AMPKBI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-AMP-activated protein kinase subunit beta, putative

Species:

Leishmania major

UniProt:

Q4QBC5_LEIMA

TriTrypDb:

LmjF.23.0490 , LMJLV39_230010600 , LMJSD75_230010800

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	12
GO:0005777	peroxisome	6	2
GO:0005929	cilium	4	2
GO:0020015	glycosome	7	2
GO:0031588	nucleotide-activated protein kinase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0042579	microbody	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1902911	protein kinase complex	5	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

Q4QBC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBC5

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	12
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0019220	regulation of phosphate metabolic process	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031399	regulation of protein modification process	6	12
GO:0042325	regulation of phosphorylation	7	12
GO:0043549	regulation of kinase activity	5	12
GO:0045859	regulation of protein kinase activity	6	12
GO:0050789	regulation of biological process	2	12
GO:0050790	regulation of catalytic activity	3	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051174	regulation of phosphorus metabolic process	5	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0051338	regulation of transferase activity	4	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0065009	regulation of molecular function	2	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0019901	protein kinase binding	5	2
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.633
CLV_C14_Caspase3-7	92	96	PF00656	0.368
CLV_NRD_NRD_1	175	177	PF00675	0.510
CLV_NRD_NRD_1	239	241	PF00675	0.300
CLV_NRD_NRD_1	46	48	PF00675	0.453
CLV_PCSK_KEX2_1	239	241	PF00082	0.287
DEG_APCC_DBOX_1	2	10	PF00400	0.619
DEG_SCF_FBW7_1	186	193	PF00400	0.300
DOC_CKS1_1	116	121	PF01111	0.526
DOC_CKS1_1	191	196	PF01111	0.300
DOC_CKS1_1	63	68	PF01111	0.385
DOC_CKS1_1	99	104	PF01111	0.488
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.300
DOC_MAPK_DCC_7	176	184	PF00069	0.316
DOC_MAPK_gen_1	135	145	PF00069	0.557
DOC_MAPK_gen_1	176	184	PF00069	0.335
DOC_MAPK_gen_1	199	208	PF00069	0.421
DOC_MAPK_gen_1	47	54	PF00069	0.303
DOC_MAPK_MEF2A_6	176	184	PF00069	0.336
DOC_MAPK_MEF2A_6	47	54	PF00069	0.303
DOC_PP2B_LxvP_1	224	227	PF13499	0.300
DOC_PP2B_LxvP_1	75	78	PF13499	0.385
DOC_SPAK_OSR1_1	85	89	PF12202	0.316
DOC_USP7_MATH_1	10	14	PF00917	0.663
DOC_USP7_MATH_1	213	217	PF00917	0.370
DOC_USP7_MATH_1	272	276	PF00917	0.666
DOC_WW_Pin1_4	115	120	PF00397	0.644
DOC_WW_Pin1_4	186	191	PF00397	0.300
DOC_WW_Pin1_4	62	67	PF00397	0.372
DOC_WW_Pin1_4	98	103	PF00397	0.550
LIG_14-3-3_CanoR_1	3	7	PF00244	0.699
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_deltaCOP1_diTrp_1	163	172	PF00928	0.560
LIG_FHA_1	123	129	PF00498	0.727
LIG_FHA_1	140	146	PF00498	0.391
LIG_FHA_1	19	25	PF00498	0.675
LIG_FHA_1	255	261	PF00498	0.326
LIG_FHA_1	26	32	PF00498	0.537
LIG_FHA_1	95	101	PF00498	0.350
LIG_FHA_2	149	155	PF00498	0.510
LIG_FHA_2	40	46	PF00498	0.480
LIG_LIR_Gen_1	69	79	PF02991	0.300
LIG_LIR_Nem_3	175	181	PF02991	0.327
LIG_LIR_Nem_3	27	32	PF02991	0.459
LIG_LIR_Nem_3	69	75	PF02991	0.355
LIG_LYPXL_yS_3	178	181	PF13949	0.316
LIG_PDZ_Class_2	273	278	PF00595	0.667
LIG_SH2_CRK	188	192	PF00017	0.300
LIG_SH2_CRK	256	260	PF00017	0.341
LIG_SH2_CRK	84	88	PF00017	0.357
LIG_SH2_PTP2	51	54	PF00017	0.335
LIG_SH2_STAP1	256	260	PF00017	0.335
LIG_SH2_STAT3	35	38	PF00017	0.526
LIG_SH2_STAT5	188	191	PF00017	0.300
LIG_SH2_STAT5	236	239	PF00017	0.300
LIG_SH2_STAT5	252	255	PF00017	0.300
LIG_SH2_STAT5	256	259	PF00017	0.117
LIG_SH2_STAT5	51	54	PF00017	0.335
LIG_SH3_1	177	183	PF00018	0.316
LIG_SH3_3	106	112	PF00018	0.694
LIG_SH3_3	121	127	PF00018	0.712
LIG_SH3_3	177	183	PF00018	0.300
LIG_SH3_3	263	269	PF00018	0.577
LIG_SH3_3	4	10	PF00018	0.634
LIG_SH3_3	60	66	PF00018	0.392
LIG_SUMO_SIM_par_1	226	231	PF11976	0.357
LIG_TYR_ITAM	69	87	PF00017	0.385
LIG_TYR_ITIM	186	191	PF00017	0.300
LIG_TYR_ITIM	260	265	PF00017	0.421
MOD_CK1_1	2	8	PF00069	0.589
MOD_CK1_1	67	73	PF00069	0.316
MOD_CK2_1	148	154	PF00069	0.570
MOD_CK2_1	39	45	PF00069	0.525
MOD_GlcNHglycan	10	13	PF01048	0.732
MOD_GlcNHglycan	66	69	PF01048	0.370
MOD_GSK3_1	10	17	PF00069	0.724
MOD_GSK3_1	186	193	PF00069	0.292
MOD_GSK3_1	39	46	PF00069	0.519
MOD_GSK3_1	94	101	PF00069	0.412
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	122	127	PF00069	0.728
MOD_NEK2_1	172	177	PF00069	0.511
MOD_NEK2_1	228	233	PF00069	0.300
MOD_NEK2_1	246	251	PF00069	0.300
MOD_NEK2_1	43	48	PF00069	0.488
MOD_NEK2_2	139	144	PF00069	0.527
MOD_NEK2_2	272	277	PF00069	0.499
MOD_PIKK_1	122	128	PF00454	0.723
MOD_PIKK_1	94	100	PF00454	0.316
MOD_PKA_2	198	204	PF00069	0.306
MOD_PKA_2	2	8	PF00069	0.707
MOD_Plk_1	94	100	PF00069	0.175
MOD_Plk_2-3	39	45	PF00069	0.478
MOD_Plk_4	139	145	PF00069	0.526
MOD_Plk_4	193	199	PF00069	0.421
MOD_Plk_4	255	261	PF00069	0.360
MOD_Plk_4	67	73	PF00069	0.316
MOD_ProDKin_1	115	121	PF00069	0.642
MOD_ProDKin_1	186	192	PF00069	0.300
MOD_ProDKin_1	62	68	PF00069	0.372
MOD_ProDKin_1	98	104	PF00069	0.564
TRG_ENDOCYTIC_2	178	181	PF00928	0.307
TRG_ENDOCYTIC_2	188	191	PF00928	0.287
TRG_ENDOCYTIC_2	256	259	PF00928	0.309
TRG_ENDOCYTIC_2	262	265	PF00928	0.403
TRG_ENDOCYTIC_2	51	54	PF00928	0.335
TRG_ENDOCYTIC_2	72	75	PF00928	0.301
TRG_ENDOCYTIC_2	84	87	PF00928	0.304
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9V7	Leptomonas seymouri	78%	82%
A0A0S4IRW9	Bodo saltans	41%	75%
A0A1X0NX44	Trypanosomatidae	56%	82%
A0A3Q8ICH1	Leishmania donovani	96%	82%
A0A3R7K3F4	Trypanosoma rangeli	57%	93%
A4HCR3	Leishmania braziliensis	89%	100%
A4I088	Leishmania infantum	96%	82%
C9ZV05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	90%
E9AW52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O43741	Homo sapiens	28%	100%
Q6PAM0	Mus musculus	28%	100%
Q9QZH4	Rattus norvegicus	28%	100%
V5ASF8	Trypanosoma cruzi	56%	91%