Putative cyclophilin type peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 3, putative

Species:

Leishmania major

UniProt:

Q4QBG3_LEIMA

TriTrypDb:

LmjF.23.0125 , LMJLV39_230006200 , LMJSD75_230006200

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QBG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBG3

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0018193	peptidyl-amino acid modification	5	9
GO:0018208	peptidyl-proline modification	6	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.431
CLV_NRD_NRD_1	40	42	PF00675	0.416
CLV_NRD_NRD_1	44	46	PF00675	0.416
CLV_PCSK_KEX2_1	40	42	PF00082	0.416
CLV_PCSK_SKI1_1	40	44	PF00082	0.418
CLV_PCSK_SKI1_1	45	49	PF00082	0.392
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.368
DOC_PP1_RVXF_1	38	45	PF00149	0.416
DOC_WW_Pin1_4	106	111	PF00397	0.402
DOC_WW_Pin1_4	144	149	PF00397	0.334
DOC_WW_Pin1_4	73	78	PF00397	0.470
LIG_14-3-3_CanoR_1	103	109	PF00244	0.416
LIG_14-3-3_CanoR_1	40	45	PF00244	0.399
LIG_FHA_1	115	121	PF00498	0.416
LIG_FHA_1	154	160	PF00498	0.456
LIG_FHA_2	64	70	PF00498	0.448
LIG_LIR_Gen_1	20	30	PF02991	0.392
LIG_LIR_Nem_3	140	146	PF02991	0.315
LIG_LIR_Nem_3	20	25	PF02991	0.370
LIG_LIR_Nem_3	28	33	PF02991	0.278
LIG_LIR_Nem_3	43	47	PF02991	0.399
LIG_SH2_CRK	125	129	PF00017	0.470
LIG_SH2_CRK	146	150	PF00017	0.368
LIG_SH2_NCK_1	146	150	PF00017	0.368
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.368
LIG_SUMO_SIM_par_1	104	109	PF11976	0.416
LIG_TYR_ITIM	144	149	PF00017	0.470
MOD_CK1_1	147	153	PF00069	0.425
MOD_CK1_1	160	166	PF00069	0.579
MOD_CK2_1	63	69	PF00069	0.416
MOD_GlcNHglycan	12	15	PF01048	0.474
MOD_GlcNHglycan	125	128	PF01048	0.334
MOD_GlcNHglycan	166	169	PF01048	0.507
MOD_GSK3_1	123	130	PF00069	0.399
MOD_GSK3_1	153	160	PF00069	0.429
MOD_GSK3_1	173	180	PF00069	0.478
MOD_GSK3_1	183	190	PF00069	0.425
MOD_GSK3_1	61	68	PF00069	0.441
MOD_GSK3_1	88	95	PF00069	0.362
MOD_N-GLC_2	24	26	PF02516	0.416
MOD_NEK2_1	104	109	PF00069	0.334
MOD_NEK2_1	114	119	PF00069	0.334
MOD_NEK2_1	152	157	PF00069	0.361
MOD_NEK2_2	88	93	PF00069	0.399
MOD_PIKK_1	178	184	PF00454	0.630
MOD_PKA_1	40	46	PF00069	0.392
MOD_PKA_2	160	166	PF00069	0.624
MOD_PKA_2	40	46	PF00069	0.433
MOD_PKA_2	92	98	PF00069	0.392
MOD_Plk_1	114	120	PF00069	0.376
MOD_Plk_4	147	153	PF00069	0.416
MOD_Plk_4	183	189	PF00069	0.520
MOD_Plk_4	26	32	PF00069	0.416
MOD_ProDKin_1	106	112	PF00069	0.402
MOD_ProDKin_1	144	150	PF00069	0.334
MOD_ProDKin_1	73	79	PF00069	0.470
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.392
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.392
TRG_ENDOCYTIC_2	125	128	PF00928	0.368
TRG_ENDOCYTIC_2	146	149	PF00928	0.334
TRG_ENDOCYTIC_2	22	25	PF00928	0.416
TRG_ER_diArg_1	39	41	PF00400	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M9	Leptomonas seymouri	58%	100%
A0A0S4J465	Bodo saltans	28%	79%
A0A1X0NGT2	Trypanosomatidae	37%	97%
A0A3S7WXE3	Leishmania donovani	89%	100%
A0A422NW48	Trypanosoma rangeli	41%	97%
A4HCM6	Leishmania braziliensis	77%	100%
A4I050	Leishmania infantum	89%	100%
E9AW13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P0C1I4	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	29%	100%
P0CP82	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	100%
P0CP83	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	100%
P0CP84	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	29%	100%
P0CP85	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	29%	100%
P52018	Caenorhabditis elegans	23%	100%
P87051	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q27774	Schistosoma japonicum	27%	90%
Q2U6U0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	27%	100%
Q4I1Y1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	100%
Q4WCR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	100%
Q5ASQ0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q7SF72	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	100%
Q8X191	Aspergillus niger	29%	100%
Q9C835	Arabidopsis thaliana	26%	81%
Q9NI62	Dictyostelium discoideum	28%	100%
Q9SIH1	Arabidopsis thaliana	28%	100%