Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBF8_LEIMA

TriTrypDb:

LmjF.23.0170 , LMJLV39_230006700 , LMJSD75_230006700

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QBF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.701
CLV_NRD_NRD_1	131	133	PF00675	0.593
CLV_NRD_NRD_1	143	145	PF00675	0.647
CLV_PCSK_KEX2_1	131	133	PF00082	0.593
CLV_PCSK_KEX2_1	142	144	PF00082	0.639
CLV_PCSK_SKI1_1	153	157	PF00082	0.603
CLV_Separin_Metazoa	41	45	PF03568	0.623
DEG_APCC_DBOX_1	190	198	PF00400	0.601
DOC_MAPK_gen_1	188	197	PF00069	0.652
DOC_MAPK_gen_1	91	100	PF00069	0.400
DOC_MAPK_MEF2A_6	91	100	PF00069	0.456
LIG_14-3-3_CanoR_1	104	110	PF00244	0.474
LIG_14-3-3_CanoR_1	11	20	PF00244	0.551
LIG_14-3-3_CanoR_1	143	149	PF00244	0.408
LIG_14-3-3_CanoR_1	150	156	PF00244	0.398
LIG_14-3-3_CanoR_1	191	195	PF00244	0.605
LIG_Actin_WH2_2	173	190	PF00022	0.415
LIG_FHA_1	182	188	PF00498	0.646
LIG_FHA_1	66	72	PF00498	0.425
LIG_FHA_2	90	96	PF00498	0.461
LIG_Integrin_isoDGR_2	189	191	PF01839	0.394
LIG_LIR_Nem_3	58	63	PF02991	0.346
LIG_Pex14_2	178	182	PF04695	0.259
LIG_RPA_C_Fungi	139	151	PF08784	0.561
LIG_SH2_SRC	63	66	PF00017	0.522
LIG_SH2_STAT5	167	170	PF00017	0.426
LIG_SH2_STAT5	63	66	PF00017	0.522
MOD_CK1_1	105	111	PF00069	0.525
MOD_CK1_1	154	160	PF00069	0.583
MOD_CK2_1	197	203	PF00069	0.705
MOD_CK2_1	3	9	PF00069	0.640
MOD_CK2_1	35	41	PF00069	0.636
MOD_GlcNHglycan	159	162	PF01048	0.589
MOD_GlcNHglycan	209	212	PF01048	0.672
MOD_GlcNHglycan	57	60	PF01048	0.438
MOD_GSK3_1	151	158	PF00069	0.565
MOD_GSK3_1	3	10	PF00069	0.700
MOD_N-GLC_1	102	107	PF02516	0.536
MOD_N-GLC_1	144	149	PF02516	0.545
MOD_NEK2_1	134	139	PF00069	0.504
MOD_NEK2_1	155	160	PF00069	0.503
MOD_NEK2_1	34	39	PF00069	0.633
MOD_NEK2_1	89	94	PF00069	0.582
MOD_NMyristoyl	1	7	PF02799	0.628
MOD_PIKK_1	35	41	PF00454	0.517
MOD_PK_1	144	150	PF00069	0.564
MOD_PKA_2	10	16	PF00069	0.454
MOD_PKA_2	190	196	PF00069	0.496
MOD_PKA_2	66	72	PF00069	0.554
MOD_PKB_1	142	150	PF00069	0.503
MOD_Plk_1	102	108	PF00069	0.553
MOD_Plk_1	144	150	PF00069	0.552
MOD_SUMO_for_1	98	101	PF00179	0.572
TRG_DiLeu_BaEn_1	102	107	PF01217	0.555
TRG_ENDOCYTIC_2	167	170	PF00928	0.422
TRG_ER_diArg_1	141	144	PF00400	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU2	Leptomonas seymouri	53%	100%
A0A1X0NGY8	Trypanosomatidae	25%	100%
A0A3S7WXJ0	Leishmania donovani	93%	100%
A4HCN1	Leishmania braziliensis	75%	100%
A4I055	Leishmania infantum	92%	100%
E9AW18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B4L7	Trypanosoma cruzi	26%	95%