DUF1767 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1767), putative

Species:

Leishmania major

UniProt:

Q4QBG7_LEIMA

TriTrypDb:

LmjF.23.0090 , LMJLV39_230005800 , LMJSD75_230005800

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.485
CLV_NRD_NRD_1	238	240	PF00675	0.518
CLV_NRD_NRD_1	295	297	PF00675	0.588
CLV_NRD_NRD_1	302	304	PF00675	0.604
CLV_PCSK_KEX2_1	107	109	PF00082	0.306
CLV_PCSK_KEX2_1	180	182	PF00082	0.528
CLV_PCSK_KEX2_1	238	240	PF00082	0.518
CLV_PCSK_KEX2_1	295	297	PF00082	0.588
CLV_PCSK_KEX2_1	302	304	PF00082	0.604
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.306
CLV_PCSK_PC7_1	103	109	PF00082	0.306
CLV_PCSK_PC7_1	291	297	PF00082	0.510
CLV_PCSK_SKI1_1	107	111	PF00082	0.306
CLV_PCSK_SKI1_1	170	174	PF00082	0.235
CLV_PCSK_SKI1_1	78	82	PF00082	0.263
DOC_CKS1_1	135	140	PF01111	0.506
DOC_MAPK_gen_1	107	114	PF00069	0.506
DOC_MAPK_gen_1	9	16	PF00069	0.376
DOC_MAPK_MEF2A_6	107	114	PF00069	0.517
DOC_MAPK_NFAT4_5	107	115	PF00069	0.506
DOC_PP4_FxxP_1	327	330	PF00568	0.504
DOC_USP7_MATH_1	27	31	PF00917	0.496
DOC_USP7_MATH_1	60	64	PF00917	0.489
DOC_USP7_MATH_1	88	92	PF00917	0.500
DOC_WW_Pin1_4	134	139	PF00397	0.506
DOC_WW_Pin1_4	225	230	PF00397	0.607
LIG_14-3-3_CanoR_1	103	110	PF00244	0.476
LIG_14-3-3_CanoR_1	111	121	PF00244	0.447
LIG_14-3-3_CanoR_1	209	213	PF00244	0.590
LIG_FHA_1	126	132	PF00498	0.561
LIG_FHA_1	49	55	PF00498	0.483
LIG_FHA_1	79	85	PF00498	0.463
LIG_FHA_2	135	141	PF00498	0.506
LIG_FHA_2	30	36	PF00498	0.506
LIG_Integrin_RGD_1	303	305	PF01839	0.583
LIG_LIR_Apic_2	324	330	PF02991	0.534
LIG_LIR_Gen_1	40	48	PF02991	0.511
LIG_LIR_Nem_3	332	337	PF02991	0.587
LIG_LIR_Nem_3	339	345	PF02991	0.495
LIG_LIR_Nem_3	40	45	PF02991	0.511
LIG_Pex14_1	281	285	PF04695	0.524
LIG_PTB_Apo_2	95	102	PF02174	0.483
LIG_SH2_STAP1	12	16	PF00017	0.517
LIG_SH2_STAT5	20	23	PF00017	0.532
LIG_SH2_STAT5	300	303	PF00017	0.558
LIG_SH3_3	80	86	PF00018	0.463
LIG_SUMO_SIM_anti_2	161	166	PF11976	0.466
LIG_TRAF2_1	91	94	PF00917	0.477
MOD_CDK_SPxxK_3	134	141	PF00069	0.506
MOD_CK1_1	15	21	PF00069	0.534
MOD_CK1_1	158	164	PF00069	0.507
MOD_CK1_1	240	246	PF00069	0.538
MOD_CK1_1	30	36	PF00069	0.519
MOD_CK2_1	119	125	PF00069	0.414
MOD_CK2_1	134	140	PF00069	0.484
MOD_CK2_1	29	35	PF00069	0.506
MOD_CK2_1	37	43	PF00069	0.506
MOD_CK2_1	88	94	PF00069	0.505
MOD_Cter_Amidation	236	239	PF01082	0.523
MOD_Cter_Amidation	293	296	PF01082	0.576
MOD_GlcNHglycan	120	124	PF01048	0.214
MOD_GlcNHglycan	214	217	PF01048	0.764
MOD_GlcNHglycan	263	266	PF01048	0.669
MOD_GlcNHglycan	62	65	PF01048	0.289
MOD_GSK3_1	10	17	PF00069	0.521
MOD_GSK3_1	208	215	PF00069	0.699
MOD_GSK3_1	74	81	PF00069	0.497
MOD_N-GLC_1	103	108	PF02516	0.317
MOD_N-GLC_1	240	245	PF02516	0.649
MOD_N-GLC_1	74	79	PF02516	0.306
MOD_N-GLC_2	152	154	PF02516	0.306
MOD_NEK2_1	124	129	PF00069	0.505
MOD_PIKK_1	78	84	PF00454	0.463
MOD_PKA_2	102	108	PF00069	0.476
MOD_PKA_2	208	214	PF00069	0.572
MOD_PKA_2	237	243	PF00069	0.577
MOD_PKA_2	261	267	PF00069	0.611
MOD_Plk_1	119	125	PF00069	0.511
MOD_Plk_1	281	287	PF00069	0.548
MOD_Plk_4	160	166	PF00069	0.507
MOD_Plk_4	37	43	PF00069	0.561
MOD_Plk_4	49	55	PF00069	0.460
MOD_ProDKin_1	134	140	PF00069	0.506
MOD_ProDKin_1	225	231	PF00069	0.608
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.463
TRG_ER_diArg_1	180	182	PF00400	0.528
TRG_ER_diArg_1	301	303	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.214
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI0	Leptomonas seymouri	69%	100%
A0A0S4IYS0	Bodo saltans	37%	96%
A0A3S7WXE9	Leishmania donovani	86%	100%
A4HCM2	Leishmania braziliensis	73%	100%
A4I046	Leishmania infantum	86%	100%
E9AW09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%