cobW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CobW/HypB/UreG, nucleotide-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBI2_LEIMA

TriTrypDb:

LmjF.22.1650 , LMJLV39_220022500 , LMJSD75_220023100

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.565
CLV_NRD_NRD_1	190	192	PF00675	0.320
CLV_NRD_NRD_1	284	286	PF00675	0.595
CLV_NRD_NRD_1	331	333	PF00675	0.671
CLV_PCSK_KEX2_1	190	192	PF00082	0.320
CLV_PCSK_KEX2_1	284	286	PF00082	0.595
CLV_PCSK_PC7_1	186	192	PF00082	0.393
CLV_PCSK_SKI1_1	190	194	PF00082	0.393
CLV_PCSK_SKI1_1	267	271	PF00082	0.596
CLV_PCSK_SKI1_1	284	288	PF00082	0.594
CLV_PCSK_SKI1_1	293	297	PF00082	0.515
DEG_APCC_DBOX_1	292	300	PF00400	0.548
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CDC14_PxL_1	117	125	PF14671	0.593
DOC_CYCLIN_RxL_1	282	289	PF00134	0.578
DOC_MAPK_gen_1	32	40	PF00069	0.593
DOC_MAPK_MEF2A_6	32	40	PF00069	0.593
DOC_MAPK_MEF2A_6	7	14	PF00069	0.468
DOC_PP1_RVXF_1	319	326	PF00149	0.624
DOC_USP7_MATH_1	137	141	PF00917	0.593
DOC_USP7_MATH_1	151	155	PF00917	0.427
DOC_USP7_MATH_1	196	200	PF00917	0.608
DOC_USP7_MATH_1	214	218	PF00917	0.277
DOC_USP7_MATH_1	380	384	PF00917	0.525
DOC_USP7_MATH_1	58	62	PF00917	0.576
DOC_WW_Pin1_4	286	291	PF00397	0.583
LIG_14-3-3_CanoR_1	267	272	PF00244	0.459
LIG_14-3-3_CanoR_1	326	331	PF00244	0.551
LIG_Actin_WH2_2	270	286	PF00022	0.577
LIG_Clathr_ClatBox_1	268	272	PF01394	0.535
LIG_FHA_1	175	181	PF00498	0.500
LIG_FHA_1	18	24	PF00498	0.457
LIG_FHA_1	268	274	PF00498	0.594
LIG_FHA_1	278	284	PF00498	0.499
LIG_FHA_1	3	9	PF00498	0.495
LIG_FHA_2	143	149	PF00498	0.593
LIG_FXI_DFP_1	362	366	PF00024	0.596
LIG_LIR_Nem_3	210	215	PF02991	0.495
LIG_LIR_Nem_3	335	339	PF02991	0.527
LIG_Pex14_2	361	365	PF04695	0.594
LIG_PTB_Apo_2	170	177	PF02174	0.565
LIG_PTB_Phospho_1	170	176	PF10480	0.565
LIG_SH2_NCK_1	238	242	PF00017	0.657
LIG_SH2_NCK_1	99	103	PF00017	0.537
LIG_SH2_PTP2	343	346	PF00017	0.629
LIG_SH2_STAP1	176	180	PF00017	0.568
LIG_SH2_STAT5	176	179	PF00017	0.565
LIG_SH2_STAT5	206	209	PF00017	0.490
LIG_SH2_STAT5	212	215	PF00017	0.440
LIG_SH2_STAT5	305	308	PF00017	0.508
LIG_SH2_STAT5	343	346	PF00017	0.629
LIG_SH3_1	25	31	PF00018	0.537
LIG_SH3_3	104	110	PF00018	0.565
LIG_SH3_3	25	31	PF00018	0.537
LIG_SH3_3	336	342	PF00018	0.548
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.587
LIG_SUMO_SIM_par_1	139	146	PF11976	0.572
LIG_TRAF2_1	253	256	PF00917	0.686
LIG_TRAF2_1	31	34	PF00917	0.593
LIG_TYR_ITIM	334	339	PF00017	0.627
LIG_UBA3_1	26	35	PF00899	0.487
LIG_UBA3_1	268	276	PF00899	0.523
LIG_WRC_WIRS_1	230	235	PF05994	0.481
LIG_WRC_WIRS_1	245	250	PF05994	0.555
MOD_CDK_SPxxK_3	286	293	PF00069	0.542
MOD_CK1_1	140	146	PF00069	0.389
MOD_CK1_1	17	23	PF00069	0.487
MOD_CK1_1	314	320	PF00069	0.629
MOD_CK1_1	56	62	PF00069	0.487
MOD_CK2_1	97	103	PF00069	0.464
MOD_GlcNHglycan	16	19	PF01048	0.487
MOD_GlcNHglycan	306	309	PF01048	0.481
MOD_GlcNHglycan	310	316	PF01048	0.554
MOD_GlcNHglycan	350	353	PF01048	0.568
MOD_GlcNHglycan	378	381	PF01048	0.517
MOD_GlcNHglycan	55	58	PF01048	0.483
MOD_GlcNHglycan	62	65	PF01048	0.375
MOD_GlcNHglycan	72	75	PF01048	0.210
MOD_GlcNHglycan	90	93	PF01048	0.447
MOD_GSK3_1	136	143	PF00069	0.382
MOD_GSK3_1	14	21	PF00069	0.487
MOD_GSK3_1	376	383	PF00069	0.583
MOD_GSK3_1	56	63	PF00069	0.437
MOD_N-GLC_1	59	64	PF02516	0.409
MOD_NEK2_1	14	19	PF00069	0.445
MOD_NEK2_1	142	147	PF00069	0.473
MOD_NEK2_1	365	370	PF00069	0.461
MOD_PIKK_1	277	283	PF00454	0.440
MOD_PKA_2	348	354	PF00069	0.545
MOD_Plk_1	180	186	PF00069	0.493
MOD_Plk_4	137	143	PF00069	0.394
MOD_Plk_4	18	24	PF00069	0.487
MOD_Plk_4	180	186	PF00069	0.379
MOD_Plk_4	214	220	PF00069	0.555
MOD_Plk_4	229	235	PF00069	0.533
MOD_Plk_4	97	103	PF00069	0.372
MOD_ProDKin_1	286	292	PF00069	0.576
TRG_DiLeu_BaEn_3	256	262	PF01217	0.453
TRG_DiLeu_BaEn_3	33	39	PF01217	0.487
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.409
TRG_ENDOCYTIC_2	212	215	PF00928	0.447
TRG_ENDOCYTIC_2	336	339	PF00928	0.521
TRG_ENDOCYTIC_2	343	346	PF00928	0.527
TRG_ENDOCYTIC_2	99	102	PF00928	0.385
TRG_ER_diArg_1	189	191	PF00400	0.385
TRG_ER_diArg_1	283	285	PF00400	0.592
TRG_NES_CRM1_1	260	272	PF08389	0.407
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8A6	Bodo saltans	27%	100%
A0A3Q8ILT9	Leishmania donovani	94%	100%
A4HCK6	Leishmania braziliensis	83%	95%
A4I024	Leishmania infantum	94%	100%
E9AVZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P31521	Pseudomonas chlororaphis	27%	92%
P94400	Bacillus subtilis (strain 168)	26%	97%