Putative beta propeller protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta propeller protein 1

Species:

Leishmania major

UniProt:

Q4QBH3_LEIMA

TriTrypDb:

LmjF.23.0030 , LMJLV39_230005200 , LMJSD75_230005200

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0016020	membrane	2	2
GO:0020016	ciliary pocket	2	2
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QBH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBH3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006356	regulation of transcription by RNA polymerase I	7	2
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	12
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045943	positive regulation of transcription by RNA polymerase I	8	2
GO:0046483	heterocycle metabolic process	3	12
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	12
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.310
CLV_NRD_NRD_1	132	134	PF00675	0.471
CLV_NRD_NRD_1	285	287	PF00675	0.412
CLV_NRD_NRD_1	441	443	PF00675	0.244
CLV_NRD_NRD_1	64	66	PF00675	0.542
CLV_PCSK_KEX2_1	340	342	PF00082	0.501
CLV_PCSK_KEX2_1	441	443	PF00082	0.244
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.484
CLV_PCSK_SKI1_1	154	158	PF00082	0.336
CLV_PCSK_SKI1_1	313	317	PF00082	0.479
CLV_PCSK_SKI1_1	418	422	PF00082	0.262
CLV_PCSK_SKI1_1	442	446	PF00082	0.225
CLV_PCSK_SKI1_1	462	466	PF00082	0.188
CLV_PCSK_SKI1_1	494	498	PF00082	0.312
CLV_PCSK_SKI1_1	500	504	PF00082	0.291
CLV_Separin_Metazoa	438	442	PF03568	0.303
DEG_Nend_Nbox_1	1	3	PF02207	0.378
DEG_SPOP_SBC_1	360	364	PF00917	0.385
DOC_CKS1_1	289	294	PF01111	0.410
DOC_CYCLIN_RxL_1	310	319	PF00134	0.370
DOC_CYCLIN_RxL_1	455	465	PF00134	0.303
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.344
DOC_MAPK_gen_1	133	140	PF00069	0.330
DOC_MAPK_gen_1	173	181	PF00069	0.420
DOC_MAPK_gen_1	441	449	PF00069	0.244
DOC_MAPK_gen_1	507	515	PF00069	0.389
DOC_MAPK_MEF2A_6	441	449	PF00069	0.281
DOC_PP1_RVXF_1	277	284	PF00149	0.445
DOC_PP1_RVXF_1	403	410	PF00149	0.309
DOC_PP1_RVXF_1	457	464	PF00149	0.259
DOC_PP2B_LxvP_1	117	120	PF13499	0.363
DOC_PP2B_LxvP_1	17	20	PF13499	0.348
DOC_USP7_MATH_1	187	191	PF00917	0.524
DOC_USP7_MATH_1	223	227	PF00917	0.500
DOC_USP7_MATH_1	359	363	PF00917	0.413
DOC_USP7_UBL2_3	392	396	PF12436	0.536
DOC_WW_Pin1_4	288	293	PF00397	0.404
LIG_14-3-3_CanoR_1	118	127	PF00244	0.365
LIG_14-3-3_CanoR_1	133	139	PF00244	0.307
LIG_14-3-3_CanoR_1	158	164	PF00244	0.369
LIG_14-3-3_CanoR_1	210	219	PF00244	0.300
LIG_14-3-3_CanoR_1	286	292	PF00244	0.385
LIG_14-3-3_CanoR_1	46	50	PF00244	0.373
LIG_14-3-3_CanoR_1	462	471	PF00244	0.303
LIG_Actin_WH2_2	144	160	PF00022	0.324
LIG_Actin_WH2_2	322	337	PF00022	0.403
LIG_APCC_ABBA_1	528	533	PF00400	0.445
LIG_BRCT_BRCA1_1	136	140	PF00533	0.308
LIG_BRCT_BRCA1_1	176	180	PF00533	0.456
LIG_BRCT_BRCA1_1	494	498	PF00533	0.338
LIG_CaM_IQ_9	404	420	PF13499	0.292
LIG_Clathr_ClatBox_1	478	482	PF01394	0.265
LIG_CtBP_PxDLS_1	383	387	PF00389	0.485
LIG_eIF4E_1	12	18	PF01652	0.361
LIG_FHA_1	120	126	PF00498	0.415
LIG_FHA_1	192	198	PF00498	0.409
LIG_FHA_1	206	212	PF00498	0.335
LIG_FHA_1	241	247	PF00498	0.432
LIG_FHA_1	255	261	PF00498	0.446
LIG_FHA_1	298	304	PF00498	0.327
LIG_FHA_1	31	37	PF00498	0.360
LIG_FHA_1	315	321	PF00498	0.280
LIG_FHA_1	362	368	PF00498	0.466
LIG_FHA_1	463	469	PF00498	0.338
LIG_FHA_1	474	480	PF00498	0.338
LIG_FHA_1	59	65	PF00498	0.499
LIG_FHA_1	79	85	PF00498	0.228
LIG_FHA_2	160	166	PF00498	0.370
LIG_FHA_2	249	255	PF00498	0.504
LIG_FHA_2	361	367	PF00498	0.505
LIG_FHA_2	433	439	PF00498	0.244
LIG_FHA_2	481	487	PF00498	0.303
LIG_LIR_Apic_2	57	63	PF02991	0.416
LIG_LIR_Gen_1	111	120	PF02991	0.424
LIG_LIR_Gen_1	434	444	PF02991	0.366
LIG_LIR_Gen_1	76	86	PF02991	0.450
LIG_LIR_LC3C_4	475	480	PF02991	0.265
LIG_LIR_Nem_3	111	117	PF02991	0.404
LIG_LIR_Nem_3	434	439	PF02991	0.366
LIG_LIR_Nem_3	482	488	PF02991	0.242
LIG_LIR_Nem_3	76	82	PF02991	0.446
LIG_LIR_Nem_3	89	94	PF02991	0.326
LIG_MLH1_MIPbox_1	494	498	PF16413	0.338
LIG_NRBOX	311	317	PF00104	0.374
LIG_Pex14_2	10	14	PF04695	0.372
LIG_Pex14_2	22	26	PF04695	0.343
LIG_Pex14_2	294	298	PF04695	0.484
LIG_Pex14_2	481	485	PF04695	0.377
LIG_PTB_Apo_2	336	343	PF02174	0.412
LIG_REV1ctd_RIR_1	495	504	PF16727	0.338
LIG_SH2_CRK	12	16	PF00017	0.364
LIG_SH2_NCK_1	99	103	PF00017	0.375
LIG_SH2_SRC	414	417	PF00017	0.338
LIG_SH2_STAP1	136	140	PF00017	0.453
LIG_SH2_STAP1	232	236	PF00017	0.409
LIG_SH2_STAP1	308	312	PF00017	0.424
LIG_SH2_STAP1	488	492	PF00017	0.272
LIG_SH2_STAP1	86	90	PF00017	0.312
LIG_SH2_STAT5	147	150	PF00017	0.423
LIG_SH2_STAT5	168	171	PF00017	0.456
LIG_SH2_STAT5	215	218	PF00017	0.409
LIG_SH2_STAT5	467	470	PF00017	0.389
LIG_SH2_STAT5	491	494	PF00017	0.389
LIG_SH3_3	279	285	PF00018	0.320
LIG_SH3_3	465	471	PF00018	0.338
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.365
LIG_SUMO_SIM_anti_2	512	517	PF11976	0.289
LIG_SUMO_SIM_par_1	33	40	PF11976	0.365
LIG_SUMO_SIM_par_1	474	483	PF11976	0.283
LIG_TRAF2_1	267	270	PF00917	0.406
LIG_TRAF2_1	382	385	PF00917	0.722
LIG_TRAF2_1	435	438	PF00917	0.244
LIG_WRC_WIRS_1	433	438	PF05994	0.389
MOD_CK1_1	159	165	PF00069	0.374
MOD_CK1_1	190	196	PF00069	0.437
MOD_CK1_1	226	232	PF00069	0.505
MOD_CK1_1	252	258	PF00069	0.308
MOD_CK1_1	297	303	PF00069	0.321
MOD_CK1_1	314	320	PF00069	0.294
MOD_CK1_1	40	46	PF00069	0.369
MOD_CK1_1	5	11	PF00069	0.368
MOD_CK1_1	52	58	PF00069	0.321
MOD_CK2_1	159	165	PF00069	0.366
MOD_CK2_1	360	366	PF00069	0.433
MOD_CK2_1	431	437	PF00069	0.244
MOD_GlcNHglycan	176	179	PF01048	0.255
MOD_GlcNHglycan	187	190	PF01048	0.178
MOD_GlcNHglycan	228	231	PF01048	0.210
MOD_GlcNHglycan	251	254	PF01048	0.403
MOD_GlcNHglycan	488	491	PF01048	0.348
MOD_GlcNHglycan	494	497	PF01048	0.326
MOD_GlcNHglycan	51	54	PF01048	0.408
MOD_GlcNHglycan	56	59	PF01048	0.361
MOD_GSK3_1	187	194	PF00069	0.409
MOD_GSK3_1	248	255	PF00069	0.362
MOD_GSK3_1	325	332	PF00069	0.446
MOD_GSK3_1	40	47	PF00069	0.368
MOD_GSK3_1	419	426	PF00069	0.250
MOD_GSK3_1	54	61	PF00069	0.542
MOD_GSK3_1	69	76	PF00069	0.592
MOD_N-GLC_1	134	139	PF02516	0.464
MOD_NEK2_1	106	111	PF00069	0.377
MOD_NEK2_1	2	7	PF00069	0.369
MOD_NEK2_1	294	299	PF00069	0.360
MOD_NEK2_1	473	478	PF00069	0.270
MOD_NEK2_1	49	54	PF00069	0.364
MOD_NEK2_1	519	524	PF00069	0.251
MOD_NEK2_2	223	228	PF00069	0.409
MOD_NEK2_2	78	83	PF00069	0.490
MOD_NEK2_2	86	91	PF00069	0.367
MOD_PIKK_1	254	260	PF00454	0.441
MOD_PIKK_1	306	312	PF00454	0.413
MOD_PK_1	134	140	PF00069	0.411
MOD_PK_1	73	79	PF00069	0.553
MOD_PKA_2	157	163	PF00069	0.391
MOD_PKA_2	45	51	PF00069	0.375
MOD_Plk_1	134	140	PF00069	0.462
MOD_Plk_1	190	196	PF00069	0.410
MOD_Plk_1	44	50	PF00069	0.618
MOD_Plk_1	453	459	PF00069	0.244
MOD_Plk_1	519	525	PF00069	0.259
MOD_Plk_1	58	64	PF00069	0.459
MOD_Plk_1	86	92	PF00069	0.385
MOD_Plk_2-3	199	205	PF00069	0.505
MOD_Plk_4	101	107	PF00069	0.280
MOD_Plk_4	223	229	PF00069	0.484
MOD_Plk_4	299	305	PF00069	0.358
MOD_Plk_4	473	479	PF00069	0.259
MOD_Plk_4	480	486	PF00069	0.259
MOD_Plk_4	5	11	PF00069	0.368
MOD_Plk_4	86	92	PF00069	0.403
MOD_ProDKin_1	288	294	PF00069	0.403
MOD_SUMO_rev_2	137	146	PF00179	0.348
TRG_DiLeu_BaEn_2	260	266	PF01217	0.432
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.364
TRG_ER_diArg_1	440	442	PF00400	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N2	Leptomonas seymouri	80%	100%
A0A0S4J5C8	Bodo saltans	48%	100%
A0A1X0NXU5	Trypanosomatidae	56%	100%
A0A3S7WXD4	Leishmania donovani	96%	100%
A0A422N5S6	Trypanosoma rangeli	53%	100%
A2RRU3	Rattus norvegicus	28%	100%
A4HCL6	Leishmania braziliensis	89%	100%
A4I040	Leishmania infantum	96%	100%
A7MB12	Bos taurus	28%	100%
C9ZUX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AW03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O82266	Arabidopsis thaliana	24%	100%
O94365	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q04305	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q5F3D7	Gallus gallus	29%	100%
Q5REE0	Pongo abelii	28%	100%
Q5XGE2	Xenopus tropicalis	28%	100%
Q7ZW33	Danio rerio	28%	100%
Q7ZXZ2	Xenopus laevis	28%	100%
Q8C7V3	Mus musculus	28%	100%
Q8TED0	Homo sapiens	28%	100%
V5D2J8	Trypanosoma cruzi	53%	100%