Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipase c-like protein

Species:

Leishmania major

UniProt:

Q4QBH9_LEIMA

TriTrypDb:

LmjF.30.2950 , LMJLV39_220022800 , LMJLV39_220022900 , LMJSD75_220023400 , LMJSD75_220023500

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBH9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	9
GO:0007165	signal transduction	2	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009987	cellular process	1	9
GO:0016042	lipid catabolic process	4	9
GO:0035556	intracellular signal transduction	3	9
GO:0044238	primary metabolic process	2	9
GO:0048015	phosphatidylinositol-mediated signaling	5	2
GO:0048017	inositol lipid-mediated signaling	4	2
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0065007	biological regulation	1	9
GO:0071704	organic substance metabolic process	2	9
GO:1901575	organic substance catabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004435	phosphatidylinositol phospholipase C activity	7	9
GO:0004620	phospholipase activity	5	9
GO:0004629	phospholipase C activity	6	9
GO:0008081	phosphoric diester hydrolase activity	5	9
GO:0016298	lipase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.572
CLV_C14_Caspase3-7	454	458	PF00656	0.326
CLV_NRD_NRD_1	232	234	PF00675	0.300
CLV_NRD_NRD_1	377	379	PF00675	0.603
CLV_NRD_NRD_1	424	426	PF00675	0.326
CLV_PCSK_KEX2_1	18	20	PF00082	0.488
CLV_PCSK_KEX2_1	232	234	PF00082	0.363
CLV_PCSK_KEX2_1	339	341	PF00082	0.436
CLV_PCSK_KEX2_1	377	379	PF00082	0.460
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.488
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.436
CLV_PCSK_SKI1_1	154	158	PF00082	0.473
CLV_PCSK_SKI1_1	186	190	PF00082	0.429
CLV_PCSK_SKI1_1	462	466	PF00082	0.404
CLV_PCSK_SKI1_1	509	513	PF00082	0.324
CLV_PCSK_SKI1_1	523	527	PF00082	0.411
CLV_PCSK_SKI1_1	79	83	PF00082	0.516
CLV_PCSK_SKI1_1	84	88	PF00082	0.486
DEG_APCC_DBOX_1	461	469	PF00400	0.247
DEG_COP1_1	512	521	PF00400	0.286
DEG_Nend_Nbox_1	1	3	PF02207	0.399
DEG_SCF_TRCP1_1	59	64	PF00400	0.286
DOC_MAPK_gen_1	377	387	PF00069	0.602
DOC_MAPK_MEF2A_6	509	518	PF00069	0.514
DOC_PP4_FxxP_1	311	314	PF00568	0.329
DOC_PP4_FxxP_1	533	536	PF00568	0.472
DOC_USP7_MATH_1	314	318	PF00917	0.416
DOC_USP7_MATH_1	393	397	PF00917	0.381
DOC_USP7_MATH_1	451	455	PF00917	0.390
DOC_USP7_MATH_1	534	538	PF00917	0.479
DOC_USP7_UBL2_3	333	337	PF12436	0.308
DOC_USP7_UBL2_3	34	38	PF12436	0.517
DOC_WW_Pin1_4	174	179	PF00397	0.543
DOC_WW_Pin1_4	323	328	PF00397	0.345
LIG_14-3-3_CanoR_1	257	263	PF00244	0.151
LIG_14-3-3_CanoR_1	386	394	PF00244	0.467
LIG_14-3-3_CanoR_1	509	514	PF00244	0.479
LIG_14-3-3_CanoR_1	523	528	PF00244	0.422
LIG_APCC_ABBA_1	176	181	PF00400	0.520
LIG_APCC_ABBA_1	86	91	PF00400	0.539
LIG_BRCT_BRCA1_1	176	180	PF00533	0.519
LIG_BRCT_BRCA1_1	307	311	PF00533	0.425
LIG_BRCT_BRCA1_1	446	450	PF00533	0.321
LIG_BRCT_BRCA1_1	480	484	PF00533	0.326
LIG_CSL_BTD_1	311	314	PF09270	0.151
LIG_deltaCOP1_diTrp_1	528	533	PF00928	0.271
LIG_FHA_1	256	262	PF00498	0.297
LIG_FHA_1	34	40	PF00498	0.606
LIG_FHA_1	524	530	PF00498	0.478
LIG_FHA_1	67	73	PF00498	0.473
LIG_FHA_1	80	86	PF00498	0.510
LIG_FHA_2	148	154	PF00498	0.422
LIG_FHA_2	21	27	PF00498	0.304
LIG_FHA_2	288	294	PF00498	0.353
LIG_FHA_2	355	361	PF00498	0.557
LIG_FHA_2	510	516	PF00498	0.511
LIG_Integrin_RGD_1	340	342	PF01839	0.576
LIG_LIR_Apic_2	308	314	PF02991	0.329
LIG_LIR_Apic_2	506	510	PF02991	0.387
LIG_LIR_Gen_1	132	141	PF02991	0.490
LIG_LIR_Gen_1	189	199	PF02991	0.471
LIG_LIR_Gen_1	278	288	PF02991	0.151
LIG_LIR_Gen_1	369	376	PF02991	0.525
LIG_LIR_Gen_1	62	72	PF02991	0.528
LIG_LIR_Gen_1	96	106	PF02991	0.445
LIG_LIR_Nem_3	111	115	PF02991	0.361
LIG_LIR_Nem_3	132	137	PF02991	0.410
LIG_LIR_Nem_3	168	174	PF02991	0.381
LIG_LIR_Nem_3	177	182	PF02991	0.398
LIG_LIR_Nem_3	278	283	PF02991	0.333
LIG_LIR_Nem_3	399	405	PF02991	0.297
LIG_LIR_Nem_3	458	464	PF02991	0.455
LIG_LIR_Nem_3	96	102	PF02991	0.448
LIG_MLH1_MIPbox_1	176	180	PF16413	0.402
LIG_NRBOX	26	32	PF00104	0.321
LIG_NRBOX	305	311	PF00104	0.409
LIG_Pex14_2	311	315	PF04695	0.321
LIG_RPA_C_Fungi	1	13	PF08784	0.351
LIG_SH2_CRK	402	406	PF00017	0.358
LIG_SH2_CRK	461	465	PF00017	0.326
LIG_SH2_GRB2like	106	109	PF00017	0.386
LIG_SH2_STAP1	106	110	PF00017	0.492
LIG_SH2_STAP1	273	277	PF00017	0.308
LIG_SH2_STAT3	117	120	PF00017	0.452
LIG_SH2_STAT5	117	120	PF00017	0.461
LIG_SH2_STAT5	174	177	PF00017	0.485
LIG_SH2_STAT5	179	182	PF00017	0.512
LIG_SH2_STAT5	202	205	PF00017	0.308
LIG_SH2_STAT5	211	214	PF00017	0.308
LIG_SH2_STAT5	255	258	PF00017	0.366
LIG_SH2_STAT5	280	283	PF00017	0.151
LIG_SH2_STAT5	370	373	PF00017	0.564
LIG_SH2_STAT5	410	413	PF00017	0.311
LIG_SH2_STAT5	501	504	PF00017	0.333
LIG_SH2_STAT5	507	510	PF00017	0.388
LIG_SH2_STAT5	521	524	PF00017	0.258
LIG_SH3_3	508	514	PF00018	0.401
LIG_SH3_3	549	555	PF00018	0.623
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.494
LIG_SUMO_SIM_anti_2	526	531	PF11976	0.481
LIG_SUMO_SIM_par_1	280	285	PF11976	0.293
LIG_SUMO_SIM_par_1	392	400	PF11976	0.333
LIG_TRAF2_1	262	265	PF00917	0.326
LIG_TRAF2_1	5	8	PF00917	0.612
LIG_TRFH_1	501	505	PF08558	0.333
LIG_WRC_WIRS_1	134	139	PF05994	0.389
MOD_CK1_1	130	136	PF00069	0.520
MOD_CK1_1	20	26	PF00069	0.553
MOD_CK1_1	207	213	PF00069	0.308
MOD_CK1_1	219	225	PF00069	0.308
MOD_CK1_1	361	367	PF00069	0.603
MOD_CK1_1	396	402	PF00069	0.310
MOD_CK1_1	420	426	PF00069	0.340
MOD_CK1_1	480	486	PF00069	0.366
MOD_CK2_1	108	114	PF00069	0.516
MOD_CK2_1	147	153	PF00069	0.429
MOD_CK2_1	2	8	PF00069	0.625
MOD_CK2_1	20	26	PF00069	0.306
MOD_CK2_1	287	293	PF00069	0.367
MOD_CK2_1	418	424	PF00069	0.358
MOD_CK2_1	61	67	PF00069	0.505
MOD_CMANNOS	312	315	PF00535	0.151
MOD_GlcNHglycan	221	224	PF01048	0.151
MOD_GlcNHglycan	277	280	PF01048	0.326
MOD_GlcNHglycan	387	390	PF01048	0.488
MOD_GlcNHglycan	391	394	PF01048	0.453
MOD_GlcNHglycan	468	471	PF01048	0.400
MOD_GlcNHglycan	495	498	PF01048	0.151
MOD_GlcNHglycan	536	539	PF01048	0.503
MOD_GlcNHglycan	58	62	PF01048	0.459
MOD_GSK3_1	104	111	PF00069	0.451
MOD_GSK3_1	13	20	PF00069	0.583
MOD_GSK3_1	203	210	PF00069	0.308
MOD_GSK3_1	215	222	PF00069	0.308
MOD_GSK3_1	29	36	PF00069	0.607
MOD_GSK3_1	319	326	PF00069	0.366
MOD_GSK3_1	354	361	PF00069	0.615
MOD_GSK3_1	385	392	PF00069	0.429
MOD_GSK3_1	393	400	PF00069	0.331
MOD_GSK3_1	451	458	PF00069	0.366
MOD_GSK3_1	57	64	PF00069	0.549
MOD_GSK3_1	75	82	PF00069	0.467
MOD_GSK3_1	93	100	PF00069	0.347
MOD_N-GLC_1	34	39	PF02516	0.663
MOD_N-GLC_1	441	446	PF02516	0.409
MOD_N-GLC_2	489	491	PF02516	0.326
MOD_NEK2_1	13	18	PF00069	0.537
MOD_NEK2_1	203	208	PF00069	0.305
MOD_NEK2_1	275	280	PF00069	0.382
MOD_NEK2_1	362	367	PF00069	0.361
MOD_NEK2_1	493	498	PF00069	0.358
MOD_OFUCOSY	440	445	PF10250	0.151
MOD_PKA_1	186	192	PF00069	0.489
MOD_PKA_2	130	136	PF00069	0.499
MOD_PKA_2	256	262	PF00069	0.329
MOD_PKA_2	385	391	PF00069	0.485
MOD_PKA_2	93	99	PF00069	0.567
MOD_Plk_1	406	412	PF00069	0.308
MOD_Plk_1	441	447	PF00069	0.377
MOD_Plk_1	61	67	PF00069	0.525
MOD_Plk_2-3	147	153	PF00069	0.465
MOD_Plk_2-3	354	360	PF00069	0.599
MOD_Plk_4	133	139	PF00069	0.406
MOD_Plk_4	207	213	PF00069	0.308
MOD_Plk_4	26	32	PF00069	0.321
MOD_Plk_4	305	311	PF00069	0.428
MOD_Plk_4	406	412	PF00069	0.325
MOD_Plk_4	44	50	PF00069	0.264
MOD_ProDKin_1	174	180	PF00069	0.538
MOD_ProDKin_1	323	329	PF00069	0.345
MOD_SUMO_rev_2	181	189	PF00179	0.485
TRG_DiLeu_BaEn_1	153	158	PF01217	0.489
TRG_DiLeu_BaEn_1	26	31	PF01217	0.289
TRG_DiLeu_BaEn_1	67	72	PF01217	0.511
TRG_DiLeu_BaEn_1	8	13	PF01217	0.330
TRG_DiLeu_BaEn_3	264	270	PF01217	0.151
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.326
TRG_ENDOCYTIC_2	179	182	PF00928	0.259
TRG_ENDOCYTIC_2	192	195	PF00928	0.376
TRG_ENDOCYTIC_2	280	283	PF00928	0.338
TRG_ENDOCYTIC_2	370	373	PF00928	0.531
TRG_ENDOCYTIC_2	402	405	PF00928	0.300
TRG_ENDOCYTIC_2	461	464	PF00928	0.326
TRG_ENDOCYTIC_2	65	68	PF00928	0.520
TRG_ER_diArg_1	232	234	PF00400	0.151
TRG_NES_CRM1_1	153	164	PF08389	0.255
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWX7	Leptomonas seymouri	60%	78%
A0A0N1I1N0	Leptomonas seymouri	33%	76%
A0A0N1IKD7	Leptomonas seymouri	31%	74%
A0A0S4J9Y4	Bodo saltans	34%	94%
A0A0S4JUS2	Bodo saltans	29%	78%
A0A1X0P2K1	Trypanosomatidae	31%	76%
A0A3Q8IF05	Leishmania donovani	31%	75%
A0A3S7WXG5	Leishmania donovani	84%	100%
A0A3S7X8U7	Leishmania donovani	29%	76%
A0A422N571	Trypanosoma rangeli	41%	91%
A4HCK9	Leishmania braziliensis	66%	78%
A4HM43	Leishmania braziliensis	31%	76%
A4I027	Leishmania infantum	85%	71%
A4I5X4	Leishmania infantum	31%	75%
A4IAQ5	Leishmania infantum	29%	76%
A5D6R3	Danio rerio	33%	71%
D0A7A3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	78%
E9AEI1	Leishmania major	30%	100%
E9B168	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	75%
E9B5P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	77%
P10688	Rattus norvegicus	31%	73%
P10895	Bos taurus	33%	73%
P21671	Bos taurus	31%	70%
P51178	Homo sapiens	32%	73%
Q1RML2	Bos taurus	28%	88%
Q2VRL0	Gallus gallus	30%	87%
Q32NH8	Xenopus laevis	33%	73%
Q39032	Arabidopsis thaliana	31%	99%
Q39033	Arabidopsis thaliana	29%	96%
Q4Q6Z7	Leishmania major	32%	75%
Q5FX52	Rattus norvegicus	29%	86%
Q5RET0	Pongo abelii	31%	73%
Q62711	Rattus norvegicus	31%	72%
Q7YRU3	Sus scrofa	32%	87%
Q86YW0	Homo sapiens	28%	91%
Q8GV43	Arabidopsis thaliana	29%	91%
Q8K2J0	Mus musculus	32%	71%
Q8K4D7	Mus musculus	30%	86%
Q8N3E9	Homo sapiens	33%	70%
Q8R3B1	Mus musculus	30%	73%
Q8SPR7	Sus scrofa	31%	72%
Q944C2	Arabidopsis thaliana	29%	96%
Q9BRC7	Homo sapiens	32%	73%
Q9LY51	Arabidopsis thaliana	28%	95%