Agmatinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

agmatinase-like protein

Species:

Leishmania major

UniProt:

Q4QBG9_LEIMA

TriTrypDb:

LmjF.23.0070 , LMJLV39_230005600 , LMJSD75_230005600

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBG9

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006525	arginine metabolic process	6	2
GO:0006576	biogenic amine metabolic process	5	2
GO:0006595	polyamine metabolic process	6	2
GO:0006596	polyamine biosynthetic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009064	glutamine family amino acid metabolic process	5	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004053	arginase activity	5	1
GO:0005488	binding	1	10
GO:0008783	agmatinase activity	5	6
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4	7
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.659
CLV_NRD_NRD_1	186	188	PF00675	0.262
CLV_NRD_NRD_1	189	191	PF00675	0.262
CLV_PCSK_KEX2_1	136	138	PF00082	0.262
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.262
CLV_PCSK_SKI1_1	136	140	PF00082	0.262
CLV_PCSK_SKI1_1	163	167	PF00082	0.261
CLV_PCSK_SKI1_1	168	172	PF00082	0.252
CLV_PCSK_SKI1_1	206	210	PF00082	0.272
CLV_PCSK_SKI1_1	248	252	PF00082	0.274

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA1	Leptomonas seymouri	81%	100%
A0A1X0NYK7	Trypanosomatidae	68%	100%
A0A3Q8IBD4	Leishmania donovani	97%	100%
A4HCM0	Leishmania braziliensis	88%	100%
A4I044	Leishmania infantum	97%	100%
A8GIX7	Serratia proteamaculans (strain 568)	25%	100%
B4F1A3	Proteus mirabilis (strain HI4320)	23%	100%
C9ZUY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AW07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q7N122	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	24%	100%

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