AMPKBI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-AMP-activated protein kinase subunit beta, putative

Species:

Leishmania major

UniProt:

Q4QBC5_LEIMA

TriTrypDb:

LmjF.23.0490 , LMJLV39_230010600 , LMJSD75_230010800

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	12
GO:0005777	peroxisome	6	2
GO:0005929	cilium	4	2
GO:0020015	glycosome	7	2
GO:0031588	nucleotide-activated protein kinase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0042579	microbody	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2

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Expansion

Sequence features

Q4QBC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBC5

Function

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Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	12
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0007165	signal transduction	2	12
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	2
GO:0019220	regulation of phosphate metabolic process	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0019901	protein kinase binding	5	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.633
CLV_C14_Caspase3-7	92	96	PF00656	0.368
CLV_NRD_NRD_1	175	177	PF00675	0.510
CLV_NRD_NRD_1	239	241	PF00675	0.300
CLV_NRD_NRD_1	46	48	PF00675	0.453
CLV_PCSK_KEX2_1	239	241	PF00082	0.287
DEG_APCC_DBOX_1	2	10	PF00400	0.619
DEG_SCF_FBW7_1	186	193	PF00400	0.300
DOC_CKS1_1	116	121	PF01111	0.526
DOC_CKS1_1	191	196	PF01111	0.300

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9V7	Leptomonas seymouri	78%	82%
A0A0S4IRW9	Bodo saltans	41%	75%
A0A1X0NX44	Trypanosomatidae	56%	82%
A0A3Q8ICH1	Leishmania donovani	96%	82%
A0A3R7K3F4	Trypanosoma rangeli	57%	93%
A4HCR3	Leishmania braziliensis	89%	100%
A4I088	Leishmania infantum	96%	82%
C9ZV05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	90%
E9AW52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O43741	Homo sapiens	28%	100%

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