Permease-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

permease-like protein

Species:

Leishmania major

UniProt:

Q4QBC9_LEIMA

TriTrypDb:

LmjF.23.0450 , LMJLV39_230010100 , LMJSD75_230010300

Length:

1104

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	11
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QBC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.382
CLV_C14_Caspase3-7	30	34	PF00656	0.472
CLV_C14_Caspase3-7	519	523	PF00656	0.573
CLV_NRD_NRD_1	1092	1094	PF00675	0.330
CLV_NRD_NRD_1	36	38	PF00675	0.366
CLV_NRD_NRD_1	626	628	PF00675	0.434
CLV_PCSK_KEX2_1	35	37	PF00082	0.372
CLV_PCSK_KEX2_1	513	515	PF00082	0.384
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.302
CLV_PCSK_SKI1_1	283	287	PF00082	0.615
CLV_PCSK_SKI1_1	513	517	PF00082	0.306
CLV_PCSK_SKI1_1	521	525	PF00082	0.348
CLV_PCSK_SKI1_1	740	744	PF00082	0.555
CLV_PCSK_SKI1_1	937	941	PF00082	0.575
DEG_APCC_DBOX_1	282	290	PF00400	0.422
DEG_APCC_DBOX_1	35	43	PF00400	0.490
DEG_SPOP_SBC_1	515	519	PF00917	0.586
DOC_CKS1_1	63	68	PF01111	0.367
DOC_CYCLIN_RxL_1	1007	1016	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	501	507	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	895	901	PF00134	0.354
DOC_MAPK_FxFP_2	1063	1066	PF00069	0.362
DOC_MAPK_gen_1	191	199	PF00069	0.431
DOC_MAPK_gen_1	219	229	PF00069	0.422
DOC_MAPK_gen_1	35	43	PF00069	0.556
DOC_MAPK_gen_1	360	370	PF00069	0.385
DOC_MAPK_gen_1	537	546	PF00069	0.686
DOC_MAPK_gen_1	636	646	PF00069	0.495
DOC_MAPK_gen_1	791	797	PF00069	0.438
DOC_MAPK_MEF2A_6	191	199	PF00069	0.372
DOC_MAPK_MEF2A_6	205	212	PF00069	0.390
DOC_MAPK_MEF2A_6	283	290	PF00069	0.398
DOC_MAPK_MEF2A_6	35	43	PF00069	0.649
DOC_MAPK_MEF2A_6	363	372	PF00069	0.418
DOC_MAPK_MEF2A_6	438	446	PF00069	0.534
DOC_MAPK_MEF2A_6	540	548	PF00069	0.624
DOC_MAPK_MEF2A_6	639	648	PF00069	0.308
DOC_MAPK_MEF2A_6	64	72	PF00069	0.313
DOC_MAPK_MEF2A_6	920	928	PF00069	0.311
DOC_PP1_RVXF_1	1008	1015	PF00149	0.534
DOC_PP1_RVXF_1	166	173	PF00149	0.456
DOC_PP1_RVXF_1	22	28	PF00149	0.599
DOC_PP2B_LxvP_1	501	504	PF13499	0.436
DOC_PP4_FxxP_1	1063	1066	PF00568	0.296
DOC_PP4_FxxP_1	452	455	PF00568	0.335
DOC_PP4_FxxP_1	684	687	PF00568	0.347
DOC_USP7_MATH_1	1096	1100	PF00917	0.598
DOC_USP7_MATH_1	515	519	PF00917	0.515
DOC_USP7_MATH_1	709	713	PF00917	0.322
DOC_USP7_MATH_1	811	815	PF00917	0.460
DOC_USP7_MATH_1	872	876	PF00917	0.378
DOC_WW_Pin1_4	299	304	PF00397	0.469
DOC_WW_Pin1_4	507	512	PF00397	0.387
DOC_WW_Pin1_4	62	67	PF00397	0.365
LIG_14-3-3_CanoR_1	142	151	PF00244	0.430
LIG_14-3-3_CanoR_1	391	401	PF00244	0.362
LIG_14-3-3_CanoR_1	514	524	PF00244	0.496
LIG_14-3-3_CanoR_1	621	626	PF00244	0.565
LIG_14-3-3_CanoR_1	740	747	PF00244	0.377
LIG_14-3-3_CanoR_1	966	972	PF00244	0.286
LIG_Actin_WH2_2	192	207	PF00022	0.416
LIG_Actin_WH2_2	55	73	PF00022	0.378
LIG_BIR_II_1	1	5	PF00653	0.761
LIG_BRCT_BRCA1_1	1010	1014	PF00533	0.511
LIG_BRCT_BRCA1_1	570	574	PF00533	0.391
LIG_BRCT_BRCA1_1	680	684	PF00533	0.348
LIG_BRCT_BRCA1_1	852	856	PF00533	0.409
LIG_FHA_1	1003	1009	PF00498	0.500
LIG_FHA_1	1014	1020	PF00498	0.534
LIG_FHA_1	1034	1040	PF00498	0.150
LIG_FHA_1	1046	1052	PF00498	0.334
LIG_FHA_1	20	26	PF00498	0.637
LIG_FHA_1	222	228	PF00498	0.390
LIG_FHA_1	310	316	PF00498	0.448
LIG_FHA_1	384	390	PF00498	0.337
LIG_FHA_1	437	443	PF00498	0.532
LIG_FHA_1	465	471	PF00498	0.490
LIG_FHA_1	489	495	PF00498	0.363
LIG_FHA_1	597	603	PF00498	0.454
LIG_FHA_1	63	69	PF00498	0.356
LIG_FHA_1	734	740	PF00498	0.397
LIG_FHA_1	882	888	PF00498	0.383
LIG_FHA_1	977	983	PF00498	0.391
LIG_FHA_1	991	997	PF00498	0.319
LIG_FHA_2	256	262	PF00498	0.379
LIG_FHA_2	28	34	PF00498	0.533
LIG_FHA_2	309	315	PF00498	0.451
LIG_FHA_2	74	80	PF00498	0.340
LIG_FHA_2	748	754	PF00498	0.366
LIG_FHA_2	808	814	PF00498	0.411
LIG_FHA_2	931	937	PF00498	0.419
LIG_GBD_Chelix_1	493	501	PF00786	0.384
LIG_GBD_Chelix_1	863	871	PF00786	0.442
LIG_LIR_Apic_2	304	310	PF02991	0.465
LIG_LIR_Apic_2	449	455	PF02991	0.378
LIG_LIR_Apic_2	681	687	PF02991	0.350
LIG_LIR_Apic_2	762	767	PF02991	0.415
LIG_LIR_Apic_2	779	784	PF02991	0.264
LIG_LIR_Apic_2	854	860	PF02991	0.393
LIG_LIR_Gen_1	17	28	PF02991	0.632
LIG_LIR_Gen_1	330	339	PF02991	0.389
LIG_LIR_Gen_1	476	485	PF02991	0.273
LIG_LIR_Gen_1	571	582	PF02991	0.386
LIG_LIR_Gen_1	585	593	PF02991	0.330
LIG_LIR_Gen_1	638	649	PF02991	0.577
LIG_LIR_Gen_1	65	75	PF02991	0.352
LIG_LIR_Gen_1	753	760	PF02991	0.364
LIG_LIR_Gen_1	868	878	PF02991	0.381
LIG_LIR_Gen_1	889	900	PF02991	0.376
LIG_LIR_Gen_1	950	960	PF02991	0.352
LIG_LIR_LC3C_4	1036	1041	PF02991	0.246
LIG_LIR_Nem_3	1005	1009	PF02991	0.527
LIG_LIR_Nem_3	1036	1040	PF02991	0.377
LIG_LIR_Nem_3	17	23	PF02991	0.646
LIG_LIR_Nem_3	183	187	PF02991	0.296
LIG_LIR_Nem_3	340	346	PF02991	0.389
LIG_LIR_Nem_3	388	393	PF02991	0.376
LIG_LIR_Nem_3	476	481	PF02991	0.255
LIG_LIR_Nem_3	508	512	PF02991	0.356
LIG_LIR_Nem_3	525	530	PF02991	0.570
LIG_LIR_Nem_3	585	589	PF02991	0.449
LIG_LIR_Nem_3	607	612	PF02991	0.537
LIG_LIR_Nem_3	638	644	PF02991	0.518
LIG_LIR_Nem_3	65	70	PF02991	0.342
LIG_LIR_Nem_3	683	688	PF02991	0.391
LIG_LIR_Nem_3	717	721	PF02991	0.343
LIG_LIR_Nem_3	748	754	PF02991	0.311
LIG_LIR_Nem_3	868	873	PF02991	0.337
LIG_LIR_Nem_3	889	895	PF02991	0.354
LIG_LIR_Nem_3	948	954	PF02991	0.430
LIG_LYPXL_yS_3	718	721	PF13949	0.319
LIG_NRBOX	497	503	PF00104	0.402
LIG_NRBOX	610	616	PF00104	0.607
LIG_PCNA_PIPBox_1	969	978	PF02747	0.442
LIG_PCNA_yPIPBox_3	468	480	PF02747	0.288
LIG_PCNA_yPIPBox_3	690	698	PF02747	0.411
LIG_PCNA_yPIPBox_3	966	976	PF02747	0.445
LIG_Pex14_1	63	67	PF04695	0.368
LIG_Pex14_2	1061	1065	PF04695	0.353
LIG_Pex14_2	59	63	PF04695	0.407
LIG_SH2_CRK	1067	1071	PF00017	0.353
LIG_SH2_CRK	509	513	PF00017	0.559
LIG_SH2_CRK	527	531	PF00017	0.575
LIG_SH2_CRK	641	645	PF00017	0.246
LIG_SH2_CRK	95	99	PF00017	0.369
LIG_SH2_CRK	952	956	PF00017	0.400
LIG_SH2_GRB2like	347	350	PF00017	0.281
LIG_SH2_NCK_1	29	33	PF00017	0.580
LIG_SH2_NCK_1	781	785	PF00017	0.394
LIG_SH2_PTP2	184	187	PF00017	0.412
LIG_SH2_PTP2	67	70	PF00017	0.345
LIG_SH2_PTP2	925	928	PF00017	0.380
LIG_SH2_SRC	764	767	PF00017	0.417
LIG_SH2_SRC	781	784	PF00017	0.336
LIG_SH2_SRC	857	860	PF00017	0.374
LIG_SH2_STAP1	1067	1071	PF00017	0.353
LIG_SH2_STAP1	270	274	PF00017	0.432
LIG_SH2_STAP1	331	335	PF00017	0.365
LIG_SH2_STAP1	343	347	PF00017	0.375
LIG_SH2_STAP1	704	708	PF00017	0.405
LIG_SH2_STAP1	710	714	PF00017	0.361
LIG_SH2_STAT3	600	603	PF00017	0.501
LIG_SH2_STAT3	704	707	PF00017	0.421
LIG_SH2_STAT5	184	187	PF00017	0.334
LIG_SH2_STAT5	230	233	PF00017	0.410
LIG_SH2_STAT5	29	32	PF00017	0.531
LIG_SH2_STAT5	308	311	PF00017	0.478
LIG_SH2_STAT5	566	569	PF00017	0.446
LIG_SH2_STAT5	600	603	PF00017	0.424
LIG_SH2_STAT5	612	615	PF00017	0.547
LIG_SH2_STAT5	67	70	PF00017	0.326
LIG_SH2_STAT5	710	713	PF00017	0.329
LIG_SH2_STAT5	843	846	PF00017	0.376
LIG_SH2_STAT5	857	860	PF00017	0.275
LIG_SH2_STAT5	925	928	PF00017	0.342
LIG_SH2_STAT5	95	98	PF00017	0.339
LIG_SH2_STAT5	977	980	PF00017	0.364
LIG_SH3_3	220	226	PF00018	0.469
LIG_SH3_3	599	605	PF00018	0.413
LIG_SH3_3	801	807	PF00018	0.478
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.384
LIG_SUMO_SIM_par_1	147	154	PF11976	0.331
LIG_SUMO_SIM_par_1	249	254	PF11976	0.443
LIG_SUMO_SIM_par_1	335	340	PF11976	0.359
LIG_SUMO_SIM_par_1	642	647	PF11976	0.256
LIG_SUMO_SIM_par_1	675	681	PF11976	0.364
LIG_SUMO_SIM_par_1	883	889	PF11976	0.380
LIG_TRFH_1	565	569	PF08558	0.378
LIG_TRFH_1	856	860	PF08558	0.389
LIG_TYR_ITIM	610	615	PF00017	0.590
LIG_TYR_ITIM	923	928	PF00017	0.385
LIG_TYR_ITIM	93	98	PF00017	0.359
LIG_TYR_ITSM	948	955	PF00017	0.364
LIG_UBA3_1	1089	1095	PF00899	0.442
LIG_Vh1_VBS_1	392	410	PF01044	0.306
LIG_WRC_WIRS_1	212	217	PF05994	0.481
LIG_WRC_WIRS_1	710	715	PF05994	0.324
LIG_WRC_WIRS_1	768	773	PF05994	0.448
MOD_CDC14_SPxK_1	510	513	PF00782	0.530
MOD_CDK_SPxK_1	507	513	PF00069	0.402
MOD_CDK_SPxxK_3	507	514	PF00069	0.434
MOD_CK1_1	10	16	PF00069	0.704
MOD_CK1_1	1033	1039	PF00069	0.368
MOD_CK1_1	123	129	PF00069	0.412
MOD_CK1_1	136	142	PF00069	0.410
MOD_CK1_1	180	186	PF00069	0.366
MOD_CK1_1	319	325	PF00069	0.535
MOD_CK1_1	476	482	PF00069	0.306
MOD_CK1_1	659	665	PF00069	0.467
MOD_CK1_1	759	765	PF00069	0.423
MOD_CK1_1	881	887	PF00069	0.281
MOD_CK1_1	930	936	PF00069	0.382
MOD_CK1_1	967	973	PF00069	0.411
MOD_CK2_1	150	156	PF00069	0.388
MOD_CK2_1	299	305	PF00069	0.498
MOD_CK2_1	308	314	PF00069	0.475
MOD_CK2_1	73	79	PF00069	0.315
MOD_CK2_1	759	765	PF00069	0.442
MOD_CK2_1	776	782	PF00069	0.354
MOD_CK2_1	807	813	PF00069	0.434
MOD_CK2_1	912	918	PF00069	0.437
MOD_CK2_1	930	936	PF00069	0.308
MOD_GlcNHglycan	1032	1035	PF01048	0.403
MOD_GlcNHglycan	135	138	PF01048	0.587
MOD_GlcNHglycan	144	147	PF01048	0.414
MOD_GlcNHglycan	179	182	PF01048	0.601
MOD_GlcNHglycan	187	190	PF01048	0.624
MOD_GlcNHglycan	271	274	PF01048	0.623
MOD_GlcNHglycan	54	57	PF01048	0.389
MOD_GlcNHglycan	653	656	PF01048	0.377
MOD_GlcNHglycan	761	764	PF01048	0.597
MOD_GlcNHglycan	822	825	PF01048	0.513
MOD_GlcNHglycan	834	837	PF01048	0.572
MOD_GlcNHglycan	867	870	PF01048	0.488
MOD_GSK3_1	10	17	PF00069	0.663
MOD_GSK3_1	119	126	PF00069	0.399
MOD_GSK3_1	19	26	PF00069	0.584
MOD_GSK3_1	195	202	PF00069	0.427
MOD_GSK3_1	211	218	PF00069	0.332
MOD_GSK3_1	221	228	PF00069	0.365
MOD_GSK3_1	251	258	PF00069	0.379
MOD_GSK3_1	297	304	PF00069	0.437
MOD_GSK3_1	316	323	PF00069	0.487
MOD_GSK3_1	379	386	PF00069	0.333
MOD_GSK3_1	446	453	PF00069	0.419
MOD_GSK3_1	568	575	PF00069	0.420
MOD_GSK3_1	617	624	PF00069	0.631
MOD_GSK3_1	656	663	PF00069	0.378
MOD_GSK3_1	722	729	PF00069	0.321
MOD_GSK3_1	807	814	PF00069	0.399
MOD_GSK3_1	98	105	PF00069	0.370
MOD_GSK3_1	990	997	PF00069	0.490
MOD_N-GLC_1	199	204	PF02516	0.630
MOD_N-GLC_1	215	220	PF02516	0.518
MOD_N-GLC_1	238	243	PF02516	0.630
MOD_N-GLC_1	316	321	PF02516	0.702
MOD_N-GLC_1	476	481	PF02516	0.553
MOD_N-GLC_1	787	792	PF02516	0.727
MOD_N-GLC_1	807	812	PF02516	0.431
MOD_N-GLC_1	845	850	PF02516	0.644
MOD_N-GLC_1	912	917	PF02516	0.621
MOD_N-GLC_1	93	98	PF02516	0.528
MOD_N-GLC_1	930	935	PF02516	0.555
MOD_NEK2_1	102	107	PF00069	0.410
MOD_NEK2_1	19	24	PF00069	0.618
MOD_NEK2_1	215	220	PF00069	0.458
MOD_NEK2_1	255	260	PF00069	0.384
MOD_NEK2_1	316	321	PF00069	0.463
MOD_NEK2_1	380	385	PF00069	0.353
MOD_NEK2_1	392	397	PF00069	0.256
MOD_NEK2_1	412	417	PF00069	0.377
MOD_NEK2_1	436	441	PF00069	0.490
MOD_NEK2_1	450	455	PF00069	0.380
MOD_NEK2_1	505	510	PF00069	0.377
MOD_NEK2_1	516	521	PF00069	0.453
MOD_NEK2_1	572	577	PF00069	0.417
MOD_NEK2_1	651	656	PF00069	0.349
MOD_NEK2_1	660	665	PF00069	0.340
MOD_NEK2_1	747	752	PF00069	0.348
MOD_NEK2_1	756	761	PF00069	0.334
MOD_NEK2_1	819	824	PF00069	0.323
MOD_NEK2_1	845	850	PF00069	0.467
MOD_NEK2_1	871	876	PF00069	0.373
MOD_NEK2_1	93	98	PF00069	0.416
MOD_NEK2_1	976	981	PF00069	0.355
MOD_NEK2_1	990	995	PF00069	0.355
MOD_NEK2_2	1088	1093	PF00069	0.363
MOD_NEK2_2	699	704	PF00069	0.358
MOD_NEK2_2	767	772	PF00069	0.394
MOD_NEK2_2	851	856	PF00069	0.325
MOD_PIKK_1	436	442	PF00454	0.464
MOD_PIKK_1	663	669	PF00454	0.356
MOD_PIKK_1	722	728	PF00454	0.404
MOD_PIKK_1	811	817	PF00454	0.432
MOD_PIKK_1	878	884	PF00454	0.349
MOD_PIKK_1	96	102	PF00454	0.338
MOD_PKA_2	141	147	PF00069	0.440
MOD_PKA_2	617	623	PF00069	0.657
MOD_PKA_2	635	641	PF00069	0.457
MOD_PKA_2	865	871	PF00069	0.322
MOD_Plk_1	123	129	PF00069	0.461
MOD_Plk_1	199	205	PF00069	0.451
MOD_Plk_1	241	247	PF00069	0.391
MOD_Plk_1	290	296	PF00069	0.456
MOD_Plk_1	316	322	PF00069	0.509
MOD_Plk_1	380	386	PF00069	0.426
MOD_Plk_1	73	79	PF00069	0.311
MOD_Plk_1	747	753	PF00069	0.387
MOD_Plk_1	845	851	PF00069	0.409
MOD_Plk_1	912	918	PF00069	0.368
MOD_Plk_1	958	964	PF00069	0.385
MOD_Plk_2-3	689	695	PF00069	0.357
MOD_Plk_4	1096	1102	PF00069	0.606
MOD_Plk_4	180	186	PF00069	0.342
MOD_Plk_4	23	29	PF00069	0.601
MOD_Plk_4	568	574	PF00069	0.374
MOD_Plk_4	596	602	PF00069	0.473
MOD_Plk_4	621	627	PF00069	0.495
MOD_Plk_4	675	681	PF00069	0.305
MOD_Plk_4	699	705	PF00069	0.368
MOD_Plk_4	726	732	PF00069	0.387
MOD_Plk_4	851	857	PF00069	0.414
MOD_Plk_4	87	93	PF00069	0.447
MOD_Plk_4	881	887	PF00069	0.352
MOD_Plk_4	891	897	PF00069	0.329
MOD_Plk_4	912	918	PF00069	0.418
MOD_Plk_4	947	953	PF00069	0.397
MOD_Plk_4	967	973	PF00069	0.245
MOD_Plk_4	977	983	PF00069	0.380
MOD_Plk_4	991	997	PF00069	0.285
MOD_ProDKin_1	299	305	PF00069	0.471
MOD_ProDKin_1	507	513	PF00069	0.387
MOD_ProDKin_1	62	68	PF00069	0.367
TRG_DiLeu_BaEn_1	859	864	PF01217	0.347
TRG_DiLeu_BaEn_2	935	941	PF01217	0.402
TRG_DiLeu_BaLyEn_6	1085	1090	PF01217	0.402
TRG_ENDOCYTIC_2	1025	1028	PF00928	0.496
TRG_ENDOCYTIC_2	1067	1070	PF00928	0.313
TRG_ENDOCYTIC_2	167	170	PF00928	0.361
TRG_ENDOCYTIC_2	184	187	PF00928	0.277
TRG_ENDOCYTIC_2	331	334	PF00928	0.345
TRG_ENDOCYTIC_2	509	512	PF00928	0.559
TRG_ENDOCYTIC_2	527	530	PF00928	0.570
TRG_ENDOCYTIC_2	565	568	PF00928	0.335
TRG_ENDOCYTIC_2	612	615	PF00928	0.602
TRG_ENDOCYTIC_2	641	644	PF00928	0.447
TRG_ENDOCYTIC_2	67	70	PF00928	0.328
TRG_ENDOCYTIC_2	710	713	PF00928	0.292
TRG_ENDOCYTIC_2	718	721	PF00928	0.319
TRG_ENDOCYTIC_2	751	754	PF00928	0.427
TRG_ENDOCYTIC_2	925	928	PF00928	0.338
TRG_ENDOCYTIC_2	95	98	PF00928	0.331
TRG_ENDOCYTIC_2	952	955	PF00928	0.401
TRG_ER_diArg_1	35	37	PF00400	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z0	Leptomonas seymouri	70%	100%
A0A0S4JD81	Bodo saltans	37%	85%
A0A0S4JGG5	Bodo saltans	35%	100%
A0A1X0NYN7	Trypanosomatidae	37%	97%
A0A3Q8ICL4	Leishmania donovani	91%	100%
A0A3S5IQL8	Trypanosoma rangeli	42%	96%
A4HCQ9	Leishmania braziliensis	76%	100%
A4I084	Leishmania infantum	91%	100%
E9AW48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%