RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBI0_LEIMA

TriTrypDb:

LmjF.22.1670 , LMJLV39_220022700 , LMJSD75_220023300

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBI0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.684
CLV_NRD_NRD_1	11	13	PF00675	0.636
CLV_NRD_NRD_1	140	142	PF00675	0.481
CLV_NRD_NRD_1	256	258	PF00675	0.387
CLV_NRD_NRD_1	532	534	PF00675	0.475
CLV_NRD_NRD_1	659	661	PF00675	0.482
CLV_NRD_NRD_1	713	715	PF00675	0.550
CLV_NRD_NRD_1	856	858	PF00675	0.406
CLV_PCSK_FUR_1	9	13	PF00082	0.608
CLV_PCSK_KEX2_1	11	13	PF00082	0.636
CLV_PCSK_KEX2_1	140	142	PF00082	0.481
CLV_PCSK_KEX2_1	256	258	PF00082	0.387
CLV_PCSK_KEX2_1	526	528	PF00082	0.407
CLV_PCSK_KEX2_1	659	661	PF00082	0.517
CLV_PCSK_KEX2_1	713	715	PF00082	0.523
CLV_PCSK_KEX2_1	856	858	PF00082	0.406
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.475
CLV_PCSK_SKI1_1	107	111	PF00082	0.722
CLV_PCSK_SKI1_1	11	15	PF00082	0.699
CLV_PCSK_SKI1_1	202	206	PF00082	0.403
CLV_PCSK_SKI1_1	257	261	PF00082	0.405
CLV_PCSK_SKI1_1	333	337	PF00082	0.455
CLV_PCSK_SKI1_1	369	373	PF00082	0.459
CLV_PCSK_SKI1_1	41	45	PF00082	0.568
CLV_PCSK_SKI1_1	477	481	PF00082	0.449
CLV_PCSK_SKI1_1	71	75	PF00082	0.550
CLV_PCSK_SKI1_1	714	718	PF00082	0.500
CLV_PCSK_SKI1_1	898	902	PF00082	0.316
DEG_APCC_DBOX_1	113	121	PF00400	0.660
DEG_APCC_DBOX_1	705	713	PF00400	0.455
DEG_Nend_UBRbox_1	1	4	PF02207	0.622
DOC_CKS1_1	195	200	PF01111	0.472
DOC_CYCLIN_RxL_1	175	186	PF00134	0.456
DOC_CYCLIN_RxL_1	474	482	PF00134	0.453
DOC_CYCLIN_RxL_1	68	79	PF00134	0.544
DOC_CYCLIN_RxL_1	710	720	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.533
DOC_MAPK_gen_1	140	147	PF00069	0.572
DOC_MAPK_gen_1	175	185	PF00069	0.470
DOC_MAPK_gen_1	46	53	PF00069	0.558
DOC_MAPK_gen_1	481	490	PF00069	0.511
DOC_MAPK_gen_1	656	666	PF00069	0.522
DOC_MAPK_gen_1	713	719	PF00069	0.461
DOC_MAPK_gen_1	880	889	PF00069	0.402
DOC_MAPK_MEF2A_6	178	187	PF00069	0.485
DOC_MAPK_MEF2A_6	659	668	PF00069	0.505
DOC_MAPK_MEF2A_6	880	889	PF00069	0.402
DOC_PP1_RVXF_1	663	669	PF00149	0.394
DOC_PP2B_LxvP_1	192	195	PF13499	0.475
DOC_PP2B_LxvP_1	372	375	PF13499	0.462
DOC_PP2B_LxvP_1	419	422	PF13499	0.396
DOC_PP2B_LxvP_1	66	69	PF13499	0.529
DOC_PP4_FxxP_1	806	809	PF00568	0.453
DOC_USP7_MATH_1	414	418	PF00917	0.553
DOC_USP7_MATH_1	522	526	PF00917	0.461
DOC_USP7_MATH_1	572	576	PF00917	0.456
DOC_USP7_MATH_1	705	709	PF00917	0.404
DOC_USP7_MATH_1	766	770	PF00917	0.414
DOC_USP7_MATH_1	909	913	PF00917	0.459
DOC_USP7_UBL2_3	549	553	PF12436	0.448
DOC_WW_Pin1_4	13	18	PF00397	0.635
DOC_WW_Pin1_4	163	168	PF00397	0.564
DOC_WW_Pin1_4	194	199	PF00397	0.484
DOC_WW_Pin1_4	654	659	PF00397	0.560
DOC_WW_Pin1_4	742	747	PF00397	0.378
LIG_14-3-3_CanoR_1	26	30	PF00244	0.508
LIG_14-3-3_CanoR_1	271	276	PF00244	0.423
LIG_14-3-3_CanoR_1	341	346	PF00244	0.427
LIG_14-3-3_CanoR_1	429	435	PF00244	0.363
LIG_14-3-3_CanoR_1	474	480	PF00244	0.510
LIG_14-3-3_CanoR_1	48	54	PF00244	0.646
LIG_14-3-3_CanoR_1	665	669	PF00244	0.554
LIG_14-3-3_CanoR_1	695	699	PF00244	0.396
LIG_14-3-3_CanoR_1	706	710	PF00244	0.395
LIG_14-3-3_CanoR_1	713	717	PF00244	0.412
LIG_Actin_WH2_2	135	150	PF00022	0.379
LIG_Actin_WH2_2	187	204	PF00022	0.452
LIG_Actin_WH2_2	240	258	PF00022	0.416
LIG_Actin_WH2_2	356	371	PF00022	0.433
LIG_BRCT_BRCA1_1	263	267	PF00533	0.527
LIG_BRCT_BRCA1_1	439	443	PF00533	0.403
LIG_BRCT_BRCA1_1	744	748	PF00533	0.480
LIG_BRCT_BRCA1_1	766	770	PF00533	0.466
LIG_CaM_NSCaTE_8	364	371	PF13499	0.445
LIG_Clathr_ClatBox_1	716	720	PF01394	0.494
LIG_CtBP_PxDLS_1	357	361	PF00389	0.461
LIG_CtBP_PxDLS_1	50	54	PF00389	0.561
LIG_FHA_1	167	173	PF00498	0.597
LIG_FHA_1	195	201	PF00498	0.430
LIG_FHA_1	26	32	PF00498	0.739
LIG_FHA_1	423	429	PF00498	0.450
LIG_FHA_1	903	909	PF00498	0.491
LIG_FHA_2	258	264	PF00498	0.410
LIG_FHA_2	583	589	PF00498	0.411
LIG_FHA_2	786	792	PF00498	0.403
LIG_LIR_Apic_2	538	542	PF02991	0.383
LIG_LIR_Gen_1	263	270	PF02991	0.435
LIG_LIR_Gen_1	313	323	PF02991	0.464
LIG_LIR_Gen_1	430	435	PF02991	0.414
LIG_LIR_Gen_1	440	450	PF02991	0.311
LIG_LIR_Gen_1	791	799	PF02991	0.394
LIG_LIR_Gen_1	91	101	PF02991	0.552
LIG_LIR_Nem_3	126	132	PF02991	0.515
LIG_LIR_Nem_3	263	268	PF02991	0.433
LIG_LIR_Nem_3	313	318	PF02991	0.473
LIG_LIR_Nem_3	379	385	PF02991	0.328
LIG_LIR_Nem_3	430	434	PF02991	0.396
LIG_LIR_Nem_3	440	446	PF02991	0.407
LIG_LIR_Nem_3	791	795	PF02991	0.419
LIG_LIR_Nem_3	826	832	PF02991	0.437
LIG_LIR_Nem_3	91	97	PF02991	0.643
LIG_NRBOX	295	301	PF00104	0.428
LIG_NRBOX	318	324	PF00104	0.415
LIG_NRBOX	475	481	PF00104	0.452
LIG_PDZ_Class_2	914	919	PF00595	0.451
LIG_Pex14_1	279	283	PF04695	0.447
LIG_PTB_Apo_2	228	235	PF02174	0.378
LIG_REV1ctd_RIR_1	232	241	PF16727	0.491
LIG_SH2_NCK_1	698	702	PF00017	0.432
LIG_SH2_PTP2	315	318	PF00017	0.443
LIG_SH2_STAP1	913	917	PF00017	0.529
LIG_SH2_STAT3	799	802	PF00017	0.424
LIG_SH2_STAT5	160	163	PF00017	0.496
LIG_SH2_STAT5	315	318	PF00017	0.363
LIG_SH2_STAT5	634	637	PF00017	0.396
LIG_SH2_STAT5	698	701	PF00017	0.396
LIG_SH2_STAT5	783	786	PF00017	0.463
LIG_SH2_STAT5	792	795	PF00017	0.494
LIG_SH3_3	192	198	PF00018	0.405
LIG_SH3_3	2	8	PF00018	0.604
LIG_SH3_3	247	253	PF00018	0.464
LIG_SH3_3	743	749	PF00018	0.292
LIG_SH3_3	878	884	PF00018	0.549
LIG_SH3_CIN85_PxpxPR_1	4	9	PF14604	0.602
LIG_SUMO_SIM_par_1	715	720	PF11976	0.489
LIG_SUMO_SIM_par_1	82	88	PF11976	0.628
LIG_WRC_WIRS_1	428	433	PF05994	0.457
MOD_CDC14_SPxK_1	16	19	PF00782	0.501
MOD_CDK_SPK_2	654	659	PF00069	0.453
MOD_CDK_SPxK_1	13	19	PF00069	0.503
MOD_CDK_SPxK_1	654	660	PF00069	0.460
MOD_CK1_1	166	172	PF00069	0.431
MOD_CK1_1	236	242	PF00069	0.499
MOD_CK1_1	430	436	PF00069	0.515
MOD_CK1_1	535	541	PF00069	0.452
MOD_CK1_1	601	607	PF00069	0.515
MOD_CK1_1	647	653	PF00069	0.410
MOD_CK1_1	654	660	PF00069	0.430
MOD_CK1_1	708	714	PF00069	0.489
MOD_CK1_1	762	768	PF00069	0.460
MOD_CK1_1	85	91	PF00069	0.656
MOD_CK2_1	859	865	PF00069	0.443
MOD_GlcNHglycan	163	166	PF01048	0.576
MOD_GlcNHglycan	285	288	PF01048	0.463
MOD_GlcNHglycan	333	336	PF01048	0.465
MOD_GlcNHglycan	416	419	PF01048	0.465
MOD_GlcNHglycan	485	488	PF01048	0.494
MOD_GlcNHglycan	53	56	PF01048	0.620
MOD_GlcNHglycan	534	537	PF01048	0.469
MOD_GlcNHglycan	600	603	PF01048	0.467
MOD_GlcNHglycan	61	64	PF01048	0.621
MOD_GlcNHglycan	764	767	PF01048	0.510
MOD_GlcNHglycan	848	851	PF01048	0.443
MOD_GlcNHglycan	861	864	PF01048	0.523
MOD_GlcNHglycan	97	100	PF01048	0.711
MOD_GSK3_1	190	197	PF00069	0.398
MOD_GSK3_1	257	264	PF00069	0.657
MOD_GSK3_1	33	40	PF00069	0.587
MOD_GSK3_1	49	56	PF00069	0.484
MOD_GSK3_1	551	558	PF00069	0.512
MOD_GSK3_1	572	579	PF00069	0.518
MOD_GSK3_1	644	651	PF00069	0.481
MOD_GSK3_1	708	715	PF00069	0.440
MOD_GSK3_1	755	762	PF00069	0.411
MOD_GSK3_1	790	797	PF00069	0.496
MOD_GSK3_1	867	874	PF00069	0.394
MOD_LATS_1	179	185	PF00433	0.457
MOD_N-GLC_1	261	266	PF02516	0.572
MOD_N-GLC_1	572	577	PF02516	0.526
MOD_N-GLC_1	644	649	PF02516	0.412
MOD_NEK2_1	147	152	PF00069	0.422
MOD_NEK2_1	161	166	PF00069	0.455
MOD_NEK2_1	205	210	PF00069	0.499
MOD_NEK2_1	323	328	PF00069	0.500
MOD_NEK2_1	427	432	PF00069	0.411
MOD_NEK2_1	51	56	PF00069	0.663
MOD_NEK2_1	532	537	PF00069	0.523
MOD_NEK2_1	644	649	PF00069	0.412
MOD_NEK2_1	664	669	PF00069	0.442
MOD_NEK2_1	712	717	PF00069	0.493
MOD_NEK2_1	785	790	PF00069	0.419
MOD_NEK2_2	705	710	PF00069	0.489
MOD_NEK2_2	755	760	PF00069	0.484
MOD_NEK2_2	766	771	PF00069	0.499
MOD_OFUCOSY	552	559	PF10250	0.506
MOD_PIKK_1	422	428	PF00454	0.375
MOD_PIKK_1	551	557	PF00454	0.444
MOD_PIKK_1	867	873	PF00454	0.410
MOD_PK_1	760	766	PF00069	0.600
MOD_PKA_2	25	31	PF00069	0.608
MOD_PKA_2	270	276	PF00069	0.485
MOD_PKA_2	532	538	PF00069	0.507
MOD_PKA_2	664	670	PF00069	0.542
MOD_PKA_2	682	688	PF00069	0.329
MOD_PKA_2	694	700	PF00069	0.326
MOD_PKA_2	705	711	PF00069	0.436
MOD_PKA_2	712	718	PF00069	0.476
MOD_PKA_2	785	791	PF00069	0.426
MOD_PKB_1	481	489	PF00069	0.502
MOD_PKB_1	857	865	PF00069	0.449
MOD_Plk_1	181	187	PF00069	0.603
MOD_Plk_1	236	242	PF00069	0.480
MOD_Plk_1	261	267	PF00069	0.563
MOD_Plk_1	436	442	PF00069	0.482
MOD_Plk_1	44	50	PF00069	0.698
MOD_Plk_1	572	578	PF00069	0.388
MOD_Plk_1	644	650	PF00069	0.391
MOD_Plk_4	187	193	PF00069	0.443
MOD_Plk_4	271	277	PF00069	0.424
MOD_Plk_4	295	301	PF00069	0.431
MOD_Plk_4	310	316	PF00069	0.314
MOD_Plk_4	33	39	PF00069	0.575
MOD_Plk_4	430	436	PF00069	0.419
MOD_Plk_4	439	445	PF00069	0.369
MOD_Plk_4	449	455	PF00069	0.265
MOD_Plk_4	535	541	PF00069	0.441
MOD_Plk_4	644	650	PF00069	0.463
MOD_Plk_4	664	670	PF00069	0.441
MOD_Plk_4	766	772	PF00069	0.525
MOD_Plk_4	79	85	PF00069	0.593
MOD_Plk_4	88	94	PF00069	0.646
MOD_ProDKin_1	13	19	PF00069	0.635
MOD_ProDKin_1	163	169	PF00069	0.554
MOD_ProDKin_1	194	200	PF00069	0.475
MOD_ProDKin_1	654	660	PF00069	0.568
MOD_ProDKin_1	742	748	PF00069	0.376
TRG_DiLeu_BaEn_1	468	473	PF01217	0.418
TRG_DiLeu_BaEn_1	810	815	PF01217	0.506
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.403
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.386
TRG_ENDOCYTIC_2	315	318	PF00928	0.467
TRG_ENDOCYTIC_2	792	795	PF00928	0.501
TRG_ER_diArg_1	114	117	PF00400	0.656
TRG_ER_diArg_1	139	141	PF00400	0.574
TRG_ER_diArg_1	255	257	PF00400	0.366
TRG_ER_diArg_1	46	49	PF00400	0.552
TRG_ER_diArg_1	658	660	PF00400	0.501
TRG_ER_diArg_1	712	714	PF00400	0.512
TRG_ER_diArg_1	8	11	PF00400	0.596
TRG_ER_diArg_1	856	859	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	830	834	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG1	Leptomonas seymouri	54%	97%
A0A0S4JKR3	Bodo saltans	29%	81%
A0A1X0P744	Trypanosomatidae	33%	100%
A0A3Q8ICH8	Leishmania donovani	93%	100%
A4HCK8	Leishmania braziliensis	82%	100%
A4I026	Leishmania infantum	93%	100%
D0A544	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AVZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%