Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBH4_LEIMA

TriTrypDb:

LmjF.23.0025 , LMJLV39_230005100 , LMJSD75_230005100

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.452
CLV_NRD_NRD_1	131	133	PF00675	0.460
CLV_NRD_NRD_1	204	206	PF00675	0.518
CLV_NRD_NRD_1	260	262	PF00675	0.400
CLV_PCSK_KEX2_1	131	133	PF00082	0.559
CLV_PCSK_KEX2_1	260	262	PF00082	0.372
CLV_PCSK_SKI1_1	126	130	PF00082	0.484
CLV_PCSK_SKI1_1	260	264	PF00082	0.265
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DEG_SPOP_SBC_1	11	15	PF00917	0.566
DOC_MAPK_gen_1	102	111	PF00069	0.463
DOC_MAPK_gen_1	131	137	PF00069	0.419
DOC_PP1_RVXF_1	3	9	PF00149	0.555
DOC_PP4_FxxP_1	93	96	PF00568	0.409
DOC_USP7_MATH_1	136	140	PF00917	0.423
DOC_USP7_MATH_1	166	170	PF00917	0.401
DOC_USP7_MATH_1	241	245	PF00917	0.461
DOC_USP7_MATH_1	249	253	PF00917	0.406
DOC_USP7_MATH_1	56	60	PF00917	0.420
DOC_USP7_MATH_1	85	89	PF00917	0.353
DOC_WW_Pin1_4	126	131	PF00397	0.510
DOC_WW_Pin1_4	91	96	PF00397	0.558
LIG_14-3-3_CanoR_1	191	199	PF00244	0.341
LIG_14-3-3_CanoR_1	260	269	PF00244	0.306
LIG_14-3-3_CanoR_1	283	292	PF00244	0.416
LIG_14-3-3_CanoR_1	71	76	PF00244	0.441
LIG_Actin_WH2_2	29	47	PF00022	0.550
LIG_AP2alpha_2	212	214	PF02296	0.379
LIG_BRCT_BRCA1_1	238	242	PF00533	0.500
LIG_BRCT_BRCA1_1	58	62	PF00533	0.467
LIG_FHA_1	27	33	PF00498	0.677
LIG_FHA_1	275	281	PF00498	0.450
LIG_FHA_1	285	291	PF00498	0.384
LIG_FHA_2	266	272	PF00498	0.382
LIG_LIR_Gen_1	138	147	PF02991	0.378
LIG_LIR_Gen_1	7	16	PF02991	0.558
LIG_LIR_Nem_3	138	143	PF02991	0.410
LIG_LIR_Nem_3	7	11	PF02991	0.526
LIG_NRBOX	178	184	PF00104	0.354
LIG_PDZ_Class_2	287	292	PF00595	0.323
LIG_SH3_3	108	114	PF00018	0.400
LIG_SH3_3	160	166	PF00018	0.433
LIG_SH3_3	93	99	PF00018	0.452
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.349
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.379
LIG_SUMO_SIM_par_1	228	234	PF11976	0.481
LIG_SUMO_SIM_par_1	26	35	PF11976	0.579
LIG_TYR_ITIM	225	230	PF00017	0.322
MOD_CDK_SPK_2	126	131	PF00069	0.356
MOD_CDK_SPxK_1	126	132	PF00069	0.371
MOD_CK2_1	71	77	PF00069	0.497
MOD_GlcNHglycan	238	241	PF01048	0.485
MOD_GlcNHglycan	243	246	PF01048	0.604
MOD_GlcNHglycan	36	39	PF01048	0.660
MOD_GSK3_1	26	33	PF00069	0.549
MOD_GSK3_1	67	74	PF00069	0.465
MOD_N-GLC_1	85	90	PF02516	0.400
MOD_NEK2_1	10	15	PF00069	0.598
MOD_NEK2_1	284	289	PF00069	0.433
MOD_NEK2_1	62	67	PF00069	0.478
MOD_OFUCOSY	189	196	PF10250	0.339
MOD_PIKK_1	218	224	PF00454	0.412
MOD_PIKK_1	284	290	PF00454	0.433
MOD_PK_1	71	77	PF00069	0.415
MOD_PKA_1	260	266	PF00069	0.350
MOD_PKA_2	204	210	PF00069	0.383
MOD_PKA_2	249	255	PF00069	0.446
MOD_PKA_2	260	266	PF00069	0.406
MOD_PKA_2	282	288	PF00069	0.414
MOD_Plk_1	25	31	PF00069	0.720
MOD_Plk_2-3	26	32	PF00069	0.571
MOD_Plk_2-3	265	271	PF00069	0.393
MOD_Plk_4	136	142	PF00069	0.574
MOD_Plk_4	204	210	PF00069	0.457
MOD_Plk_4	249	255	PF00069	0.460
MOD_Plk_4	265	271	PF00069	0.388
MOD_ProDKin_1	126	132	PF00069	0.524
MOD_ProDKin_1	91	97	PF00069	0.570
MOD_SUMO_rev_2	2	7	PF00179	0.689
MOD_SUMO_rev_2	265	275	PF00179	0.465
TRG_ENDOCYTIC_2	227	230	PF00928	0.328
TRG_ER_diArg_1	130	132	PF00400	0.414
TRG_ER_diArg_1	259	261	PF00400	0.408
TRG_NES_CRM1_1	173	188	PF08389	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU6	Leptomonas seymouri	37%	100%
A0A1X0NX74	Trypanosomatidae	27%	97%
A0A3Q8IAU7	Leishmania donovani	91%	100%
A0A3R7KT29	Trypanosoma rangeli	25%	93%
A4HCL5	Leishmania braziliensis	75%	100%
A4I039	Leishmania infantum	91%	100%
C9ZUX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
E9AW02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B6S5	Trypanosoma cruzi	25%	92%