Centrosomal protein of 104 kDa

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBB8_LEIMA

TriTrypDb:

LmjF.23.0547 , LMJLV39_230011400 , LMJSD75_230011700

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	116	122	PF00089	0.486
CLV_NRD_NRD_1	143	145	PF00675	0.452
CLV_NRD_NRD_1	29	31	PF00675	0.400
CLV_NRD_NRD_1	72	74	PF00675	0.405
CLV_NRD_NRD_1	726	728	PF00675	0.633
CLV_NRD_NRD_1	84	86	PF00675	0.453
CLV_PCSK_KEX2_1	72	74	PF00082	0.401
CLV_PCSK_KEX2_1	726	728	PF00082	0.633
CLV_PCSK_SKI1_1	241	245	PF00082	0.501
CLV_PCSK_SKI1_1	338	342	PF00082	0.526
CLV_PCSK_SKI1_1	72	76	PF00082	0.439
DEG_SPOP_SBC_1	529	533	PF00917	0.662
DEG_SPOP_SBC_1	689	693	PF00917	0.559
DOC_AGCK_PIF_2	77	82	PF00069	0.404
DOC_CKS1_1	136	141	PF01111	0.510
DOC_CKS1_1	440	445	PF01111	0.643
DOC_CKS1_1	515	520	PF01111	0.681
DOC_CYCLIN_yClb3_PxF_3	719	727	PF00134	0.627
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	637	643	PF00134	0.577
DOC_MAPK_gen_1	70	77	PF00069	0.392
DOC_MAPK_JIP1_4	60	66	PF00069	0.427
DOC_MAPK_MEF2A_6	19	27	PF00069	0.343
DOC_MAPK_MEF2A_6	747	755	PF00069	0.473
DOC_MAPK_MEF2A_6	829	838	PF00069	0.470
DOC_PP1_RVXF_1	112	119	PF00149	0.420
DOC_PP1_RVXF_1	429	436	PF00149	0.594
DOC_PP1_RVXF_1	71	78	PF00149	0.390
DOC_PP2B_LxvP_1	637	640	PF13499	0.678
DOC_PP4_FxxP_1	66	69	PF00568	0.440
DOC_PP4_FxxP_1	94	97	PF00568	0.394
DOC_USP7_MATH_1	106	110	PF00917	0.415
DOC_USP7_MATH_1	169	173	PF00917	0.616
DOC_USP7_MATH_1	333	337	PF00917	0.545
DOC_USP7_MATH_1	497	501	PF00917	0.656
DOC_USP7_MATH_1	524	528	PF00917	0.678
DOC_USP7_MATH_1	529	533	PF00917	0.785
DOC_USP7_MATH_1	535	539	PF00917	0.663
DOC_USP7_MATH_1	542	546	PF00917	0.634
DOC_USP7_MATH_1	548	552	PF00917	0.635
DOC_USP7_MATH_1	573	577	PF00917	0.701
DOC_USP7_MATH_1	595	599	PF00917	0.682
DOC_USP7_MATH_1	612	616	PF00917	0.620
DOC_USP7_MATH_1	621	625	PF00917	0.575
DOC_USP7_MATH_1	645	649	PF00917	0.788
DOC_USP7_MATH_1	663	667	PF00917	0.555
DOC_USP7_MATH_1	828	832	PF00917	0.535
DOC_USP7_UBL2_3	280	284	PF12436	0.522
DOC_USP7_UBL2_3	387	391	PF12436	0.562
DOC_USP7_UBL2_3	86	90	PF12436	0.426
DOC_WW_Pin1_4	135	140	PF00397	0.502
DOC_WW_Pin1_4	35	40	PF00397	0.343
DOC_WW_Pin1_4	439	444	PF00397	0.658
DOC_WW_Pin1_4	479	484	PF00397	0.619
DOC_WW_Pin1_4	514	519	PF00397	0.662
DOC_WW_Pin1_4	596	601	PF00397	0.672
DOC_WW_Pin1_4	65	70	PF00397	0.444
DOC_WW_Pin1_4	655	660	PF00397	0.619
DOC_WW_Pin1_4	787	792	PF00397	0.592
DOC_WW_Pin1_4	845	850	PF00397	0.454
LIG_14-3-3_CanoR_1	816	823	PF00244	0.475
LIG_14-3-3_CterR_2	853	856	PF00244	0.478
LIG_APCC_ABBA_1	751	756	PF00400	0.509
LIG_APCC_ABBA_1	839	844	PF00400	0.408
LIG_BIR_III_2	592	596	PF00653	0.577
LIG_BIR_III_4	158	162	PF00653	0.594
LIG_BIR_III_4	469	473	PF00653	0.638
LIG_BIR_III_4	52	56	PF00653	0.447
LIG_BRCT_BRCA1_1	226	230	PF00533	0.483
LIG_CSL_BTD_1	808	811	PF09270	0.450
LIG_FHA_1	146	152	PF00498	0.603
LIG_FHA_1	224	230	PF00498	0.486
LIG_FHA_1	242	248	PF00498	0.453
LIG_FHA_1	354	360	PF00498	0.582
LIG_FHA_1	397	403	PF00498	0.568
LIG_FHA_1	460	466	PF00498	0.709
LIG_FHA_1	589	595	PF00498	0.817
LIG_FHA_2	504	510	PF00498	0.751
LIG_FHA_2	90	96	PF00498	0.390
LIG_KLC1_Yacidic_2	752	756	PF13176	0.506
LIG_LIR_Apic_2	506	511	PF02991	0.605
LIG_LIR_Apic_2	63	69	PF02991	0.432
LIG_LIR_Apic_2	683	687	PF02991	0.561
LIG_LIR_Apic_2	737	743	PF02991	0.473
LIG_LIR_Apic_2	92	97	PF02991	0.390
LIG_LIR_Gen_1	22	28	PF02991	0.390
LIG_LIR_Gen_1	383	393	PF02991	0.520
LIG_LIR_Gen_1	773	781	PF02991	0.447
LIG_LIR_Nem_3	22	27	PF02991	0.390
LIG_LIR_Nem_3	383	388	PF02991	0.532
LIG_LIR_Nem_3	495	501	PF02991	0.539
LIG_LIR_Nem_3	733	739	PF02991	0.503
LIG_LIR_Nem_3	844	850	PF02991	0.470
LIG_PDZ_Class_2	851	856	PF00595	0.458
LIG_Pex14_2	62	66	PF04695	0.398
LIG_Pex14_2	850	854	PF04695	0.455
LIG_PTB_Apo_2	768	775	PF02174	0.453
LIG_PTB_Phospho_1	768	774	PF10480	0.450
LIG_SH2_CRK	684	688	PF00017	0.802
LIG_SH2_CRK	740	744	PF00017	0.464
LIG_SH2_NCK_1	376	380	PF00017	0.566
LIG_SH2_PTP2	24	27	PF00017	0.325
LIG_SH2_SRC	376	379	PF00017	0.593
LIG_SH2_SRC	508	511	PF00017	0.650
LIG_SH2_SRC	754	757	PF00017	0.538
LIG_SH2_STAP1	252	256	PF00017	0.490
LIG_SH2_STAP1	4	8	PF00017	0.328
LIG_SH2_STAT3	252	255	PF00017	0.486
LIG_SH2_STAT5	16	19	PF00017	0.391
LIG_SH2_STAT5	24	27	PF00017	0.384
LIG_SH2_STAT5	313	316	PF00017	0.484
LIG_SH2_STAT5	417	420	PF00017	0.656
LIG_SH2_STAT5	736	739	PF00017	0.462
LIG_SH2_STAT5	754	757	PF00017	0.551
LIG_SH2_STAT5	840	843	PF00017	0.433
LIG_SH2_STAT5	847	850	PF00017	0.443
LIG_SH3_1	656	662	PF00018	0.572
LIG_SH3_3	133	139	PF00018	0.426
LIG_SH3_3	516	522	PF00018	0.688
LIG_SH3_3	572	578	PF00018	0.670
LIG_SH3_3	629	635	PF00018	0.727
LIG_SH3_3	656	662	PF00018	0.652
LIG_SH3_3	676	682	PF00018	0.743
LIG_SH3_3	700	706	PF00018	0.598
LIG_SH3_3	716	722	PF00018	0.698
LIG_SH3_3	822	828	PF00018	0.515
LIG_SUMO_SIM_par_1	24	29	PF11976	0.325
LIG_SUMO_SIM_par_1	356	364	PF11976	0.496
LIG_TRAF2_1	730	733	PF00917	0.591
LIG_UBA3_1	357	362	PF00899	0.467
MOD_CDK_SPK_2	65	70	PF00069	0.444
MOD_CDK_SPxxK_3	65	72	PF00069	0.432
MOD_CK1_1	121	127	PF00069	0.454
MOD_CK1_1	164	170	PF00069	0.741
MOD_CK1_1	172	178	PF00069	0.580
MOD_CK1_1	185	191	PF00069	0.441
MOD_CK1_1	266	272	PF00069	0.525
MOD_CK1_1	616	622	PF00069	0.669
MOD_CK1_1	65	71	PF00069	0.468
MOD_CK1_1	655	661	PF00069	0.678
MOD_CK1_1	795	801	PF00069	0.573
MOD_CK1_1	815	821	PF00069	0.290
MOD_CK2_1	106	112	PF00069	0.404
MOD_CK2_1	394	400	PF00069	0.496
MOD_CK2_1	48	54	PF00069	0.482
MOD_CK2_1	503	509	PF00069	0.749
MOD_CK2_1	651	657	PF00069	0.849
MOD_CK2_1	727	733	PF00069	0.612
MOD_CK2_1	89	95	PF00069	0.394
MOD_GlcNHglycan	120	123	PF01048	0.493
MOD_GlcNHglycan	166	169	PF01048	0.688
MOD_GlcNHglycan	174	177	PF01048	0.545
MOD_GlcNHglycan	184	187	PF01048	0.466
MOD_GlcNHglycan	265	268	PF01048	0.488
MOD_GlcNHglycan	287	292	PF01048	0.583
MOD_GlcNHglycan	522	525	PF01048	0.842
MOD_GlcNHglycan	526	529	PF01048	0.741
MOD_GlcNHglycan	544	547	PF01048	0.702
MOD_GlcNHglycan	57	60	PF01048	0.486
MOD_GlcNHglycan	575	578	PF01048	0.785
MOD_GlcNHglycan	615	618	PF01048	0.699
MOD_GlcNHglycan	619	622	PF01048	0.691
MOD_GlcNHglycan	794	797	PF01048	0.567
MOD_GSK3_1	114	121	PF00069	0.483
MOD_GSK3_1	182	189	PF00069	0.554
MOD_GSK3_1	448	455	PF00069	0.798
MOD_GSK3_1	497	504	PF00069	0.805
MOD_GSK3_1	520	527	PF00069	0.674
MOD_GSK3_1	612	619	PF00069	0.690
MOD_GSK3_1	645	652	PF00069	0.723
MOD_GSK3_1	848	855	PF00069	0.436
MOD_N-GLC_1	529	534	PF02516	0.602
MOD_N-GLC_1	595	600	PF02516	0.675
MOD_NEK2_1	11	16	PF00069	0.498
MOD_NEK2_1	118	123	PF00069	0.489
MOD_NEK2_1	402	407	PF00069	0.519
MOD_NEK2_1	425	430	PF00069	0.613
MOD_NEK2_1	503	508	PF00069	0.772
MOD_NEK2_1	62	67	PF00069	0.502
MOD_PIKK_1	307	313	PF00454	0.597
MOD_PIKK_1	535	541	PF00454	0.735
MOD_PIKK_1	621	627	PF00454	0.579
MOD_PIKK_1	663	669	PF00454	0.640
MOD_PIKK_1	798	804	PF00454	0.581
MOD_PK_1	19	25	PF00069	0.409
MOD_PK_1	829	835	PF00069	0.479
MOD_PKA_2	118	124	PF00069	0.488
MOD_PKA_2	186	192	PF00069	0.528
MOD_PKA_2	224	230	PF00069	0.509
MOD_PKA_2	613	619	PF00069	0.697
MOD_PKA_2	761	767	PF00069	0.474
MOD_PKA_2	815	821	PF00069	0.474
MOD_PKA_2	828	834	PF00069	0.513
MOD_Plk_1	548	554	PF00069	0.775
MOD_Plk_1	62	68	PF00069	0.447
MOD_Plk_1	764	770	PF00069	0.450
MOD_Plk_2-3	327	333	PF00069	0.508
MOD_Plk_2-3	394	400	PF00069	0.496
MOD_Plk_4	100	106	PF00069	0.469
MOD_Plk_4	19	25	PF00069	0.409
MOD_Plk_4	224	230	PF00069	0.509
MOD_Plk_4	353	359	PF00069	0.522
MOD_Plk_4	402	408	PF00069	0.535
MOD_Plk_4	764	770	PF00069	0.450
MOD_Plk_4	829	835	PF00069	0.494
MOD_ProDKin_1	135	141	PF00069	0.499
MOD_ProDKin_1	35	41	PF00069	0.344
MOD_ProDKin_1	439	445	PF00069	0.662
MOD_ProDKin_1	479	485	PF00069	0.622
MOD_ProDKin_1	514	520	PF00069	0.666
MOD_ProDKin_1	596	602	PF00069	0.671
MOD_ProDKin_1	65	71	PF00069	0.440
MOD_ProDKin_1	655	661	PF00069	0.619
MOD_ProDKin_1	787	793	PF00069	0.595
MOD_ProDKin_1	845	851	PF00069	0.454
MOD_SUMO_for_1	361	364	PF00179	0.520
MOD_SUMO_for_1	783	786	PF00179	0.492
MOD_SUMO_rev_2	108	116	PF00179	0.421
MOD_SUMO_rev_2	281	291	PF00179	0.491
MOD_SUMO_rev_2	752	760	PF00179	0.537
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.485
TRG_DiLeu_BaLyEn_6	740	745	PF01217	0.339
TRG_ENDOCYTIC_2	24	27	PF00928	0.325
TRG_ENDOCYTIC_2	736	739	PF00928	0.470
TRG_ENDOCYTIC_2	774	777	PF00928	0.443
TRG_ENDOCYTIC_2	847	850	PF00928	0.453
TRG_ER_diArg_1	72	74	PF00400	0.459
TRG_ER_diArg_1	726	728	PF00400	0.638
TRG_NES_CRM1_1	208	221	PF08389	0.468
TRG_NES_CRM1_1	349	360	PF08389	0.403
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRN9	Leptomonas seymouri	57%	100%
A0A3S7WXK3	Leishmania donovani	89%	97%
A4HCS2	Leishmania braziliensis	63%	88%
A4I096	Leishmania infantum	89%	97%
E9AW60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	94%
V5BH01	Trypanosoma cruzi	45%	100%