Putative NADP-dependent alcohol dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADP-dependent alcohol dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4QBD8_LEIMA

TriTrypDb:

LmjF.23.0360 , LMJLV39_230009100 , LMJSD75_230009300

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBD8

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004022	alcohol dehydrogenase (NAD+) activity	6	6
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	6
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	6
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	5	6
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.477
CLV_NRD_NRD_1	24	26	PF00675	0.471
CLV_NRD_NRD_1	282	284	PF00675	0.407
CLV_PCSK_KEX2_1	24	26	PF00082	0.471
CLV_PCSK_KEX2_1	282	284	PF00082	0.437
CLV_PCSK_SKI1_1	265	269	PF00082	0.488
DOC_MAPK_gen_1	175	185	PF00069	0.502
DOC_MAPK_gen_1	79	88	PF00069	0.389
DOC_MAPK_MEF2A_6	254	262	PF00069	0.535
DOC_MAPK_RevD_3	267	283	PF00069	0.473

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A075TMP0	Penicillium expansum	33%	100%
A0A0C5DM37	Catharanthus roseus	24%	94%
A0A0N1PAV7	Leptomonas seymouri	64%	100%
A0A0N1PBK4	Leptomonas seymouri	81%	100%
A0A0N1PDX1	Leptomonas seymouri	23%	100%
A0A0S4IT20	Bodo saltans	25%	100%
A0A0S4JG37	Bodo saltans	54%	94%
A0A161CAI1	Catharanthus roseus	40%	99%
A0A1B1FHP3	Catharanthus roseus	43%	96%
A0A1X0NYI6	Trypanosomatidae	64%	100%

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