SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBC2_LEIMA

TriTrypDb:

LmjF.23.0520 , LMJLV39_230010900 , LMJSD75_230011100

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.512
CLV_PCSK_KEX2_1	28	30	PF00082	0.491
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.491
CLV_PCSK_SKI1_1	7	11	PF00082	0.452
DEG_APCC_DBOX_1	6	14	PF00400	0.504
DEG_SPOP_SBC_1	257	261	PF00917	0.543
DOC_CKS1_1	235	240	PF01111	0.552
DOC_MAPK_MEF2A_6	125	133	PF00069	0.562
DOC_PP1_RVXF_1	342	348	PF00149	0.409
DOC_PP2B_LxvP_1	182	185	PF13499	0.562
DOC_PP2B_LxvP_1	255	258	PF13499	0.562
DOC_PP2B_LxvP_1	98	101	PF13499	0.552
DOC_PP4_FxxP_1	285	288	PF00568	0.478
DOC_USP7_MATH_1	106	110	PF00917	0.512
DOC_USP7_MATH_1	113	117	PF00917	0.517
DOC_USP7_MATH_1	119	123	PF00917	0.477
DOC_USP7_MATH_1	191	195	PF00917	0.512
DOC_USP7_MATH_1	258	262	PF00917	0.522
DOC_USP7_MATH_1	274	278	PF00917	0.517
DOC_WW_Pin1_4	12	17	PF00397	0.462
DOC_WW_Pin1_4	149	154	PF00397	0.546
DOC_WW_Pin1_4	234	239	PF00397	0.484
DOC_WW_Pin1_4	43	48	PF00397	0.589
LIG_14-3-3_CanoR_1	29	37	PF00244	0.509
LIG_eIF4E_1	58	64	PF01652	0.447
LIG_FHA_1	134	140	PF00498	0.499
LIG_FHA_1	308	314	PF00498	0.518
LIG_FHA_1	79	85	PF00498	0.552
LIG_FHA_2	200	206	PF00498	0.496
LIG_LIR_Apic_2	284	288	PF02991	0.552
LIG_LIR_Gen_1	136	144	PF02991	0.442
LIG_LIR_Gen_1	159	165	PF02991	0.496
LIG_LIR_Gen_1	168	179	PF02991	0.445
LIG_LIR_Gen_1	34	43	PF02991	0.460
LIG_LIR_Nem_3	136	140	PF02991	0.476
LIG_LIR_Nem_3	159	163	PF02991	0.496
LIG_LIR_Nem_3	168	174	PF02991	0.445
LIG_LIR_Nem_3	22	26	PF02991	0.490
LIG_LIR_Nem_3	34	40	PF02991	0.475
LIG_LIR_Nem_3	93	99	PF02991	0.498
LIG_PCNA_PIPBox_1	192	201	PF02747	0.496
LIG_PCNA_yPIPBox_3	121	134	PF02747	0.481
LIG_SH2_GRB2like	160	163	PF00017	0.496
LIG_SH2_STAP1	212	216	PF00017	0.552
LIG_SH2_STAP1	218	222	PF00017	0.552
LIG_SH2_STAP1	232	236	PF00017	0.552
LIG_SH2_STAT3	232	235	PF00017	0.552
LIG_SH2_STAT5	137	140	PF00017	0.479
LIG_SH2_STAT5	160	163	PF00017	0.464
LIG_SH2_STAT5	26	29	PF00017	0.392
LIG_SH2_STAT5	42	45	PF00017	0.461
LIG_SH2_STAT5	58	61	PF00017	0.371
LIG_SH3_3	276	282	PF00018	0.485
LIG_SH3_3	300	306	PF00018	0.555
LIG_SH3_3	310	316	PF00018	0.557
LIG_SH3_3	73	79	PF00018	0.519
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.437
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.478
MOD_CDK_SPxxK_3	234	241	PF00069	0.562
MOD_CDK_SPxxK_3	43	50	PF00069	0.527
MOD_CK1_1	105	111	PF00069	0.512
MOD_CK1_1	194	200	PF00069	0.576
MOD_CK1_1	260	266	PF00069	0.548
MOD_CK1_1	268	274	PF00069	0.566
MOD_CK1_1	3	9	PF00069	0.659
MOD_CK2_1	199	205	PF00069	0.479
MOD_CK2_1	293	299	PF00069	0.478
MOD_GlcNHglycan	104	107	PF01048	0.358
MOD_GlcNHglycan	149	152	PF01048	0.362
MOD_GlcNHglycan	189	192	PF01048	0.322
MOD_GlcNHglycan	260	263	PF01048	0.338
MOD_GlcNHglycan	270	273	PF01048	0.342
MOD_GSK3_1	102	109	PF00069	0.519
MOD_GSK3_1	187	194	PF00069	0.502
MOD_GSK3_1	256	263	PF00069	0.510
MOD_GSK3_1	307	314	PF00069	0.546
MOD_GSK3_1	50	57	PF00069	0.606
MOD_LATS_1	52	58	PF00433	0.442
MOD_N-GLC_1	274	279	PF02516	0.317
MOD_N-GLC_1	293	298	PF02516	0.264
MOD_NEK2_1	133	138	PF00069	0.504
MOD_NEK2_1	19	24	PF00069	0.496
MOD_NEK2_1	199	204	PF00069	0.479
MOD_NEK2_1	216	221	PF00069	0.452
MOD_NEK2_1	332	337	PF00069	0.461
MOD_NEK2_2	265	270	PF00069	0.512
MOD_NEK2_2	319	324	PF00069	0.461
MOD_PIKK_1	199	205	PF00454	0.487
MOD_PKA_2	30	36	PF00069	0.431
MOD_PKA_2	307	313	PF00069	0.512
MOD_PKB_1	29	37	PF00069	0.410
MOD_Plk_1	119	125	PF00069	0.481
MOD_Plk_1	274	280	PF00069	0.517
MOD_Plk_1	330	336	PF00069	0.496
MOD_Plk_4	133	139	PF00069	0.484
MOD_Plk_4	19	25	PF00069	0.480
MOD_Plk_4	274	280	PF00069	0.552
MOD_Plk_4	54	60	PF00069	0.653
MOD_ProDKin_1	12	18	PF00069	0.457
MOD_ProDKin_1	149	155	PF00069	0.546
MOD_ProDKin_1	234	240	PF00069	0.484
MOD_ProDKin_1	43	49	PF00069	0.601
MOD_SUMO_for_1	327	330	PF00179	0.547
MOD_SUMO_for_1	70	73	PF00179	0.512
TRG_DiLeu_BaEn_2	158	164	PF01217	0.512
TRG_ENDOCYTIC_2	137	140	PF00928	0.464
TRG_ENDOCYTIC_2	160	163	PF00928	0.471
TRG_ENDOCYTIC_2	218	221	PF00928	0.552
TRG_ER_diArg_1	29	32	PF00400	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P305	Leptomonas seymouri	71%	99%
A0A0S4JT92	Bodo saltans	29%	100%
A0A1X0NX61	Trypanosomatidae	49%	100%
A0A3Q8IAX9	Leishmania donovani	97%	100%
A4HCR7	Leishmania braziliensis	84%	100%
A4I091	Leishmania infantum	97%	100%
C9ZV09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AW55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BCF3	Trypanosoma cruzi	49%	100%