Putative ser/thr protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QBI7_LEIMA

TriTrypDb:

LmjF.22.1600 , LMJLV39_220022000 , LMJSD75_220022600

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBI7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006797	polyphosphate metabolic process	4	2
GO:0006798	polyphosphate catabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000298	endopolyphosphatase activity	6	2
GO:0003824	catalytic activity	1	8
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.588
CLV_NRD_NRD_1	254	256	PF00675	0.810
CLV_NRD_NRD_1	414	416	PF00675	0.380
CLV_NRD_NRD_1	480	482	PF00675	0.463
CLV_NRD_NRD_1	75	77	PF00675	0.853
CLV_PCSK_FUR_1	411	415	PF00082	0.430
CLV_PCSK_KEX2_1	413	415	PF00082	0.430
CLV_PCSK_KEX2_1	427	429	PF00082	0.430
CLV_PCSK_KEX2_1	480	482	PF00082	0.463
CLV_PCSK_KEX2_1	75	77	PF00082	0.853
CLV_PCSK_KEX2_1	799	801	PF00082	0.541
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.430
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.541
CLV_PCSK_PC7_1	423	429	PF00082	0.430
CLV_PCSK_SKI1_1	361	365	PF00082	0.451
CLV_PCSK_SKI1_1	415	419	PF00082	0.430
CLV_PCSK_SKI1_1	6	10	PF00082	0.797
CLV_PCSK_SKI1_1	611	615	PF00082	0.711
CLV_PCSK_SKI1_1	663	667	PF00082	0.681
CLV_PCSK_SKI1_1	739	743	PF00082	0.463
CLV_PCSK_SKI1_1	785	789	PF00082	0.515
CLV_PCSK_SKI1_1	800	804	PF00082	0.384
CLV_Separin_Metazoa	333	337	PF03568	0.627
DEG_APCC_DBOX_1	5	13	PF00400	0.799
DEG_APCC_DBOX_1	687	695	PF00400	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.744
DEG_SCF_FBW7_1	652	659	PF00400	0.784
DEG_SPOP_SBC_1	172	176	PF00917	0.714
DEG_SPOP_SBC_1	267	271	PF00917	0.767
DEG_SPOP_SBC_1	280	284	PF00917	0.581
DEG_SPOP_SBC_1	293	297	PF00917	0.700
DEG_SPOP_SBC_1	45	49	PF00917	0.736
DEG_SPOP_SBC_1	656	660	PF00917	0.707
DOC_CDC14_PxL_1	557	565	PF14671	0.490
DOC_CKS1_1	416	421	PF01111	0.430
DOC_CKS1_1	653	658	PF01111	0.716
DOC_CKS1_1	664	669	PF01111	0.714
DOC_CYCLIN_RxL_1	3	13	PF00134	0.801
DOC_CYCLIN_yClb5_NLxxxL_5	4	12	PF00134	0.727
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.714
DOC_MAPK_gen_1	361	371	PF00069	0.436
DOC_MAPK_gen_1	449	458	PF00069	0.345
DOC_MAPK_gen_1	506	516	PF00069	0.527
DOC_MAPK_gen_1	799	810	PF00069	0.516
DOC_MAPK_MEF2A_6	698	707	PF00069	0.490
DOC_PP2B_LxvP_1	573	576	PF13499	0.692
DOC_PP2B_LxvP_1	615	618	PF13499	0.656
DOC_PP2B_LxvP_1	707	710	PF13499	0.619
DOC_PP4_FxxP_1	558	561	PF00568	0.472
DOC_PP4_FxxP_1	733	736	PF00568	0.435
DOC_USP7_MATH_1	116	120	PF00917	0.762
DOC_USP7_MATH_1	171	175	PF00917	0.745
DOC_USP7_MATH_1	205	209	PF00917	0.760
DOC_USP7_MATH_1	221	225	PF00917	0.611
DOC_USP7_MATH_1	236	240	PF00917	0.734
DOC_USP7_MATH_1	266	270	PF00917	0.717
DOC_USP7_MATH_1	281	285	PF00917	0.706
DOC_USP7_MATH_1	38	42	PF00917	0.734
DOC_USP7_MATH_1	57	61	PF00917	0.604
DOC_USP7_MATH_1	624	628	PF00917	0.712
DOC_USP7_MATH_1	92	96	PF00917	0.728
DOC_USP7_UBL2_3	493	497	PF12436	0.551
DOC_USP7_UBL2_3	799	803	PF12436	0.482
DOC_WW_Pin1_4	141	146	PF00397	0.728
DOC_WW_Pin1_4	158	163	PF00397	0.685
DOC_WW_Pin1_4	193	198	PF00397	0.777
DOC_WW_Pin1_4	271	276	PF00397	0.786
DOC_WW_Pin1_4	29	34	PF00397	0.727
DOC_WW_Pin1_4	41	46	PF00397	0.786
DOC_WW_Pin1_4	415	420	PF00397	0.430
DOC_WW_Pin1_4	549	554	PF00397	0.532
DOC_WW_Pin1_4	597	602	PF00397	0.719
DOC_WW_Pin1_4	652	657	PF00397	0.704
DOC_WW_Pin1_4	663	668	PF00397	0.716
DOC_WW_Pin1_4	791	796	PF00397	0.619
DOC_WW_Pin1_4	88	93	PF00397	0.758
LIG_14-3-3_CanoR_1	16	23	PF00244	0.677
LIG_14-3-3_CanoR_1	166	171	PF00244	0.747
LIG_14-3-3_CanoR_1	6	15	PF00244	0.769
LIG_14-3-3_CanoR_1	688	692	PF00244	0.520
LIG_14-3-3_CanoR_1	698	707	PF00244	0.474
LIG_BIR_III_4	313	317	PF00653	0.646
LIG_deltaCOP1_diTrp_1	502	508	PF00928	0.480
LIG_deltaCOP1_diTrp_1	731	737	PF00928	0.510
LIG_FHA_1	175	181	PF00498	0.727
LIG_FHA_1	232	238	PF00498	0.730
LIG_FHA_1	322	328	PF00498	0.464
LIG_FHA_1	533	539	PF00498	0.394
LIG_FHA_1	542	548	PF00498	0.367
LIG_FHA_1	642	648	PF00498	0.737
LIG_FHA_1	657	663	PF00498	0.664
LIG_FHA_1	666	672	PF00498	0.776
LIG_FHA_1	676	682	PF00498	0.480
LIG_FHA_1	695	701	PF00498	0.367
LIG_FHA_1	736	742	PF00498	0.428
LIG_FHA_1	751	757	PF00498	0.596
LIG_FHA_1	760	766	PF00498	0.570
LIG_FHA_1	805	811	PF00498	0.531
LIG_FHA_1	91	97	PF00498	0.748
LIG_FHA_2	416	422	PF00498	0.376
LIG_LIR_Apic_2	556	561	PF02991	0.529
LIG_LIR_Apic_2	731	736	PF02991	0.465
LIG_LIR_Gen_1	337	346	PF02991	0.376
LIG_LIR_Gen_1	402	410	PF02991	0.430
LIG_LIR_Gen_1	502	511	PF02991	0.503
LIG_LIR_Gen_1	735	745	PF02991	0.555
LIG_LIR_Nem_3	313	318	PF02991	0.625
LIG_LIR_Nem_3	337	343	PF02991	0.376
LIG_LIR_Nem_3	402	406	PF02991	0.430
LIG_LIR_Nem_3	502	507	PF02991	0.485
LIG_LIR_Nem_3	519	524	PF02991	0.508
LIG_LIR_Nem_3	556	560	PF02991	0.469
LIG_LIR_Nem_3	731	737	PF02991	0.507
LIG_MYND_1	145	149	PF01753	0.794
LIG_MYND_3	563	567	PF01753	0.608
LIG_PCNA_PIPBox_1	781	790	PF02747	0.520
LIG_PCNA_yPIPBox_3	210	219	PF02747	0.777
LIG_PCNA_yPIPBox_3	470	481	PF02747	0.501
LIG_PCNA_yPIPBox_3	778	788	PF02747	0.528
LIG_PDZ_Class_2	806	811	PF00595	0.529
LIG_Pex14_2	733	737	PF04695	0.428
LIG_PTB_Apo_2	397	404	PF02174	0.430
LIG_PTB_Phospho_1	397	403	PF10480	0.430
LIG_REV1ctd_RIR_1	214	223	PF16727	0.800
LIG_SH2_CRK	395	399	PF00017	0.430
LIG_SH2_CRK	403	407	PF00017	0.430
LIG_SH2_GRB2like	375	378	PF00017	0.501
LIG_SH2_PTP2	340	343	PF00017	0.376
LIG_SH2_SRC	340	343	PF00017	0.376
LIG_SH2_STAP1	712	716	PF00017	0.537
LIG_SH2_STAT5	340	343	PF00017	0.376
LIG_SH2_STAT5	362	365	PF00017	0.430
LIG_SH2_STAT5	375	378	PF00017	0.360
LIG_SH2_STAT5	403	406	PF00017	0.423
LIG_SH2_STAT5	440	443	PF00017	0.376
LIG_SH3_1	329	335	PF00018	0.605
LIG_SH3_1	413	419	PF00018	0.430
LIG_SH3_3	139	145	PF00018	0.558
LIG_SH3_3	165	171	PF00018	0.768
LIG_SH3_3	175	181	PF00018	0.647
LIG_SH3_3	223	229	PF00018	0.725
LIG_SH3_3	329	335	PF00018	0.605
LIG_SH3_3	413	419	PF00018	0.390
LIG_SH3_3	445	451	PF00018	0.413
LIG_SH3_3	483	489	PF00018	0.510
LIG_SH3_3	558	564	PF00018	0.616
LIG_SH3_3	650	656	PF00018	0.778
LIG_Sin3_3	702	709	PF02671	0.590
LIG_SUMO_SIM_anti_2	701	707	PF11976	0.458
LIG_SUMO_SIM_anti_2	738	744	PF11976	0.482
LIG_SUMO_SIM_par_1	690	695	PF11976	0.454
LIG_UBA3_1	491	497	PF00899	0.619
MOD_CDC14_SPxK_1	660	663	PF00782	0.692
MOD_CDK_SPxK_1	657	663	PF00069	0.696
MOD_CK1_1	10	16	PF00069	0.732
MOD_CK1_1	119	125	PF00069	0.759
MOD_CK1_1	132	138	PF00069	0.652
MOD_CK1_1	150	156	PF00069	0.759
MOD_CK1_1	160	166	PF00069	0.721
MOD_CK1_1	174	180	PF00069	0.672
MOD_CK1_1	18	24	PF00069	0.732
MOD_CK1_1	193	199	PF00069	0.623
MOD_CK1_1	269	275	PF00069	0.774
MOD_CK1_1	29	35	PF00069	0.733
MOD_CK1_1	296	302	PF00069	0.787
MOD_CK1_1	41	47	PF00069	0.791
MOD_CK1_1	49	55	PF00069	0.488
MOD_CK1_1	607	613	PF00069	0.687
MOD_CK1_1	633	639	PF00069	0.650
MOD_CK1_1	641	647	PF00069	0.632
MOD_CK1_1	91	97	PF00069	0.737
MOD_CK2_1	296	302	PF00069	0.769
MOD_Cter_Amidation	253	256	PF01082	0.732
MOD_DYRK1A_RPxSP_1	415	419	PF00069	0.430
MOD_GlcNHglycan	113	116	PF01048	0.823
MOD_GlcNHglycan	12	15	PF01048	0.739
MOD_GlcNHglycan	120	124	PF01048	0.748
MOD_GlcNHglycan	192	195	PF01048	0.706
MOD_GlcNHglycan	238	241	PF01048	0.729
MOD_GlcNHglycan	271	274	PF01048	0.656
MOD_GlcNHglycan	28	31	PF01048	0.743
MOD_GlcNHglycan	288	291	PF01048	0.718
MOD_GlcNHglycan	36	39	PF01048	0.705
MOD_GlcNHglycan	55	58	PF01048	0.578
MOD_GlcNHglycan	606	609	PF01048	0.649
MOD_GlcNHglycan	625	630	PF01048	0.676
MOD_GlcNHglycan	694	697	PF01048	0.467
MOD_GlcNHglycan	700	703	PF01048	0.426
MOD_GlcNHglycan	723	726	PF01048	0.661
MOD_GSK3_1	107	114	PF00069	0.610
MOD_GSK3_1	115	122	PF00069	0.728
MOD_GSK3_1	125	132	PF00069	0.482
MOD_GSK3_1	141	148	PF00069	0.801
MOD_GSK3_1	150	157	PF00069	0.751
MOD_GSK3_1	160	167	PF00069	0.575
MOD_GSK3_1	267	274	PF00069	0.718
MOD_GSK3_1	282	289	PF00069	0.623
MOD_GSK3_1	292	299	PF00069	0.677
MOD_GSK3_1	300	307	PF00069	0.514
MOD_GSK3_1	34	41	PF00069	0.824
MOD_GSK3_1	44	51	PF00069	0.706
MOD_GSK3_1	53	60	PF00069	0.626
MOD_GSK3_1	593	600	PF00069	0.658
MOD_GSK3_1	630	637	PF00069	0.671
MOD_GSK3_1	641	648	PF00069	0.776
MOD_GSK3_1	652	659	PF00069	0.688
MOD_GSK3_1	694	701	PF00069	0.484
MOD_GSK3_1	791	798	PF00069	0.610
MOD_GSK3_1	88	95	PF00069	0.764
MOD_N-GLC_1	150	155	PF02516	0.599
MOD_N-GLC_1	604	609	PF02516	0.784
MOD_N-GLC_1	641	646	PF02516	0.710
MOD_N-GLC_1	66	71	PF02516	0.763
MOD_NEK2_1	111	116	PF00069	0.819
MOD_NEK2_1	321	326	PF00069	0.461
MOD_NEK2_1	638	643	PF00069	0.661
MOD_NEK2_1	66	71	PF00069	0.763
MOD_NEK2_1	675	680	PF00069	0.690
MOD_NEK2_1	692	697	PF00069	0.340
MOD_PIKK_1	296	302	PF00454	0.608
MOD_PIKK_1	7	13	PF00454	0.729
MOD_PIKK_1	726	732	PF00454	0.674
MOD_PK_1	182	188	PF00069	0.804
MOD_PKA_2	125	131	PF00069	0.628
MOD_PKA_2	15	21	PF00069	0.675
MOD_PKA_2	593	599	PF00069	0.652
MOD_PKA_2	687	693	PF00069	0.492
MOD_Plk_1	401	407	PF00069	0.376
MOD_Plk_1	625	631	PF00069	0.707
MOD_Plk_1	759	765	PF00069	0.517
MOD_Plk_4	129	135	PF00069	0.681
MOD_Plk_4	18	24	PF00069	0.732
MOD_Plk_4	401	407	PF00069	0.342
MOD_Plk_4	687	693	PF00069	0.483
MOD_Plk_4	804	810	PF00069	0.494
MOD_ProDKin_1	141	147	PF00069	0.732
MOD_ProDKin_1	158	164	PF00069	0.685
MOD_ProDKin_1	193	199	PF00069	0.779
MOD_ProDKin_1	271	277	PF00069	0.784
MOD_ProDKin_1	29	35	PF00069	0.730
MOD_ProDKin_1	41	47	PF00069	0.786
MOD_ProDKin_1	415	421	PF00069	0.430
MOD_ProDKin_1	549	555	PF00069	0.527
MOD_ProDKin_1	597	603	PF00069	0.720
MOD_ProDKin_1	652	658	PF00069	0.703
MOD_ProDKin_1	663	669	PF00069	0.716
MOD_ProDKin_1	791	797	PF00069	0.612
MOD_ProDKin_1	88	94	PF00069	0.756
MOD_SUMO_for_1	564	567	PF00179	0.624
MOD_SUMO_rev_2	567	573	PF00179	0.673
TRG_DiLeu_BaEn_2	782	788	PF01217	0.517
TRG_DiLeu_BaEn_4	474	480	PF01217	0.430
TRG_DiLeu_BaLyEn_6	736	741	PF01217	0.551
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.723
TRG_ENDOCYTIC_2	340	343	PF00928	0.376
TRG_ENDOCYTIC_2	395	398	PF00928	0.430
TRG_ENDOCYTIC_2	403	406	PF00928	0.430
TRG_ENDOCYTIC_2	521	524	PF00928	0.600
TRG_ER_diArg_1	410	413	PF00400	0.431
TRG_ER_diArg_1	414	416	PF00400	0.428
TRG_ER_diArg_1	479	481	PF00400	0.376
TRG_NES_CRM1_1	699	713	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.797
TRG_Pf-PMV_PEXEL_1	778	783	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q2	Leptomonas seymouri	64%	100%
A0A3Q8IBC4	Leishmania donovani	95%	100%
A0A3R7K273	Trypanosoma rangeli	43%	100%
A4HCK0	Leishmania braziliensis	82%	100%
A4I019	Leishmania infantum	95%	100%
E9AVZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%