Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBF2_LEIMA

TriTrypDb:

LmjF.23.0225 , LMJLV39_230007400 , LMJSD75_230007700

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QBF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.695
CLV_NRD_NRD_1	71	73	PF00675	0.481
CLV_PCSK_KEX2_1	71	73	PF00082	0.481
CLV_PCSK_SKI1_1	108	112	PF00082	0.492
CLV_PCSK_SKI1_1	160	164	PF00082	0.416
CLV_PCSK_SKI1_1	90	94	PF00082	0.443
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DEG_SCF_FBW7_1	39	46	PF00400	0.641
DEG_SPOP_SBC_1	26	30	PF00917	0.636
DOC_CKS1_1	40	45	PF01111	0.641
DOC_PP2B_LxvP_1	92	95	PF13499	0.684
DOC_PP4_FxxP_1	119	122	PF00568	0.737
DOC_PP4_MxPP_1	129	132	PF00568	0.730
DOC_USP7_MATH_1	13	17	PF00917	0.626
DOC_WW_Pin1_4	108	113	PF00397	0.682
DOC_WW_Pin1_4	39	44	PF00397	0.629
DOC_WW_Pin1_4	50	55	PF00397	0.596
LIG_14-3-3_CanoR_1	160	165	PF00244	0.633
LIG_deltaCOP1_diTrp_1	199	209	PF00928	0.543
LIG_FHA_1	27	33	PF00498	0.694
LIG_FHA_1	34	40	PF00498	0.665
LIG_FHA_2	123	129	PF00498	0.707
LIG_FHA_2	44	50	PF00498	0.585
LIG_FHA_2	82	88	PF00498	0.686
LIG_LIR_Apic_2	75	81	PF02991	0.629
LIG_LIR_Gen_1	200	211	PF02991	0.543
LIG_LIR_Nem_3	199	205	PF02991	0.543
LIG_LIR_Nem_3	208	212	PF02991	0.417
LIG_MYND_1	181	185	PF01753	0.715
LIG_Pex14_2	209	213	PF04695	0.417
LIG_SH2_CRK	191	195	PF00017	0.706
LIG_SH2_STAT3	115	118	PF00017	0.707
LIG_SH2_STAT3	41	44	PF00017	0.681
LIG_SH2_STAT5	35	38	PF00017	0.700
LIG_SH2_STAT5	41	44	PF00017	0.617
LIG_SH2_STAT5	50	53	PF00017	0.587
LIG_SH3_1	37	43	PF00018	0.609
LIG_SH3_3	174	180	PF00018	0.654
LIG_SH3_3	182	188	PF00018	0.647
LIG_SH3_3	37	43	PF00018	0.619
LIG_SH3_3	88	94	PF00018	0.642
LIG_UBA3_1	212	221	PF00899	0.417
LIG_WRC_WIRS_1	206	211	PF05994	0.372
LIG_WW_1	112	115	PF00397	0.710
LIG_WW_3	105	109	PF00397	0.670
MOD_CDK_SPK_2	50	55	PF00069	0.682
MOD_CK1_1	25	31	PF00069	0.668
MOD_CK2_1	165	171	PF00069	0.655
MOD_GlcNHglycan	15	18	PF01048	0.380
MOD_GlcNHglycan	24	27	PF01048	0.436
MOD_GSK3_1	22	29	PF00069	0.753
MOD_GSK3_1	39	46	PF00069	0.623
MOD_N-GLC_1	26	31	PF02516	0.458
MOD_NEK2_1	205	210	PF00069	0.367
MOD_PKB_1	158	166	PF00069	0.632
MOD_ProDKin_1	108	114	PF00069	0.682
MOD_ProDKin_1	39	45	PF00069	0.629
MOD_ProDKin_1	50	56	PF00069	0.594
TRG_ER_diArg_1	158	161	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG6	Leptomonas seymouri	60%	100%
A0A0S4JGN0	Bodo saltans	37%	88%
A0A1X0NGS3	Trypanosomatidae	36%	100%
A0A3Q8ICE4	Leishmania donovani	96%	100%
A0A3S7WXM6	Leishmania donovani	97%	100%
A4HCN7	Leishmania braziliensis	79%	100%
A4I062	Leishmania infantum	98%	100%
E9AW25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
V5B7Q1	Trypanosoma cruzi	43%	91%