Poly(A)-specific ribonuclease PARN

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania major

UniProt:

Q4QBB3_LEIMA

TriTrypDb:

LmjF.23.1630 , LMJLV39_230011900 , LMJSD75_230012200

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

Q4QBB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBB3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	5
GO:0003676	nucleic acid binding	3	25
GO:0003723	RNA binding	4	4
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004527	exonuclease activity	5	5
GO:0004532	RNA exonuclease activity	5	5
GO:0004540	RNA nuclease activity	4	5
GO:0005488	binding	1	25
GO:0008408	3'-5' exonuclease activity	6	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	5
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	5
GO:0097159	organic cyclic compound binding	2	25
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5
GO:1901363	heterocyclic compound binding	2	25
GO:0004535	poly(A)-specific ribonuclease activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.406
CLV_C14_Caspase3-7	506	510	PF00656	0.346
CLV_NRD_NRD_1	130	132	PF00675	0.227
CLV_NRD_NRD_1	195	197	PF00675	0.364
CLV_NRD_NRD_1	209	211	PF00675	0.151
CLV_NRD_NRD_1	260	262	PF00675	0.233
CLV_NRD_NRD_1	291	293	PF00675	0.216
CLV_NRD_NRD_1	310	312	PF00675	0.361
CLV_NRD_NRD_1	361	363	PF00675	0.376
CLV_NRD_NRD_1	4	6	PF00675	0.320
CLV_NRD_NRD_1	528	530	PF00675	0.497
CLV_NRD_NRD_1	586	588	PF00675	0.683
CLV_NRD_NRD_1	596	598	PF00675	0.706
CLV_NRD_NRD_1	72	74	PF00675	0.315
CLV_PCSK_FUR_1	258	262	PF00082	0.320
CLV_PCSK_FUR_1	594	598	PF00082	0.505
CLV_PCSK_KEX2_1	130	132	PF00082	0.239
CLV_PCSK_KEX2_1	195	197	PF00082	0.189
CLV_PCSK_KEX2_1	209	211	PF00082	0.265
CLV_PCSK_KEX2_1	260	262	PF00082	0.226
CLV_PCSK_KEX2_1	291	293	PF00082	0.333
CLV_PCSK_KEX2_1	361	363	PF00082	0.376
CLV_PCSK_KEX2_1	4	6	PF00082	0.320
CLV_PCSK_KEX2_1	528	530	PF00082	0.475
CLV_PCSK_KEX2_1	54	56	PF00082	0.258
CLV_PCSK_KEX2_1	586	588	PF00082	0.683
CLV_PCSK_KEX2_1	596	598	PF00082	0.706
CLV_PCSK_KEX2_1	72	74	PF00082	0.194
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.267
CLV_PCSK_SKI1_1	292	296	PF00082	0.261
CLV_PCSK_SKI1_1	301	305	PF00082	0.210
CLV_PCSK_SKI1_1	346	350	PF00082	0.296
CLV_PCSK_SKI1_1	362	366	PF00082	0.173
CLV_PCSK_SKI1_1	449	453	PF00082	0.328
CLV_Separin_Metazoa	17	21	PF03568	0.389
DEG_APCC_DBOX_1	291	299	PF00400	0.520
DEG_COP1_1	28	39	PF00400	0.482
DEG_Nend_UBRbox_3	1	3	PF02207	0.302
DEG_ODPH_VHL_1	88	100	PF01847	0.356
DOC_ANK_TNKS_1	577	584	PF00023	0.450
DOC_MAPK_gen_1	130	136	PF00069	0.448
DOC_MAPK_gen_1	209	218	PF00069	0.528
DOC_MAPK_gen_1	238	248	PF00069	0.503
DOC_MAPK_MEF2A_6	241	250	PF00069	0.464
DOC_MAPK_MEF2A_6	60	68	PF00069	0.465
DOC_MAPK_NFAT4_5	241	249	PF00069	0.520
DOC_MAPK_RevD_3	246	261	PF00069	0.356
DOC_PP1_RVXF_1	213	219	PF00149	0.365
DOC_PP1_RVXF_1	299	305	PF00149	0.451
DOC_PP2B_LxvP_1	88	91	PF13499	0.391
DOC_PP4_FxxP_1	568	571	PF00568	0.670
DOC_USP7_MATH_1	162	166	PF00917	0.538
DOC_USP7_MATH_1	553	557	PF00917	0.671
DOC_USP7_MATH_1	563	567	PF00917	0.607
DOC_USP7_MATH_1	75	79	PF00917	0.488
DOC_WW_Pin1_4	119	124	PF00397	0.453
DOC_WW_Pin1_4	272	277	PF00397	0.501
DOC_WW_Pin1_4	549	554	PF00397	0.640
LIG_14-3-3_CanoR_1	187	194	PF00244	0.458
LIG_14-3-3_CanoR_1	215	219	PF00244	0.473
LIG_14-3-3_CanoR_1	586	590	PF00244	0.692
LIG_Actin_WH2_2	523	541	PF00022	0.322
LIG_APCC_ABBA_1	172	177	PF00400	0.381
LIG_BRCT_BRCA1_1	366	370	PF00533	0.444
LIG_deltaCOP1_diTrp_1	322	325	PF00928	0.520
LIG_eIF4E_1	400	406	PF01652	0.520
LIG_eIF4E_1	96	102	PF01652	0.520
LIG_FHA_1	167	173	PF00498	0.522
LIG_FHA_1	268	274	PF00498	0.463
LIG_FHA_1	303	309	PF00498	0.563
LIG_FHA_1	343	349	PF00498	0.438
LIG_FHA_1	353	359	PF00498	0.417
LIG_FHA_1	38	44	PF00498	0.423
LIG_FHA_1	388	394	PF00498	0.434
LIG_FHA_1	422	428	PF00498	0.425
LIG_FHA_1	494	500	PF00498	0.502
LIG_FHA_1	510	516	PF00498	0.360
LIG_FHA_2	109	115	PF00498	0.457
LIG_FHA_2	174	180	PF00498	0.409
LIG_FHA_2	463	469	PF00498	0.504
LIG_LIR_Apic_2	566	571	PF02991	0.670
LIG_LIR_Gen_1	322	330	PF02991	0.518
LIG_LIR_Gen_1	416	427	PF02991	0.420
LIG_LIR_Gen_1	59	68	PF02991	0.455
LIG_LIR_Nem_3	21	27	PF02991	0.451
LIG_LIR_Nem_3	297	303	PF02991	0.490
LIG_LIR_Nem_3	322	326	PF02991	0.518
LIG_LIR_Nem_3	347	352	PF02991	0.436
LIG_LIR_Nem_3	367	373	PF02991	0.469
LIG_LIR_Nem_3	398	403	PF02991	0.476
LIG_LIR_Nem_3	416	422	PF02991	0.429
LIG_LIR_Nem_3	59	64	PF02991	0.451
LIG_LIR_Nem_3	6	11	PF02991	0.437
LIG_NRBOX	427	433	PF00104	0.460
LIG_Pex14_1	353	357	PF04695	0.520
LIG_Pex14_2	300	304	PF04695	0.432
LIG_Pex14_2	349	353	PF04695	0.460
LIG_Pex14_2	8	12	PF04695	0.419
LIG_RPA_C_Fungi	182	194	PF08784	0.428
LIG_SH2_CRK	400	404	PF00017	0.321
LIG_SH2_CRK	419	423	PF00017	0.262
LIG_SH2_CRK	61	65	PF00017	0.329
LIG_SH2_NCK_1	400	404	PF00017	0.442
LIG_SH2_NCK_1	61	65	PF00017	0.333
LIG_SH2_PTP2	543	546	PF00017	0.321
LIG_SH2_SRC	400	403	PF00017	0.234
LIG_SH2_SRC	543	546	PF00017	0.492
LIG_SH2_STAP1	419	423	PF00017	0.274
LIG_SH2_STAP1	457	461	PF00017	0.376
LIG_SH2_STAT5	110	113	PF00017	0.333
LIG_SH2_STAT5	267	270	PF00017	0.415
LIG_SH2_STAT5	357	360	PF00017	0.276
LIG_SH2_STAT5	382	385	PF00017	0.273
LIG_SH2_STAT5	437	440	PF00017	0.414
LIG_SH2_STAT5	543	546	PF00017	0.456
LIG_SH3_1	539	545	PF00018	0.311
LIG_SH3_3	117	123	PF00018	0.287
LIG_SH3_3	270	276	PF00018	0.341
LIG_SH3_3	388	394	PF00018	0.297
LIG_SH3_3	539	545	PF00018	0.440
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.394
LIG_SUMO_SIM_anti_2	401	407	PF11976	0.234
LIG_SUMO_SIM_par_1	267	272	PF11976	0.349
LIG_SUMO_SIM_par_1	475	480	PF11976	0.307
LIG_TRAF2_1	111	114	PF00917	0.341
LIG_TRAF2_1	275	278	PF00917	0.394
LIG_TRFH_1	100	104	PF08558	0.280
LIG_WW_1	90	93	PF00397	0.199
LIG_WW_3	89	93	PF00397	0.199
MOD_CK1_1	167	173	PF00069	0.373
MOD_CK1_1	256	262	PF00069	0.400
MOD_CK1_1	387	393	PF00069	0.362
MOD_CK1_1	503	509	PF00069	0.471
MOD_CK1_1	556	562	PF00069	0.671
MOD_CK1_1	59	65	PF00069	0.407
MOD_CK2_1	108	114	PF00069	0.305
MOD_CK2_1	162	168	PF00069	0.376
MOD_CK2_1	173	179	PF00069	0.279
MOD_CK2_1	272	278	PF00069	0.393
MOD_CK2_1	462	468	PF00069	0.515
MOD_GlcNHglycan	123	126	PF01048	0.407
MOD_GlcNHglycan	264	267	PF01048	0.350
MOD_GlcNHglycan	327	330	PF01048	0.254
MOD_GlcNHglycan	366	369	PF01048	0.412
MOD_GlcNHglycan	521	524	PF01048	0.485
MOD_GlcNHglycan	555	558	PF01048	0.510
MOD_GlcNHglycan	77	80	PF01048	0.393
MOD_GSK3_1	162	169	PF00069	0.379
MOD_GSK3_1	214	221	PF00069	0.474
MOD_GSK3_1	37	44	PF00069	0.250
MOD_GSK3_1	383	390	PF00069	0.425
MOD_GSK3_1	489	496	PF00069	0.411
MOD_GSK3_1	505	512	PF00069	0.439
MOD_GSK3_1	549	556	PF00069	0.617
MOD_N-GLC_1	532	537	PF02516	0.500
MOD_NEK2_1	218	223	PF00069	0.321
MOD_NEK2_1	294	299	PF00069	0.350
MOD_NEK2_1	307	312	PF00069	0.298
MOD_NEK2_1	325	330	PF00069	0.330
MOD_NEK2_1	383	388	PF00069	0.451
MOD_NEK2_1	423	428	PF00069	0.262
MOD_NEK2_1	452	457	PF00069	0.397
MOD_NEK2_1	56	61	PF00069	0.321
MOD_NEK2_1	585	590	PF00069	0.638
MOD_NEK2_2	253	258	PF00069	0.383
MOD_PIKK_1	162	168	PF00454	0.400
MOD_PIKK_1	444	450	PF00454	0.266
MOD_PIKK_1	493	499	PF00454	0.267
MOD_PK_1	369	375	PF00069	0.272
MOD_PKA_2	186	192	PF00069	0.234
MOD_PKA_2	214	220	PF00069	0.176
MOD_PKA_2	259	265	PF00069	0.371
MOD_PKA_2	585	591	PF00069	0.686
MOD_PKA_2	59	65	PF00069	0.400
MOD_Plk_1	167	173	PF00069	0.199
MOD_Plk_1	500	506	PF00069	0.465
MOD_Plk_1	532	538	PF00069	0.413
MOD_Plk_4	214	220	PF00069	0.350
MOD_Plk_4	269	275	PF00069	0.303
MOD_Plk_4	401	407	PF00069	0.375
MOD_Plk_4	423	429	PF00069	0.239
MOD_Plk_4	500	506	PF00069	0.439
MOD_Plk_4	59	65	PF00069	0.398
MOD_ProDKin_1	119	125	PF00069	0.300
MOD_ProDKin_1	272	278	PF00069	0.367
MOD_ProDKin_1	549	555	PF00069	0.644
TRG_DiLeu_BaEn_1	290	295	PF01217	0.252
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.490
TRG_ENDOCYTIC_2	141	144	PF00928	0.262
TRG_ENDOCYTIC_2	400	403	PF00928	0.262
TRG_ENDOCYTIC_2	419	422	PF00928	0.272
TRG_ENDOCYTIC_2	61	64	PF00928	0.311
TRG_ER_diArg_1	129	131	PF00400	0.280
TRG_ER_diArg_1	155	158	PF00400	0.305
TRG_ER_diArg_1	194	196	PF00400	0.211
TRG_ER_diArg_1	257	260	PF00400	0.277
TRG_ER_diArg_1	3	5	PF00400	0.394
TRG_ER_diArg_1	528	530	PF00400	0.499
TRG_ER_diArg_1	585	587	PF00400	0.671
TRG_ER_diArg_1	593	596	PF00400	0.639
TRG_ER_diArg_1	71	73	PF00400	0.372
TRG_NLS_Bipartite_1	195	214	PF00514	0.164
TRG_NLS_MonoExtN_4	209	214	PF00514	0.164
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P603	Leptomonas seymouri	26%	100%
A0A0N1ILJ1	Leptomonas seymouri	67%	98%
A0A0S4IMW3	Bodo saltans	26%	100%
A0A1X0NLC6	Trypanosomatidae	25%	100%
A0A1X0NXI3	Trypanosomatidae	43%	99%
A0A3Q8ICI3	Leishmania donovani	93%	100%
A0A3R7K5K5	Trypanosoma rangeli	27%	100%
A0A3S7X9D8	Leishmania donovani	27%	88%
A0A3S7XC77	Leishmania donovani	26%	100%
A0A422N5N5	Trypanosoma rangeli	49%	100%
A4HCS6	Leishmania braziliensis	89%	100%
A4HQF5	Leishmania braziliensis	27%	100%
A4I0A0	Leishmania infantum	93%	100%
A4IBC6	Leishmania infantum	27%	88%
A4IC91	Leishmania infantum	26%	100%
B2RXZ1	Mus musculus	25%	100%
C9ZV58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AF58	Leishmania major	27%	88%
E9AU71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AW65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B6B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	88%
H9JAQ7	Bombyx mori	24%	100%
O95453	Homo sapiens	22%	94%
P69341	Bos taurus	23%	94%
Q4Q0C3	Leishmania major	26%	100%
Q5RC51	Pongo abelii	23%	94%
Q7ZU92	Danio rerio	23%	91%
Q8NA58	Homo sapiens	23%	100%
Q8VDG3	Mus musculus	23%	96%
Q90ZA1	Xenopus laevis	23%	95%
Q9LG26	Arabidopsis thaliana	22%	87%
V5ASU9	Trypanosoma cruzi	27%	100%
V5BCG2	Trypanosoma cruzi	46%	100%