CST complex subunit CTC1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBH6_LEIMA

TriTrypDb:

LmjF.23.0010

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.686
CLV_C14_Caspase3-7	444	448	PF00656	0.602
CLV_NRD_NRD_1	145	147	PF00675	0.564
CLV_NRD_NRD_1	297	299	PF00675	0.502
CLV_NRD_NRD_1	538	540	PF00675	0.588
CLV_PCSK_KEX2_1	147	149	PF00082	0.557
CLV_PCSK_KEX2_1	297	299	PF00082	0.502
CLV_PCSK_KEX2_1	538	540	PF00082	0.588
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.513
CLV_PCSK_SKI1_1	33	37	PF00082	0.701
CLV_PCSK_SKI1_1	599	603	PF00082	0.457
CLV_Separin_Metazoa	352	356	PF03568	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DOC_AGCK_PIF_1	495	500	PF00069	0.583
DOC_CYCLIN_RxL_1	52	61	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.554
DOC_MAPK_gen_1	114	123	PF00069	0.464
DOC_MAPK_gen_1	212	222	PF00069	0.635
DOC_MAPK_gen_1	303	313	PF00069	0.716
DOC_MAPK_MEF2A_6	117	125	PF00069	0.476
DOC_PP1_RVXF_1	50	56	PF00149	0.720
DOC_PP1_RVXF_1	597	603	PF00149	0.458
DOC_PP2B_LxvP_1	149	152	PF13499	0.640
DOC_PP2B_LxvP_1	465	468	PF13499	0.678
DOC_PP4_FxxP_1	423	426	PF00568	0.593
DOC_USP7_MATH_1	11	15	PF00917	0.723
DOC_USP7_MATH_1	153	157	PF00917	0.528
DOC_USP7_MATH_1	278	282	PF00917	0.675
DOC_USP7_MATH_1	316	320	PF00917	0.714
DOC_USP7_MATH_1	346	350	PF00917	0.413
DOC_USP7_MATH_1	445	449	PF00917	0.561
DOC_USP7_MATH_1	501	505	PF00917	0.354
DOC_USP7_MATH_1	54	58	PF00917	0.606
DOC_WW_Pin1_4	332	337	PF00397	0.421
DOC_WW_Pin1_4	372	377	PF00397	0.653
DOC_WW_Pin1_4	476	481	PF00397	0.586
LIG_14-3-3_CanoR_1	150	156	PF00244	0.437
LIG_14-3-3_CanoR_1	217	223	PF00244	0.606
LIG_14-3-3_CanoR_1	427	432	PF00244	0.512
LIG_14-3-3_CanoR_1	441	450	PF00244	0.528
LIG_14-3-3_CanoR_1	471	476	PF00244	0.408
LIG_BIR_III_2	554	558	PF00653	0.643
LIG_BRCT_BRCA1_1	163	167	PF00533	0.663
LIG_BRCT_BRCA1_1	472	476	PF00533	0.617
LIG_BRCT_BRCA1_1	498	502	PF00533	0.570
LIG_BRCT_BRCA1_1	58	62	PF00533	0.566
LIG_BRCT_BRCA1_1	588	592	PF00533	0.562
LIG_BRCT_BRCA1_1	76	80	PF00533	0.368
LIG_Clathr_ClatBox_1	579	583	PF01394	0.530
LIG_FHA_1	131	137	PF00498	0.499
LIG_FHA_1	155	161	PF00498	0.575
LIG_FHA_1	177	183	PF00498	0.540
LIG_FHA_1	297	303	PF00498	0.674
LIG_FHA_1	385	391	PF00498	0.552
LIG_FHA_1	477	483	PF00498	0.580
LIG_FHA_1	503	509	PF00498	0.592
LIG_FHA_1	517	523	PF00498	0.412
LIG_FHA_1	529	535	PF00498	0.484
LIG_FHA_1	551	557	PF00498	0.706
LIG_FHA_1	566	572	PF00498	0.411
LIG_FHA_1	574	580	PF00498	0.430
LIG_FHA_2	250	256	PF00498	0.681
LIG_FHA_2	524	530	PF00498	0.556
LIG_GBD_Chelix_1	87	95	PF00786	0.340
LIG_LIR_Apic_2	404	410	PF02991	0.574
LIG_LIR_Gen_1	164	169	PF02991	0.642
LIG_LIR_Gen_1	216	223	PF02991	0.614
LIG_LIR_Gen_1	349	359	PF02991	0.530
LIG_LIR_Gen_1	470	480	PF02991	0.365
LIG_LIR_Gen_1	589	600	PF02991	0.589
LIG_LIR_Nem_3	164	168	PF02991	0.496
LIG_LIR_Nem_3	216	222	PF02991	0.617
LIG_LIR_Nem_3	26	30	PF02991	0.537
LIG_LIR_Nem_3	349	354	PF02991	0.527
LIG_LIR_Nem_3	470	475	PF02991	0.392
LIG_LIR_Nem_3	540	544	PF02991	0.652
LIG_LIR_Nem_3	589	595	PF02991	0.586
LIG_LIR_Nem_3	6	12	PF02991	0.575
LIG_LIR_Nem_3	99	105	PF02991	0.651
LIG_Pex14_2	219	223	PF04695	0.408
LIG_Pex14_2	472	476	PF04695	0.501
LIG_Pex14_2	481	485	PF04695	0.550
LIG_Pex14_2	498	502	PF04695	0.292
LIG_PTB_Apo_2	545	552	PF02174	0.441
LIG_PTB_Phospho_1	545	551	PF10480	0.444
LIG_REV1ctd_RIR_1	533	543	PF16727	0.609
LIG_SH2_CRK	9	13	PF00017	0.651
LIG_SH2_STAP1	274	278	PF00017	0.641
LIG_SH2_STAP1	67	71	PF00017	0.625
LIG_SH2_STAT3	7	10	PF00017	0.768
LIG_SH2_STAT5	135	138	PF00017	0.542
LIG_SH2_STAT5	30	33	PF00017	0.643
LIG_SH2_STAT5	350	353	PF00017	0.571
LIG_SH2_STAT5	478	481	PF00017	0.571
LIG_SH2_STAT5	551	554	PF00017	0.647
LIG_SH2_STAT5	7	10	PF00017	0.610
LIG_SH3_3	342	348	PF00018	0.570
LIG_SUMO_SIM_par_1	156	161	PF11976	0.617
LIG_SUMO_SIM_par_1	364	370	PF11976	0.606
LIG_SUMO_SIM_par_1	593	598	PF11976	0.580
LIG_TYR_ITIM	189	194	PF00017	0.694
LIG_WRC_WIRS_1	24	29	PF05994	0.754
MOD_CK1_1	100	106	PF00069	0.581
MOD_CK1_1	130	136	PF00069	0.588
MOD_CK1_1	14	20	PF00069	0.710
MOD_CK1_1	281	287	PF00069	0.707
MOD_CK1_1	470	476	PF00069	0.594
MOD_CK1_1	523	529	PF00069	0.565
MOD_CK2_1	221	227	PF00069	0.663
MOD_CK2_1	23	29	PF00069	0.762
MOD_CK2_1	346	352	PF00069	0.573
MOD_GlcNHglycan	102	105	PF01048	0.516
MOD_GlcNHglycan	20	23	PF01048	0.544
MOD_GlcNHglycan	209	212	PF01048	0.681
MOD_GlcNHglycan	223	226	PF01048	0.477
MOD_GlcNHglycan	282	286	PF01048	0.737
MOD_GlcNHglycan	443	446	PF01048	0.622
MOD_GlcNHglycan	447	450	PF01048	0.561
MOD_GSK3_1	14	21	PF00069	0.604
MOD_GSK3_1	172	179	PF00069	0.441
MOD_GSK3_1	197	204	PF00069	0.599
MOD_GSK3_1	207	214	PF00069	0.632
MOD_GSK3_1	435	442	PF00069	0.548
MOD_GSK3_1	467	474	PF00069	0.667
MOD_GSK3_1	516	523	PF00069	0.444
MOD_GSK3_1	54	61	PF00069	0.488
MOD_GSK3_1	70	77	PF00069	0.423
MOD_N-GLC_1	458	463	PF02516	0.636
MOD_NEK2_1	201	206	PF00069	0.670
MOD_NEK2_1	338	343	PF00069	0.620
MOD_NEK2_1	367	372	PF00069	0.590
MOD_NEK2_1	502	507	PF00069	0.552
MOD_NEK2_1	58	63	PF00069	0.466
MOD_NEK2_1	586	591	PF00069	0.611
MOD_NEK2_1	593	598	PF00069	0.507
MOD_NEK2_2	218	223	PF00069	0.412
MOD_NEK2_2	261	266	PF00069	0.454
MOD_NEK2_2	530	535	PF00069	0.379
MOD_NEK2_2	542	547	PF00069	0.399
MOD_NEK2_2	573	578	PF00069	0.514
MOD_PK_1	427	433	PF00069	0.378
MOD_PK_1	97	103	PF00069	0.598
MOD_PKA_2	161	167	PF00069	0.661
MOD_PKA_2	211	217	PF00069	0.664
MOD_PKA_2	296	302	PF00069	0.533
MOD_PKA_2	470	476	PF00069	0.384
MOD_PKA_2	74	80	PF00069	0.429
MOD_Plk_1	127	133	PF00069	0.684
MOD_Plk_1	246	252	PF00069	0.421
MOD_Plk_1	281	287	PF00069	0.694
MOD_Plk_1	439	445	PF00069	0.628
MOD_Plk_1	565	571	PF00069	0.517
MOD_Plk_1	587	593	PF00069	0.618
MOD_Plk_2-3	74	80	PF00069	0.429
MOD_Plk_4	130	136	PF00069	0.541
MOD_Plk_4	154	160	PF00069	0.638
MOD_Plk_4	218	224	PF00069	0.622
MOD_Plk_4	23	29	PF00069	0.436
MOD_Plk_4	261	267	PF00069	0.477
MOD_Plk_4	3	9	PF00069	0.756
MOD_Plk_4	346	352	PF00069	0.489
MOD_Plk_4	384	390	PF00069	0.573
MOD_Plk_4	471	477	PF00069	0.579
MOD_Plk_4	566	572	PF00069	0.621
MOD_Plk_4	581	587	PF00069	0.441
MOD_Plk_4	588	594	PF00069	0.504
MOD_Plk_4	97	103	PF00069	0.598
MOD_ProDKin_1	332	338	PF00069	0.416
MOD_ProDKin_1	372	378	PF00069	0.650
MOD_ProDKin_1	476	482	PF00069	0.583
MOD_SUMO_for_1	169	172	PF00179	0.562
MOD_SUMO_for_1	37	40	PF00179	0.545
TRG_DiLeu_BaEn_1	566	571	PF01217	0.555
TRG_DiLeu_BaEn_2	587	593	PF01217	0.618
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.595
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.469
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.530
TRG_ENDOCYTIC_2	102	105	PF00928	0.493
TRG_ENDOCYTIC_2	191	194	PF00928	0.568
TRG_ENDOCYTIC_2	350	353	PF00928	0.596
TRG_ENDOCYTIC_2	478	481	PF00928	0.571
TRG_ENDOCYTIC_2	541	544	PF00928	0.649
TRG_ENDOCYTIC_2	549	552	PF00928	0.565
TRG_ENDOCYTIC_2	9	12	PF00928	0.583
TRG_ER_diArg_1	145	148	PF00400	0.563
TRG_ER_diArg_1	297	300	PF00400	0.608
TRG_ER_diArg_1	537	539	PF00400	0.554
TRG_NLS_MonoExtC_3	145	150	PF00514	0.519
TRG_NLS_MonoExtN_4	146	151	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	578	583	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICD4	Leishmania donovani	84%	100%
A4HCL3	Leishmania braziliensis	59%	100%
A4I037	Leishmania infantum	84%	100%
E9AW00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%