Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania major

UniProt:

Q4QBB7_LEIMA

TriTrypDb:

LmjF.23.1590 , LMJLV39_230011500 , LMJSD75_230011800

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBB7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0005488	binding	1	21
GO:0036094	small molecule binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.468
CLV_C14_Caspase3-7	409	413	PF00656	0.556
CLV_C14_Caspase3-7	461	465	PF00656	0.678
CLV_NRD_NRD_1	1	3	PF00675	0.601
CLV_NRD_NRD_1	265	267	PF00675	0.568
CLV_PCSK_KEX2_1	265	267	PF00082	0.568
CLV_PCSK_KEX2_1	99	101	PF00082	0.417
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.417
CLV_PCSK_SKI1_1	138	142	PF00082	0.369
CLV_PCSK_SKI1_1	207	211	PF00082	0.342
CLV_Separin_Metazoa	4	8	PF03568	0.476
DEG_APCC_DBOX_1	206	214	PF00400	0.354
DEG_Nend_UBRbox_1	1	4	PF02207	0.601
DEG_SCF_FBW7_1	115	122	PF00400	0.202
DEG_SPOP_SBC_1	243	247	PF00917	0.492
DEG_SPOP_SBC_1	289	293	PF00917	0.643
DEG_SPOP_SBC_1	457	461	PF00917	0.730
DOC_CYCLIN_yClb1_LxF_4	136	141	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.476
DOC_MAPK_gen_1	2	10	PF00069	0.433
DOC_MAPK_gen_1	99	106	PF00069	0.417
DOC_MAPK_MEF2A_6	2	10	PF00069	0.433
DOC_MAPK_MEF2A_6	250	259	PF00069	0.537
DOC_PP1_RVXF_1	136	142	PF00149	0.382
DOC_PP1_RVXF_1	5	11	PF00149	0.386
DOC_PP4_FxxP_1	215	218	PF00568	0.398
DOC_PP4_FxxP_1	285	288	PF00568	0.512
DOC_PP4_FxxP_1	71	74	PF00568	0.417
DOC_USP7_MATH_1	120	124	PF00917	0.303
DOC_USP7_MATH_1	171	175	PF00917	0.418
DOC_USP7_MATH_1	290	294	PF00917	0.650
DOC_USP7_MATH_1	356	360	PF00917	0.539
DOC_USP7_MATH_1	458	462	PF00917	0.633
DOC_USP7_MATH_1	72	76	PF00917	0.332
DOC_WW_Pin1_4	115	120	PF00397	0.427
DOC_WW_Pin1_4	175	180	PF00397	0.557
DOC_WW_Pin1_4	390	395	PF00397	0.505
LIG_14-3-3_CanoR_1	224	231	PF00244	0.546
LIG_14-3-3_CanoR_1	312	316	PF00244	0.259
LIG_BRCT_BRCA1_1	177	181	PF00533	0.426
LIG_Clathr_ClatBox_1	139	143	PF01394	0.363
LIG_deltaCOP1_diTrp_1	200	208	PF00928	0.347
LIG_FHA_1	320	326	PF00498	0.436
LIG_FHA_1	329	335	PF00498	0.427
LIG_FHA_1	359	365	PF00498	0.600
LIG_FHA_1	438	444	PF00498	0.377
LIG_FHA_2	224	230	PF00498	0.483
LIG_FHA_2	275	281	PF00498	0.463
LIG_FHA_2	289	295	PF00498	0.631
LIG_FHA_2	339	345	PF00498	0.559
LIG_LIR_Apic_2	214	218	PF02991	0.440
LIG_LIR_Apic_2	284	288	PF02991	0.514
LIG_LIR_Gen_1	280	290	PF02991	0.296
LIG_LIR_Gen_1	434	444	PF02991	0.386
LIG_LIR_Gen_1	78	85	PF02991	0.342
LIG_LIR_Gen_1	89	96	PF02991	0.322
LIG_LIR_Nem_3	200	206	PF02991	0.345
LIG_LIR_Nem_3	277	282	PF02991	0.255
LIG_LIR_Nem_3	373	379	PF02991	0.532
LIG_LIR_Nem_3	404	410	PF02991	0.435
LIG_LIR_Nem_3	434	439	PF02991	0.465
LIG_LIR_Nem_3	78	82	PF02991	0.342
LIG_LIR_Nem_3	89	95	PF02991	0.322
LIG_MYND_1	190	194	PF01753	0.437
LIG_Pex14_2	311	315	PF04695	0.428
LIG_SH2_PTP2	92	95	PF00017	0.331
LIG_SH2_STAT3	438	441	PF00017	0.339
LIG_SH2_STAT5	204	207	PF00017	0.320
LIG_SH2_STAT5	282	285	PF00017	0.272
LIG_SH2_STAT5	438	441	PF00017	0.477
LIG_SH2_STAT5	92	95	PF00017	0.331
LIG_SH3_3	173	179	PF00018	0.349
LIG_SH3_3	329	335	PF00018	0.473
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.391
LIG_TYR_ITIM	90	95	PF00017	0.334
MOD_CK1_1	75	81	PF00069	0.504
MOD_CK1_1	94	100	PF00069	0.339
MOD_CK2_1	120	126	PF00069	0.384
MOD_CK2_1	274	280	PF00069	0.474
MOD_GlcNHglycan	122	125	PF01048	0.369
MOD_GlcNHglycan	247	250	PF01048	0.775
MOD_GlcNHglycan	358	361	PF01048	0.723
MOD_GlcNHglycan	367	370	PF01048	0.642
MOD_GlcNHglycan	461	464	PF01048	0.682
MOD_GSK3_1	115	122	PF00069	0.325
MOD_GSK3_1	171	178	PF00069	0.446
MOD_GSK3_1	303	310	PF00069	0.467
MOD_GSK3_1	390	397	PF00069	0.560
MOD_GSK3_1	91	98	PF00069	0.434
MOD_N-GLC_1	328	333	PF02516	0.308
MOD_N-GLC_1	56	61	PF02516	0.409
MOD_NEK2_1	11	16	PF00069	0.368
MOD_NEK2_1	142	147	PF00069	0.402
MOD_NEK2_1	283	288	PF00069	0.449
MOD_NEK2_1	311	316	PF00069	0.396
MOD_NEK2_1	364	369	PF00069	0.455
MOD_PIKK_1	147	153	PF00454	0.541
MOD_PIKK_1	437	443	PF00454	0.358
MOD_PKA_1	265	271	PF00069	0.462
MOD_PKA_1	431	437	PF00069	0.477
MOD_PKA_2	223	229	PF00069	0.516
MOD_PKA_2	265	271	PF00069	0.462
MOD_PKA_2	29	35	PF00069	0.371
MOD_PKA_2	311	317	PF00069	0.261
MOD_Plk_1	283	289	PF00069	0.458
MOD_Plk_1	319	325	PF00069	0.447
MOD_Plk_4	177	183	PF00069	0.504
MOD_Plk_4	410	416	PF00069	0.440
MOD_Plk_4	75	81	PF00069	0.369
MOD_ProDKin_1	115	121	PF00069	0.427
MOD_ProDKin_1	175	181	PF00069	0.551
MOD_ProDKin_1	390	396	PF00069	0.511
MOD_SUMO_rev_2	52	59	PF00179	0.418
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.394
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.381
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.557
TRG_ENDOCYTIC_2	282	285	PF00928	0.266
TRG_ENDOCYTIC_2	379	382	PF00928	0.653
TRG_ENDOCYTIC_2	79	82	PF00928	0.342
TRG_ENDOCYTIC_2	92	95	PF00928	0.313
TRG_ER_diArg_1	345	348	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	61%	100%
A0A0N1I5Z7	Leptomonas seymouri	31%	100%
A0A0N1I7E8	Leptomonas seymouri	34%	100%
A0A1X0NX10	Trypanosomatidae	31%	100%
A0A1X0NX22	Trypanosomatidae	37%	100%
A0A1X0NXP4	Trypanosomatidae	28%	100%
A0A3Q8IM07	Leishmania donovani	31%	100%
A0A3S7WXP2	Leishmania donovani	93%	100%
A0A3S7WXT7	Leishmania donovani	31%	100%
A4HCS3	Leishmania braziliensis	77%	100%
A4I097	Leishmania infantum	93%	100%
A4I0B8	Leishmania infantum	31%	100%
E9AH12	Leishmania infantum	31%	100%
E9AW61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AW62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AW82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4QBB6	Leishmania major	30%	81%
Q9U0V7	Leishmania major	32%	100%
V5BH08	Trypanosoma cruzi	35%	100%