LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QBC4_LEIMA
TriTrypDb:
LmjF.23.0500 * , LMJLV39_230010700 * , LMJSD75_230010900 *
Length:
284

Annotations

LeishMANIAdb annotations

An absolutely unique fold restricted to kinetoplastids. most predictions are too weak to assume any secure topology.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 5
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

Q4QBC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBC4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.414
CLV_C14_Caspase3-7 274 278 PF00656 0.626
CLV_NRD_NRD_1 142 144 PF00675 0.432
CLV_NRD_NRD_1 260 262 PF00675 0.408
CLV_PCSK_KEX2_1 260 262 PF00082 0.408
DEG_Nend_UBRbox_1 1 4 PF02207 0.642
DEG_ODPH_VHL_1 76 89 PF01847 0.335
DOC_CDC14_PxL_1 206 214 PF14671 0.435
DOC_CKS1_1 187 192 PF01111 0.266
DOC_CKS1_1 94 99 PF01111 0.443
DOC_CYCLIN_yCln2_LP_2 205 211 PF00134 0.536
DOC_MAPK_MEF2A_6 2 10 PF00069 0.483
DOC_MAPK_NFAT4_5 2 10 PF00069 0.483
DOC_MAPK_RevD_3 245 261 PF00069 0.328
DOC_USP7_MATH_1 25 29 PF00917 0.422
DOC_USP7_MATH_1 266 270 PF00917 0.666
DOC_USP7_MATH_1 271 275 PF00917 0.682
DOC_USP7_MATH_1 30 34 PF00917 0.396
DOC_USP7_MATH_1 99 103 PF00917 0.470
DOC_USP7_MATH_2 271 277 PF00917 0.607
DOC_WW_Pin1_4 186 191 PF00397 0.266
DOC_WW_Pin1_4 267 272 PF00397 0.678
DOC_WW_Pin1_4 93 98 PF00397 0.425
LIG_14-3-3_CanoR_1 149 159 PF00244 0.471
LIG_14-3-3_CanoR_1 49 58 PF00244 0.462
LIG_FHA_1 171 177 PF00498 0.353
LIG_FHA_1 187 193 PF00498 0.279
LIG_FHA_1 215 221 PF00498 0.376
LIG_FHA_1 226 232 PF00498 0.363
LIG_FHA_1 239 245 PF00498 0.199
LIG_FHA_2 51 57 PF00498 0.522
LIG_LIR_Gen_1 213 224 PF02991 0.360
LIG_LIR_Gen_1 238 248 PF02991 0.306
LIG_LIR_Nem_3 213 219 PF02991 0.360
LIG_LIR_Nem_3 238 243 PF02991 0.419
LIG_MAD2 64 72 PF02301 0.406
LIG_MYND_1 207 211 PF01753 0.360
LIG_NRBOX 158 164 PF00104 0.352
LIG_Pex14_1 223 227 PF04695 0.531
LIG_Pex14_2 219 223 PF04695 0.349
LIG_RPA_C_Fungi 46 58 PF08784 0.513
LIG_SH2_STAP1 216 220 PF00017 0.360
LIG_SH2_STAT3 139 142 PF00017 0.530
LIG_SH2_STAT5 180 183 PF00017 0.455
LIG_SH2_STAT5 188 191 PF00017 0.262
LIG_SH2_STAT5 201 204 PF00017 0.343
LIG_SH2_STAT5 216 219 PF00017 0.300
LIG_SH3_1 64 70 PF00018 0.501
LIG_SH3_3 184 190 PF00018 0.445
LIG_SH3_3 204 210 PF00018 0.171
LIG_SH3_3 265 271 PF00018 0.630
LIG_SH3_3 64 70 PF00018 0.447
LIG_SH3_3 91 97 PF00018 0.501
LIG_Sin3_3 158 165 PF02671 0.279
LIG_SUMO_SIM_anti_2 127 132 PF11976 0.360
LIG_SUMO_SIM_par_1 158 164 PF11976 0.341
LIG_TRAF2_1 270 273 PF00917 0.581
LIG_TYR_ITIM 178 183 PF00017 0.480
MOD_CK1_1 32 38 PF00069 0.598
MOD_CK2_1 267 273 PF00069 0.596
MOD_GlcNHglycan 101 104 PF01048 0.594
MOD_GlcNHglycan 20 23 PF01048 0.390
MOD_GlcNHglycan 212 215 PF01048 0.360
MOD_GlcNHglycan 231 234 PF01048 0.570
MOD_GlcNHglycan 257 260 PF01048 0.556
MOD_GlcNHglycan 43 46 PF01048 0.583
MOD_GSK3_1 14 21 PF00069 0.384
MOD_GSK3_1 182 189 PF00069 0.366
MOD_GSK3_1 210 217 PF00069 0.360
MOD_GSK3_1 225 232 PF00069 0.537
MOD_GSK3_1 25 32 PF00069 0.457
MOD_GSK3_1 267 274 PF00069 0.548
MOD_NEK2_1 110 115 PF00069 0.539
MOD_NEK2_1 150 155 PF00069 0.360
MOD_NEK2_1 170 175 PF00069 0.285
MOD_NEK2_1 181 186 PF00069 0.376
MOD_NEK2_1 253 258 PF00069 0.424
MOD_PIKK_1 182 188 PF00454 0.461
MOD_PKA_2 50 56 PF00069 0.499
MOD_Plk_1 171 177 PF00069 0.460
MOD_Plk_2-3 273 279 PF00069 0.632
MOD_Plk_4 171 177 PF00069 0.418
MOD_Plk_4 196 202 PF00069 0.361
MOD_Plk_4 83 89 PF00069 0.413
MOD_ProDKin_1 186 192 PF00069 0.305
MOD_ProDKin_1 267 273 PF00069 0.603
MOD_ProDKin_1 93 99 PF00069 0.534
TRG_ENDOCYTIC_2 180 183 PF00928 0.488
TRG_ENDOCYTIC_2 216 219 PF00928 0.360

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P307 Leptomonas seymouri 61% 100%
A0A3Q8ICG4 Leishmania donovani 94% 100%
A4HCR4 Leishmania braziliensis 81% 100%
A4I089 Leishmania infantum 94% 100%
C9ZV06 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AW53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS