RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4QB91_LEIMA

TriTrypDb:

LmjF.23.0720 , LMJLV39_230015800 , LMJSD75_230016100

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB91

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	454	458	PF00656	0.667
CLV_C14_Caspase3-7	76	80	PF00656	0.607
CLV_NRD_NRD_1	288	290	PF00675	0.426
CLV_PCSK_KEX2_1	288	290	PF00082	0.426
CLV_PCSK_SKI1_1	193	197	PF00082	0.497
CLV_PCSK_SKI1_1	207	211	PF00082	0.432
DEG_SCF_FBW7_1	90	96	PF00400	0.629
DEG_SPOP_SBC_1	469	473	PF00917	0.690
DOC_CKS1_1	109	114	PF01111	0.661
DOC_CKS1_1	133	138	PF01111	0.570
DOC_CKS1_1	312	317	PF01111	0.593
DOC_CKS1_1	363	368	PF01111	0.559
DOC_CKS1_1	90	95	PF01111	0.629
DOC_MAPK_gen_1	253	262	PF00069	0.475
DOC_PP2B_LxvP_1	487	490	PF13499	0.683
DOC_PP4_FxxP_1	109	112	PF00568	0.545
DOC_PP4_FxxP_1	363	366	PF00568	0.606
DOC_PP4_FxxP_1	585	588	PF00568	0.579
DOC_PP4_MxPP_1	513	516	PF00568	0.609
DOC_USP7_MATH_1	134	138	PF00917	0.588
DOC_USP7_MATH_1	145	149	PF00917	0.592
DOC_USP7_MATH_1	21	25	PF00917	0.558
DOC_USP7_MATH_1	248	252	PF00917	0.495
DOC_USP7_MATH_1	35	39	PF00917	0.645
DOC_USP7_MATH_1	393	397	PF00917	0.615
DOC_USP7_MATH_1	410	414	PF00917	0.799
DOC_USP7_MATH_1	470	474	PF00917	0.615
DOC_USP7_MATH_1	501	505	PF00917	0.694
DOC_USP7_MATH_1	550	554	PF00917	0.642
DOC_USP7_MATH_1	575	579	PF00917	0.585
DOC_USP7_MATH_2	534	540	PF00917	0.619
DOC_WW_Pin1_4	108	113	PF00397	0.666
DOC_WW_Pin1_4	132	137	PF00397	0.568
DOC_WW_Pin1_4	24	29	PF00397	0.606
DOC_WW_Pin1_4	311	316	PF00397	0.612
DOC_WW_Pin1_4	337	342	PF00397	0.641
DOC_WW_Pin1_4	362	367	PF00397	0.558
DOC_WW_Pin1_4	401	406	PF00397	0.604
DOC_WW_Pin1_4	457	462	PF00397	0.660
DOC_WW_Pin1_4	584	589	PF00397	0.582
DOC_WW_Pin1_4	89	94	PF00397	0.704
LIG_14-3-3_CanoR_1	105	110	PF00244	0.636
LIG_14-3-3_CanoR_1	521	526	PF00244	0.583
LIG_APCC_ABBA_1	259	264	PF00400	0.475
LIG_BRCT_BRCA1_1	579	583	PF00533	0.647
LIG_BRCT_BRCA1_1	60	64	PF00533	0.547
LIG_Clathr_ClatBox_1	570	574	PF01394	0.541
LIG_FHA_1	180	186	PF00498	0.530
LIG_FHA_1	282	288	PF00498	0.529
LIG_FHA_1	402	408	PF00498	0.665
LIG_FHA_1	67	73	PF00498	0.647
LIG_LIR_Apic_2	108	112	PF02991	0.547
LIG_LIR_Apic_2	128	134	PF02991	0.566
LIG_LIR_Apic_2	362	366	PF02991	0.555
LIG_LIR_Nem_3	11	16	PF02991	0.547
LIG_LIR_Nem_3	128	133	PF02991	0.606
LIG_LIR_Nem_3	333	339	PF02991	0.574
LIG_LIR_Nem_3	580	586	PF02991	0.576
LIG_LIR_Nem_3	61	66	PF02991	0.629
LIG_MLH1_MIPbox_1	60	64	PF16413	0.623
LIG_Pex14_2	62	66	PF04695	0.630
LIG_PTAP_UEV_1	135	140	PF05743	0.576
LIG_SH2_CRK	131	135	PF00017	0.567
LIG_SH2_GRB2like	86	89	PF00017	0.674
LIG_SH2_STAP1	86	90	PF00017	0.674
LIG_SH2_STAT5	129	132	PF00017	0.557
LIG_SH2_STAT5	569	572	PF00017	0.632
LIG_SH2_STAT5	584	587	PF00017	0.607
LIG_SH2_STAT5	63	66	PF00017	0.632
LIG_SH3_2	136	141	PF14604	0.581
LIG_SH3_2	516	521	PF14604	0.623
LIG_SH3_3	133	139	PF00018	0.569
LIG_SH3_3	165	171	PF00018	0.726
LIG_SH3_3	295	301	PF00018	0.537
LIG_SH3_3	310	316	PF00018	0.610
LIG_SH3_3	325	331	PF00018	0.675
LIG_SH3_3	338	344	PF00018	0.591
LIG_SH3_3	366	372	PF00018	0.611
LIG_SH3_3	439	445	PF00018	0.714
LIG_SH3_3	44	50	PF00018	0.578
LIG_SH3_3	506	512	PF00018	0.654
LIG_SH3_3	513	519	PF00018	0.649
LIG_SH3_3	87	93	PF00018	0.592
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.553
LIG_WRC_WIRS_1	63	68	PF05994	0.629
MOD_CK1_1	108	114	PF00069	0.644
MOD_CK1_1	148	154	PF00069	0.663
MOD_CK1_1	24	30	PF00069	0.703
MOD_CK1_1	267	273	PF00069	0.490
MOD_CK1_1	38	44	PF00069	0.703
MOD_CK1_1	380	386	PF00069	0.662
MOD_CK1_1	394	400	PF00069	0.624
MOD_CK1_1	403	409	PF00069	0.644
MOD_CK1_1	411	417	PF00069	0.614
MOD_CK1_1	446	452	PF00069	0.794
MOD_CK1_1	468	474	PF00069	0.613
MOD_CK1_1	524	530	PF00069	0.595
MOD_CK1_1	557	563	PF00069	0.666
MOD_CK1_1	98	104	PF00069	0.708
MOD_GlcNHglycan	117	120	PF01048	0.604
MOD_GlcNHglycan	136	139	PF01048	0.562
MOD_GlcNHglycan	147	150	PF01048	0.593
MOD_GlcNHglycan	17	20	PF01048	0.605
MOD_GlcNHglycan	188	191	PF01048	0.718
MOD_GlcNHglycan	217	220	PF01048	0.299
MOD_GlcNHglycan	226	229	PF01048	0.303
MOD_GlcNHglycan	23	26	PF01048	0.668
MOD_GlcNHglycan	266	269	PF01048	0.302
MOD_GlcNHglycan	28	31	PF01048	0.536
MOD_GlcNHglycan	291	295	PF01048	0.492
MOD_GlcNHglycan	309	312	PF01048	0.609
MOD_GlcNHglycan	356	359	PF01048	0.696
MOD_GlcNHglycan	379	382	PF01048	0.665
MOD_GlcNHglycan	393	396	PF01048	0.538
MOD_GlcNHglycan	435	438	PF01048	0.762
MOD_GlcNHglycan	445	448	PF01048	0.611
MOD_GlcNHglycan	472	475	PF01048	0.665
MOD_GlcNHglycan	478	481	PF01048	0.597
MOD_GlcNHglycan	539	542	PF01048	0.678
MOD_GlcNHglycan	548	551	PF01048	0.591
MOD_GlcNHglycan	552	555	PF01048	0.606
MOD_GlcNHglycan	556	559	PF01048	0.593
MOD_GlcNHglycan	95	98	PF01048	0.665
MOD_GSK3_1	101	108	PF00069	0.605
MOD_GSK3_1	144	151	PF00069	0.598
MOD_GSK3_1	159	166	PF00069	0.640
MOD_GSK3_1	20	27	PF00069	0.702
MOD_GSK3_1	267	274	PF00069	0.475
MOD_GSK3_1	307	314	PF00069	0.609
MOD_GSK3_1	342	349	PF00069	0.570
MOD_GSK3_1	35	42	PF00069	0.689
MOD_GSK3_1	379	386	PF00069	0.587
MOD_GSK3_1	391	398	PF00069	0.779
MOD_GSK3_1	399	406	PF00069	0.653
MOD_GSK3_1	410	417	PF00069	0.674
MOD_GSK3_1	448	455	PF00069	0.647
MOD_GSK3_1	460	467	PF00069	0.659
MOD_GSK3_1	546	553	PF00069	0.762
MOD_GSK3_1	58	65	PF00069	0.575
MOD_GSK3_1	82	89	PF00069	0.662
MOD_GSK3_1	91	98	PF00069	0.622
MOD_N-GLC_1	151	156	PF02516	0.597
MOD_N-GLC_1	305	310	PF02516	0.645
MOD_N-GLC_1	383	388	PF02516	0.798
MOD_N-GLC_1	391	396	PF02516	0.714
MOD_N-GLC_1	411	416	PF02516	0.679
MOD_N-GLC_1	546	551	PF02516	0.558
MOD_N-GLC_1	575	580	PF02516	0.618
MOD_N-GLC_1	80	85	PF02516	0.684
MOD_N-GLC_1	98	103	PF02516	0.612
MOD_N-GLC_2	269	271	PF02516	0.382
MOD_NEK2_1	39	44	PF00069	0.617
MOD_NEK2_1	399	404	PF00069	0.606
MOD_NEK2_1	415	420	PF00069	0.595
MOD_NEK2_1	448	453	PF00069	0.715
MOD_NEK2_1	478	483	PF00069	0.660
MOD_NEK2_1	546	551	PF00069	0.577
MOD_NEK2_1	62	67	PF00069	0.630
MOD_NEK2_1	82	87	PF00069	0.460
MOD_NEK2_1	95	100	PF00069	0.643
MOD_NEK2_2	347	352	PF00069	0.599
MOD_NEK2_2	58	63	PF00069	0.626
MOD_PIKK_1	300	306	PF00454	0.592
MOD_PIKK_1	478	484	PF00454	0.618
MOD_PIKK_1	489	495	PF00454	0.627
MOD_PK_1	521	527	PF00069	0.628
MOD_PKA_2	163	169	PF00069	0.690
MOD_PKA_2	224	230	PF00069	0.475
MOD_PKB_1	305	313	PF00069	0.608
MOD_Plk_1	383	389	PF00069	0.565
MOD_Plk_1	411	417	PF00069	0.676
MOD_Plk_4	372	378	PF00069	0.623
MOD_Plk_4	403	409	PF00069	0.597
MOD_Plk_4	411	417	PF00069	0.600
MOD_Plk_4	49	55	PF00069	0.623
MOD_Plk_4	58	64	PF00069	0.523
MOD_ProDKin_1	108	114	PF00069	0.663
MOD_ProDKin_1	132	138	PF00069	0.570
MOD_ProDKin_1	24	30	PF00069	0.607
MOD_ProDKin_1	311	317	PF00069	0.614
MOD_ProDKin_1	337	343	PF00069	0.633
MOD_ProDKin_1	362	368	PF00069	0.558
MOD_ProDKin_1	401	407	PF00069	0.605
MOD_ProDKin_1	457	463	PF00069	0.660
MOD_ProDKin_1	89	95	PF00069	0.707
TRG_ENDOCYTIC_2	532	535	PF00928	0.623
TRG_ENDOCYTIC_2	63	66	PF00928	0.632
TRG_ER_diArg_1	287	289	PF00400	0.422
TRG_ER_FFAT_2	104	115	PF00635	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ5	Leptomonas seymouri	48%	90%
A0A3S7WXP3	Leishmania donovani	94%	100%
A4HCU2	Leishmania braziliensis	78%	99%
A4I0C3	Leishmania infantum	94%	100%
E9AW87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%