Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBA2_LEIMA

TriTrypDb:

LmjF.23.0610 , LMJLV39_230014200 , LMJSD75_230014500

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.354
CLV_NRD_NRD_1	452	454	PF00675	0.563
CLV_NRD_NRD_1	509	511	PF00675	0.677
CLV_NRD_NRD_1	532	534	PF00675	0.544
CLV_NRD_NRD_1	582	584	PF00675	0.603
CLV_PCSK_KEX2_1	10	12	PF00082	0.354
CLV_PCSK_KEX2_1	160	162	PF00082	0.445
CLV_PCSK_KEX2_1	409	411	PF00082	0.702
CLV_PCSK_KEX2_1	452	454	PF00082	0.590
CLV_PCSK_KEX2_1	509	511	PF00082	0.676
CLV_PCSK_KEX2_1	581	583	PF00082	0.599
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.445
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.590
CLV_PCSK_SKI1_1	157	161	PF00082	0.443
CLV_PCSK_SKI1_1	432	436	PF00082	0.681
CLV_PCSK_SKI1_1	61	65	PF00082	0.336
CLV_PCSK_SKI1_1	77	81	PF00082	0.416
DEG_APCC_DBOX_1	277	285	PF00400	0.421
DEG_SCF_FBW7_1	476	482	PF00400	0.610
DEG_SPOP_SBC_1	144	148	PF00917	0.478
DEG_SPOP_SBC_1	261	265	PF00917	0.577
DEG_SPOP_SBC_1	558	562	PF00917	0.575
DOC_CKS1_1	476	481	PF01111	0.693
DOC_CYCLIN_RxL_1	157	167	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.366
DOC_MAPK_DCC_7	452	462	PF00069	0.585
DOC_MAPK_gen_1	10	18	PF00069	0.336
DOC_MAPK_gen_1	244	252	PF00069	0.437
DOC_MAPK_gen_1	452	459	PF00069	0.552
DOC_MAPK_gen_1	530	540	PF00069	0.583
DOC_MAPK_MEF2A_6	10	18	PF00069	0.336
DOC_MAPK_MEF2A_6	453	462	PF00069	0.583
DOC_MAPK_MEF2A_6	533	542	PF00069	0.651
DOC_PP2B_LxvP_1	108	111	PF13499	0.431
DOC_PP2B_LxvP_1	250	253	PF13499	0.543
DOC_PP2B_LxvP_1	32	35	PF13499	0.445
DOC_PP2B_LxvP_1	417	420	PF13499	0.651
DOC_PP2B_LxvP_1	488	491	PF13499	0.593
DOC_PP4_FxxP_1	368	371	PF00568	0.501
DOC_PP4_FxxP_1	525	528	PF00568	0.534
DOC_USP7_MATH_1	136	140	PF00917	0.613
DOC_USP7_MATH_1	144	148	PF00917	0.399
DOC_USP7_MATH_1	204	208	PF00917	0.603
DOC_USP7_MATH_1	214	218	PF00917	0.645
DOC_USP7_MATH_1	251	255	PF00917	0.573
DOC_USP7_MATH_1	259	263	PF00917	0.689
DOC_USP7_MATH_1	288	292	PF00917	0.547
DOC_USP7_MATH_1	38	42	PF00917	0.553
DOC_USP7_MATH_1	382	386	PF00917	0.768
DOC_USP7_MATH_1	408	412	PF00917	0.709
DOC_USP7_MATH_1	442	446	PF00917	0.742
DOC_USP7_MATH_1	45	49	PF00917	0.487
DOC_USP7_MATH_1	451	455	PF00917	0.538
DOC_USP7_MATH_1	483	487	PF00917	0.625
DOC_USP7_MATH_1	519	523	PF00917	0.680
DOC_USP7_MATH_1	558	562	PF00917	0.710
DOC_WW_Pin1_4	145	150	PF00397	0.528
DOC_WW_Pin1_4	268	273	PF00397	0.579
DOC_WW_Pin1_4	292	297	PF00397	0.694
DOC_WW_Pin1_4	404	409	PF00397	0.582
DOC_WW_Pin1_4	438	443	PF00397	0.649
DOC_WW_Pin1_4	447	452	PF00397	0.670
DOC_WW_Pin1_4	475	480	PF00397	0.659
DOC_WW_Pin1_4	499	504	PF00397	0.599
DOC_WW_Pin1_4	554	559	PF00397	0.679
DOC_WW_Pin1_4	586	591	PF00397	0.638
LIG_14-3-3_CanoR_1	356	361	PF00244	0.414
LIG_14-3-3_CanoR_1	410	416	PF00244	0.585
LIG_14-3-3_CanoR_1	452	460	PF00244	0.610
LIG_14-3-3_CanoR_1	494	503	PF00244	0.626
LIG_14-3-3_CanoR_1	544	554	PF00244	0.647
LIG_APCC_ABBA_1	14	19	PF00400	0.379
LIG_BIR_III_2	387	391	PF00653	0.558
LIG_BRCT_BRCA1_1	244	248	PF00533	0.368
LIG_BRCT_BRCA1_1	521	525	PF00533	0.559
LIG_CtBP_PxDLS_1	337	341	PF00389	0.373
LIG_FHA_1	22	28	PF00498	0.451
LIG_FHA_1	564	570	PF00498	0.653
LIG_FHA_1	76	82	PF00498	0.465
LIG_FHA_2	186	192	PF00498	0.492
LIG_FHA_2	53	59	PF00498	0.351
LIG_FHA_2	546	552	PF00498	0.586
LIG_FHA_2	571	577	PF00498	0.555
LIG_GBD_Chelix_1	155	163	PF00786	0.368
LIG_LIR_Apic_2	365	371	PF02991	0.498
LIG_LIR_Apic_2	48	53	PF02991	0.501
LIG_LIR_Apic_2	522	528	PF02991	0.547
LIG_LIR_Nem_3	150	155	PF02991	0.528
LIG_LIR_Nem_3	412	418	PF02991	0.555
LIG_LIR_Nem_3	454	459	PF02991	0.586
LIG_LIR_Nem_3	82	86	PF02991	0.381
LIG_NRBOX	158	164	PF00104	0.441
LIG_PCNA_yPIPBox_3	231	244	PF02747	0.352
LIG_PTAP_UEV_1	443	448	PF05743	0.616
LIG_PTB_Apo_2	189	196	PF02174	0.546
LIG_SH2_CRK	152	156	PF00017	0.373
LIG_SH2_PTP2	50	53	PF00017	0.383
LIG_SH2_SRC	418	421	PF00017	0.549
LIG_SH2_SRC	50	53	PF00017	0.415
LIG_SH2_STAT5	418	421	PF00017	0.549
LIG_SH2_STAT5	50	53	PF00017	0.415
LIG_SH2_STAT5	86	89	PF00017	0.417
LIG_SH3_1	601	607	PF00018	0.664
LIG_SH3_2	508	513	PF14604	0.671
LIG_SH3_3	208	214	PF00018	0.618
LIG_SH3_3	366	372	PF00018	0.508
LIG_SH3_3	441	447	PF00018	0.635
LIG_SH3_3	473	479	PF00018	0.676
LIG_SH3_3	497	503	PF00018	0.672
LIG_SH3_3	505	511	PF00018	0.599
LIG_SH3_3	596	602	PF00018	0.687
LIG_SH3_CIN85_PxpxPR_1	447	452	PF14604	0.567
LIG_SUMO_SIM_anti_2	55	62	PF11976	0.399
LIG_SUMO_SIM_par_1	248	255	PF11976	0.506
LIG_SUMO_SIM_par_1	336	341	PF11976	0.369
LIG_SUMO_SIM_par_1	356	362	PF11976	0.308
LIG_SUMO_SIM_par_1	371	377	PF11976	0.471
LIG_SxIP_EBH_1	305	316	PF03271	0.555
LIG_TYR_ITSM	148	155	PF00017	0.417
LIG_UBA3_1	357	361	PF00899	0.408
LIG_WRC_WIRS_1	80	85	PF05994	0.351
LIG_WW_3	598	602	PF00397	0.578
MOD_CDC14_SPxK_1	407	410	PF00782	0.545
MOD_CDC14_SPxK_1	450	453	PF00782	0.559
MOD_CDK_SPK_2	404	409	PF00069	0.569
MOD_CDK_SPK_2	438	443	PF00069	0.578
MOD_CDK_SPK_2	447	452	PF00069	0.567
MOD_CDK_SPK_2	475	480	PF00069	0.574
MOD_CDK_SPxK_1	404	410	PF00069	0.549
MOD_CDK_SPxK_1	447	453	PF00069	0.567
MOD_CDK_SPxxK_3	292	299	PF00069	0.535
MOD_CDK_SPxxK_3	586	593	PF00069	0.651
MOD_CK1_1	139	145	PF00069	0.625
MOD_CK1_1	147	153	PF00069	0.338
MOD_CK1_1	262	268	PF00069	0.565
MOD_CK1_1	298	304	PF00069	0.628
MOD_CK1_1	392	398	PF00069	0.676
MOD_CK1_1	411	417	PF00069	0.766
MOD_CK1_1	445	451	PF00069	0.618
MOD_CK1_1	470	476	PF00069	0.593
MOD_CK1_1	557	563	PF00069	0.784
MOD_CK1_1	570	576	PF00069	0.666
MOD_CK2_1	185	191	PF00069	0.490
MOD_CK2_1	356	362	PF00069	0.424
MOD_GlcNHglycan	107	111	PF01048	0.442
MOD_GlcNHglycan	141	144	PF01048	0.648
MOD_GlcNHglycan	183	186	PF01048	0.732
MOD_GlcNHglycan	300	303	PF01048	0.662
MOD_GlcNHglycan	305	308	PF01048	0.685
MOD_GlcNHglycan	384	387	PF01048	0.765
MOD_GlcNHglycan	41	44	PF01048	0.559
MOD_GlcNHglycan	444	447	PF01048	0.772
MOD_GlcNHglycan	469	472	PF01048	0.633
MOD_GlcNHglycan	47	50	PF01048	0.484
MOD_GlcNHglycan	514	517	PF01048	0.765
MOD_GlcNHglycan	521	524	PF01048	0.654
MOD_GlcNHglycan	590	593	PF01048	0.772
MOD_GSK3_1	139	146	PF00069	0.613
MOD_GSK3_1	179	186	PF00069	0.580
MOD_GSK3_1	21	28	PF00069	0.389
MOD_GSK3_1	260	267	PF00069	0.580
MOD_GSK3_1	288	295	PF00069	0.498
MOD_GSK3_1	303	310	PF00069	0.680
MOD_GSK3_1	318	325	PF00069	0.451
MOD_GSK3_1	404	411	PF00069	0.772
MOD_GSK3_1	438	445	PF00069	0.608
MOD_GSK3_1	447	454	PF00069	0.705
MOD_GSK3_1	466	473	PF00069	0.503
MOD_GSK3_1	475	482	PF00069	0.670
MOD_GSK3_1	495	502	PF00069	0.609
MOD_GSK3_1	554	561	PF00069	0.729
MOD_GSK3_1	563	570	PF00069	0.712
MOD_GSK3_1	71	78	PF00069	0.446
MOD_GSK3_1	87	94	PF00069	0.386
MOD_N-GLC_1	136	141	PF02516	0.493
MOD_N-GLC_1	432	437	PF02516	0.780
MOD_N-GLC_1	465	470	PF02516	0.623
MOD_N-GLC_2	138	140	PF02516	0.550
MOD_N-GLC_2	192	194	PF02516	0.518
MOD_NEK2_1	179	184	PF00069	0.692
MOD_NEK2_1	190	195	PF00069	0.638
MOD_NEK2_1	297	302	PF00069	0.616
MOD_NEK2_1	39	44	PF00069	0.555
MOD_NEK2_1	567	572	PF00069	0.621
MOD_NEK2_2	185	190	PF00069	0.514
MOD_NEK2_2	79	84	PF00069	0.356
MOD_PIKK_1	433	439	PF00454	0.614
MOD_PIKK_1	552	558	PF00454	0.618
MOD_PIKK_1	576	582	PF00454	0.651
MOD_PK_1	183	189	PF00069	0.553
MOD_PK_1	71	77	PF00069	0.460
MOD_PKA_1	409	415	PF00069	0.553
MOD_PKA_2	298	304	PF00069	0.594
MOD_PKA_2	362	368	PF00069	0.506
MOD_PKA_2	409	415	PF00069	0.581
MOD_PKA_2	451	457	PF00069	0.581
MOD_PKA_2	479	485	PF00069	0.578
MOD_PKA_2	493	499	PF00069	0.570
MOD_PKA_2	512	518	PF00069	0.563
MOD_PKA_2	570	576	PF00069	0.548
MOD_Plk_1	190	196	PF00069	0.541
MOD_Plk_1	21	27	PF00069	0.384
MOD_Plk_1	322	328	PF00069	0.487
MOD_Plk_4	129	135	PF00069	0.450
MOD_Plk_4	147	153	PF00069	0.578
MOD_Plk_4	185	191	PF00069	0.504
MOD_Plk_4	389	395	PF00069	0.614
MOD_Plk_4	483	489	PF00069	0.716
MOD_Plk_4	570	576	PF00069	0.650
MOD_ProDKin_1	145	151	PF00069	0.515
MOD_ProDKin_1	268	274	PF00069	0.576
MOD_ProDKin_1	292	298	PF00069	0.697
MOD_ProDKin_1	404	410	PF00069	0.583
MOD_ProDKin_1	438	444	PF00069	0.647
MOD_ProDKin_1	447	453	PF00069	0.670
MOD_ProDKin_1	475	481	PF00069	0.658
MOD_ProDKin_1	499	505	PF00069	0.600
MOD_ProDKin_1	554	560	PF00069	0.678
MOD_ProDKin_1	586	592	PF00069	0.638
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.424
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.427
TRG_ENDOCYTIC_2	152	155	PF00928	0.425
TRG_ER_diArg_1	243	246	PF00400	0.348
TRG_ER_diArg_1	451	453	PF00400	0.556
TRG_ER_diArg_1	508	510	PF00400	0.681
TRG_ER_diArg_1	581	583	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	530	535	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I2	Leptomonas seymouri	37%	77%
A4H6H0	Leishmania braziliensis	57%	86%
E9AW76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	82%