G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania major

UniProt:

Q4QB89_LEIMA

TriTrypDb:

LmjF.23.0740 , LMJLV39_230016000 , LMJSD75_230016300

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QB89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QB89

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.664
CLV_C14_Caspase3-7	356	360	PF00656	0.359
CLV_NRD_NRD_1	13	15	PF00675	0.498
CLV_NRD_NRD_1	261	263	PF00675	0.585
CLV_NRD_NRD_1	64	66	PF00675	0.546
CLV_NRD_NRD_1	67	69	PF00675	0.554
CLV_PCSK_KEX2_1	139	141	PF00082	0.741
CLV_PCSK_KEX2_1	261	263	PF00082	0.578
CLV_PCSK_KEX2_1	322	324	PF00082	0.344
CLV_PCSK_KEX2_1	64	66	PF00082	0.535
CLV_PCSK_KEX2_1	71	73	PF00082	0.559
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.779
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.336
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.557
CLV_PCSK_SKI1_1	110	114	PF00082	0.488
CLV_PCSK_SKI1_1	142	146	PF00082	0.617
CLV_PCSK_SKI1_1	319	323	PF00082	0.351
CLV_PCSK_SKI1_1	51	55	PF00082	0.493
CLV_PCSK_SKI1_1	68	72	PF00082	0.568
DEG_APCC_DBOX_1	50	58	PF00400	0.493
DEG_Nend_Nbox_1	1	3	PF02207	0.469
DEG_SCF_FBW7_1	127	134	PF00400	0.580
DEG_SPOP_SBC_1	35	39	PF00917	0.670
DOC_CKS1_1	195	200	PF01111	0.488
DOC_CKS1_1	232	237	PF01111	0.415
DOC_CYCLIN_yClb1_LxF_4	206	212	PF00134	0.440
DOC_MAPK_DCC_7	167	176	PF00069	0.554
DOC_MAPK_gen_1	379	388	PF00069	0.294
DOC_MAPK_MEF2A_6	167	176	PF00069	0.454
DOC_PP1_RVXF_1	70	77	PF00149	0.519
DOC_USP7_MATH_1	166	170	PF00917	0.593
DOC_USP7_MATH_1	294	298	PF00917	0.683
DOC_USP7_UBL2_3	145	149	PF12436	0.611
DOC_WW_Pin1_4	127	132	PF00397	0.703
DOC_WW_Pin1_4	157	162	PF00397	0.568
DOC_WW_Pin1_4	194	199	PF00397	0.530
DOC_WW_Pin1_4	231	236	PF00397	0.416
DOC_WW_Pin1_4	415	420	PF00397	0.515
LIG_14-3-3_CanoR_1	110	115	PF00244	0.533
LIG_14-3-3_CanoR_1	167	171	PF00244	0.575
LIG_14-3-3_CanoR_1	179	187	PF00244	0.400
LIG_14-3-3_CanoR_1	267	273	PF00244	0.680
LIG_14-3-3_CanoR_1	72	77	PF00244	0.580
LIG_Actin_WH2_2	188	205	PF00022	0.488
LIG_BIR_III_2	359	363	PF00653	0.412
LIG_BRCT_BRCA1_1	207	211	PF00533	0.453
LIG_eIF4E_1	338	344	PF01652	0.423
LIG_eIF4E_1	372	378	PF01652	0.438
LIG_FHA_1	204	210	PF00498	0.451
LIG_FHA_1	232	238	PF00498	0.423
LIG_FHA_1	308	314	PF00498	0.610
LIG_FHA_1	387	393	PF00498	0.358
LIG_FHA_1	84	90	PF00498	0.560
LIG_FHA_2	217	223	PF00498	0.480
LIG_FHA_2	354	360	PF00498	0.328
LIG_GBD_Chelix_1	187	195	PF00786	0.330
LIG_LIR_Apic_2	345	350	PF02991	0.462
LIG_LIR_Gen_1	337	347	PF02991	0.400
LIG_LIR_Gen_1	418	425	PF02991	0.500
LIG_LIR_Nem_3	197	202	PF02991	0.466
LIG_LIR_Nem_3	208	214	PF02991	0.391
LIG_LIR_Nem_3	337	343	PF02991	0.354
LIG_LIR_Nem_3	418	424	PF02991	0.495
LIG_LIR_Nem_3	56	61	PF02991	0.488
LIG_PCNA_yPIPBox_3	184	196	PF02747	0.439
LIG_PDZ_Class_1	420	425	PF00595	0.561
LIG_SH2_CRK	347	351	PF00017	0.394
LIG_SH2_NCK_1	212	216	PF00017	0.428
LIG_SH2_STAT5	249	252	PF00017	0.369
LIG_SH2_STAT5	340	343	PF00017	0.305
LIG_SH2_STAT5	372	375	PF00017	0.526
LIG_SH2_STAT5	58	61	PF00017	0.624
LIG_SH3_3	218	224	PF00018	0.428
LIG_SH3_3	269	275	PF00018	0.699
LIG_SUMO_SIM_par_1	118	123	PF11976	0.468
LIG_WRC_WIRS_1	404	409	PF05994	0.505
MOD_CDC14_SPxK_1	160	163	PF00782	0.573
MOD_CDK_SPxK_1	157	163	PF00069	0.577
MOD_CK1_1	182	188	PF00069	0.267
MOD_CK1_1	36	42	PF00069	0.669
MOD_CK2_1	294	300	PF00069	0.531
MOD_CK2_1	36	42	PF00069	0.669
MOD_CMANNOS	76	79	PF00535	0.527
MOD_Cter_Amidation	137	140	PF01082	0.737
MOD_Cter_Amidation	62	65	PF01082	0.495
MOD_GlcNHglycan	136	139	PF01048	0.729
MOD_GlcNHglycan	181	184	PF01048	0.304
MOD_GlcNHglycan	282	285	PF01048	0.728
MOD_GlcNHglycan	328	331	PF01048	0.416
MOD_GSK3_1	127	134	PF00069	0.689
MOD_GSK3_1	178	185	PF00069	0.267
MOD_GSK3_1	29	36	PF00069	0.642
MOD_GSK3_1	415	422	PF00069	0.520
MOD_LATS_1	201	207	PF00433	0.349
MOD_LATS_1	305	311	PF00433	0.708
MOD_N-GLC_1	83	88	PF02516	0.585
MOD_N-GLC_1	90	95	PF02516	0.556
MOD_NEK2_1	202	207	PF00069	0.295
MOD_NEK2_1	326	331	PF00069	0.442
MOD_NEK2_1	387	392	PF00069	0.347
MOD_NEK2_1	403	408	PF00069	0.363
MOD_NEK2_1	90	95	PF00069	0.555
MOD_PIKK_1	372	378	PF00454	0.497
MOD_PKA_2	166	172	PF00069	0.558
MOD_PKA_2	178	184	PF00069	0.242
MOD_PKA_2	202	208	PF00069	0.457
MOD_PKA_2	29	35	PF00069	0.620
MOD_PKA_2	367	373	PF00069	0.479
MOD_PKA_2	6	12	PF00069	0.566
MOD_Plk_1	419	425	PF00069	0.506
MOD_Plk_4	166	172	PF00069	0.540
MOD_Plk_4	183	189	PF00069	0.201
MOD_Plk_4	216	222	PF00069	0.339
MOD_ProDKin_1	127	133	PF00069	0.705
MOD_ProDKin_1	157	163	PF00069	0.569
MOD_ProDKin_1	194	200	PF00069	0.408
MOD_ProDKin_1	231	237	PF00069	0.417
MOD_ProDKin_1	415	421	PF00069	0.514
MOD_SUMO_rev_2	3	11	PF00179	0.619
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.632
TRG_ENDOCYTIC_2	199	202	PF00928	0.267
TRG_ENDOCYTIC_2	229	232	PF00928	0.385
TRG_ENDOCYTIC_2	340	343	PF00928	0.398
TRG_ENDOCYTIC_2	58	61	PF00928	0.482
TRG_ER_diArg_1	44	47	PF00400	0.543
TRG_ER_diArg_1	64	66	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I045	Leptomonas seymouri	64%	72%
A0A0S4IVC3	Bodo saltans	49%	94%
A0A1X0NWZ9	Trypanosomatidae	57%	89%
A0A422MX57	Trypanosoma rangeli	55%	90%
A4HCU4	Leishmania braziliensis	84%	81%
C9ZV46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	89%
E9AW89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5ARP5	Trypanosoma cruzi	56%	89%