Leucine-rich repeat-containing protein 34

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBG0_LEIMA

TriTrypDb:

LmjF.23.0150 , LMJLV39_230006500 , LMJSD75_230006500

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

Q4QBG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.434
CLV_NRD_NRD_1	320	322	PF00675	0.450
CLV_PCSK_KEX2_1	259	261	PF00082	0.434
CLV_PCSK_KEX2_1	320	322	PF00082	0.450
CLV_PCSK_PC7_1	255	261	PF00082	0.426
CLV_PCSK_SKI1_1	182	186	PF00082	0.426
CLV_PCSK_SKI1_1	320	324	PF00082	0.412
DEG_APCC_DBOX_1	181	189	PF00400	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.344
DOC_CYCLIN_RxL_1	179	189	PF00134	0.462
DOC_CYCLIN_RxL_1	314	328	PF00134	0.402
DOC_MAPK_MEF2A_6	142	149	PF00069	0.399
DOC_MAPK_MEF2A_6	345	354	PF00069	0.331
DOC_MAPK_NFAT4_5	142	150	PF00069	0.395
DOC_PP2B_LxvP_1	65	68	PF13499	0.370
DOC_USP7_MATH_1	11	15	PF00917	0.420
DOC_USP7_MATH_1	332	336	PF00917	0.518
DOC_USP7_MATH_1	60	64	PF00917	0.425
DOC_WW_Pin1_4	327	332	PF00397	0.430
LIG_14-3-3_CanoR_1	204	209	PF00244	0.460
LIG_14-3-3_CanoR_1	320	325	PF00244	0.510
LIG_14-3-3_CanoR_1	33	38	PF00244	0.471
LIG_14-3-3_CanoR_1	43	49	PF00244	0.207
LIG_FHA_1	223	229	PF00498	0.435
LIG_FHA_1	235	241	PF00498	0.471
LIG_FHA_1	25	31	PF00498	0.417
LIG_FHA_1	328	334	PF00498	0.441
LIG_FHA_1	91	97	PF00498	0.431
LIG_FHA_2	205	211	PF00498	0.443
LIG_FHA_2	298	304	PF00498	0.417
LIG_FHA_2	338	344	PF00498	0.408
LIG_FHA_2	43	49	PF00498	0.301
LIG_GBD_Chelix_1	194	202	PF00786	0.345
LIG_LIR_Gen_1	338	349	PF02991	0.576
LIG_LIR_Gen_1	36	44	PF02991	0.469
LIG_LIR_Gen_1	95	105	PF02991	0.358
LIG_LIR_LC3C_4	303	308	PF02991	0.395
LIG_LIR_Nem_3	262	266	PF02991	0.352
LIG_LIR_Nem_3	338	344	PF02991	0.455
LIG_LIR_Nem_3	346	352	PF02991	0.368
LIG_LIR_Nem_3	36	40	PF02991	0.491
LIG_LIR_Nem_3	63	69	PF02991	0.355
LIG_LIR_Nem_3	95	101	PF02991	0.363
LIG_NRBOX	252	258	PF00104	0.317
LIG_PCNA_yPIPBox_3	142	153	PF02747	0.389
LIG_PDZ_Class_2	361	366	PF00595	0.440
LIG_Pex14_1	2	6	PF04695	0.320
LIG_SH2_CRK	69	73	PF00017	0.339
LIG_SH2_CRK	98	102	PF00017	0.333
LIG_SH2_NCK_1	69	73	PF00017	0.305
LIG_SH2_PTP2	349	352	PF00017	0.250
LIG_SH2_SRC	349	352	PF00017	0.250
LIG_SH2_STAT5	215	218	PF00017	0.396
LIG_SH2_STAT5	349	352	PF00017	0.468
LIG_SH2_STAT5	66	69	PF00017	0.503
LIG_SUMO_SIM_par_1	305	312	PF11976	0.399
LIG_SUMO_SIM_par_1	89	95	PF11976	0.442
LIG_TRAF2_1	207	210	PF00917	0.411
LIG_TYR_ITIM	347	352	PF00017	0.264
LIG_TYR_ITIM	67	72	PF00017	0.327
LIG_TYR_ITIM	96	101	PF00017	0.342
MOD_CK1_1	233	239	PF00069	0.336
MOD_CK1_1	24	30	PF00069	0.447
MOD_CK1_1	312	318	PF00069	0.427
MOD_CK1_1	335	341	PF00069	0.431
MOD_CK1_1	90	96	PF00069	0.387
MOD_CK2_1	203	209	PF00069	0.476
MOD_CK2_1	297	303	PF00069	0.376
MOD_GlcNHglycan	12	16	PF01048	0.383
MOD_GlcNHglycan	23	26	PF01048	0.391
MOD_GlcNHglycan	232	235	PF01048	0.307
MOD_GlcNHglycan	62	65	PF01048	0.372
MOD_GSK3_1	20	27	PF00069	0.479
MOD_GSK3_1	230	237	PF00069	0.346
MOD_GSK3_1	295	302	PF00069	0.372
MOD_GSK3_1	333	340	PF00069	0.507
MOD_N-GLC_1	115	120	PF02516	0.411
MOD_N-GLC_1	204	209	PF02516	0.326
MOD_N-GLC_1	70	75	PF02516	0.323
MOD_NEK2_1	230	235	PF00069	0.362
MOD_NEK2_1	266	271	PF00069	0.304
MOD_NEK2_1	309	314	PF00069	0.473
MOD_NEK2_1	337	342	PF00069	0.388
MOD_PIKK_1	243	249	PF00454	0.353
MOD_PKA_1	320	326	PF00069	0.401
MOD_PKA_2	203	209	PF00069	0.493
MOD_PKA_2	320	326	PF00069	0.447
MOD_PKA_2	42	48	PF00069	0.314
MOD_Plk_1	115	121	PF00069	0.412
MOD_Plk_1	204	210	PF00069	0.328
MOD_Plk_2-3	297	303	PF00069	0.410
MOD_Plk_4	190	196	PF00069	0.409
MOD_Plk_4	222	228	PF00069	0.367
MOD_Plk_4	320	326	PF00069	0.504
MOD_Plk_4	87	93	PF00069	0.440
MOD_ProDKin_1	327	333	PF00069	0.424
TRG_DiLeu_BaEn_1	75	80	PF01217	0.389
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.420
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.404
TRG_ENDOCYTIC_2	215	218	PF00928	0.396
TRG_ENDOCYTIC_2	349	352	PF00928	0.250
TRG_ENDOCYTIC_2	69	72	PF00928	0.290
TRG_ENDOCYTIC_2	98	101	PF00928	0.346
TRG_ER_diArg_1	319	321	PF00400	0.450
TRG_NES_CRM1_1	189	203	PF08389	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N0	Leptomonas seymouri	60%	100%
A0A0N1HUH0	Leptomonas seymouri	23%	78%
A0A0N1I317	Leptomonas seymouri	25%	92%
A0A0S4JGH2	Bodo saltans	32%	100%
A0A0S4JV86	Bodo saltans	21%	97%
A0A1X0NG92	Trypanosomatidae	40%	100%
A0A1X0NTY3	Trypanosomatidae	25%	82%
A0A1X0P4Z4	Trypanosomatidae	27%	93%
A0A3Q8IDE6	Leishmania donovani	26%	92%
A0A3R7L7Y9	Trypanosoma rangeli	28%	82%
A0A3R7NL91	Trypanosoma rangeli	25%	92%
A0A3R7NVI2	Trypanosoma rangeli	25%	88%
A0A3S7WXH1	Leishmania donovani	95%	100%
A0A3S7WZL6	Leishmania donovani	23%	85%
A0A422NW39	Trypanosoma rangeli	39%	99%
A0JPI9	Rattus norvegicus	25%	76%
A4H461	Leishmania braziliensis	24%	83%
A4HCM9	Leishmania braziliensis	88%	100%
A4HEQ6	Leishmania braziliensis	26%	88%
A4I053	Leishmania infantum	95%	100%
A4I1Y5	Leishmania infantum	23%	85%
A4I2T1	Leishmania infantum	26%	92%
D0A5Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	88%
E9ADA9	Leishmania major	25%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	83%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	77%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	92%
Q0VAA2	Homo sapiens	25%	75%
Q4Q9E1	Leishmania major	25%	100%
Q4QJI8	Leishmania major	24%	83%
Q4V8D9	Rattus norvegicus	32%	88%
Q6ZQY2	Homo sapiens	27%	93%
Q8IZ02	Homo sapiens	31%	79%
Q9DAM1	Mus musculus	32%	88%
Q9LE82	Arabidopsis thaliana	25%	68%
Q9M651	Arabidopsis thaliana	23%	67%
V5BJF0	Trypanosoma cruzi	24%	74%
V5DHF2	Trypanosoma cruzi	24%	93%