Putative ser/thr protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QBI7_LEIMA

TriTrypDb:

LmjF.22.1600 , LMJLV39_220022000 , LMJSD75_220022600

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2

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Expansion

Sequence features

Q4QBI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBI7

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006797	polyphosphate metabolic process	4	2
GO:0006798	polyphosphate catabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0000298	endopolyphosphatase activity	6	2
GO:0003824	catalytic activity	1	8
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0042578	phosphoric ester hydrolase activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.588
CLV_NRD_NRD_1	254	256	PF00675	0.810
CLV_NRD_NRD_1	414	416	PF00675	0.380
CLV_NRD_NRD_1	480	482	PF00675	0.463
CLV_NRD_NRD_1	75	77	PF00675	0.853
CLV_PCSK_FUR_1	411	415	PF00082	0.430
CLV_PCSK_KEX2_1	413	415	PF00082	0.430
CLV_PCSK_KEX2_1	427	429	PF00082	0.430
CLV_PCSK_KEX2_1	480	482	PF00082	0.463
CLV_PCSK_KEX2_1	75	77	PF00082	0.853

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q2	Leptomonas seymouri	64%	100%
A0A3Q8IBC4	Leishmania donovani	95%	100%
A0A3R7K273	Trypanosoma rangeli	43%	100%
A4HCK0	Leishmania braziliensis	82%	100%
A4I019	Leishmania infantum	95%	100%
E9AVZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%

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