A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 40 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 24 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 19 |
| NetGPI | no | yes: 0, no: 19 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005730 | nucleolus | 5 | 2 |
| GO:0005737 | cytoplasm | 2 | 4 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043228 | non-membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043232 | intracellular non-membrane-bounded organelle | 4 | 2 |
| GO:0110165 | cellular anatomical entity | 1 | 6 |
| GO:0016020 | membrane | 2 | 2 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | 7 | 20 |
| GO:0006457 | protein folding | 2 | 20 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 20 |
| GO:0008152 | metabolic process | 1 | 20 |
| GO:0009987 | cellular process | 1 | 20 |
| GO:0018193 | peptidyl-amino acid modification | 5 | 20 |
| GO:0018208 | peptidyl-proline modification | 6 | 20 |
| GO:0019538 | protein metabolic process | 3 | 20 |
| GO:0036211 | protein modification process | 4 | 20 |
| GO:0043170 | macromolecule metabolic process | 3 | 20 |
| GO:0043412 | macromolecule modification | 4 | 20 |
| GO:0044238 | primary metabolic process | 2 | 20 |
| GO:0071704 | organic substance metabolic process | 2 | 20 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 20 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | 3 | 20 |
| GO:0003824 | catalytic activity | 1 | 20 |
| GO:0005488 | binding | 1 | 4 |
| GO:0016018 | cyclosporin A binding | 4 | 4 |
| GO:0016853 | isomerase activity | 2 | 20 |
| GO:0016859 | cis-trans isomerase activity | 3 | 20 |
| GO:0033218 | amide binding | 2 | 4 |
| GO:0042277 | peptide binding | 3 | 4 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 20 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_KEX2_1 | 219 | 221 | PF00082 | 0.505 |
| CLV_PCSK_KEX2_1 | 262 | 264 | PF00082 | 0.468 |
| CLV_PCSK_PC1ET2_1 | 219 | 221 | PF00082 | 0.505 |
| CLV_PCSK_PC1ET2_1 | 262 | 264 | PF00082 | 0.468 |
| CLV_PCSK_SKI1_1 | 25 | 29 | PF00082 | 0.353 |
| CLV_PCSK_SKI1_1 | 280 | 284 | PF00082 | 0.414 |
| DOC_MAPK_gen_1 | 181 | 188 | PF00069 | 0.240 |
| DOC_MAPK_MEF2A_6 | 20 | 28 | PF00069 | 0.310 |
| DOC_MAPK_MEF2A_6 | 9 | 18 | PF00069 | 0.602 |
| DOC_PP1_RVXF_1 | 153 | 160 | PF00149 | 0.317 |
| DOC_PP1_RVXF_1 | 23 | 29 | PF00149 | 0.355 |
| DOC_PP2B_PxIxI_1 | 13 | 19 | PF00149 | 0.595 |
| DOC_USP7_MATH_1 | 196 | 200 | PF00917 | 0.509 |
| DOC_USP7_MATH_1 | 212 | 216 | PF00917 | 0.531 |
| DOC_USP7_MATH_1 | 255 | 259 | PF00917 | 0.648 |
| DOC_USP7_MATH_1 | 286 | 290 | PF00917 | 0.559 |
| DOC_WW_Pin1_4 | 146 | 151 | PF00397 | 0.240 |
| DOC_WW_Pin1_4 | 232 | 237 | PF00397 | 0.617 |
| DOC_WW_Pin1_4 | 247 | 252 | PF00397 | 0.658 |
| LIG_14-3-3_CanoR_1 | 185 | 194 | PF00244 | 0.304 |
| LIG_14-3-3_CanoR_1 | 3 | 7 | PF00244 | 0.600 |
| LIG_APCC_ABBA_1 | 42 | 47 | PF00400 | 0.317 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.580 |
| LIG_BRCT_BRCA1_1 | 139 | 143 | PF00533 | 0.317 |
| LIG_BRCT_BRCA1_1 | 76 | 80 | PF00533 | 0.205 |
| LIG_FHA_1 | 147 | 153 | PF00498 | 0.283 |
| LIG_FHA_2 | 107 | 113 | PF00498 | 0.283 |
| LIG_FHA_2 | 98 | 104 | PF00498 | 0.283 |
| LIG_LIR_Gen_1 | 77 | 88 | PF02991 | 0.399 |
| LIG_LIR_Nem_3 | 54 | 59 | PF02991 | 0.282 |
| LIG_LIR_Nem_3 | 77 | 83 | PF02991 | 0.399 |
| LIG_MLH1_MIPbox_1 | 139 | 143 | PF16413 | 0.317 |
| LIG_SH2_STAP1 | 45 | 49 | PF00017 | 0.240 |
| LIG_SH3_3 | 251 | 257 | PF00018 | 0.691 |
| LIG_SUMO_SIM_anti_2 | 164 | 170 | PF11976 | 0.231 |
| MOD_CK1_1 | 179 | 185 | PF00069 | 0.288 |
| MOD_CK1_1 | 2 | 8 | PF00069 | 0.554 |
| MOD_CK2_1 | 97 | 103 | PF00069 | 0.283 |
| MOD_GlcNHglycan | 115 | 118 | PF01048 | 0.306 |
| MOD_GlcNHglycan | 178 | 181 | PF01048 | 0.283 |
| MOD_GlcNHglycan | 214 | 217 | PF01048 | 0.562 |
| MOD_GlcNHglycan | 244 | 247 | PF01048 | 0.556 |
| MOD_GlcNHglycan | 289 | 292 | PF01048 | 0.465 |
| MOD_GlcNHglycan | 68 | 71 | PF01048 | 0.286 |
| MOD_GSK3_1 | 175 | 182 | PF00069 | 0.375 |
| MOD_GSK3_1 | 45 | 52 | PF00069 | 0.339 |
| MOD_GSK3_1 | 97 | 104 | PF00069 | 0.317 |
| MOD_N-GLC_1 | 137 | 142 | PF02516 | 0.317 |
| MOD_N-GLC_1 | 97 | 102 | PF02516 | 0.317 |
| MOD_NEK2_1 | 1 | 6 | PF00069 | 0.813 |
| MOD_NEK2_1 | 143 | 148 | PF00069 | 0.317 |
| MOD_NEK2_1 | 175 | 180 | PF00069 | 0.414 |
| MOD_NEK2_1 | 231 | 236 | PF00069 | 0.524 |
| MOD_NEK2_1 | 287 | 292 | PF00069 | 0.447 |
| MOD_NEK2_2 | 101 | 106 | PF00069 | 0.317 |
| MOD_NEK2_2 | 75 | 80 | PF00069 | 0.330 |
| MOD_PIKK_1 | 137 | 143 | PF00454 | 0.317 |
| MOD_PKA_2 | 120 | 126 | PF00069 | 0.251 |
| MOD_PKA_2 | 2 | 8 | PF00069 | 0.657 |
| MOD_PKA_2 | 287 | 293 | PF00069 | 0.448 |
| MOD_Plk_1 | 111 | 117 | PF00069 | 0.352 |
| MOD_Plk_1 | 269 | 275 | PF00069 | 0.400 |
| MOD_Plk_1 | 28 | 34 | PF00069 | 0.276 |
| MOD_Plk_4 | 101 | 107 | PF00069 | 0.335 |
| MOD_Plk_4 | 75 | 81 | PF00069 | 0.330 |
| MOD_ProDKin_1 | 146 | 152 | PF00069 | 0.240 |
| MOD_ProDKin_1 | 232 | 238 | PF00069 | 0.618 |
| MOD_ProDKin_1 | 247 | 253 | PF00069 | 0.658 |
| MOD_SUMO_for_1 | 246 | 249 | PF00179 | 0.686 |
| MOD_SUMO_rev_2 | 215 | 221 | PF00179 | 0.782 |
| MOD_SUMO_rev_2 | 29 | 37 | PF00179 | 0.255 |
| TRG_DiLeu_BaEn_4 | 269 | 275 | PF01217 | 0.400 |
| TRG_ER_diArg_1 | 183 | 186 | PF00400 | 0.248 |
| TRG_NLS_Bipartite_1 | 247 | 266 | PF00514 | 0.597 |
| TRG_NLS_MonoExtC_3 | 260 | 265 | PF00514 | 0.488 |
| TRG_NLS_MonoExtN_4 | 261 | 266 | PF00514 | 0.472 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P364 | Leptomonas seymouri | 43% | 100% |
| A0A0N0P523 | Leptomonas seymouri | 74% | 100% |
| A0A0S4J465 | Bodo saltans | 27% | 100% |
| A0A0S4JAB5 | Bodo saltans | 44% | 83% |
| A0A1X0P2K2 | Trypanosomatidae | 35% | 100% |
| A0A3Q8ICB3 | Leishmania donovani | 45% | 100% |
| A0A3R7RE54 | Trypanosoma rangeli | 63% | 100% |
| A0A3S5H7U6 | Leishmania donovani | 67% | 100% |
| A0A3S7WXF4 | Leishmania donovani | 91% | 100% |
| A0A3S7WYD9 | Leishmania donovani | 31% | 100% |
| A0A3S7X325 | Leishmania donovani | 34% | 100% |
| A0A3S7X410 | Leishmania donovani | 59% | 100% |
| A0A3S7XB52 | Leishmania donovani | 38% | 100% |
| A0A422NQ98 | Trypanosoma rangeli | 24% | 82% |
| A4H8P7 | Leishmania braziliensis | 33% | 100% |
| A4HCI8 | Leishmania braziliensis | 45% | 100% |
| A4HCL8 | Leishmania braziliensis | 82% | 100% |
| A4HHU7 | Leishmania braziliensis | 33% | 100% |
| A4HIW9 | Leishmania braziliensis | 57% | 100% |
| A4HLM4 | Leishmania braziliensis | 74% | 100% |
| A4HMJ2 | Leishmania braziliensis | 28% | 66% |
| A4HPH9 | Leishmania braziliensis | 39% | 100% |
| A4I004 | Leishmania infantum | 45% | 100% |
| A4I042 | Leishmania infantum | 91% | 100% |
| A4I0X0 | Leishmania infantum | 31% | 100% |
| A4I4Z7 | Leishmania infantum | 34% | 100% |
| A4I698 | Leishmania infantum | 59% | 100% |
| A4I935 | Leishmania infantum | 67% | 100% |
| A4IDA1 | Leishmania infantum | 38% | 100% |
| C9ZQE6 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 38% | 100% |
| C9ZUX8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 60% | 98% |
| C9ZZI1 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 24% | 77% |
| E9AQT1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 82% |
| E9AT91 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 38% | 100% |
| E9AVX7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 44% | 100% |
| E9AW05 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 90% | 100% |
| E9AWX4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E9B0C7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
| E9B1F3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 58% | 100% |
| E9B400 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 68% | 100% |
| P0CP80 | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) | 49% | 79% |
| P0CP81 | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) | 49% | 79% |
| P26882 | Bos taurus | 53% | 80% |
| P35176 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 47% | 100% |
| P53691 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 52% | 80% |
| Q08752 | Homo sapiens | 53% | 80% |
| Q11004 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 47% | 83% |
| Q2U0E0 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 49% | 80% |
| Q4HXF6 | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) | 49% | 79% |
| Q4P0V4 | Ustilago maydis (strain 521 / FGSC 9021) | 48% | 74% |
| Q4Q1A6 | Leishmania major | 38% | 100% |
| Q4Q424 | Leishmania major | 68% | 100% |
| Q4Q6Q9 | Leishmania major | 59% | 100% |
| Q4Q7V7 | Leishmania major | 34% | 100% |
| Q4QAK0 | Leishmania major | 31% | 100% |
| Q4QBK2 | Leishmania major | 45% | 100% |
| Q4WIF3 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 46% | 78% |
| Q5B4E7 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 48% | 79% |
| Q5UP71 | Acanthamoeba polyphaga mimivirus | 29% | 100% |
| Q6CL78 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 53% | 79% |
| Q6DGG0 | Rattus norvegicus | 53% | 80% |
| Q7S7Z6 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 54% | 100% |
| Q9CR16 | Mus musculus | 53% | 80% |
| Q9P3X9 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 50% | 79% |
| V5B2A0 | Trypanosoma cruzi | 63% | 100% |