Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBF7_LEIMA

TriTrypDb:

LmjF.23.0180 , LMJLV39_230006800 , LMJSD75_230006800

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.757
CLV_NRD_NRD_1	219	221	PF00675	0.331
CLV_NRD_NRD_1	251	253	PF00675	0.514
CLV_NRD_NRD_1	260	262	PF00675	0.420
CLV_NRD_NRD_1	79	81	PF00675	0.413
CLV_PCSK_KEX2_1	251	253	PF00082	0.514
CLV_PCSK_KEX2_1	260	262	PF00082	0.420
CLV_PCSK_KEX2_1	79	81	PF00082	0.513
DEG_APCC_DBOX_1	259	267	PF00400	0.490
DEG_APCC_DBOX_1	27	35	PF00400	0.485
DEG_Nend_UBRbox_4	1	3	PF02207	0.498
DEG_SPOP_SBC_1	110	114	PF00917	0.565
DOC_CYCLIN_yCln2_LP_2	127	133	PF00134	0.362
DOC_MAPK_gen_1	220	226	PF00069	0.354
DOC_PP2B_LxvP_1	127	130	PF13499	0.664
DOC_PP2B_LxvP_1	146	149	PF13499	0.338
DOC_PP4_FxxP_1	5	8	PF00568	0.474
DOC_USP7_MATH_1	110	114	PF00917	0.725
DOC_USP7_MATH_1	196	200	PF00917	0.403
DOC_WW_Pin1_4	10	15	PF00397	0.467
DOC_WW_Pin1_4	111	116	PF00397	0.687
DOC_WW_Pin1_4	4	9	PF00397	0.477
DOC_WW_Pin1_4	51	56	PF00397	0.524
LIG_14-3-3_CanoR_1	164	174	PF00244	0.312
LIG_14-3-3_CanoR_1	28	32	PF00244	0.712
LIG_14-3-3_CanoR_1	79	88	PF00244	0.451
LIG_APCC_ABBA_1	88	93	PF00400	0.546
LIG_eIF4E_1	174	180	PF01652	0.350
LIG_FHA_1	28	34	PF00498	0.494
LIG_FHA_1	66	72	PF00498	0.366
LIG_FHA_2	148	154	PF00498	0.528
LIG_FHA_2	254	260	PF00498	0.376
LIG_LIR_Gen_1	159	170	PF02991	0.518
LIG_LIR_Gen_1	241	250	PF02991	0.354
LIG_LIR_Gen_1	282	290	PF02991	0.505
LIG_LIR_Nem_3	128	134	PF02991	0.426
LIG_LIR_Nem_3	150	154	PF02991	0.492
LIG_LIR_Nem_3	159	165	PF02991	0.420
LIG_LIR_Nem_3	241	247	PF02991	0.356
LIG_LIR_Nem_3	282	288	PF02991	0.530
LIG_MYND_1	273	277	PF01753	0.581
LIG_SH2_CRK	285	289	PF00017	0.466
LIG_SH2_CRK	97	101	PF00017	0.342
LIG_SH2_NCK_1	97	101	PF00017	0.342
LIG_SH2_STAP1	151	155	PF00017	0.492
LIG_SH2_STAP1	158	162	PF00017	0.485
LIG_SH2_STAP1	167	171	PF00017	0.477
LIG_SH2_STAP1	244	248	PF00017	0.361
LIG_SH2_STAT5	133	136	PF00017	0.340
LIG_SH2_STAT5	145	148	PF00017	0.306
LIG_SH2_STAT5	154	157	PF00017	0.376
LIG_SH2_STAT5	158	161	PF00017	0.391
LIG_SH2_STAT5	174	177	PF00017	0.235
LIG_TRAF2_1	256	259	PF00917	0.317
LIG_TRFH_1	145	149	PF08558	0.309
LIG_TYR_ITIM	242	247	PF00017	0.349
LIG_UBA3_1	71	77	PF00899	0.370
MOD_CDK_SPxxK_3	10	17	PF00069	0.496
MOD_CDK_SPxxK_3	51	58	PF00069	0.480
MOD_CK1_1	82	88	PF00069	0.427
MOD_CK2_1	253	259	PF00069	0.519
MOD_CK2_1	41	47	PF00069	0.552
MOD_GlcNHglycan	107	110	PF01048	0.645
MOD_GlcNHglycan	118	122	PF01048	0.659
MOD_GlcNHglycan	35	38	PF01048	0.658
MOD_GlcNHglycan	43	46	PF01048	0.625
MOD_GlcNHglycan	81	84	PF01048	0.525
MOD_GSK3_1	105	112	PF00069	0.580
MOD_NEK2_1	156	161	PF00069	0.430
MOD_NEK2_2	189	194	PF00069	0.381
MOD_PKA_1	79	85	PF00069	0.395
MOD_PKA_2	27	33	PF00069	0.690
MOD_PKA_2	79	85	PF00069	0.423
MOD_Plk_1	156	162	PF00069	0.482
MOD_Plk_1	196	202	PF00069	0.401
MOD_Plk_4	175	181	PF00069	0.286
MOD_ProDKin_1	111	117	PF00069	0.688
MOD_ProDKin_1	4	10	PF00069	0.479
MOD_ProDKin_1	51	57	PF00069	0.512
TRG_ENDOCYTIC_2	145	148	PF00928	0.310
TRG_ENDOCYTIC_2	167	170	PF00928	0.555
TRG_ENDOCYTIC_2	244	247	PF00928	0.357
TRG_ENDOCYTIC_2	285	288	PF00928	0.558
TRG_ENDOCYTIC_2	97	100	PF00928	0.338
TRG_ER_diArg_1	60	63	PF00400	0.571
TRG_ER_diArg_1	78	80	PF00400	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY1	Leptomonas seymouri	54%	100%
A0A3Q8ICJ3	Leishmania donovani	91%	100%
A0A422NVZ5	Trypanosoma rangeli	37%	100%
A4HCN2	Leishmania braziliensis	77%	100%
A4I056	Leishmania infantum	92%	100%
E9AW19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AYT6	Trypanosoma cruzi	37%	100%
V5D0F5	Trypanosoma cruzi	37%	100%