TRAPP trafficking subunit Trs65-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4QBB4_LEIMA

TriTrypDb:

LmjF.23.1620 , LMJLV39_230011800 , LMJSD75_230012100

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.601
CLV_MEL_PAP_1	587	593	PF00089	0.631
CLV_NRD_NRD_1	238	240	PF00675	0.604
CLV_NRD_NRD_1	556	558	PF00675	0.390
CLV_PCSK_KEX2_1	238	240	PF00082	0.604
CLV_PCSK_KEX2_1	516	518	PF00082	0.717
CLV_PCSK_KEX2_1	556	558	PF00082	0.390
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.717
CLV_PCSK_SKI1_1	320	324	PF00082	0.408
CLV_PCSK_SKI1_1	368	372	PF00082	0.418
CLV_PCSK_SKI1_1	38	42	PF00082	0.445
CLV_PCSK_SKI1_1	444	448	PF00082	0.376
CLV_PCSK_SKI1_1	556	560	PF00082	0.422
CLV_PCSK_SKI1_1	63	67	PF00082	0.495
DEG_Nend_UBRbox_2	1	3	PF02207	0.417
DEG_SPOP_SBC_1	358	362	PF00917	0.482
DOC_ANK_TNKS_1	219	226	PF00023	0.417
DOC_CDC14_PxL_1	474	482	PF14671	0.369
DOC_CYCLIN_RxL_1	32	42	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.343
DOC_MAPK_DCC_7	444	453	PF00069	0.415
DOC_MAPK_MEF2A_6	267	274	PF00069	0.461
DOC_MAPK_MEF2A_6	368	375	PF00069	0.373
DOC_MAPK_NFAT4_5	267	275	PF00069	0.464
DOC_MAPK_NFAT4_5	368	376	PF00069	0.373
DOC_PP1_RVXF_1	7	13	PF00149	0.396
DOC_PP2B_LxvP_1	171	174	PF13499	0.684
DOC_PP2B_LxvP_1	272	275	PF13499	0.396
DOC_PP2B_LxvP_1	293	296	PF13499	0.306
DOC_USP7_MATH_1	116	120	PF00917	0.734
DOC_USP7_MATH_1	155	159	PF00917	0.752
DOC_USP7_MATH_1	182	186	PF00917	0.665
DOC_USP7_MATH_1	193	197	PF00917	0.565
DOC_USP7_MATH_1	198	202	PF00917	0.601
DOC_USP7_MATH_1	242	246	PF00917	0.663
DOC_USP7_MATH_1	306	310	PF00917	0.616
DOC_USP7_MATH_1	589	593	PF00917	0.615
DOC_USP7_MATH_1	61	65	PF00917	0.438
DOC_USP7_UBL2_3	54	58	PF12436	0.473
DOC_WW_Pin1_4	105	110	PF00397	0.713
DOC_WW_Pin1_4	111	116	PF00397	0.807
DOC_WW_Pin1_4	134	139	PF00397	0.504
DOC_WW_Pin1_4	158	163	PF00397	0.647
DOC_WW_Pin1_4	191	196	PF00397	0.593
DOC_WW_Pin1_4	22	27	PF00397	0.600
DOC_WW_Pin1_4	233	238	PF00397	0.589
DOC_WW_Pin1_4	359	364	PF00397	0.410
DOC_WW_Pin1_4	446	451	PF00397	0.406
DOC_WW_Pin1_4	585	590	PF00397	0.616
LIG_14-3-3_CanoR_1	139	148	PF00244	0.563
LIG_14-3-3_CanoR_1	38	44	PF00244	0.435
LIG_14-3-3_CanoR_1	556	564	PF00244	0.381
LIG_14-3-3_CanoR_1	607	611	PF00244	0.568
LIG_APCC_ABBA_1	567	572	PF00400	0.319
LIG_BRCT_BRCA1_1	193	197	PF00533	0.538
LIG_BRCT_BRCA1_1	386	390	PF00533	0.542
LIG_BRCT_BRCA1_1	564	568	PF00533	0.351
LIG_BRCT_BRCA1_1	78	82	PF00533	0.465
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.388
LIG_FHA_1	267	273	PF00498	0.385
LIG_FHA_1	359	365	PF00498	0.409
LIG_FHA_1	377	383	PF00498	0.391
LIG_FHA_1	40	46	PF00498	0.459
LIG_FHA_1	441	447	PF00498	0.381
LIG_FHA_2	14	20	PF00498	0.598
LIG_FHA_2	165	171	PF00498	0.692
LIG_FHA_2	328	334	PF00498	0.478
LIG_FHA_2	386	392	PF00498	0.381
LIG_FHA_2	97	103	PF00498	0.611
LIG_LIR_Apic_2	494	500	PF02991	0.535
LIG_LIR_Gen_1	353	363	PF02991	0.382
LIG_LIR_Gen_1	46	56	PF02991	0.485
LIG_LIR_Gen_1	467	478	PF02991	0.404
LIG_LIR_Gen_1	64	71	PF02991	0.467
LIG_LIR_Gen_1	75	85	PF02991	0.344
LIG_LIR_Nem_3	11	15	PF02991	0.423
LIG_LIR_Nem_3	353	358	PF02991	0.379
LIG_LIR_Nem_3	467	473	PF02991	0.409
LIG_LIR_Nem_3	565	571	PF02991	0.377
LIG_LIR_Nem_3	75	81	PF02991	0.392
LIG_NRBOX	479	485	PF00104	0.385
LIG_PDZ_Class_2	607	612	PF00595	0.577
LIG_Pex14_1	78	82	PF04695	0.389
LIG_SH2_CRK	497	501	PF00017	0.549
LIG_SH2_GRB2like	49	52	PF00017	0.397
LIG_SH2_NCK_1	571	575	PF00017	0.400
LIG_SH2_STAP1	268	272	PF00017	0.455
LIG_SH2_STAP1	386	390	PF00017	0.366
LIG_SH2_STAP1	468	472	PF00017	0.373
LIG_SH2_STAP1	49	53	PF00017	0.488
LIG_SH2_STAP1	493	497	PF00017	0.516
LIG_SH2_STAP1	546	550	PF00017	0.470
LIG_SH2_STAP1	571	575	PF00017	0.388
LIG_SH2_STAT5	268	271	PF00017	0.459
LIG_SH2_STAT5	468	471	PF00017	0.507
LIG_SH2_STAT5	482	485	PF00017	0.328
LIG_SH2_STAT5	491	494	PF00017	0.495
LIG_SH2_STAT5	563	566	PF00017	0.356
LIG_SH3_3	112	118	PF00018	0.620
LIG_SH3_3	23	29	PF00018	0.701
LIG_SUMO_SIM_par_1	437	443	PF11976	0.379
LIG_SUMO_SIM_par_1	444	449	PF11976	0.384
LIG_TRAF2_1	17	20	PF00917	0.644
LIG_TRAF2_1	409	412	PF00917	0.620
LIG_UBA3_1	3	9	PF00899	0.395
LIG_UBA3_1	438	444	PF00899	0.355
LIG_WRC_WIRS_1	40	45	PF05994	0.413
MOD_CDC14_SPxK_1	236	239	PF00782	0.589
MOD_CDK_SPK_2	134	139	PF00069	0.432
MOD_CDK_SPK_2	233	238	PF00069	0.589
MOD_CDK_SPK_2	585	590	PF00069	0.616
MOD_CDK_SPxK_1	233	239	PF00069	0.591
MOD_CK1_1	119	125	PF00069	0.543
MOD_CK1_1	151	157	PF00069	0.640
MOD_CK1_1	158	164	PF00069	0.739
MOD_CK1_1	166	172	PF00069	0.544
MOD_CK1_1	266	272	PF00069	0.377
MOD_CK1_1	359	365	PF00069	0.442
MOD_CK1_1	509	515	PF00069	0.694
MOD_CK1_1	540	546	PF00069	0.423
MOD_CK1_1	562	568	PF00069	0.501
MOD_CK1_1	580	586	PF00069	0.708
MOD_CK1_1	64	70	PF00069	0.371
MOD_CK1_1	97	103	PF00069	0.563
MOD_CK2_1	13	19	PF00069	0.571
MOD_CK2_1	164	170	PF00069	0.733
MOD_CK2_1	327	333	PF00069	0.480
MOD_CK2_1	548	554	PF00069	0.400
MOD_CK2_1	96	102	PF00069	0.595
MOD_Cter_Amidation	514	517	PF01082	0.636
MOD_GlcNHglycan	119	122	PF01048	0.690
MOD_GlcNHglycan	130	133	PF01048	0.512
MOD_GlcNHglycan	157	160	PF01048	0.693
MOD_GlcNHglycan	200	203	PF01048	0.677
MOD_GlcNHglycan	204	207	PF01048	0.684
MOD_GlcNHglycan	214	218	PF01048	0.595
MOD_GlcNHglycan	243	247	PF01048	0.646
MOD_GlcNHglycan	308	311	PF01048	0.655
MOD_GlcNHglycan	337	340	PF01048	0.470
MOD_GlcNHglycan	343	346	PF01048	0.366
MOD_GlcNHglycan	513	516	PF01048	0.693
MOD_GlcNHglycan	530	533	PF01048	0.704
MOD_GlcNHglycan	550	553	PF01048	0.356
MOD_GlcNHglycan	591	594	PF01048	0.745
MOD_GSK3_1	147	154	PF00069	0.595
MOD_GSK3_1	173	180	PF00069	0.682
MOD_GSK3_1	182	189	PF00069	0.571
MOD_GSK3_1	198	205	PF00069	0.580
MOD_GSK3_1	323	330	PF00069	0.492
MOD_GSK3_1	358	365	PF00069	0.412
MOD_GSK3_1	373	380	PF00069	0.383
MOD_GSK3_1	39	46	PF00069	0.465
MOD_GSK3_1	440	447	PF00069	0.401
MOD_GSK3_1	528	535	PF00069	0.709
MOD_GSK3_1	577	584	PF00069	0.595
MOD_GSK3_1	585	592	PF00069	0.652
MOD_GSK3_1	96	103	PF00069	0.600
MOD_N-GLC_1	198	203	PF02516	0.633
MOD_N-GLC_1	371	376	PF02516	0.367
MOD_N-GLC_1	431	436	PF02516	0.550
MOD_N-GLC_1	580	585	PF02516	0.626
MOD_NEK2_1	110	115	PF00069	0.710
MOD_NEK2_1	140	145	PF00069	0.583
MOD_NEK2_1	163	168	PF00069	0.627
MOD_NEK2_1	177	182	PF00069	0.594
MOD_NEK2_1	263	268	PF00069	0.448
MOD_NEK2_1	3	8	PF00069	0.437
MOD_NEK2_1	323	328	PF00069	0.452
MOD_NEK2_1	356	361	PF00069	0.414
MOD_NEK2_1	371	376	PF00069	0.326
MOD_NEK2_1	385	390	PF00069	0.381
MOD_NEK2_1	392	397	PF00069	0.390
MOD_NEK2_1	43	48	PF00069	0.398
MOD_NEK2_1	483	488	PF00069	0.427
MOD_NEK2_1	559	564	PF00069	0.379
MOD_NEK2_1	594	599	PF00069	0.571
MOD_PIKK_1	327	333	PF00454	0.529
MOD_PIKK_1	483	489	PF00454	0.495
MOD_PKA_2	126	132	PF00069	0.548
MOD_PKA_2	146	152	PF00069	0.692
MOD_PKA_2	43	49	PF00069	0.364
MOD_PKA_2	506	512	PF00069	0.685
MOD_PKA_2	589	595	PF00069	0.666
MOD_PKA_2	606	612	PF00069	0.479
MOD_PKB_1	145	153	PF00069	0.578
MOD_Plk_1	371	377	PF00069	0.364
MOD_Plk_1	431	437	PF00069	0.542
MOD_Plk_1	546	552	PF00069	0.461
MOD_Plk_2-3	466	472	PF00069	0.381
MOD_Plk_4	173	179	PF00069	0.602
MOD_Plk_4	3	9	PF00069	0.399
MOD_Plk_4	419	425	PF00069	0.612
MOD_Plk_4	537	543	PF00069	0.500
MOD_Plk_4	559	565	PF00069	0.371
MOD_Plk_4	61	67	PF00069	0.532
MOD_ProDKin_1	105	111	PF00069	0.714
MOD_ProDKin_1	134	140	PF00069	0.502
MOD_ProDKin_1	158	164	PF00069	0.649
MOD_ProDKin_1	191	197	PF00069	0.600
MOD_ProDKin_1	22	28	PF00069	0.599
MOD_ProDKin_1	233	239	PF00069	0.591
MOD_ProDKin_1	359	365	PF00069	0.409
MOD_ProDKin_1	446	452	PF00069	0.415
MOD_ProDKin_1	585	591	PF00069	0.615
TRG_ENDOCYTIC_2	49	52	PF00928	0.473
TRG_ENDOCYTIC_2	570	573	PF00928	0.440
TRG_ER_diArg_1	237	239	PF00400	0.593
TRG_ER_diArg_1	555	557	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ40	Leptomonas seymouri	51%	98%
A0A3Q8ICM5	Leishmania donovani	92%	100%
A4HCS5	Leishmania braziliensis	75%	100%
A4I099	Leishmania infantum	91%	100%
E9AW64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%