AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4QBG1_LEIMA

TriTrypDb:

LmjF.23.0140 , LMJLV39_230006400 , LMJSD75_230006400

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QBG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBG1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006654	phosphatidic acid biosynthetic process	6	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0042592	homeostatic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046473	phosphatidic acid metabolic process	6	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0048878	chemical homeostasis	4	2
GO:0055088	lipid homeostasis	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	2
GO:0016746	acyltransferase activity	3	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0042171	lysophosphatidic acid acyltransferase activity	6	2
GO:0052689	carboxylic ester hydrolase activity	4	2
GO:0071617	lysophospholipid acyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.402
CLV_NRD_NRD_1	23	25	PF00675	0.702
CLV_NRD_NRD_1	277	279	PF00675	0.541
CLV_NRD_NRD_1	28	30	PF00675	0.621
CLV_NRD_NRD_1	4	6	PF00675	0.547
CLV_PCSK_KEX2_1	167	169	PF00082	0.402
CLV_PCSK_KEX2_1	23	25	PF00082	0.698
CLV_PCSK_KEX2_1	277	279	PF00082	0.541
CLV_PCSK_KEX2_1	28	30	PF00082	0.667
CLV_PCSK_KEX2_1	6	8	PF00082	0.566
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.474
CLV_PCSK_PC7_1	24	30	PF00082	0.612
CLV_PCSK_SKI1_1	224	228	PF00082	0.415
CLV_PCSK_SKI1_1	250	254	PF00082	0.403
CLV_PCSK_SKI1_1	48	52	PF00082	0.479
CLV_Separin_Metazoa	263	267	PF03568	0.312
DEG_APCC_DBOX_1	279	287	PF00400	0.345
DEG_Nend_UBRbox_4	1	3	PF02207	0.464
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.284
DOC_MAPK_gen_1	122	131	PF00069	0.322
DOC_MAPK_gen_1	241	251	PF00069	0.427
DOC_MAPK_gen_1	277	285	PF00069	0.334
DOC_MAPK_gen_1	45	51	PF00069	0.406
DOC_MAPK_MEF2A_6	122	131	PF00069	0.322
DOC_MAPK_MEF2A_6	243	251	PF00069	0.327
DOC_MAPK_MEF2A_6	277	285	PF00069	0.334
DOC_PP1_RVXF_1	190	196	PF00149	0.310
DOC_PP4_FxxP_1	157	160	PF00568	0.365
DOC_PP4_FxxP_1	195	198	PF00568	0.268
DOC_WW_Pin1_4	106	111	PF00397	0.703
DOC_WW_Pin1_4	8	13	PF00397	0.494
LIG_14-3-3_CanoR_1	167	176	PF00244	0.417
LIG_Actin_RPEL_3	234	253	PF02755	0.457
LIG_Actin_WH2_2	252	268	PF00022	0.455
LIG_BRCT_BRCA1_1	143	147	PF00533	0.310
LIG_CaM_IQ_9	38	54	PF13499	0.337
LIG_FHA_1	106	112	PF00498	0.762
LIG_FHA_1	67	73	PF00498	0.467
LIG_LIR_Apic_2	194	198	PF02991	0.274
LIG_LIR_Gen_1	144	152	PF02991	0.268
LIG_LIR_Nem_3	144	148	PF02991	0.329
LIG_LIR_Nem_3	205	209	PF02991	0.293
LIG_LIR_Nem_3	229	235	PF02991	0.586
LIG_NRBOX	50	56	PF00104	0.356
LIG_Pex14_2	130	134	PF04695	0.445
LIG_Pex14_2	157	161	PF04695	0.336
LIG_PTB_Apo_2	255	262	PF02174	0.336
LIG_SH2_CRK	58	62	PF00017	0.240
LIG_SH2_NCK_1	58	62	PF00017	0.240
LIG_SH2_SRC	185	188	PF00017	0.197
LIG_SH2_STAP1	33	37	PF00017	0.623
LIG_SH2_STAP1	58	62	PF00017	0.240
LIG_SH2_STAT5	181	184	PF00017	0.417
LIG_SH2_STAT5	185	188	PF00017	0.393
LIG_SH3_3	107	113	PF00018	0.679
LIG_SH3_3	267	273	PF00018	0.404
LIG_SUMO_SIM_anti_2	282	287	PF11976	0.355
LIG_SUMO_SIM_par_1	224	230	PF11976	0.284
LIG_WW_3	25	29	PF00397	0.608
MOD_CK1_1	11	17	PF00069	0.483
MOD_CK1_1	170	176	PF00069	0.326
MOD_CK1_1	95	101	PF00069	0.758
MOD_CK2_1	171	177	PF00069	0.355
MOD_GlcNHglycan	88	92	PF01048	0.655
MOD_GSK3_1	105	112	PF00069	0.518
MOD_GSK3_1	167	174	PF00069	0.392
MOD_GSK3_1	31	38	PF00069	0.562
MOD_NEK2_1	202	207	PF00069	0.366
MOD_NEK2_2	18	23	PF00069	0.578
MOD_NEK2_2	219	224	PF00069	0.309
MOD_PIKK_1	11	17	PF00454	0.596
MOD_PIKK_1	38	44	PF00454	0.661
MOD_PKA_1	167	173	PF00069	0.365
MOD_PKA_2	167	173	PF00069	0.413
MOD_Plk_1	18	24	PF00069	0.638
MOD_Plk_1	38	44	PF00069	0.551
MOD_Plk_4	31	37	PF00069	0.628
MOD_ProDKin_1	106	112	PF00069	0.700
MOD_ProDKin_1	8	14	PF00069	0.494
MOD_SUMO_for_1	121	124	PF00179	0.432
MOD_SUMO_for_1	93	96	PF00179	0.464
TRG_DiLeu_BaEn_1	221	226	PF01217	0.309
TRG_DiLeu_BaEn_1	230	235	PF01217	0.362
TRG_ENDOCYTIC_2	33	36	PF00928	0.587
TRG_ENDOCYTIC_2	58	61	PF00928	0.417
TRG_ER_diArg_1	22	24	PF00400	0.643
TRG_ER_diArg_1	27	29	PF00400	0.557
TRG_ER_diArg_1	276	278	PF00400	0.540
TRG_NLS_MonoExtC_3	4	9	PF00514	0.473
TRG_NLS_MonoExtN_4	5	10	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P520	Leptomonas seymouri	52%	71%
A0A1X0NG89	Trypanosomatidae	34%	75%
A0A3S7WXG3	Leishmania donovani	83%	71%
A0A422NW44	Trypanosoma rangeli	39%	70%
A4HCM8	Leishmania braziliensis	69%	71%
A4I052	Leishmania infantum	83%	71%
E9AW15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	71%
V5B077	Trypanosoma cruzi	40%	78%