Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBD9_LEIMA

TriTrypDb:

LmjF.23.0350 , LMJLV39_230008800 , LMJSD75_230009000

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.382
CLV_NRD_NRD_1	138	140	PF00675	0.482
CLV_NRD_NRD_1	23	25	PF00675	0.718
CLV_NRD_NRD_1	270	272	PF00675	0.592
CLV_PCSK_KEX2_1	138	140	PF00082	0.524
CLV_PCSK_KEX2_1	154	156	PF00082	0.399
CLV_PCSK_KEX2_1	205	207	PF00082	0.580
CLV_PCSK_KEX2_1	22	24	PF00082	0.724
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.539
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.563
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.645
CLV_PCSK_PC7_1	134	140	PF00082	0.514
CLV_PCSK_PC7_1	19	25	PF00082	0.605
CLV_PCSK_SKI1_1	142	146	PF00082	0.564
CLV_PCSK_SKI1_1	171	175	PF00082	0.621
CLV_PCSK_SKI1_1	176	180	PF00082	0.587
CLV_PCSK_SKI1_1	247	251	PF00082	0.624
CLV_PCSK_SKI1_1	57	61	PF00082	0.528
DEG_SPOP_SBC_1	58	62	PF00917	0.463
DOC_AGCK_PIF_2	289	294	PF00069	0.470
DOC_MAPK_gen_1	138	146	PF00069	0.517
DOC_MAPK_gen_1	201	210	PF00069	0.554
DOC_MAPK_MEF2A_6	204	212	PF00069	0.600
DOC_PP1_RVXF_1	169	175	PF00149	0.514
DOC_PP4_FxxP_1	72	75	PF00568	0.411
DOC_USP7_UBL2_3	138	142	PF12436	0.551
DOC_USP7_UBL2_3	201	205	PF12436	0.623
DOC_USP7_UBL2_3	272	276	PF12436	0.548
DOC_WW_Pin1_4	212	217	PF00397	0.605
DOC_WW_Pin1_4	218	223	PF00397	0.554
LIG_14-3-3_CanoR_1	57	66	PF00244	0.603
LIG_BRCT_BRCA1_1	60	64	PF00533	0.535
LIG_CAP-Gly_1	288	294	PF01302	0.471
LIG_FHA_1	58	64	PF00498	0.515
LIG_FHA_2	131	137	PF00498	0.487
LIG_FHA_2	182	188	PF00498	0.547
LIG_FHA_2	192	198	PF00498	0.467
LIG_FHA_2	256	262	PF00498	0.557
LIG_LIR_Apic_2	123	129	PF02991	0.541
LIG_LIR_Apic_2	48	54	PF02991	0.632
LIG_LIR_Gen_1	280	289	PF02991	0.574
LIG_LIR_Nem_3	148	152	PF02991	0.444
LIG_LIR_Nem_3	280	286	PF02991	0.606
LIG_LIR_Nem_3	287	292	PF02991	0.550
LIG_Pex14_1	141	145	PF04695	0.447
LIG_SH2_GRB2like	105	108	PF00017	0.413
LIG_SH2_STAT5	126	129	PF00017	0.585
LIG_SH2_STAT5	152	155	PF00017	0.501
LIG_SH2_STAT5	257	260	PF00017	0.635
LIG_SH3_3	217	223	PF00018	0.712
LIG_TRAF2_1	194	197	PF00917	0.536
LIG_WW_3	19	23	PF00397	0.520
MOD_CK1_1	253	259	PF00069	0.429
MOD_CK1_1	38	44	PF00069	0.591
MOD_CK2_1	181	187	PF00069	0.536
MOD_CK2_1	191	197	PF00069	0.481
MOD_CK2_1	228	234	PF00069	0.511
MOD_Cter_Amidation	136	139	PF01082	0.455
MOD_Cter_Amidation	14	17	PF01082	0.634
MOD_GSK3_1	253	260	PF00069	0.558
MOD_GSK3_1	277	284	PF00069	0.592
MOD_GSK3_1	35	42	PF00069	0.678
MOD_GSK3_1	92	99	PF00069	0.459
MOD_LATS_1	275	281	PF00433	0.600
MOD_NEK2_1	59	64	PF00069	0.520
MOD_NEK2_1	92	97	PF00069	0.452
MOD_PIKK_1	36	42	PF00454	0.613
MOD_PKA_1	250	256	PF00069	0.645
MOD_PKA_2	281	287	PF00069	0.706
MOD_PKA_2	82	88	PF00069	0.468
MOD_Plk_1	191	197	PF00069	0.559
MOD_Plk_4	127	133	PF00069	0.625
MOD_Plk_4	59	65	PF00069	0.532
MOD_ProDKin_1	212	218	PF00069	0.605
MOD_SUMO_rev_2	117	127	PF00179	0.568
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.564
TRG_ER_diArg_1	21	24	PF00400	0.541
TRG_NLS_Bipartite_1	124	143	PF00514	0.480
TRG_NLS_MonoExtC_3	137	142	PF00514	0.476
TRG_NLS_MonoExtC_3	15	20	PF00514	0.613
TRG_NLS_MonoExtC_3	203	209	PF00514	0.623
TRG_NLS_MonoExtN_4	13	20	PF00514	0.613
TRG_NLS_MonoExtN_4	138	143	PF00514	0.649
TRG_NLS_MonoExtN_4	201	208	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P555	Leptomonas seymouri	60%	84%
A0A0S4IRA8	Bodo saltans	25%	93%
A0A1X0NX54	Trypanosomatidae	37%	100%
A0A3Q8IAW9	Leishmania donovani	94%	100%
A0A422NW66	Trypanosoma rangeli	38%	100%
A4HCP9	Leishmania braziliensis	71%	98%
A4I075	Leishmania infantum	93%	100%
C9ZUZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AW38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%