Myosin_tail_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBG8_LEIMA

TriTrypDb:

LmjF.23.0080 , LMJLV39_230005700 , LMJSD75_230005700

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	30	36	PF00089	0.435
CLV_NRD_NRD_1	23	25	PF00675	0.430
CLV_NRD_NRD_1	35	37	PF00675	0.400
CLV_NRD_NRD_1	356	358	PF00675	0.440
CLV_NRD_NRD_1	394	396	PF00675	0.564
CLV_NRD_NRD_1	62	64	PF00675	0.599
CLV_PCSK_KEX2_1	133	135	PF00082	0.609
CLV_PCSK_KEX2_1	159	161	PF00082	0.516
CLV_PCSK_KEX2_1	22	24	PF00082	0.451
CLV_PCSK_KEX2_1	254	256	PF00082	0.573
CLV_PCSK_KEX2_1	393	395	PF00082	0.579
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.542
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.548
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.573
CLV_PCSK_SKI1_1	127	131	PF00082	0.430
CLV_PCSK_SKI1_1	159	163	PF00082	0.374
CLV_PCSK_SKI1_1	233	237	PF00082	0.509
CLV_PCSK_SKI1_1	254	258	PF00082	0.464
CLV_PCSK_SKI1_1	273	277	PF00082	0.423
CLV_PCSK_SKI1_1	297	301	PF00082	0.625
CLV_PCSK_SKI1_1	415	419	PF00082	0.369
DOC_CYCLIN_RxL_1	124	131	PF00134	0.442
DOC_MAPK_gen_1	229	237	PF00069	0.601
DOC_MAPK_gen_1	399	407	PF00069	0.444
DOC_MAPK_gen_1	52	62	PF00069	0.495
DOC_MAPK_MEF2A_6	273	282	PF00069	0.424
DOC_MAPK_NFAT4_5	273	281	PF00069	0.435
DOC_USP7_MATH_1	132	136	PF00917	0.597
DOC_USP7_MATH_1	150	154	PF00917	0.401
DOC_USP7_MATH_1	365	369	PF00917	0.422
DOC_USP7_MATH_1	389	393	PF00917	0.472
DOC_WW_Pin1_4	77	82	PF00397	0.539
DOC_WW_Pin1_4	9	14	PF00397	0.568
LIG_14-3-3_CanoR_1	160	166	PF00244	0.553
LIG_14-3-3_CanoR_1	170	179	PF00244	0.528
LIG_14-3-3_CanoR_1	22	30	PF00244	0.436
LIG_14-3-3_CanoR_1	233	238	PF00244	0.619
LIG_14-3-3_CanoR_1	273	279	PF00244	0.549
LIG_Actin_WH2_2	282	299	PF00022	0.593
LIG_Actin_WH2_2	87	102	PF00022	0.353
LIG_APCC_ABBA_1	321	326	PF00400	0.368
LIG_APCC_ABBAyCdc20_2	254	260	PF00400	0.484
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_CtBP_PxDLS_1	81	85	PF00389	0.502
LIG_FHA_1	229	235	PF00498	0.586
LIG_FHA_1	99	105	PF00498	0.435
LIG_FHA_2	134	140	PF00498	0.518
LIG_FHA_2	147	153	PF00498	0.533
LIG_FHA_2	169	175	PF00498	0.572
LIG_FHA_2	285	291	PF00498	0.447
LIG_FHA_2	398	404	PF00498	0.447
LIG_FHA_2	54	60	PF00498	0.579
LIG_LIR_Gen_1	298	308	PF02991	0.650
LIG_LIR_Nem_3	242	247	PF02991	0.431
LIG_LIR_Nem_3	298	303	PF02991	0.625
LIG_SH2_CRK	244	248	PF00017	0.472
LIG_SH2_GRB2like	388	391	PF00017	0.378
LIG_SH2_SRC	388	391	PF00017	0.378
LIG_SH3_3	314	320	PF00018	0.640
LIG_SUMO_SIM_par_1	274	279	PF11976	0.435
LIG_SUMO_SIM_par_1	318	326	PF11976	0.378
LIG_TRAF2_1	44	47	PF00917	0.434
MOD_CK1_1	12	18	PF00069	0.623
MOD_CK1_1	144	150	PF00069	0.590
MOD_CK1_1	163	169	PF00069	0.398
MOD_CK1_1	173	179	PF00069	0.401
MOD_CK1_1	274	280	PF00069	0.445
MOD_CK1_1	334	340	PF00069	0.436
MOD_CK1_1	80	86	PF00069	0.464
MOD_CK2_1	12	18	PF00069	0.572
MOD_CK2_1	146	152	PF00069	0.630
MOD_CK2_1	168	174	PF00069	0.625
MOD_CK2_1	284	290	PF00069	0.446
MOD_CK2_1	32	38	PF00069	0.301
MOD_CK2_1	53	59	PF00069	0.512
MOD_CK2_1	80	86	PF00069	0.483
MOD_GlcNHglycan	143	146	PF01048	0.601
MOD_GlcNHglycan	152	155	PF01048	0.526
MOD_GlcNHglycan	325	330	PF01048	0.563
MOD_GlcNHglycan	371	374	PF01048	0.437
MOD_GSK3_1	118	125	PF00069	0.630
MOD_GSK3_1	146	153	PF00069	0.589
MOD_GSK3_1	160	167	PF00069	0.559
MOD_GSK3_1	233	240	PF00069	0.585
MOD_GSK3_1	267	274	PF00069	0.534
MOD_GSK3_1	365	372	PF00069	0.411
MOD_GSK3_1	379	386	PF00069	0.439
MOD_GSK3_1	389	396	PF00069	0.411
MOD_LATS_1	391	397	PF00433	0.464
MOD_N-GLC_1	267	272	PF02516	0.433
MOD_N-GLC_1	389	394	PF02516	0.382
MOD_NEK2_1	161	166	PF00069	0.462
MOD_NEK2_1	264	269	PF00069	0.471
MOD_NEK2_1	32	37	PF00069	0.561
MOD_PIKK_1	237	243	PF00454	0.563
MOD_PIKK_1	379	385	PF00454	0.514
MOD_PIKK_1	393	399	PF00454	0.580
MOD_PKA_1	133	139	PF00069	0.619
MOD_PKA_1	22	28	PF00069	0.566
MOD_PKA_1	393	399	PF00069	0.525
MOD_PKA_2	133	139	PF00069	0.622
MOD_PKA_2	141	147	PF00069	0.677
MOD_PKA_2	22	28	PF00069	0.434
MOD_PKA_2	264	270	PF00069	0.454
MOD_PKA_2	32	38	PF00069	0.414
MOD_PKA_2	334	340	PF00069	0.421
MOD_PKA_2	379	385	PF00069	0.500
MOD_PKA_2	393	399	PF00069	0.580
MOD_Plk_1	118	124	PF00069	0.601
MOD_Plk_1	407	413	PF00069	0.478
MOD_Plk_2-3	168	174	PF00069	0.494
MOD_Plk_2-3	53	59	PF00069	0.512
MOD_Plk_4	334	340	PF00069	0.387
MOD_Plk_4	407	413	PF00069	0.421
MOD_ProDKin_1	77	83	PF00069	0.532
MOD_ProDKin_1	9	15	PF00069	0.562
MOD_SUMO_for_1	44	47	PF00179	0.434
MOD_SUMO_rev_2	126	135	PF00179	0.592
MOD_SUMO_rev_2	152	161	PF00179	0.484
MOD_SUMO_rev_2	343	352	PF00179	0.438
MOD_SUMO_rev_2	353	360	PF00179	0.406
TRG_DiLeu_BaEn_1	157	162	PF01217	0.486
TRG_DiLeu_BaEn_1	46	51	PF01217	0.438
TRG_DiLeu_BaEn_4	46	52	PF01217	0.436
TRG_DiLeu_LyEn_5	157	162	PF01217	0.369
TRG_ENDOCYTIC_2	214	217	PF00928	0.432
TRG_ENDOCYTIC_2	244	247	PF00928	0.473
TRG_ER_diArg_1	22	24	PF00400	0.566
TRG_ER_diArg_1	280	283	PF00400	0.411
TRG_ER_diArg_1	393	395	PF00400	0.658
TRG_ER_diArg_1	412	415	PF00400	0.459
TRG_NES_CRM1_1	53	66	PF08389	0.444
TRG_NES_CRM1_1	68	82	PF08389	0.508
TRG_NES_CRM1_1	86	97	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV61	Leptomonas seymouri	71%	100%
A0A0S4J5N8	Bodo saltans	37%	96%
A0A1X0NXM5	Trypanosomatidae	45%	100%
A0A3S7WXH9	Leishmania donovani	94%	100%
A0A422N5Q1	Trypanosoma rangeli	45%	99%
A4HCM1	Leishmania braziliensis	78%	100%
A4I045	Leishmania infantum	94%	100%
C9ZUY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AW08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B6S0	Trypanosoma cruzi	47%	84%