CCR4-NOT transcription complex subunit 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBH5_LEIMA

TriTrypDb:

LmjF.23.0020 , LMJLV39_230005000 , LMJSD75_230005000

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0030014	CCR4-NOT complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11

Expansion

Sequence features

Q4QBH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBH5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006417	regulation of translation	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	11
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010605	negative regulation of macromolecule metabolic process	5	11
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010629	negative regulation of gene expression	6	11
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0017148	negative regulation of translation	7	2
GO:0019222	regulation of metabolic process	3	11
GO:0019439	aromatic compound catabolic process	4	2
GO:0031047	RNA-mediated gene silencing	7	11
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034249	negative regulation of amide metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0048519	negative regulation of biological process	3	11
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.550
CLV_NRD_NRD_1	24	26	PF00675	0.518
CLV_NRD_NRD_1	48	50	PF00675	0.536
CLV_PCSK_KEX2_1	213	215	PF00082	0.514
CLV_PCSK_KEX2_1	48	50	PF00082	0.543
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.514
CLV_PCSK_SKI1_1	213	217	PF00082	0.452
CLV_PCSK_SKI1_1	344	348	PF00082	0.580
CLV_PCSK_SKI1_1	350	354	PF00082	0.557
CLV_PCSK_SKI1_1	49	53	PF00082	0.522
DEG_APCC_DBOX_1	173	181	PF00400	0.503
DEG_APCC_DBOX_1	358	366	PF00400	0.552
DEG_APCC_KENBOX_2	346	350	PF00400	0.502
DEG_Nend_UBRbox_4	1	3	PF02207	0.671
DOC_CYCLIN_RxL_1	210	218	PF00134	0.540
DOC_MAPK_DCC_7	174	182	PF00069	0.532
DOC_MAPK_gen_1	344	354	PF00069	0.445
DOC_MAPK_MEF2A_6	174	182	PF00069	0.495
DOC_PP2B_LxvP_1	168	171	PF13499	0.649
DOC_PP2B_LxvP_1	267	270	PF13499	0.451
DOC_USP7_MATH_1	192	196	PF00917	0.656
DOC_USP7_MATH_1	219	223	PF00917	0.598
DOC_USP7_MATH_1	31	35	PF00917	0.584
DOC_USP7_MATH_1	327	331	PF00917	0.540
DOC_USP7_UBL2_3	123	127	PF12436	0.629
DOC_USP7_UBL2_3	58	62	PF12436	0.507
DOC_USP7_UBL2_3	65	69	PF12436	0.494
DOC_WW_Pin1_4	244	249	PF00397	0.585
DOC_WW_Pin1_4	255	260	PF00397	0.522
LIG_14-3-3_CanoR_1	297	302	PF00244	0.542
LIG_14-3-3_CanoR_1	308	318	PF00244	0.465
LIG_14-3-3_CanoR_1	321	331	PF00244	0.491
LIG_Clathr_ClatBox_1	40	44	PF01394	0.442
LIG_FHA_1	10	16	PF00498	0.585
LIG_FHA_1	152	158	PF00498	0.672
LIG_FHA_1	291	297	PF00498	0.363
LIG_FHA_2	33	39	PF00498	0.534
LIG_FHA_2	58	64	PF00498	0.567
LIG_FHA_2	72	78	PF00498	0.510
LIG_FHA_2	94	100	PF00498	0.559
LIG_LIR_Apic_2	186	192	PF02991	0.563
LIG_LIR_Gen_1	34	43	PF02991	0.521
LIG_LIR_Nem_3	34	40	PF02991	0.470
LIG_NRBOX	164	170	PF00104	0.599
LIG_NRBOX	231	237	PF00104	0.513
LIG_NRP_CendR_1	382	383	PF00754	0.665
LIG_PCNA_yPIPBox_3	297	311	PF02747	0.448
LIG_SH2_CRK	37	41	PF00017	0.445
LIG_SH2_NCK_1	152	156	PF00017	0.696
LIG_SH2_STAP1	152	156	PF00017	0.667
LIG_SH2_STAP1	37	41	PF00017	0.464
LIG_SH2_STAT5	189	192	PF00017	0.631
LIG_SH2_STAT5	19	22	PF00017	0.559
LIG_SH2_STAT5	310	313	PF00017	0.299
LIG_SH2_STAT5	59	62	PF00017	0.627
LIG_SH3_3	175	181	PF00018	0.580
LIG_Sin3_3	196	203	PF02671	0.642
LIG_SUMO_SIM_par_1	195	202	PF11976	0.656
LIG_SUMO_SIM_par_1	38	44	PF11976	0.448
LIG_TRAF2_1	181	184	PF00917	0.686
LIG_UBA3_1	314	319	PF00899	0.494
LIG_UBA3_1	78	86	PF00899	0.437
LIG_WRC_WIRS_1	331	336	PF05994	0.394
MOD_CK1_1	105	111	PF00069	0.540
MOD_CK1_1	222	228	PF00069	0.517
MOD_CK1_1	239	245	PF00069	0.563
MOD_CK1_1	330	336	PF00069	0.445
MOD_CK1_1	64	70	PF00069	0.469
MOD_CK2_1	110	116	PF00069	0.518
MOD_CK2_1	147	153	PF00069	0.717
MOD_CK2_1	323	329	PF00069	0.626
MOD_CK2_1	367	373	PF00069	0.552
MOD_CK2_1	57	63	PF00069	0.552
MOD_CK2_1	71	77	PF00069	0.540
MOD_CK2_1	93	99	PF00069	0.423
MOD_GlcNHglycan	194	197	PF01048	0.623
MOD_GlcNHglycan	201	204	PF01048	0.626
MOD_GlcNHglycan	272	275	PF01048	0.486
MOD_GlcNHglycan	325	328	PF01048	0.537
MOD_GlcNHglycan	7	10	PF01048	0.556
MOD_GSK3_1	147	154	PF00069	0.641
MOD_GSK3_1	199	206	PF00069	0.591
MOD_GSK3_1	249	256	PF00069	0.554
MOD_GSK3_1	306	313	PF00069	0.473
MOD_GSK3_1	323	330	PF00069	0.317
MOD_GSK3_1	5	12	PF00069	0.591
MOD_GSK3_1	57	64	PF00069	0.585
MOD_GSK3_1	67	74	PF00069	0.464
MOD_N-GLC_1	236	241	PF02516	0.564
MOD_NEK2_1	14	19	PF00069	0.477
MOD_NEK2_1	151	156	PF00069	0.715
MOD_NEK2_1	199	204	PF00069	0.653
MOD_NEK2_1	236	241	PF00069	0.522
MOD_NEK2_1	296	301	PF00069	0.475
MOD_NEK2_1	334	339	PF00069	0.368
MOD_NEK2_1	365	370	PF00069	0.562
MOD_NEK2_1	71	76	PF00069	0.532
MOD_NEK2_1	93	98	PF00069	0.572
MOD_NEK2_2	32	37	PF00069	0.561
MOD_NEK2_2	327	332	PF00069	0.567
MOD_PK_1	110	116	PF00069	0.594
MOD_PK_1	297	303	PF00069	0.552
MOD_PKA_2	219	225	PF00069	0.557
MOD_PKA_2	296	302	PF00069	0.551
MOD_Plk_1	228	234	PF00069	0.540
MOD_Plk_1	236	242	PF00069	0.565
MOD_Plk_4	14	20	PF00069	0.470
MOD_Plk_4	147	153	PF00069	0.684
MOD_Plk_4	228	234	PF00069	0.538
MOD_Plk_4	236	242	PF00069	0.556
MOD_Plk_4	261	267	PF00069	0.455
MOD_Plk_4	290	296	PF00069	0.390
MOD_Plk_4	297	303	PF00069	0.435
MOD_Plk_4	310	316	PF00069	0.259
MOD_Plk_4	32	38	PF00069	0.501
MOD_ProDKin_1	244	250	PF00069	0.580
MOD_ProDKin_1	255	261	PF00069	0.517
MOD_SUMO_for_1	141	144	PF00179	0.687
MOD_SUMO_rev_2	63	70	PF00179	0.526
MOD_SUMO_rev_2	95	104	PF00179	0.584
TRG_DiLeu_BaEn_1	10	15	PF01217	0.531
TRG_DiLeu_BaEn_1	186	191	PF01217	0.571
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.544
TRG_ENDOCYTIC_2	37	40	PF00928	0.443
TRG_ER_diArg_1	47	49	PF00400	0.568
TRG_NES_CRM1_1	42	55	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4T3	Leptomonas seymouri	74%	88%
A0A0S4J1J3	Bodo saltans	31%	85%
A0A1X0NX78	Trypanosomatidae	44%	88%
A0A3R7NCY2	Trypanosoma rangeli	43%	88%
A0A3S7WXH7	Leishmania donovani	93%	100%
A4HCL4	Leishmania braziliensis	88%	100%
A4I038	Leishmania infantum	93%	100%
C9ZUX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	88%
E9AW01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BBD7	Trypanosoma cruzi	44%	88%