Putative trypanothione synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trypanothione synthetase, putative

Species:

Leishmania major

UniProt:

Q4QBC8_LEIMA

TriTrypDb:

LmjF.23.0460 , LMJLV39_230010200 , LMJSD75_230010400

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBC8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016874	ligase activity	2	7
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	7
GO:0016880	acid-ammonia (or amide) ligase activity	4	7
GO:0047479	trypanothione synthase activity	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.440
CLV_PCSK_KEX2_1	123	125	PF00082	0.440
CLV_PCSK_KEX2_1	136	138	PF00082	0.440
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.394
CLV_PCSK_SKI1_1	131	135	PF00082	0.481
CLV_PCSK_SKI1_1	209	213	PF00082	0.456
DEG_MDM2_SWIB_1	121	128	PF02201	0.320
DEG_SPOP_SBC_1	67	71	PF00917	0.664
DOC_CKS1_1	26	31	PF01111	0.621
DOC_CYCLIN_RxL_1	128	138	PF00134	0.253
DOC_CYCLIN_yCln2_LP_2	216	219	PF00134	0.239
DOC_PP2B_LxvP_1	132	135	PF13499	0.240
DOC_PP2B_LxvP_1	216	219	PF13499	0.239
DOC_USP7_MATH_1	135	139	PF00917	0.239
DOC_USP7_MATH_1	179	183	PF00917	0.288
DOC_USP7_MATH_1	196	200	PF00917	0.162
DOC_USP7_MATH_1	67	71	PF00917	0.620
DOC_USP7_MATH_1	9	13	PF00917	0.582
DOC_USP7_UBL2_3	205	209	PF12436	0.292
DOC_WW_Pin1_4	13	18	PF00397	0.708
DOC_WW_Pin1_4	175	180	PF00397	0.275
DOC_WW_Pin1_4	230	235	PF00397	0.331
DOC_WW_Pin1_4	25	30	PF00397	0.548
DOC_WW_Pin1_4	58	63	PF00397	0.617
LIG_14-3-3_CanoR_1	23	29	PF00244	0.706
LIG_14-3-3_CanoR_1	68	76	PF00244	0.515
LIG_deltaCOP1_diTrp_1	201	210	PF00928	0.320
LIG_FHA_1	127	133	PF00498	0.348
LIG_FHA_2	196	202	PF00498	0.239
LIG_FHA_2	240	246	PF00498	0.334
LIG_FHA_2	26	32	PF00498	0.632
LIG_LIR_Apic_2	230	234	PF02991	0.334
LIG_LIR_Gen_1	201	211	PF02991	0.320
LIG_LIR_Nem_3	108	114	PF02991	0.338
LIG_LIR_Nem_3	201	206	PF02991	0.320
LIG_LIR_Nem_3	233	238	PF02991	0.298
LIG_Pex14_1	102	106	PF04695	0.306
LIG_Pex14_2	121	125	PF04695	0.240
LIG_RPA_C_Fungi	63	75	PF08784	0.435
LIG_SH2_GRB2like	92	95	PF00017	0.371
LIG_SH2_STAP1	148	152	PF00017	0.409
LIG_SH2_STAT3	114	117	PF00017	0.277
LIG_SH2_STAT5	141	144	PF00017	0.424
LIG_SH2_STAT5	252	255	PF00017	0.343
LIG_SH2_STAT5	259	262	PF00017	0.465
LIG_SH2_STAT5	84	87	PF00017	0.501
LIG_SH3_3	23	29	PF00018	0.664
LIG_TRAF2_1	43	46	PF00917	0.576
MOD_CDK_SPxxK_3	13	20	PF00069	0.524
MOD_CDK_SPxxK_3	25	32	PF00069	0.479
MOD_CK1_1	144	150	PF00069	0.324
MOD_CK1_1	157	163	PF00069	0.492
MOD_CK1_1	178	184	PF00069	0.361
MOD_CK1_1	199	205	PF00069	0.473
MOD_CK1_1	22	28	PF00069	0.667
MOD_CK1_1	230	236	PF00069	0.414
MOD_CK1_1	63	69	PF00069	0.663
MOD_CK1_1	93	99	PF00069	0.427
MOD_CK2_1	178	184	PF00069	0.401
MOD_CK2_1	2	8	PF00069	0.606
MOD_GlcNHglycan	17	20	PF01048	0.596
MOD_GlcNHglycan	5	8	PF01048	0.567
MOD_GSK3_1	153	160	PF00069	0.233
MOD_GSK3_1	171	178	PF00069	0.418
MOD_GSK3_1	195	202	PF00069	0.468
MOD_GSK3_1	63	70	PF00069	0.686
MOD_GSK3_1	9	16	PF00069	0.660
MOD_GSK3_1	90	97	PF00069	0.496
MOD_N-GLC_1	93	98	PF02516	0.432
MOD_N-GLC_2	105	107	PF02516	0.273
MOD_NEK2_1	126	131	PF00069	0.423
MOD_NEK2_2	74	79	PF00069	0.528
MOD_NMyristoyl	1	7	PF02799	0.602
MOD_OFUCOSY	139	146	PF10250	0.409
MOD_PIKK_1	157	163	PF00454	0.299
MOD_PKA_1	153	159	PF00069	0.212
MOD_PKA_2	19	25	PF00069	0.723
MOD_PKA_2	199	205	PF00069	0.212
MOD_PKA_2	67	73	PF00069	0.663
MOD_Plk_1	154	160	PF00069	0.212
MOD_Plk_4	154	160	PF00069	0.227
MOD_Plk_4	212	218	PF00069	0.325
MOD_Plk_4	220	226	PF00069	0.271
MOD_Plk_4	60	66	PF00069	0.564
MOD_ProDKin_1	13	19	PF00069	0.710
MOD_ProDKin_1	175	181	PF00069	0.324
MOD_ProDKin_1	230	236	PF00069	0.404
MOD_ProDKin_1	25	31	PF00069	0.549
MOD_ProDKin_1	58	64	PF00069	0.615
MOD_SPalmitoyl_4	1	7	PF01529	0.540
MOD_SUMO_rev_2	5	12	PF00179	0.603
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.409
TRG_ER_diArg_1	123	125	PF00400	0.277
TRG_ER_diArg_1	248	251	PF00400	0.212

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II02	Leptomonas seymouri	55%	100%
A0A0S4IVA9	Bodo saltans	35%	87%
A0A3S7WXK4	Leishmania donovani	84%	82%
A0A422N6B5	Trypanosoma rangeli	36%	100%
A4HCR0	Leishmania braziliensis	69%	100%
A4I085	Leishmania infantum	84%	82%
C9ZV01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AW49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	89%
V5BCE6	Trypanosoma cruzi	36%	93%