Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBJ0_LEIMA

TriTrypDb:

LmjF.22.1570 , LMJLV39_220021700 , LMJSD75_220022300

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.718
CLV_C14_Caspase3-7	224	228	PF00656	0.734
CLV_C14_Caspase3-7	254	258	PF00656	0.497
CLV_NRD_NRD_1	121	123	PF00675	0.526
CLV_NRD_NRD_1	145	147	PF00675	0.562
CLV_NRD_NRD_1	187	189	PF00675	0.747
CLV_NRD_NRD_1	59	61	PF00675	0.651
CLV_NRD_NRD_1	74	76	PF00675	0.587
CLV_PCSK_FUR_1	143	147	PF00082	0.576
CLV_PCSK_KEX2_1	145	147	PF00082	0.562
CLV_PCSK_KEX2_1	177	179	PF00082	0.645
CLV_PCSK_KEX2_1	187	189	PF00082	0.724
CLV_PCSK_KEX2_1	59	61	PF00082	0.684
CLV_PCSK_KEX2_1	63	65	PF00082	0.691
CLV_PCSK_KEX2_1	74	76	PF00082	0.697
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.534
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.684
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.691
CLV_PCSK_SKI1_1	145	149	PF00082	0.552
CLV_PCSK_SKI1_1	187	191	PF00082	0.608
CLV_PCSK_SKI1_1	260	264	PF00082	0.607
CLV_Separin_Metazoa	287	291	PF03568	0.538
DEG_COP1_1	263	272	PF00400	0.492
DEG_Nend_UBRbox_4	1	3	PF02207	0.507
DEG_SPOP_SBC_1	53	57	PF00917	0.594
DOC_CYCLIN_RxL_1	139	152	PF00134	0.496
DOC_MAPK_gen_1	122	129	PF00069	0.534
DOC_PP2B_LxvP_1	267	270	PF13499	0.608
DOC_PP2B_LxvP_1	315	318	PF13499	0.495
DOC_USP7_MATH_1	183	187	PF00917	0.691
DOC_USP7_MATH_1	213	217	PF00917	0.623
DOC_USP7_MATH_1	258	262	PF00917	0.648
DOC_USP7_MATH_1	299	303	PF00917	0.639
DOC_USP7_MATH_1	328	332	PF00917	0.640
DOC_USP7_MATH_1	53	57	PF00917	0.736
DOC_USP7_MATH_1	66	70	PF00917	0.588
DOC_USP7_MATH_1	79	83	PF00917	0.569
DOC_USP7_UBL2_3	59	63	PF12436	0.691
DOC_WW_Pin1_4	189	194	PF00397	0.728
DOC_WW_Pin1_4	20	25	PF00397	0.710
DOC_WW_Pin1_4	62	67	PF00397	0.611
DOC_WW_Pin1_4	68	73	PF00397	0.628
LIG_14-3-3_CanoR_1	18	25	PF00244	0.582
LIG_14-3-3_CanoR_1	187	193	PF00244	0.719
LIG_14-3-3_CanoR_1	27	33	PF00244	0.604
LIG_14-3-3_CanoR_1	282	289	PF00244	0.501
LIG_14-3-3_CanoR_1	42	49	PF00244	0.595
LIG_14-3-3_CanoR_1	64	72	PF00244	0.589
LIG_14-3-3_CanoR_1	97	105	PF00244	0.466
LIG_BRCT_BRCA1_1	45	49	PF00533	0.664
LIG_EH_1	178	182	PF12763	0.452
LIG_FHA_1	264	270	PF00498	0.542
LIG_FHA_1	305	311	PF00498	0.630
LIG_FHA_1	65	71	PF00498	0.742
LIG_FHA_2	252	258	PF00498	0.671
LIG_FHA_2	317	323	PF00498	0.707
LIG_FHA_2	97	103	PF00498	0.479
LIG_LIR_Apic_2	12	16	PF02991	0.433
LIG_LIR_Gen_1	113	121	PF02991	0.453
LIG_LIR_Gen_1	231	239	PF02991	0.557
LIG_LIR_Nem_3	113	118	PF02991	0.481
LIG_LIR_Nem_3	231	237	PF02991	0.559
LIG_PDZ_Class_2	360	365	PF00595	0.659
LIG_SH2_NCK_1	350	354	PF00017	0.547
LIG_SH2_STAP1	234	238	PF00017	0.586
LIG_SH2_STAP1	350	354	PF00017	0.634
LIG_SH2_STAT5	350	353	PF00017	0.622
LIG_SUMO_SIM_par_1	265	271	PF11976	0.493
LIG_TRAF2_1	135	138	PF00917	0.507
LIG_TRAF2_1	92	95	PF00917	0.521
LIG_UBA3_1	169	177	PF00899	0.571
LIG_WRC_WIRS_1	234	239	PF05994	0.588
MOD_CDC14_SPxK_1	71	74	PF00782	0.504
MOD_CDK_SPxK_1	68	74	PF00069	0.507
MOD_CDK_SPxxK_3	20	27	PF00069	0.458
MOD_CDK_SPxxK_3	68	75	PF00069	0.645
MOD_CK1_1	113	119	PF00069	0.585
MOD_CK1_1	303	309	PF00069	0.675
MOD_CK1_1	45	51	PF00069	0.618
MOD_CK1_1	52	58	PF00069	0.652
MOD_CK1_1	65	71	PF00069	0.465
MOD_CK2_1	227	233	PF00069	0.651
MOD_CK2_1	246	252	PF00069	0.440
MOD_CK2_1	79	85	PF00069	0.654
MOD_GlcNHglycan	260	263	PF01048	0.575
MOD_GlcNHglycan	302	305	PF01048	0.614
MOD_GlcNHglycan	328	331	PF01048	0.587
MOD_GlcNHglycan	51	54	PF01048	0.573
MOD_GSK3_1	106	113	PF00069	0.531
MOD_GSK3_1	183	190	PF00069	0.713
MOD_GSK3_1	238	245	PF00069	0.633
MOD_GSK3_1	26	33	PF00069	0.610
MOD_GSK3_1	299	306	PF00069	0.550
MOD_GSK3_1	322	329	PF00069	0.739
MOD_GSK3_1	45	52	PF00069	0.481
MOD_GSK3_1	62	69	PF00069	0.608
MOD_NEK2_1	110	115	PF00069	0.540
MOD_NEK2_1	181	186	PF00069	0.629
MOD_NEK2_1	206	211	PF00069	0.584
MOD_NEK2_1	238	243	PF00069	0.598
MOD_NEK2_1	30	35	PF00069	0.664
MOD_NEK2_1	49	54	PF00069	0.689
MOD_NEK2_2	270	275	PF00069	0.610
MOD_NEK2_2	34	39	PF00069	0.572
MOD_PIKK_1	206	212	PF00454	0.601
MOD_PKA_1	187	193	PF00069	0.718
MOD_PKA_2	17	23	PF00069	0.588
MOD_PKA_2	187	193	PF00069	0.633
MOD_PKA_2	26	32	PF00069	0.612
MOD_PKA_2	326	332	PF00069	0.588
MOD_PKA_2	49	55	PF00069	0.680
MOD_PKA_2	96	102	PF00069	0.473
MOD_Plk_1	151	157	PF00069	0.558
MOD_Plk_1	270	276	PF00069	0.474
MOD_Plk_1	348	354	PF00069	0.588
MOD_Plk_2-3	227	233	PF00069	0.584
MOD_Plk_4	233	239	PF00069	0.608
MOD_Plk_4	270	276	PF00069	0.571
MOD_ProDKin_1	189	195	PF00069	0.726
MOD_ProDKin_1	20	26	PF00069	0.709
MOD_ProDKin_1	62	68	PF00069	0.611
TRG_DiLeu_BaEn_2	232	238	PF01217	0.480
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.614
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.515
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.648
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.461
TRG_ENDOCYTIC_2	234	237	PF00928	0.579
TRG_ER_diArg_1	143	146	PF00400	0.521
TRG_NLS_MonoExtC_3	58	63	PF00514	0.718
TRG_NLS_MonoExtN_4	59	64	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4X3	Leptomonas seymouri	40%	97%
A0A1X0NTI1	Trypanosomatidae	32%	100%
A0A3Q8IAT9	Leishmania donovani	91%	100%
A0A422N4X5	Trypanosoma rangeli	31%	100%
A4HCJ6	Leishmania braziliensis	71%	97%
A4I016	Leishmania infantum	91%	100%
C9ZQ77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AVY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5ARZ4	Trypanosoma cruzi	31%	100%