Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 11, putative

Species:

Leishmania major

UniProt:

Q4QBH1_LEIMA

TriTrypDb:

LmjF.23.0050 , LMJLV39_230005400 , LMJSD75_230005400

Length:

295

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	2

Expansion

Sequence features

Q4QBH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBH1

PDB structure(s): 2hqj_A

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	20
GO:0006457	protein folding	2	20
GO:0006807	nitrogen compound metabolic process	2	20
GO:0008152	metabolic process	1	20
GO:0009987	cellular process	1	20
GO:0018193	peptidyl-amino acid modification	5	20
GO:0018208	peptidyl-proline modification	6	20
GO:0019538	protein metabolic process	3	20
GO:0036211	protein modification process	4	20
GO:0043170	macromolecule metabolic process	3	20
GO:0043412	macromolecule modification	4	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20
GO:1901564	organonitrogen compound metabolic process	3	20

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	20
GO:0003824	catalytic activity	1	20
GO:0005488	binding	1	4
GO:0016018	cyclosporin A binding	4	4
GO:0016853	isomerase activity	2	20
GO:0016859	cis-trans isomerase activity	3	20
GO:0033218	amide binding	2	4
GO:0042277	peptide binding	3	4
GO:0140096	catalytic activity, acting on a protein	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	219	221	PF00082	0.505
CLV_PCSK_KEX2_1	262	264	PF00082	0.468
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.505
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.468
CLV_PCSK_SKI1_1	25	29	PF00082	0.353
CLV_PCSK_SKI1_1	280	284	PF00082	0.414
DOC_MAPK_gen_1	181	188	PF00069	0.240
DOC_MAPK_MEF2A_6	20	28	PF00069	0.310
DOC_MAPK_MEF2A_6	9	18	PF00069	0.602
DOC_PP1_RVXF_1	153	160	PF00149	0.317
DOC_PP1_RVXF_1	23	29	PF00149	0.355
DOC_PP2B_PxIxI_1	13	19	PF00149	0.595
DOC_USP7_MATH_1	196	200	PF00917	0.509
DOC_USP7_MATH_1	212	216	PF00917	0.531
DOC_USP7_MATH_1	255	259	PF00917	0.648
DOC_USP7_MATH_1	286	290	PF00917	0.559
DOC_WW_Pin1_4	146	151	PF00397	0.240
DOC_WW_Pin1_4	232	237	PF00397	0.617
DOC_WW_Pin1_4	247	252	PF00397	0.658
LIG_14-3-3_CanoR_1	185	194	PF00244	0.304
LIG_14-3-3_CanoR_1	3	7	PF00244	0.600
LIG_APCC_ABBA_1	42	47	PF00400	0.317
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	139	143	PF00533	0.317
LIG_BRCT_BRCA1_1	76	80	PF00533	0.205
LIG_FHA_1	147	153	PF00498	0.283
LIG_FHA_2	107	113	PF00498	0.283
LIG_FHA_2	98	104	PF00498	0.283
LIG_LIR_Gen_1	77	88	PF02991	0.399
LIG_LIR_Nem_3	54	59	PF02991	0.282
LIG_LIR_Nem_3	77	83	PF02991	0.399
LIG_MLH1_MIPbox_1	139	143	PF16413	0.317
LIG_SH2_STAP1	45	49	PF00017	0.240
LIG_SH3_3	251	257	PF00018	0.691
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.231
MOD_CK1_1	179	185	PF00069	0.288
MOD_CK1_1	2	8	PF00069	0.554
MOD_CK2_1	97	103	PF00069	0.283
MOD_GlcNHglycan	115	118	PF01048	0.306
MOD_GlcNHglycan	178	181	PF01048	0.283
MOD_GlcNHglycan	214	217	PF01048	0.562
MOD_GlcNHglycan	244	247	PF01048	0.556
MOD_GlcNHglycan	289	292	PF01048	0.465
MOD_GlcNHglycan	68	71	PF01048	0.286
MOD_GSK3_1	175	182	PF00069	0.375
MOD_GSK3_1	45	52	PF00069	0.339
MOD_GSK3_1	97	104	PF00069	0.317
MOD_N-GLC_1	137	142	PF02516	0.317
MOD_N-GLC_1	97	102	PF02516	0.317
MOD_NEK2_1	1	6	PF00069	0.813
MOD_NEK2_1	143	148	PF00069	0.317
MOD_NEK2_1	175	180	PF00069	0.414
MOD_NEK2_1	231	236	PF00069	0.524
MOD_NEK2_1	287	292	PF00069	0.447
MOD_NEK2_2	101	106	PF00069	0.317
MOD_NEK2_2	75	80	PF00069	0.330
MOD_PIKK_1	137	143	PF00454	0.317
MOD_PKA_2	120	126	PF00069	0.251
MOD_PKA_2	2	8	PF00069	0.657
MOD_PKA_2	287	293	PF00069	0.448
MOD_Plk_1	111	117	PF00069	0.352
MOD_Plk_1	269	275	PF00069	0.400
MOD_Plk_1	28	34	PF00069	0.276
MOD_Plk_4	101	107	PF00069	0.335
MOD_Plk_4	75	81	PF00069	0.330
MOD_ProDKin_1	146	152	PF00069	0.240
MOD_ProDKin_1	232	238	PF00069	0.618
MOD_ProDKin_1	247	253	PF00069	0.658
MOD_SUMO_for_1	246	249	PF00179	0.686
MOD_SUMO_rev_2	215	221	PF00179	0.782
MOD_SUMO_rev_2	29	37	PF00179	0.255
TRG_DiLeu_BaEn_4	269	275	PF01217	0.400
TRG_ER_diArg_1	183	186	PF00400	0.248
TRG_NLS_Bipartite_1	247	266	PF00514	0.597
TRG_NLS_MonoExtC_3	260	265	PF00514	0.488
TRG_NLS_MonoExtN_4	261	266	PF00514	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P364	Leptomonas seymouri	43%	100%
A0A0N0P523	Leptomonas seymouri	74%	100%
A0A0S4J465	Bodo saltans	27%	100%
A0A0S4JAB5	Bodo saltans	44%	83%
A0A1X0P2K2	Trypanosomatidae	35%	100%
A0A3Q8ICB3	Leishmania donovani	45%	100%
A0A3R7RE54	Trypanosoma rangeli	63%	100%
A0A3S5H7U6	Leishmania donovani	67%	100%
A0A3S7WXF4	Leishmania donovani	91%	100%
A0A3S7WYD9	Leishmania donovani	31%	100%
A0A3S7X325	Leishmania donovani	34%	100%
A0A3S7X410	Leishmania donovani	59%	100%
A0A3S7XB52	Leishmania donovani	38%	100%
A0A422NQ98	Trypanosoma rangeli	24%	82%
A4H8P7	Leishmania braziliensis	33%	100%
A4HCI8	Leishmania braziliensis	45%	100%
A4HCL8	Leishmania braziliensis	82%	100%
A4HHU7	Leishmania braziliensis	33%	100%
A4HIW9	Leishmania braziliensis	57%	100%
A4HLM4	Leishmania braziliensis	74%	100%
A4HMJ2	Leishmania braziliensis	28%	66%
A4HPH9	Leishmania braziliensis	39%	100%
A4I004	Leishmania infantum	45%	100%
A4I042	Leishmania infantum	91%	100%
A4I0X0	Leishmania infantum	31%	100%
A4I4Z7	Leishmania infantum	34%	100%
A4I698	Leishmania infantum	59%	100%
A4I935	Leishmania infantum	67%	100%
A4IDA1	Leishmania infantum	38%	100%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	98%
C9ZZI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	77%
E9AQT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	82%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AWX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
P0CP80	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	49%	79%
P0CP81	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	49%	79%
P26882	Bos taurus	53%	80%
P35176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P53691	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	80%
Q08752	Homo sapiens	53%	80%
Q11004	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	83%
Q2U0E0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	49%	80%
Q4HXF6	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	49%	79%
Q4P0V4	Ustilago maydis (strain 521 / FGSC 9021)	48%	74%
Q4Q1A6	Leishmania major	38%	100%
Q4Q424	Leishmania major	68%	100%
Q4Q6Q9	Leishmania major	59%	100%
Q4Q7V7	Leishmania major	34%	100%
Q4QAK0	Leishmania major	31%	100%
Q4QBK2	Leishmania major	45%	100%
Q4WIF3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	46%	78%
Q5B4E7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	48%	79%
Q5UP71	Acanthamoeba polyphaga mimivirus	29%	100%
Q6CL78	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	53%	79%
Q6DGG0	Rattus norvegicus	53%	80%
Q7S7Z6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	54%	100%
Q9CR16	Mus musculus	53%	80%
Q9P3X9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	50%	79%
V5B2A0	Trypanosoma cruzi	63%	100%