Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBF9_LEIMA

TriTrypDb:

LmjF.23.0160 , LMJLV39_230006600 , LMJSD75_230006600

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	8
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4QBF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.460
CLV_C14_Caspase3-7	432	436	PF00656	0.311
CLV_NRD_NRD_1	248	250	PF00675	0.410
CLV_NRD_NRD_1	447	449	PF00675	0.457
CLV_NRD_NRD_1	466	468	PF00675	0.379
CLV_PCSK_KEX2_1	447	449	PF00082	0.340
CLV_PCSK_KEX2_1	468	470	PF00082	0.405
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.498
CLV_PCSK_PC7_1	443	449	PF00082	0.360
CLV_PCSK_SKI1_1	105	109	PF00082	0.299
CLV_PCSK_SKI1_1	259	263	PF00082	0.462
CLV_PCSK_SKI1_1	27	31	PF00082	0.380
CLV_PCSK_SKI1_1	450	454	PF00082	0.457
CLV_PCSK_SKI1_1	481	485	PF00082	0.496
CLV_PCSK_SKI1_1	503	507	PF00082	0.386
CLV_PCSK_SKI1_1	94	98	PF00082	0.557
CLV_Separin_Metazoa	21	25	PF03568	0.414
DEG_APCC_DBOX_1	104	112	PF00400	0.331
DEG_APCC_DBOX_1	26	34	PF00400	0.410
DOC_CDC14_PxL_1	114	122	PF14671	0.249
DOC_CDC14_PxL_1	241	249	PF14671	0.501
DOC_CYCLIN_RxL_1	253	265	PF00134	0.452
DOC_MAPK_DCC_7	105	113	PF00069	0.401
DOC_MAPK_DCC_7	94	102	PF00069	0.577
DOC_MAPK_gen_1	160	169	PF00069	0.460
DOC_MAPK_gen_1	24	32	PF00069	0.380
DOC_MAPK_gen_1	467	475	PF00069	0.393
DOC_MAPK_gen_1	500	509	PF00069	0.469
DOC_MAPK_HePTP_8	497	509	PF00069	0.425
DOC_MAPK_MEF2A_6	105	113	PF00069	0.345
DOC_MAPK_MEF2A_6	233	241	PF00069	0.410
DOC_MAPK_MEF2A_6	500	509	PF00069	0.432
DOC_PP1_RVXF_1	158	164	PF00149	0.371
DOC_PP1_RVXF_1	192	198	PF00149	0.359
DOC_USP7_MATH_1	138	142	PF00917	0.451
DOC_USP7_MATH_1	173	177	PF00917	0.531
DOC_USP7_MATH_1	2	6	PF00917	0.499
DOC_USP7_MATH_1	275	279	PF00917	0.440
DOC_USP7_MATH_1	359	363	PF00917	0.456
DOC_USP7_MATH_1	433	437	PF00917	0.370
DOC_USP7_UBL2_3	229	233	PF12436	0.420
DOC_WW_Pin1_4	75	80	PF00397	0.415
DOC_WW_Pin1_4	95	100	PF00397	0.473
LIG_14-3-3_CanoR_1	162	168	PF00244	0.383
LIG_14-3-3_CanoR_1	249	253	PF00244	0.454
LIG_14-3-3_CanoR_1	259	268	PF00244	0.390
LIG_14-3-3_CanoR_1	27	33	PF00244	0.439
LIG_14-3-3_CanoR_1	285	294	PF00244	0.358
LIG_14-3-3_CanoR_1	317	326	PF00244	0.408
LIG_14-3-3_CanoR_1	397	406	PF00244	0.380
LIG_14-3-3_CanoR_1	447	453	PF00244	0.443
LIG_14-3-3_CanoR_1	467	475	PF00244	0.254
LIG_14-3-3_CanoR_1	486	490	PF00244	0.348
LIG_14-3-3_CanoR_1	511	516	PF00244	0.376
LIG_APCC_ABBA_1	316	321	PF00400	0.425
LIG_CaM_NSCaTE_8	370	377	PF13499	0.360
LIG_EH1_1	458	466	PF00400	0.389
LIG_FHA_1	120	126	PF00498	0.415
LIG_FHA_1	164	170	PF00498	0.425
LIG_FHA_1	197	203	PF00498	0.449
LIG_FHA_1	226	232	PF00498	0.453
LIG_FHA_1	267	273	PF00498	0.470
LIG_FHA_1	281	287	PF00498	0.409
LIG_FHA_1	313	319	PF00498	0.434
LIG_FHA_1	362	368	PF00498	0.451
LIG_FHA_1	408	414	PF00498	0.436
LIG_FHA_1	485	491	PF00498	0.476
LIG_FHA_2	198	204	PF00498	0.534
LIG_FHA_2	211	217	PF00498	0.441
LIG_FHA_2	249	255	PF00498	0.424
LIG_FHA_2	271	277	PF00498	0.458
LIG_FHA_2	398	404	PF00498	0.447
LIG_FHA_2	410	416	PF00498	0.485
LIG_FHA_2	452	458	PF00498	0.439
LIG_GBD_Chelix_1	150	158	PF00786	0.445
LIG_Integrin_RGD_1	302	304	PF01839	0.336
LIG_Integrin_RGD_1	329	331	PF01839	0.335
LIG_LIR_Gen_1	428	435	PF02991	0.386
LIG_LIR_Gen_1	451	461	PF02991	0.442
LIG_LIR_Nem_3	335	340	PF02991	0.421
LIG_LIR_Nem_3	428	434	PF02991	0.358
LIG_LIR_Nem_3	451	456	PF02991	0.455
LIG_LYPXL_yS_3	337	340	PF13949	0.453
LIG_MAD2	496	504	PF02301	0.384
LIG_MYND_3	117	121	PF01753	0.256
LIG_NRBOX	257	263	PF00104	0.436
LIG_PCNA_PIPBox_1	6	15	PF02747	0.320
LIG_PCNA_yPIPBox_3	249	262	PF02747	0.406
LIG_PCNA_yPIPBox_3	6	16	PF02747	0.347
LIG_PTB_Apo_2	131	138	PF02174	0.515
LIG_SH2_CRK	356	360	PF00017	0.344
LIG_SH2_GRB2like	132	135	PF00017	0.548
LIG_SH2_SRC	235	238	PF00017	0.446
LIG_SH2_SRC	356	359	PF00017	0.428
LIG_SH2_STAT5	101	104	PF00017	0.465
LIG_SH2_STAT5	13	16	PF00017	0.409
LIG_SH2_STAT5	205	208	PF00017	0.404
LIG_SH2_STAT5	240	243	PF00017	0.489
LIG_SH2_STAT5	332	335	PF00017	0.306
LIG_SH2_STAT5	424	427	PF00017	0.386
LIG_SH3_1	220	226	PF00018	0.529
LIG_SH3_3	19	25	PF00018	0.406
LIG_SH3_3	220	226	PF00018	0.520
LIG_SH3_3	337	343	PF00018	0.459
LIG_SH3_3	403	409	PF00018	0.367
LIG_SUMO_SIM_par_1	121	126	PF11976	0.421
LIG_TRAF2_1	213	216	PF00917	0.429
LIG_UBA3_1	308	312	PF00899	0.372
MOD_CK1_1	141	147	PF00069	0.492
MOD_CK1_1	267	273	PF00069	0.503
MOD_CK1_1	336	342	PF00069	0.488
MOD_CK1_1	362	368	PF00069	0.393
MOD_CK1_1	407	413	PF00069	0.551
MOD_CK1_1	451	457	PF00069	0.483
MOD_CK2_1	210	216	PF00069	0.508
MOD_CK2_1	248	254	PF00069	0.415
MOD_CK2_1	270	276	PF00069	0.458
MOD_CK2_1	285	291	PF00069	0.299
MOD_CK2_1	317	323	PF00069	0.407
MOD_CK2_1	342	348	PF00069	0.500
MOD_CK2_1	36	42	PF00069	0.465
MOD_CK2_1	397	403	PF00069	0.440
MOD_CK2_1	409	415	PF00069	0.484
MOD_CK2_1	511	517	PF00069	0.413
MOD_GlcNHglycan	145	148	PF01048	0.443
MOD_GlcNHglycan	269	272	PF01048	0.461
MOD_GlcNHglycan	312	315	PF01048	0.353
MOD_GlcNHglycan	431	434	PF01048	0.471
MOD_GSK3_1	119	126	PF00069	0.345
MOD_GSK3_1	133	140	PF00069	0.429
MOD_GSK3_1	260	267	PF00069	0.494
MOD_GSK3_1	429	436	PF00069	0.399
MOD_N-GLC_1	133	138	PF02516	0.596
MOD_NEK2_1	137	142	PF00069	0.579
MOD_NEK2_1	182	187	PF00069	0.464
MOD_NEK2_1	197	202	PF00069	0.492
MOD_NEK2_1	239	244	PF00069	0.418
MOD_NEK2_1	280	285	PF00069	0.473
MOD_NEK2_1	325	330	PF00069	0.394
MOD_NEK2_1	333	338	PF00069	0.387
MOD_NEK2_1	360	365	PF00069	0.375
MOD_NEK2_1	484	489	PF00069	0.419
MOD_OFUCOSY	395	401	PF10250	0.332
MOD_PIKK_1	138	144	PF00454	0.556
MOD_PIKK_1	2	8	PF00454	0.484
MOD_PK_1	448	454	PF00069	0.291
MOD_PK_1	469	475	PF00069	0.385
MOD_PKA_1	468	474	PF00069	0.356
MOD_PKA_2	248	254	PF00069	0.401
MOD_PKA_2	42	48	PF00069	0.370
MOD_PKA_2	468	474	PF00069	0.415
MOD_PKA_2	485	491	PF00069	0.252
MOD_PKB_1	467	475	PF00069	0.397
MOD_Plk_1	133	139	PF00069	0.511
MOD_Plk_2-3	248	254	PF00069	0.425
MOD_Plk_4	127	133	PF00069	0.379
MOD_Plk_4	153	159	PF00069	0.333
MOD_Plk_4	188	194	PF00069	0.390
MOD_Plk_4	28	34	PF00069	0.396
MOD_Plk_4	336	342	PF00069	0.492
MOD_Plk_4	362	368	PF00069	0.494
MOD_Plk_4	409	415	PF00069	0.484
MOD_Plk_4	485	491	PF00069	0.262
MOD_ProDKin_1	75	81	PF00069	0.407
MOD_ProDKin_1	95	101	PF00069	0.467
TRG_DiLeu_BaEn_3	349	355	PF01217	0.275
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.273
TRG_ENDOCYTIC_2	19	22	PF00928	0.431
TRG_ENDOCYTIC_2	319	322	PF00928	0.499
TRG_ENDOCYTIC_2	337	340	PF00928	0.283
TRG_ER_diArg_1	159	162	PF00400	0.516
TRG_ER_diArg_1	219	222	PF00400	0.646
TRG_ER_diArg_1	447	450	PF00400	0.333
TRG_ER_FFAT_2	263	273	PF00635	0.419
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4S8	Leptomonas seymouri	57%	94%
A0A0S4JG45	Bodo saltans	31%	86%
A0A1X0NG29	Trypanosomatidae	37%	96%
A0A3S5H7B5	Leishmania donovani	92%	100%
A0A422NVZ8	Trypanosoma rangeli	41%	100%
A4HCN0	Leishmania braziliensis	79%	100%
A4I054	Leishmania infantum	92%	100%
E9AW17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%