM_par_1	40	46	PF11976	0.494
LIG_SUMO_SIM_par_1	566	572	PF11976	0.514
LIG_TRAF2_1	29	32	PF00917	0.595
LIG_TRAF2_1	337	340	PF00917	0.596
LIG_TYR_ITIM	109	114	PF00017	0.321
LIG_UBA3_1	462	468	PF00899	0.596
LIG_WRC_WIRS_1	211	216	PF05994	0.400
MOD_CDC14_SPxK_1	403	406	PF00782	0.774
MOD_CDK_SPxK_1	400	406	PF00069	0.770
MOD_CK1_1	14	20	PF00069	0.617
MOD_CK1_1	248	254	PF00069	0.518
MOD_CK1_1	4	10	PF00069	0.706
MOD_CK1_1	409	415	PF00069	0.645
MOD_CK1_1	417	423	PF00069	0.631
MOD_CK1_1	428	434	PF00069	0.586
MOD_CK1_1	466	472	PF00069	0.494
MOD_CK1_1	51	57	PF00069	0.591
MOD_CK1_1	518	524	PF00069	0.506
MOD_CK1_1	569	575	PF00069	0.538
MOD_CK1_1	80	86	PF00069	0.596
MOD_CK2_1	190	196	PF00069	0.592
MOD_CK2_1	417	423	PF00069	0.707
MOD_CK2_1	97	103	PF00069	0.581
MOD_Cter_Amidation	129	132	PF01082	0.593
MOD_GlcNHglycan	14	17	PF01048	0.570
MOD_GlcNHglycan	247	250	PF01048	0.530
MOD_GlcNHglycan	271	274	PF01048	0.447
MOD_GlcNHglycan	298	301	PF01048	0.466
MOD_GlcNHglycan	3	6	PF01048	0.700
MOD_GlcNHglycan	356	359	PF01048	0.627
MOD_GlcNHglycan	411	414	PF01048	0.713
MOD_GlcNHglycan	416	419	PF01048	0.697
MOD_GlcNHglycan	426	430	PF01048	0.644
MOD_GlcNHglycan	520	523	PF01048	0.476
MOD_GlcNHglycan	99	102	PF01048	0.496
MOD_GSK3_1	1	8	PF00069	0.714
MOD_GSK3_1	14	21	PF00069	0.589
MOD_GSK3_1	146	153	PF00069	0.546
MOD_GSK3_1	198	205	PF00069	0.412
MOD_GSK3_1	210	217	PF00069	0.347
MOD_GSK3_1	231	238	PF00069	0.514
MOD_GSK3_1	248	255	PF00069	0.495
MOD_GSK3_1	271	278	PF00069	0.421
MOD_GSK3_1	292	299	PF00069	0.492
MOD_GSK3_1	310	317	PF00069	0.519
MOD_GSK3_1	324	331	PF00069	0.405
MOD_GSK3_1	405	412	PF00069	0.705
MOD_GSK3_1	417	424	PF00069	0.693
MOD_GSK3_1	428	435	PF00069	0.760
MOD_GSK3_1	43	50	PF00069	0.456
MOD_GSK3_1	466	473	PF00069	0.480
MOD_GSK3_1	486	493	PF00069	0.324
MOD_GSK3_1	518	525	PF00069	0.458
MOD_GSK3_1	91	98	PF00069	0.684
MOD_N-GLC_1	190	195	PF02516	0.622
MOD_N-GLC_1	231	236	PF02516	0.419
MOD_N-GLC_1	275	280	PF02516	0.532
MOD_N-GLC_1	292	297	PF02516	0.496
MOD_N-GLC_1	325	330	PF02516	0.424
MOD_N-GLC_1	360	365	PF02516	0.616
MOD_N-GLC_1	441	446	PF02516	0.675
MOD_N-GLC_1	463	468	PF02516	0.561
MOD_N-GLC_1	548	553	PF02516	0.448
MOD_N-GLC_1	598	603	PF02516	0.586
MOD_NEK2_1	1	6	PF00069	0.758
MOD_NEK2_1	146	151	PF00069	0.422
MOD_NEK2_1	18	23	PF00069	0.441
MOD_NEK2_1	214	219	PF00069	0.434
MOD_NEK2_1	271	276	PF00069	0.356
MOD_NEK2_1	425	430	PF00069	0.682
MOD_NEK2_1	463	468	PF00069	0.540
MOD_NEK2_1	496	501	PF00069	0.393
MOD_NEK2_1	598	603	PF00069	0.486
MOD_NEK2_1	67	72	PF00069	0.453
MOD_NEK2_2	522	527	PF00069	0.507
MOD_PIKK_1	255	261	PF00454	0.505
MOD_PIKK_1	292	298	PF00454	0.492
MOD_PIKK_1	335	341	PF00454	0.501
MOD_PIKK_1	406	412	PF00454	0.694
MOD_PIKK_1	463	469	PF00454	0.554
MOD_PIKK_1	48	54	PF00454	0.564
MOD_PIKK_1	575	581	PF00454	0.599
MOD_PIKK_1	91	97	PF00454	0.619
MOD_PKA_2	179	185	PF00069	0.342
MOD_PKA_2	202	208	PF00069	0.369
MOD_PKA_2	405	411	PF00069	0.730
MOD_PKA_2	447	453	PF00069	0.701
MOD_Plk_1	18	24	PF00069	0.537
MOD_Plk_1	234	240	PF00069	0.438
MOD_Plk_1	30	36	PF00069	0.398
MOD_Plk_1	325	331	PF00069	0.424
MOD_Plk_1	425	431	PF00069	0.704
MOD_Plk_1	441	447	PF00069	0.651
MOD_Plk_1	48	54	PF00069	0.458
MOD_Plk_1	598	604	PF00069	0.568
MOD_Plk_2-3	590	596	PF00069	0.483
MOD_Plk_4	130	136	PF00069	0.427
MOD_Plk_4	141	147	PF00069	0.487
MOD_Plk_4	179	185	PF00069	0.500
MOD_Plk_4	210	216	PF00069	0.383
MOD_Plk_4	248	254	PF00069	0.528
MOD_Plk_4	441	447	PF00069	0.641
MOD_Plk_4	498	504	PF00069	0.513
MOD_Plk_4	590	596	PF00069	0.483
MOD_Plk_4	599	605	PF00069	0.452
MOD_ProDKin_1	190	196	PF00069	0.570
MOD_ProDKin_1	310	316	PF00069	0.465
MOD_ProDKin_1	400	406	PF00069	0.755
MOD_ProDKin_1	432	438	PF00069	0.763
MOD_ProDKin_1	490	496	PF00069	0.482
MOD_ProDKin_1	558	564	PF00069	0.480
TRG_DiLeu_BaEn_1	32	37	PF01217	0.530
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.514
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.630
TRG_ENDOCYTIC_2	111	114	PF00928	0.319
TRG_ENDOCYTIC_2	152	155	PF00928	0.556
TRG_ENDOCYTIC_2	199	202	PF00928	0.529
TRG_ENDOCYTIC_2	211	214	PF00928	0.492
TRG_ENDOCYTIC_2	351	354	PF00928	0.591
TRG_ENDOCYTIC_2	595	598	PF00928	0.494
TRG_ER_diArg_1	553	556	PF00400	0.527
TRG_ER_FFAT_2	514	525	PF00635	0.568
TRG_NES_CRM1_1	221	235	PF08389	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRF1	Leptomonas seymouri	78%	100%
A0A0S4J7N2	Bodo saltans	29%	74%
A0A1X0NTT4	Trypanosomatidae	53%	100%
A0A3Q8ICD1	Leishmania donovani	96%	100%
A0A3R7K4C8	Trypanosoma rangeli	54%	100%
A4HCJ4	Leishmania braziliensis	86%	99%
A4I014	Leishmania infantum	96%	100%
C9ZQ83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BGJ4	Trypanosoma cruzi	54%	100%