Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBB5_LEIMA

TriTrypDb:

LmjF.23.1610 , LMJLV39_230011700 , LMJSD75_230012000

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.652
CLV_NRD_NRD_1	103	105	PF00675	0.536
CLV_NRD_NRD_1	217	219	PF00675	0.688
CLV_NRD_NRD_1	357	359	PF00675	0.553
CLV_PCSK_KEX2_1	103	105	PF00082	0.480
CLV_PCSK_KEX2_1	170	172	PF00082	0.664
CLV_PCSK_KEX2_1	219	221	PF00082	0.711
CLV_PCSK_KEX2_1	344	346	PF00082	0.669
CLV_PCSK_KEX2_1	357	359	PF00082	0.553
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.625
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.711
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.669
CLV_PCSK_SKI1_1	347	351	PF00082	0.503
CLV_PCSK_SKI1_1	357	361	PF00082	0.563
DEG_SCF_FBW7_1	131	136	PF00400	0.698
DEG_SPOP_SBC_1	285	289	PF00917	0.728
DOC_ANK_TNKS_1	226	233	PF00023	0.800
DOC_CKS1_1	27	32	PF01111	0.695
DOC_CYCLIN_RxL_1	205	217	PF00134	0.716
DOC_CYCLIN_RxL_1	301	312	PF00134	0.686
DOC_CYCLIN_RxL_1	355	365	PF00134	0.581
DOC_PP1_RVXF_1	302	309	PF00149	0.735
DOC_PP1_RVXF_1	355	362	PF00149	0.560
DOC_PP1_RVXF_1	81	88	PF00149	0.570
DOC_PP4_FxxP_1	87	90	PF00568	0.539
DOC_USP7_MATH_1	110	114	PF00917	0.643
DOC_USP7_MATH_1	213	217	PF00917	0.732
DOC_USP7_MATH_1	230	234	PF00917	0.598
DOC_USP7_MATH_1	302	306	PF00917	0.712
DOC_USP7_MATH_1	4	8	PF00917	0.716
DOC_USP7_MATH_2	221	227	PF00917	0.825
DOC_USP7_UBL2_3	120	124	PF12436	0.642
DOC_WW_Pin1_4	129	134	PF00397	0.664
DOC_WW_Pin1_4	162	167	PF00397	0.653
DOC_WW_Pin1_4	26	31	PF00397	0.704
DOC_WW_Pin1_4	86	91	PF00397	0.545
LIG_14-3-3_CanoR_1	358	366	PF00244	0.705
LIG_APCC_ABBA_1	308	313	PF00400	0.592
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_4	75	79	PF00653	0.542
LIG_BRCT_BRCA1_1	304	308	PF00533	0.613
LIG_BRCT_BRCA1_1	44	48	PF00533	0.669
LIG_FHA_1	209	215	PF00498	0.780
LIG_FHA_1	348	354	PF00498	0.536
LIG_FHA_1	35	41	PF00498	0.514
LIG_FHA_2	226	232	PF00498	0.836
LIG_FHA_2	289	295	PF00498	0.734
LIG_FHA_2	312	318	PF00498	0.670
LIG_FHA_2	322	328	PF00498	0.514
LIG_FHA_2	335	341	PF00498	0.447
LIG_FHA_2	360	366	PF00498	0.720
LIG_FHA_2	56	62	PF00498	0.498
LIG_LIR_Gen_1	113	122	PF02991	0.744
LIG_LIR_Gen_1	319	328	PF02991	0.507
LIG_LIR_Nem_3	113	117	PF02991	0.747
LIG_LIR_Nem_3	305	311	PF02991	0.590
LIG_LIR_Nem_3	319	325	PF02991	0.445
LIG_LIR_Nem_3	45	51	PF02991	0.590
LIG_SH2_PTP2	322	325	PF00017	0.557
LIG_SH2_STAT5	100	103	PF00017	0.501
LIG_SH2_STAT5	114	117	PF00017	0.644
LIG_SH2_STAT5	322	325	PF00017	0.526
LIG_SH3_3	128	134	PF00018	0.609
LIG_SH3_3	27	33	PF00018	0.776
LIG_SH3_5	196	200	PF00018	0.611
LIG_SUMO_SIM_par_1	209	217	PF11976	0.576
LIG_SUMO_SIM_par_1	274	279	PF11976	0.751
LIG_TRAF2_1	336	339	PF00917	0.661
LIG_WRC_WIRS_1	114	119	PF05994	0.744
MOD_CK1_1	113	119	PF00069	0.592
MOD_CK1_1	15	21	PF00069	0.666
MOD_CK1_1	2	8	PF00069	0.596
MOD_CK1_1	206	212	PF00069	0.771
MOD_CK1_1	233	239	PF00069	0.769
MOD_CK1_1	254	260	PF00069	0.811
MOD_CK1_1	279	285	PF00069	0.699
MOD_CK1_1	288	294	PF00069	0.773
MOD_CK1_1	316	322	PF00069	0.689
MOD_CK1_1	55	61	PF00069	0.481
MOD_CK2_1	225	231	PF00069	0.717
MOD_CK2_1	284	290	PF00069	0.719
MOD_CK2_1	294	300	PF00069	0.570
MOD_CK2_1	334	340	PF00069	0.565
MOD_CK2_1	359	365	PF00069	0.677
MOD_CK2_1	67	73	PF00069	0.508
MOD_GlcNHglycan	1	4	PF01048	0.672
MOD_GlcNHglycan	14	17	PF01048	0.718
MOD_GlcNHglycan	150	153	PF01048	0.746
MOD_GlcNHglycan	159	162	PF01048	0.777
MOD_GlcNHglycan	186	189	PF01048	0.775
MOD_GlcNHglycan	231	235	PF01048	0.731
MOD_GlcNHglycan	254	257	PF01048	0.714
MOD_GlcNHglycan	278	281	PF01048	0.775
MOD_GlcNHglycan	354	357	PF01048	0.628
MOD_GlcNHglycan	6	9	PF01048	0.693
MOD_GlcNHglycan	95	98	PF01048	0.520
MOD_GSK3_1	129	136	PF00069	0.683
MOD_GSK3_1	180	187	PF00069	0.813
MOD_GSK3_1	204	211	PF00069	0.573
MOD_GSK3_1	22	29	PF00069	0.685
MOD_GSK3_1	236	243	PF00069	0.726
MOD_GSK3_1	276	283	PF00069	0.693
MOD_GSK3_1	284	291	PF00069	0.632
MOD_GSK3_1	309	316	PF00069	0.613
MOD_N-GLC_1	203	208	PF02516	0.573
MOD_N-GLC_1	21	26	PF02516	0.716
MOD_N-GLC_1	260	265	PF02516	0.752
MOD_N-GLC_1	66	71	PF02516	0.494
MOD_NEK2_1	276	281	PF00069	0.697
MOD_NEK2_1	311	316	PF00069	0.700
MOD_NEK2_1	66	71	PF00069	0.509
MOD_NEK2_2	302	307	PF00069	0.747
MOD_PIKK_1	236	242	PF00454	0.760
MOD_PIKK_1	334	340	PF00454	0.663
MOD_PKA_2	204	210	PF00069	0.736
MOD_Plk_1	180	186	PF00069	0.630
MOD_Plk_1	203	209	PF00069	0.698
MOD_Plk_1	21	27	PF00069	0.738
MOD_Plk_1	260	266	PF00069	0.573
MOD_Plk_1	294	300	PF00069	0.712
MOD_Plk_1	66	72	PF00069	0.508
MOD_Plk_2-3	294	300	PF00069	0.714
MOD_Plk_4	110	116	PF00069	0.757
MOD_Plk_4	22	28	PF00069	0.684
MOD_Plk_4	260	266	PF00069	0.690
MOD_Plk_4	318	324	PF00069	0.592
MOD_Plk_4	34	40	PF00069	0.453
MOD_Plk_4	67	73	PF00069	0.508
MOD_ProDKin_1	129	135	PF00069	0.667
MOD_ProDKin_1	162	168	PF00069	0.651
MOD_ProDKin_1	26	32	PF00069	0.697
MOD_ProDKin_1	86	92	PF00069	0.539
MOD_SUMO_rev_2	215	221	PF00179	0.810
TRG_ENDOCYTIC_2	114	117	PF00928	0.746
TRG_ENDOCYTIC_2	322	325	PF00928	0.557
TRG_ER_diArg_1	218	221	PF00400	0.812
TRG_ER_diArg_1	357	359	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE95	Leptomonas seymouri	48%	94%
A0A3S5H7B8	Leishmania donovani	88%	100%
A4HCS4	Leishmania braziliensis	78%	100%
A4I098	Leishmania infantum	87%	80%
E9AW63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%