Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBI6_LEIMA

TriTrypDb:

LmjF.22.1610 , LMJLV39_220022100 , LMJSD75_220022700

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	496	500	PF00656	0.452
CLV_NRD_NRD_1	210	212	PF00675	0.447
CLV_NRD_NRD_1	27	29	PF00675	0.484
CLV_NRD_NRD_1	398	400	PF00675	0.736
CLV_NRD_NRD_1	531	533	PF00675	0.553
CLV_NRD_NRD_1	634	636	PF00675	0.590
CLV_NRD_NRD_1	75	77	PF00675	0.491
CLV_PCSK_FUR_1	529	533	PF00082	0.474
CLV_PCSK_KEX2_1	131	133	PF00082	0.387
CLV_PCSK_KEX2_1	210	212	PF00082	0.447
CLV_PCSK_KEX2_1	362	364	PF00082	0.606
CLV_PCSK_KEX2_1	531	533	PF00082	0.498
CLV_PCSK_KEX2_1	592	594	PF00082	0.419
CLV_PCSK_KEX2_1	633	635	PF00082	0.643
CLV_PCSK_KEX2_1	720	722	PF00082	0.636
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.387
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.569
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.400
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.622
CLV_PCSK_SKI1_1	128	132	PF00082	0.467
CLV_PCSK_SKI1_1	320	324	PF00082	0.450
CLV_PCSK_SKI1_1	603	607	PF00082	0.465
CLV_PCSK_SKI1_1	615	619	PF00082	0.381
CLV_Separin_Metazoa	526	530	PF03568	0.410
DEG_SPOP_SBC_1	701	705	PF00917	0.627
DOC_CKS1_1	432	437	PF01111	0.692
DOC_CYCLIN_RxL_1	128	139	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	432	438	PF00134	0.583
DOC_MAPK_gen_1	237	246	PF00069	0.424
DOC_MAPK_MEF2A_6	158	167	PF00069	0.466
DOC_MAPK_MEF2A_6	240	248	PF00069	0.396
DOC_PP1_RVXF_1	129	136	PF00149	0.474
DOC_PP1_RVXF_1	613	619	PF00149	0.454
DOC_PP4_FxxP_1	219	222	PF00568	0.389
DOC_PP4_FxxP_1	261	264	PF00568	0.466
DOC_USP7_MATH_1	179	183	PF00917	0.475
DOC_USP7_MATH_1	325	329	PF00917	0.517
DOC_USP7_MATH_1	419	423	PF00917	0.653
DOC_USP7_MATH_1	439	443	PF00917	0.639
DOC_USP7_MATH_1	546	550	PF00917	0.554
DOC_USP7_MATH_1	569	573	PF00917	0.418
DOC_USP7_MATH_1	584	588	PF00917	0.513
DOC_USP7_MATH_1	605	609	PF00917	0.408
DOC_USP7_MATH_1	671	675	PF00917	0.617
DOC_USP7_MATH_1	719	723	PF00917	0.643
DOC_USP7_MATH_1	88	92	PF00917	0.494
DOC_WW_Pin1_4	138	143	PF00397	0.580
DOC_WW_Pin1_4	168	173	PF00397	0.441
DOC_WW_Pin1_4	218	223	PF00397	0.589
DOC_WW_Pin1_4	251	256	PF00397	0.477
DOC_WW_Pin1_4	272	277	PF00397	0.533
DOC_WW_Pin1_4	284	289	PF00397	0.542
DOC_WW_Pin1_4	382	387	PF00397	0.758
DOC_WW_Pin1_4	431	436	PF00397	0.724
DOC_WW_Pin1_4	46	51	PF00397	0.445
DOC_WW_Pin1_4	95	100	PF00397	0.679
LIG_14-3-3_CanoR_1	158	163	PF00244	0.536
LIG_14-3-3_CanoR_1	210	218	PF00244	0.497
LIG_14-3-3_CanoR_1	28	34	PF00244	0.417
LIG_14-3-3_CanoR_1	388	392	PF00244	0.557
LIG_14-3-3_CanoR_1	424	432	PF00244	0.644
LIG_14-3-3_CanoR_1	623	628	PF00244	0.426
LIG_Actin_WH2_2	117	133	PF00022	0.391
LIG_Actin_WH2_2	544	560	PF00022	0.312
LIG_BIR_II_1	1	5	PF00653	0.393
LIG_BRCT_BRCA1_1	347	351	PF00533	0.431
LIG_BRCT_BRCA1_1	571	575	PF00533	0.453
LIG_BRCT_BRCA1_1	581	585	PF00533	0.541
LIG_CSL_BTD_1	58	61	PF09270	0.323
LIG_CtBP_PxDLS_1	276	280	PF00389	0.400
LIG_EH1_1	521	529	PF00400	0.443
LIG_eIF4E_1	522	528	PF01652	0.439
LIG_FHA_1	11	17	PF00498	0.504
LIG_FHA_1	151	157	PF00498	0.303
LIG_FHA_1	252	258	PF00498	0.418
LIG_FHA_1	28	34	PF00498	0.512
LIG_FHA_1	321	327	PF00498	0.589
LIG_FHA_1	469	475	PF00498	0.554
LIG_FHA_1	485	491	PF00498	0.472
LIG_FHA_1	584	590	PF00498	0.528
LIG_FHA_2	521	527	PF00498	0.385
LIG_FHA_2	548	554	PF00498	0.417
LIG_FHA_2	651	657	PF00498	0.415
LIG_FHA_2	95	101	PF00498	0.576
LIG_Integrin_RGD_1	37	39	PF01839	0.487
LIG_LIR_Apic_2	258	264	PF02991	0.443
LIG_LIR_Apic_2	271	276	PF02991	0.310
LIG_LIR_Gen_1	461	472	PF02991	0.523
LIG_LIR_Nem_3	461	467	PF02991	0.539
LIG_MYND_1	58	62	PF01753	0.431
LIG_SH2_CRK	121	125	PF00017	0.439
LIG_SH2_CRK	512	516	PF00017	0.467
LIG_SH2_STAP1	12	16	PF00017	0.366
LIG_SH2_STAP1	81	85	PF00017	0.352
LIG_SH2_STAT3	32	35	PF00017	0.407
LIG_SH2_STAT5	12	15	PF00017	0.477
LIG_SH2_STAT5	17	20	PF00017	0.406
LIG_SH2_STAT5	32	35	PF00017	0.235
LIG_SH2_STAT5	473	476	PF00017	0.393
LIG_SH2_STAT5	522	525	PF00017	0.404
LIG_SH2_STAT5	594	597	PF00017	0.449
LIG_SH2_STAT5	664	667	PF00017	0.499
LIG_SH3_3	157	163	PF00018	0.441
LIG_SH3_3	432	438	PF00018	0.777
LIG_SH3_3	55	61	PF00018	0.374
LIG_SH3_3	679	685	PF00018	0.668
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.450
LIG_SUMO_SIM_anti_2	656	663	PF11976	0.468
LIG_SUMO_SIM_par_1	123	129	PF11976	0.366
LIG_SUMO_SIM_par_1	165	171	PF11976	0.457
LIG_SUMO_SIM_par_1	543	550	PF11976	0.450
LIG_TRAF2_1	275	278	PF00917	0.493
LIG_TRFH_1	260	264	PF08558	0.453
LIG_TYR_ITIM	119	124	PF00017	0.442
LIG_TYR_ITIM	510	515	PF00017	0.366
MOD_CDC14_SPxK_1	385	388	PF00782	0.509
MOD_CDK_SPK_2	251	256	PF00069	0.391
MOD_CDK_SPxK_1	382	388	PF00069	0.537
MOD_CDK_SPxxK_3	168	175	PF00069	0.436
MOD_CK1_1	137	143	PF00069	0.522
MOD_CK1_1	146	152	PF00069	0.478
MOD_CK1_1	202	208	PF00069	0.498
MOD_CK1_1	221	227	PF00069	0.550
MOD_CK1_1	284	290	PF00069	0.518
MOD_CK1_1	336	342	PF00069	0.587
MOD_CK1_1	381	387	PF00069	0.756
MOD_CK1_1	422	428	PF00069	0.684
MOD_CK1_1	462	468	PF00069	0.479
MOD_CK1_1	479	485	PF00069	0.540
MOD_CK1_1	492	498	PF00069	0.571
MOD_CK1_1	578	584	PF00069	0.406
MOD_CK1_1	91	97	PF00069	0.728
MOD_CK2_1	272	278	PF00069	0.530
MOD_CK2_1	407	413	PF00069	0.692
MOD_CK2_1	520	526	PF00069	0.484
MOD_CK2_1	584	590	PF00069	0.509
MOD_CK2_1	650	656	PF00069	0.429
MOD_CK2_1	660	666	PF00069	0.492
MOD_CK2_1	94	100	PF00069	0.508
MOD_GlcNHglycan	175	178	PF01048	0.576
MOD_GlcNHglycan	202	205	PF01048	0.454
MOD_GlcNHglycan	214	217	PF01048	0.468
MOD_GlcNHglycan	283	286	PF01048	0.526
MOD_GlcNHglycan	335	338	PF01048	0.580
MOD_GlcNHglycan	347	350	PF01048	0.576
MOD_GlcNHglycan	371	374	PF01048	0.664
MOD_GlcNHglycan	408	412	PF01048	0.611
MOD_GlcNHglycan	427	430	PF01048	0.535
MOD_GlcNHglycan	445	448	PF01048	0.594
MOD_GlcNHglycan	476	479	PF01048	0.656
MOD_GlcNHglycan	481	484	PF01048	0.632
MOD_GlcNHglycan	491	494	PF01048	0.382
MOD_GlcNHglycan	534	537	PF01048	0.542
MOD_GlcNHglycan	571	574	PF01048	0.442
MOD_GlcNHglycan	581	584	PF01048	0.595
MOD_GlcNHglycan	607	610	PF01048	0.476
MOD_GlcNHglycan	678	681	PF01048	0.642
MOD_GlcNHglycan	90	93	PF01048	0.586
MOD_GSK3_1	134	141	PF00069	0.438
MOD_GSK3_1	142	149	PF00069	0.475
MOD_GSK3_1	217	224	PF00069	0.488
MOD_GSK3_1	251	258	PF00069	0.445
MOD_GSK3_1	268	275	PF00069	0.517
MOD_GSK3_1	309	316	PF00069	0.534
MOD_GSK3_1	332	339	PF00069	0.535
MOD_GSK3_1	357	364	PF00069	0.508
MOD_GSK3_1	369	376	PF00069	0.655
MOD_GSK3_1	377	384	PF00069	0.631
MOD_GSK3_1	407	414	PF00069	0.717
MOD_GSK3_1	419	426	PF00069	0.694
MOD_GSK3_1	439	446	PF00069	0.597
MOD_GSK3_1	458	465	PF00069	0.466
MOD_GSK3_1	474	481	PF00069	0.558
MOD_GSK3_1	575	582	PF00069	0.575
MOD_GSK3_1	656	663	PF00069	0.553
MOD_GSK3_1	665	672	PF00069	0.642
MOD_GSK3_1	91	98	PF00069	0.656
MOD_N-GLC_1	10	15	PF02516	0.377
MOD_N-GLC_1	381	386	PF02516	0.652
MOD_NEK2_1	120	125	PF00069	0.320
MOD_NEK2_1	194	199	PF00069	0.448
MOD_NEK2_1	279	284	PF00069	0.554
MOD_NEK2_1	308	313	PF00069	0.451
MOD_NEK2_1	330	335	PF00069	0.494
MOD_NEK2_1	377	382	PF00069	0.698
MOD_NEK2_1	458	463	PF00069	0.579
MOD_NEK2_1	575	580	PF00069	0.501
MOD_NEK2_1	660	665	PF00069	0.571
MOD_NEK2_1	669	674	PF00069	0.638
MOD_NEK2_1	713	718	PF00069	0.630
MOD_NEK2_2	126	131	PF00069	0.396
MOD_NEK2_2	354	359	PF00069	0.298
MOD_NEK2_2	459	464	PF00069	0.376
MOD_PIKK_1	158	164	PF00454	0.561
MOD_PKA_2	209	215	PF00069	0.444
MOD_PKA_2	255	261	PF00069	0.433
MOD_PKA_2	27	33	PF00069	0.393
MOD_PKA_2	291	297	PF00069	0.363
MOD_PKA_2	387	393	PF00069	0.536
MOD_PKA_2	423	429	PF00069	0.712
MOD_PKA_2	468	474	PF00069	0.486
MOD_Plk_1	10	16	PF00069	0.400
MOD_Plk_1	179	185	PF00069	0.469
MOD_Plk_1	401	407	PF00069	0.594
MOD_Plk_1	422	428	PF00069	0.580
MOD_Plk_1	43	49	PF00069	0.579
MOD_Plk_1	650	656	PF00069	0.460
MOD_Plk_1	665	671	PF00069	0.577
MOD_Plk_4	120	126	PF00069	0.328
MOD_Plk_4	194	200	PF00069	0.482
MOD_Plk_4	313	319	PF00069	0.451
MOD_Plk_4	354	360	PF00069	0.411
MOD_Plk_4	459	465	PF00069	0.570
MOD_Plk_4	468	474	PF00069	0.444
MOD_Plk_4	52	58	PF00069	0.286
MOD_Plk_4	520	526	PF00069	0.422
MOD_Plk_4	623	629	PF00069	0.465
MOD_ProDKin_1	138	144	PF00069	0.580
MOD_ProDKin_1	168	174	PF00069	0.450
MOD_ProDKin_1	218	224	PF00069	0.592
MOD_ProDKin_1	251	257	PF00069	0.470
MOD_ProDKin_1	272	278	PF00069	0.530
MOD_ProDKin_1	284	290	PF00069	0.532
MOD_ProDKin_1	382	388	PF00069	0.761
MOD_ProDKin_1	431	437	PF00069	0.724
MOD_ProDKin_1	46	52	PF00069	0.449
MOD_ProDKin_1	95	101	PF00069	0.668
MOD_SUMO_rev_2	21	31	PF00179	0.492
TRG_DiLeu_BaEn_1	656	661	PF01217	0.506
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.465
TRG_ENDOCYTIC_2	12	15	PF00928	0.364
TRG_ENDOCYTIC_2	121	124	PF00928	0.461
TRG_ENDOCYTIC_2	512	515	PF00928	0.356
TRG_ENDOCYTIC_2	522	525	PF00928	0.319
TRG_ENDOCYTIC_2	81	84	PF00928	0.350
TRG_ER_diArg_1	209	211	PF00400	0.471
TRG_ER_diArg_1	509	512	PF00400	0.384
TRG_ER_diArg_1	530	532	PF00400	0.481
TRG_ER_diArg_1	633	635	PF00400	0.550
TRG_NES_CRM1_1	109	122	PF08389	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC5	Leptomonas seymouri	48%	100%
A0A1X0NTM2	Trypanosomatidae	26%	100%
A0A3S7WXI7	Leishmania donovani	90%	99%
A0A422N4V7	Trypanosoma rangeli	23%	100%
A4HCK2	Leishmania braziliensis	75%	89%
A4I020	Leishmania infantum	91%	99%
E9AVZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5B7G6	Trypanosoma cruzi	26%	100%